LOCUS       NM_130740               3200 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus protein kinase C and casein kinase substrate in
            neurons 2 (Pacsin2), mRNA.
ACCESSION   NM_130740
VERSION     NM_130740.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3200)
  AUTHORS   Bouslama,R., Dumont,V., Lindfors,S., Paavolainen,L., Tienari,J.,
            Nisen,H., Mirtti,T., Saleem,M.A., Gordin,D., Groop,P.H.,
            Suetsugu,S. and Lehtonen,S.
  TITLE     Phosphorylation of PACSIN2 at S313 Regulates Podocyte Architecture
            in Coordination with N-WASP
  JOURNAL   Cells 12 (11), 1487 (2023)
   PUBMED   37296607
  REMARK    GeneRIF: Phosphorylation of PACSIN2 at S313 Regulates Podocyte
            Architecture in Coordination with N-WASP.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3200)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3200)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3200)
  AUTHORS   Anggono,V., Koc-Schmitz,Y., Widagdo,J., Kormann,J., Quan,A.,
            Chen,C.M., Robinson,P.J., Choi,S.Y., Linden,D.J., Plomann,M. and
            Huganir,R.L.
  TITLE     PICK1 interacts with PACSIN to regulate AMPA receptor
            internalization and cerebellar long-term depression
  JOURNAL   Proc Natl Acad Sci U S A 110 (34), 13976-13981 (2013)
   PUBMED   23918399
REFERENCE   5  (bases 1 to 3200)
  AUTHORS   Ludwig,A., Howard,G., Mendoza-Topaz,C., Deerinck,T., Mackey,M.,
            Sandin,S., Ellisman,M.H. and Nichols,B.J.
  TITLE     Molecular composition and ultrastructure of the caveolar coat
            complex
  JOURNAL   PLoS Biol 11 (8), e1001640 (2013)
   PUBMED   24013648
REFERENCE   6  (bases 1 to 3200)
  AUTHORS   Xu,Y., Shi,H., Wei,S., Wong,S.H. and Hong,W.
  TITLE     Mutually exclusive interactions of EHD1 with GS32 and syndapin II
  JOURNAL   Mol Membr Biol 21 (4), 269-277 (2004)
   PUBMED   15371016
  REMARK    GeneRIF: EHD1 may regulate/participate in the functional pathways
            of both GS32 and syndapin II in a mutual exclusive manner
REFERENCE   7  (bases 1 to 3200)
  AUTHORS   Kessels,M.M. and Qualmann,B.
  TITLE     Syndapins integrate N-WASP in receptor-mediated endocytosis
  JOURNAL   EMBO J 21 (22), 6083-6094 (2002)
   PUBMED   12426380
  REMARK    GeneRIF: Syndapins may coordinate N-WASP and dynamin functions
            during receptor-mediated endocytosis. Local actin polymerization
            induced by syndapin-N-WASP interactions may support clathrin-coated
            vesicle detachment and movement away from the plasma membrane.
REFERENCE   8  (bases 1 to 3200)
  AUTHORS   Modregger,J., Ritter,B., Witter,B., Paulsson,M. and Plomann,M.
  TITLE     All three PACSIN isoforms bind to endocytic proteins and inhibit
            endocytosis
  JOURNAL   J Cell Sci 113 Pt 24, 4511-4521 (2000)
   PUBMED   11082044
REFERENCE   9  (bases 1 to 3200)
  AUTHORS   Qualmann,B. and Kelly,R.B.
  TITLE     Syndapin isoforms participate in receptor-mediated endocytosis and
            actin organization
  JOURNAL   J Cell Biol 148 (5), 1047-1062 (2000)
   PUBMED   10704453
REFERENCE   10 (bases 1 to 3200)
  AUTHORS   Ritter,B., Modregger,J., Paulsson,M. and Plomann,M.
  TITLE     PACSIN 2, a novel member of the PACSIN family of cytoplasmic
            adapter proteins
  JOURNAL   FEBS Lett 454 (3), 356-362 (1999)
   PUBMED   10431838
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC070911.1.
