LOCUS       NM_017294               1597 bp    mRNA    linear   ROD 12-DEC-2024
DEFINITION  Rattus norvegicus protein kinase C and casein kinase substrate in
            neurons 1 (Pacsin1), mRNA.
ACCESSION   NM_017294 XM_001078122
VERSION     NM_017294.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1597)
  AUTHORS   Regan,P., Mitchell,S.J., Kim,S.C., Lee,Y., Yi,J.H., Barbati,S.A.,
            Shaw,C. and Cho,K.
  TITLE     Regulation of Synapse Weakening through Interactions of the
            Microtubule Associated Protein Tau with PACSIN1
  JOURNAL   J Neurosci 41 (34), 7162-7170 (2021)
   PUBMED   34290082
  REMARK    GeneRIF: Regulation of Synapse Weakening through Interactions of
            the Microtubule Associated Protein Tau with PACSIN1.
REFERENCE   2  (bases 1 to 1597)
  AUTHORS   Widagdo,J., Fang,H., Jang,S.E. and Anggono,V.
  TITLE     PACSIN1 regulates the dynamics of AMPA receptor trafficking
  JOURNAL   Sci Rep 6, 31070 (2016)
   PUBMED   27488904
  REMARK    GeneRIF: PACSIN1 is a versatile membrane deformation protein that
            links the endocytic and recycling machineries essential for dynamic
            AMPA receptor trafficking in neurons.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1597)
  AUTHORS   Hou,W., Izadi,M., Nemitz,S., Haag,N., Kessels,M.M. and Qualmann,B.
  TITLE     The Actin Nucleator Cobl Is Controlled by Calcium and Calmodulin
  JOURNAL   PLoS Biol 13 (9), e1002233 (2015)
   PUBMED   26334624
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1597)
  AUTHORS   Wilhelm,B.G., Mandad,S., Truckenbrodt,S., Krohnert,K., Schafer,C.,
            Rammner,B., Koo,S.J., Classen,G.A., Krauss,M., Haucke,V., Urlaub,H.
            and Rizzoli,S.O.
  TITLE     Composition of isolated synaptic boutons reveals the amounts of
            vesicle trafficking proteins
  JOURNAL   Science 344 (6187), 1023-1028 (2014)
   PUBMED   24876496
REFERENCE   5  (bases 1 to 1597)
  AUTHORS   Del Pino,I., Koch,D., Schemm,R., Qualmann,B., Betz,H. and
            Paarmann,I.
  TITLE     Proteomic analysis of glycine receptor beta subunit
            (GlyRbeta)-interacting proteins: evidence for syndapin I regulating
            synaptic glycine receptors
  JOURNAL   J Biol Chem 289 (16), 11396-11409 (2014)
   PUBMED   24509844
  REMARK    GeneRIF: The SdpI-binding site was mapped to a proline-rich
            sequence of 22 amino acids within the intracellular loop of
            GlyRbeta.
REFERENCE   6  (bases 1 to 1597)
  AUTHORS   Wasiak,S., Quinn,C.C., Ritter,B., de Heuvel,E., Baranes,D.,
            Plomann,M. and McPherson,P.S.
  TITLE     The Ras/Rac guanine nucleotide exchange factor mammalian
            Son-of-sevenless interacts with PACSIN 1/syndapin I, a regulator of
            endocytosis and the actin cytoskeleton
  JOURNAL   J Biol Chem 276 (28), 26622-26628 (2001)
   PUBMED   11352907
REFERENCE   7  (bases 1 to 1597)
  AUTHORS   Zucconi,A., Dente,L., Santonico,E., Castagnoli,L. and Cesareni,G.
  TITLE     Selection of ligands by panning of domain libraries displayed on
            phage lambda reveals new potential partners of synaptojanin 1
  JOURNAL   J Mol Biol 307 (5), 1329-1339 (2001)
   PUBMED   11292345
REFERENCE   8  (bases 1 to 1597)
  AUTHORS   Modregger,J., Ritter,B., Witter,B., Paulsson,M. and Plomann,M.
  TITLE     All three PACSIN isoforms bind to endocytic proteins and inhibit
            endocytosis
  JOURNAL   J Cell Sci 113 Pt 24, 4511-4521 (2000)
   PUBMED   11082044
REFERENCE   9  (bases 1 to 1597)
  AUTHORS   Qualmann,B., Roos,J., DiGregorio,P.J. and Kelly,R.B.
  TITLE     Syndapin I, a synaptic dynamin-binding protein that associates with
            the neural Wiskott-Aldrich syndrome protein
  JOURNAL   Mol Biol Cell 10 (2), 501-513 (1999)
   PUBMED   9950691
REFERENCE   10 (bases 1 to 1597)
  AUTHORS   Plomann,M., Lange,R., Vopper,G., Cremer,H., Heinlein,U.A.,
            Scheff,S., Baldwin,S.A., Leitges,M., Cramer,M., Paulsson,M. and
            Barthels,D.
  TITLE     PACSIN, a brain protein that is upregulated upon differentiation
            into neuronal cells
  JOURNAL   Eur J Biochem 256 (1), 201-211 (1998)
   PUBMED   9746365
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF104402.1.
