LOCUS       NM_001009966            1751 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus protein kinase C and casein kinase substrate in
            neurons 3 (Pacsin3), mRNA.
ACCESSION   NM_001009966 XM_230279
VERSION     NM_001009966.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1751)
  AUTHORS   Milewska,M., Domoradzki,T., Majewska,A., Blaszczyk,M., Gajewska,M.,
            Hulanicka,M. and Grzelkowska-Kowalczyk,K.
  TITLE     Interleukin-6 affects pacsin3, ephrinA4 expression and cytoskeletal
            proteins in differentiating primary skeletal myoblasts through
            transcriptional and post-transcriptional mechanisms
  JOURNAL   Cell Tissue Res 380 (1), 155-172 (2020)
   PUBMED   31820147
  REMARK    GeneRIF: Interleukin-6 affects pacsin3, ephrinA4 expression and
            cytoskeletal proteins in differentiating primary skeletal myoblasts
            through transcriptional and post-transcriptional mechanisms.
REFERENCE   2  (bases 1 to 1751)
  AUTHORS   Bai,X., Meng,G., Luo,M. and Zheng,X.
  TITLE     Rigidity of wedge loop in PACSIN 3 protein is a key factor in
            dictating diameters of tubules
  JOURNAL   J Biol Chem 287 (26), 22387-22396 (2012)
   PUBMED   22573331
REFERENCE   3  (bases 1 to 1751)
  AUTHORS   Goh,S.L., Wang,Q., Byrnes,L.J. and Sondermann,H.
  TITLE     Versatile membrane deformation potential of activated pacsin
  JOURNAL   PLoS One 7 (12), e51628 (2012)
   PUBMED   23236520
REFERENCE   4  (bases 1 to 1751)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 1751)
  AUTHORS   D'hoedt,D., Owsianik,G., Prenen,J., Cuajungco,M.P., Grimm,C.,
            Heller,S., Voets,T. and Nilius,B.
  TITLE     Stimulus-specific modulation of the cation channel TRPV4 by PACSIN
            3
  JOURNAL   J Biol Chem 283 (10), 6272-6280 (2008)
   PUBMED   18174177
REFERENCE   6  (bases 1 to 1751)
  AUTHORS   Cuajungco,M.P., Grimm,C., Oshima,K., D'hoedt,D., Nilius,B.,
            Mensenkamp,A.R., Bindels,R.J., Plomann,M. and Heller,S.
  TITLE     PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the
            subcellular localization of TRPV4
  JOURNAL   J Biol Chem 281 (27), 18753-18762 (2006)
   PUBMED   16627472
REFERENCE   7  (bases 1 to 1751)
  AUTHORS   Tanaka,M., Nanba,D., Mori,S., Shiba,F., Ishiguro,H., Yoshino,K.,
            Matsuura,N. and Higashiyama,S.
  TITLE     ADAM binding protein Eve-1 is required for ectodomain shedding of
            epidermal growth factor receptor ligands
  JOURNAL   J Biol Chem 279 (40), 41950-41959 (2004)
   PUBMED   15280379
REFERENCE   8  (bases 1 to 1751)
  AUTHORS   Modregger,J., Ritter,B., Witter,B., Paulsson,M. and Plomann,M.
  TITLE     All three PACSIN isoforms bind to endocytic proteins and inhibit
            endocytosis
  JOURNAL   J Cell Sci 113 Pt 24, 4511-4521 (2000)
   PUBMED   11082044
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001009966.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100636.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                JAXUCZ010000003.1  97683054-97683103
            51-141              JAXUCZ010000003.1  97686860-97686950
            142-298             JAXUCZ010000003.1  97687093-97687249
            299-534             JAXUCZ010000003.1  97687852-97688087
            535-690             JAXUCZ010000003.1  97688188-97688343
            691-866             JAXUCZ010000003.1  97689710-97689885
            867-987             JAXUCZ010000003.1  97689989-97690109
            988-1124            JAXUCZ010000003.1  97690218-97690354
            1125-1246           JAXUCZ010000003.1  97690701-97690822
            1247-1751           JAXUCZ010000003.1  97691115-97691619
FEATURES             Location/Qualifiers
     source          1..1751
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     gene            1..1751
                     /gene="Pacsin3"
                     /gene_synonym="SdpIII"
                     /note="protein kinase C and casein kinase substrate in
                     neurons 3"
                     /db_xref="GeneID:311187"
                     /db_xref="RGD:1307327"
     exon            1..50
                     /gene="Pacsin3"
                     /gene_synonym="SdpIII"
                     /inference="alignment:Splign:2.1.0"
     exon            51..141
                     /gene="Pacsin3"
                     /gene_synonym="SdpIII"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1362
                     /gene="Pacsin3"
                     /gene_synonym="SdpIII"