            
            On Oct 4, 2005 this sequence version replaced NM_130740.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070911.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760476, SAMN16676806
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3200
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..3200
                     /gene="Pacsin2"
                     /gene_synonym="SdpII"
                     /note="protein kinase C and casein kinase substrate in
                     neurons 2"
                     /db_xref="GeneID:124461"
                     /db_xref="RGD:69411"
     exon            1..148
                     /gene="Pacsin2"
                     /gene_synonym="SdpII"
                     /inference="alignment:Splign:2.1.0"
     exon            149..281
                     /gene="Pacsin2"
                     /gene_synonym="SdpII"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..1682
                     /gene="Pacsin2"
                     /gene_synonym="SdpII"
                     /note="syndapin-II; synaptic dynamin-associated protein
                     II; SdpIIsyndapin II; syndapin-2"
                     /codon_start=1
                     /product="protein kinase C and casein kinase substrate in
                     neurons 2 protein"
                     /protein_id="NP_570096.2"
                     /db_xref="GeneID:124461"
                     /db_xref="RGD:69411"
                     /translation="MSVTYDDSVGVEVSSDSFWEVGNYKRTVKRIDDGHRLCGDLMNC
                     LHERARIEKAYAQQLTEWARRWRQLVEKGPQYGTVEKAWMAVMSEAERVSELHLEVKA
                     SLMNEDFEKIKNWQKEAFHKQMMGGFKETKEAEDGFRKAQKPWAKKLKEVDAAKKAHH
                     TACKEEKLAVSREANSKADPSLNPEQLKKLQDKIEKCKQDVLKTKDKYEKALKELDQT
                     TPQYMENMEQVFEQCQQFEEKRLRFFREVLLEVQKHLDLSNVASYKGIYRELEQSIKA
                     ADAVEDLRWFRANHGPGMAMNWPQFEEWSADLNRTLSRREKKKAADGVTLTGINQTGD
                     QSGQNKPSSNLSVPSNPAQSTQLQSSYNPFEDEDDTGSSVSEKEDIKAKNVSSYEKTQ
                     NYPADWSDDESNNPFSSTDANGDSNPFDEDTTSGTEVRVRALYDYEGQEHDELSFKAG
                     DELTKIEDEDEQGWCKGRLDSGQVGLYPANYVEAIQ"
     exon            282..438
                     /gene="Pacsin2"
                     /gene_synonym="SdpII"
                     /inference="alignment:Splign:2.1.0"
     exon            439..674
                     /gene="Pacsin2"
                     /gene_synonym="SdpII"
                     /inference="alignment:Splign:2.1.0"
     exon            675..830
                     /gene="Pacsin2"
                     /gene_synonym="SdpII"
                     /inference="alignment:Splign:2.1.0"
     exon            831..1006
                     /gene="Pacsin2"
                     /gene_synonym="SdpII"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1127
                     /gene="Pacsin2"
                     /gene_synonym="SdpII"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1249
                     /gene="Pacsin2"
                     /gene_synonym="SdpII"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1372
                     /gene="Pacsin2"
                     /gene_synonym="SdpII"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1569
                     /gene="Pacsin2"
                     /gene_synonym="SdpII"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..3174
                     /gene="Pacsin2"
                     /gene_synonym="SdpII"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caggtactga gcagatctgc aaagttaggc tgctgcagcc agcgcttgac agagaaacgt
       61 gagtgtactt taaggtagac ctgtctgaaa ggagaatttc tgcactttcg ttttttcttg
      121 ttcgcgtgat tgccagcctt ctcaccttgt ctgtctacag gttttgagca tctgatccct
      181 gaactggagt gtctgctgcc gcccccttat tctctgcaga gatgtctgtc acctacgatg