            
            On Jun 25, 2006 this sequence version replaced XM_001078122.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF104402.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1597
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1597
                     /gene="Pacsin1"
                     /note="protein kinase C and casein kinase substrate in
                     neurons 1"
                     /db_xref="GeneID:29704"
                     /db_xref="RGD:3247"
     exon            1..97
                     /gene="Pacsin1"
                     /inference="alignment:Splign:2.1.0"
     exon            98..209
                     /gene="Pacsin1"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..1481
                     /gene="Pacsin1"
                     /note="synaptic dynamin-binding protein; sdpI; syndapin-I;
                     dynamin PRD-interacting protein; synaptic,
                     dynamin-associated protein I; dynamin proline-rich
                     domain-interacting protein; syndapin-1"
                     /codon_start=1
                     /product="protein kinase C and casein kinase substrate in
                     neurons protein 1"
                     /protein_id="NP_058990.1"
                     /db_xref="GeneID:29704"
                     /db_xref="RGD:3247"
                     /translation="MSGPYDEASEEITDSFWEVGNYKRTVKRIDDGHRLCNDLMSCVQ
                     ERAKIEKAYAQQLTDWAKRWRQLIEKGPQYGSLERAWGAMMTEADKVSELHQEVKNSL
                     LNEDLEKVKNWQKDAYHKQIMGGFKETKEAEDGFRKAQKPWAKKMKELEAAKKAYHLA
                     CKEEKLAMTREMNSKTEQSVTPEQQKKLVDKVDKCRQDVQKTQEKYEKVLEDVGKTTP
                     QYMEGMEQVFEQCQQFEEKRLVFLKEVLLDIKRHLNLAENSSYIHVYRELEQAIRGAD
                     AQEDLRWFRSTSGPGMPMNWPQFEEWNPDLPHTAAKKEKQPKKAEGAALSNATGAVES
                     TSQAGDRGSVSSYDRGQAYATEWSDDESGNPFGGNEANGGANPFEDDAKGVRVRALYD
                     YDGQEQDELSFKAGDELTKLGEEDEQGWCRGRLDSGQLGLYPANYVEAI"
     exon            210..366
                     /gene="Pacsin1"
                     /inference="alignment:Splign:2.1.0"
     exon            367..602
                     /gene="Pacsin1"
                     /inference="alignment:Splign:2.1.0"
     exon            603..758
                     /gene="Pacsin1"
                     /inference="alignment:Splign:2.1.0"
     exon            759..934
                     /gene="Pacsin1"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1055
                     /gene="Pacsin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1183
                     /gene="Pacsin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1371
                     /gene="Pacsin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1597
                     /gene="Pacsin1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgggaagcc atccgggctt gaggctgggc cgccgccgcc gccgccgccc actttgctac
       61 ccgccccgcc gatggtgtcc ggtgctccgg cacccagcct gtgagcagcg agctaactgc
      121 agatccacgc ctgcccagct ccctacagtt gcgccatgtc tggcccctac gatgaggcct
      181 cggaggagat cacagatagc ttctgggagg tggggaacta caagcggacg gtgaagcgca
      241 tcgacgatgg gcaccgcttg tgcaacgacc tcatgagctg cgtgcaggag cgcgccaaga
      301 tcgagaaggc atacgcgcag cagctcaccg actgggccaa gcgctggcgc cagctcatcg
      361 agaaaggtcc ccagtatggc agcctggagc gggcctgggg cgccatgatg actgaggcag
      421 acaaagtcag cgagctgcac caggaggtga agaacagcct actgaacgag gacctggaga
      481 aagtcaagaa ctggcagaag gatgcctacc acaagcagat catgggcggc ttcaaggaga
      541 cgaaggaggc ggaggatggc ttccgaaagg ctcagaagcc ctgggctaag aagatgaagg
      601 agctggaggc agccaagaag gcctatcact tggcttgcaa ggaggagaag ttggccatga
      661 cccgggagat gaacagtaag acggagcagt cggtcacccc tgaacagcag aagaaacttg
      721 tggataaagt ggacaaatgc aggcaggatg tacaaaagac tcaggagaag tatgagaagg
      781 tgctggaaga tgtgggcaag accacaccgc agtacatgga gggtatggag caggtgttcg
      841 agcagtgcca gcagtttgag gagaagcggc tggtcttcct gaaggaagtc ctgctagata
      901 tcaaacggca tctcaaccta gcggagaaca gcagctacat tcacgtctat cgagaactgg
      961 agcaggccat ccgaggggcc gatgcccagg aggacctcag gtggttccgt agcaccagtg
     1021 gccccgggat gcccatgaac tggccgcagt tcgaggagtg gaacccagac ctcccccaca
     1081 ccgctgccaa gaaggagaaa cagcctaaga aggcagaggg ggccgccctg agcaatgcca
     1141 ctggggctgt agaatctaca tcccaggctg gggaccgtgg cagtgtcagc agctatgacc
     1201 gaggccaagc gtatgccacc gagtggtcag acgatgagag cggaaacccc tttgggggga
     1261 acgaggccaa tggtggcgcc aaccccttcg aggacgatgc caagggagtt cgtgtacggg
     1321 cactctatga ctacgacggt caggagcagg atgagctcag cttcaaggcc ggagacgagc
     1381 tcaccaagct cggagaggag gacgaacagg gttggtgccg cgggcggctg gacagcgggc
     1441 agctgggcct ctatcctgcc aactacgttg aggctatata gctactttgc ccacccgcct
     1501 cctctcactc cttgtccacc gccttctgcc cttcccctcc cctcgccata gagttccaga
     1561 catattttcc gatcaagctt ttattttttt aaaagtc
//