                     /note="syndapin III; protein kinase C and casein kinase II
                     substrate protein 3"
                     /codon_start=1
                     /product="protein kinase C and casein kinase substrate in
                     neurons protein 3"
                     /protein_id="NP_001009966.2"
                     /db_xref="GeneID:311187"
                     /db_xref="RGD:1307327"
                     /translation="MAPEEDAGGEVLGGSFWEAGNYRRTVQRVEDGHRLCGDLISCFQ
                     ERARIEKAYAQQLADWARKWRGAVEKGPQYGTLEKAWHAFFTAAERLSELHLEVREKL
                     HGPDSERVRTWQRGAFHRPVLGGFRESRAAEDGFRKAQKPWLKRLKEVEASKKSYHTA
                     RKDEKTAQTRESHAKADSSMSQEQLRKLQERVGRCTKEAEKMKTQYEQTLAELNRYTP
                     RYMEDMEQAFESCQAAERQRLLFFKDVLLTLHQHLDLSSSDKFHELHRDLQRGIEDAS
                     DEEDLRWWRSTHGPGMAMNWPQFEEWSLDTQRAISRKEKGGRSPDEVTLTSIVPTRDG
                     TAPPPQSPSSPGSGQDEDWSDEESPRKAGTGVRVRALYDYAGQEADELSFRAGEELLK
                     MSEEDEQGWCQGQLQSGRIGLYPANYVECVGA"
     exon            142..298
                     /gene="Pacsin3"
                     /gene_synonym="SdpIII"
                     /inference="alignment:Splign:2.1.0"
     exon            299..534
                     /gene="Pacsin3"
                     /gene_synonym="SdpIII"
                     /inference="alignment:Splign:2.1.0"
     exon            535..690
                     /gene="Pacsin3"
                     /gene_synonym="SdpIII"
                     /inference="alignment:Splign:2.1.0"
     exon            691..866
                     /gene="Pacsin3"
                     /gene_synonym="SdpIII"
                     /inference="alignment:Splign:2.1.0"
     exon            867..987
                     /gene="Pacsin3"
                     /gene_synonym="SdpIII"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1124
                     /gene="Pacsin3"
                     /gene_synonym="SdpIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1246
                     /gene="Pacsin3"
                     /gene_synonym="SdpIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1751
                     /gene="Pacsin3"
                     /gene_synonym="SdpIII"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgagcgtgac cagattcccc taacccactg aaggcccctg agaggacacg caccacagct
       61 gccaccattc cgtgctgcag ggataccatg gctccagaag aggatgctgg aggggaggtc
      121 ctagggggca gtttctggga ggctggcaac tacagacgga cggtgcagag ggttgaggat
      181 gggcacaggc tgtgtgggga cctgattagt tgcttccaag aacgcgcccg aattgagaag
      241 gcctatgccc agcagctggc tgactgggcc cgcaagtgga ggggtgccgt cgagaagggc
      301 ccacaatatg gcactctgga gaaggcctgg cacgccttct tcactgcggc tgagcggctg
      361 agcgagctgc acttggaagt gagggagaag ttgcatggtc cagacagcga gcgagtgcgg
      421 acttggcagc gcggggcttt ccaccggcca gtgctggggg gctttcggga aagccgggct
      481 gcagaggatg gtttccgtaa ggcccagaag ccctggctaa aaaggctgaa ggaggttgag
      541 gcgtctaaga agagctacca cacagcccgc aaggacgaga agacagccca gacccgggag
      601 agccacgcga aggccgacag ctccatgtcc caggagcagc ttcgaaagtt acaggagcgg
      661 gtgggacgct gcaccaagga ggcagagaag atgaaaaccc agtatgagca gaccctggca
      721 gagctaaatc gctatacccc acgctacatg gaggacatgg agcaggcctt cgagagctgc
      781 caggctgctg agcgccagcg acttctcttc ttcaaggatg tgttgctcac cttgcatcaa
      841 cacctcgacc tctccagtag tgacaagttc catgagctcc atcgagacct gcagcggggc
      901 atcgaggatg ccagcgatga agaagacctg cgctggtggc gcagcacaca tgggcctggc
      961 atggccatga actggccaca gtttgaggaa tggtccttag acacacagag agccatcagc
     1021 cggaaggaga agggtggccg gagcccagat gaggttactc tgaccagcat tgtacctaca
     1081 agagatggca ccgcaccccc accccagtcc ccatcatccc caggtagtgg gcaggacgag
     1141 gactggtcag atgaggagag tccccggaaa gctggcactg gggtgagggt acgggcactt
     1201 tatgactatg ctggccagga agccgatgag ctgagcttca gagcagggga agagctgctg
     1261 aagatgagtg aggaggatga gcagggctgg tgccagggcc agctgcagag tggccgcatt
     1321 ggtctgtacc ctgccaatta tgtagaatgt gtgggtgcct gagtgccctg acagccctgt
     1381 gaaatggcca gagctcaacc cttcctggac tgctggacct gaaagccctg aaccatatgc
     1441 tgctgctgtc cctctgttcc cacaggagga agtcttaggg cccatgatgg gaagggggtc
     1501 tgggtttaga aagaggacaa cagtttaggt tgagggcagg atgggagatt ggagtgacag
     1561 agggttgaga agggcctgaa cctcccaggg agcatttggg tcatcccaca agtaggggga
     1621 tccagttcct aaactgttta ggagttcctg gtgtgaggtt ggggagaatg tagtttgggg
     1681 ctagcagcac cctcttttgt gacttcttgt agtgtgtatt aaatttgatc aagaataaaa
     1741 actccatcaa g
//