      241 attctgtggg agtggaagtg tccagcgaca gcttctggga ggtcgggaac tacaaacgga
      301 ctgtgaagcg gattgatgat ggccaccgcc tgtgtggtga cctcatgaac tgtttgcacg
      361 agcgggcacg tatcgagaag gcatatgcac agcagctcac tgagtgggcc cgacgctgga
      421 gacagcttgt agagaaggga ccacagtatg ggaccgtgga gaaggcctgg atggctgtca
      481 tgtctgaggc agagagagtg agcgagctac acctggaagt gaaggcatca ctgatgaacg
      541 aagactttga gaagatcaag aactggcaga aggaagcctt tcacaagcag atgatgggag
      601 gcttcaagga gaccaaggaa gcagaggatg gctttcggaa ggcccagaag ccctgggcca
      661 agaagctgaa agaggtggat gcggcaaaga aagcacacca cacagcgtgc aaagaggaga
      721 agctggccgt ctcccgggaa gccaacagca aagcagatcc atccctcaac cctgagcagc
      781 tgaagaaatt gcaagacaag atagaaaagt gcaagcagga cgttctaaag accaaggaca
      841 agtatgagaa ggccctgaag gagcttgacc agactacacc gcagtacatg gagaacatgg
      901 agcaggtgtt cgagcagtgc cagcagtttg aagagaagcg cctgcgcttc ttccgagagg
      961 ttctgctgga ggttcagaag cacttggacc tgtccaatgt ggctagctac aaaggcattt
     1021 accgggagct ggagcagagc atcaaagcag ctgatgctgt ggaggacctg aggtggttcc
     1081 gagctaacca tgggccaggc atggctatga actggccaca gtttgaggag tggtctgcag
     1141 atctgaatcg aactctcagc cgaagagaga agaagaaggc tgctgatggt gtcaccctaa
     1201 caggaatcaa ccagacaggt gaccagtctg gacagaacaa gcctagcagc aaccttagtg
     1261 tcccgagcaa ccccgcccag tccacgcagt tacagtccag ctacaacccc ttcgaggacg
     1321 aggacgacac gggcagcagc gtcagtgaga aggaggacat taaggccaaa aatgtcagca
     1381 gctatgagaa gactcagaat taccccgctg actggtctga tgatgagtct aacaaccctt
     1441 tctcctccac ggatgccaat ggggactcta acccgtttga cgaggacact acctcaggaa
     1501 cagaagtgcg agttcgagcc ctctatgact atgagggaca agaacacgat gagctgagct
     1561 tcaaggctgg ggatgagctg accaagatag aggatgaaga tgaacagggt tggtgcaagg
     1621 gacgtttaga cagtggccag gttggcctat acccagccaa ctatgtcgag gctatccagt
     1681 gacagtccat gggcaggctg gcggagagat ggacacgggc agttcaggag ctccgttagc
     1741 cttgacctgg gcagtgacac ctctagtgcc ccagcagcca tgtaggcatc cactccccct
     1801 gcaaaagacg atggctctgc tgtccttggc ttcctggtgt gctgtgaagg cagatgagct
     1861 ggtgatctca ctgcacactt ggcccctttc caagcacatc tgggcagatc tgggcacagg
     1921 aagatacggt ccaacagcga gccaggtccc tcccaccctc cagctctcta tcatggatct
     1981 gcaccttctt gcccttctct ctcctgagtc aatgacggat catactgatt ctggttccat
     2041 tgattatttt ctctgatgag gccctacctg caagttcagt gaacatttct tacgtgccat
     2101 ttctgagtaa agagtttgag gttttaattt aaaggcaatg tacagttata cttttttata
     2161 tgctcttcca gtcagttaaa ttatggccta cactgatctg agatgttctt ctccacgtga
     2221 gctgtcttca tttctctgtg ctgtgtccag attggggttg ctacagcagg ggttcactgg
     2281 caagtgccag ttgcaggagt aacctgtgca atgtccccaa cacttccata tttagaaagt
     2341 attttcactc tatccatgct tcagtttttg cagattaaca gttttattag tgatttggaa
     2401 agttaacagt gagaagacta acttttcaca acagctgcct ctgtagactg aggtgcttta
     2461 cattagaccg tcgtgtctcc tgtatgtctg tatatattat ttgatactga gagtctctag
     2521 agttcaccct ctgctgaatg agagctggtg gcttctgata gcagatcctg ccaactgctt
     2581 gaagcccacg acattgaagt ccaggcatgg ctggctaaca gccccaccca gttaagatgt
     2641 ggctctaacc tcagagtgga gatactgggg agactgattc cactggtcag ggcccaagct
     2701 ttgtgacagc actggaaaag ctcctaggat tttgtagtag tcacaggctt cacagtccct
     2761 gtgtcactca ctggagagtt ggaggggttc aactcccccc cccccccgaa acacacacac
     2821 acacacacac acacacacac acacacacac acacacacac acacgtgttc ctccaattgc
     2881 cctgtcctca ggtgcagtgg gactgttatg agccccaggg atgggcacaa agaggacttt
     2941 tattttgtta gctcggacag tgtgcaatgg tgcacatcac aacttgtgtt tcttcagtgt
     3001 ttggcacgag cgctgttttg ctgtggctgt gtcatgagaa cttaccagca gaaatccttg
     3061 ttcctaagct acagaatgac caaacgctgt caagaactta atgtttggaa actcctttaa
     3121 atgtatagta ttttagaaca acaacaacaa aactcaataa acagttgatc tgtgaaaaaa
     3181 aaaaaaaaaa aaaaaaaaaa
//
