LOCUS       NM_001007679            1419 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus proton activated chloride channel 1 (Pacc1),
            mRNA.
ACCESSION   NM_001007679 XM_223071
VERSION     NM_001007679.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1419)
  AUTHORS   Ullrich,F., Blin,S., Lazarow,K., Daubitz,T., von Kries,J.P. and
            Jentsch,T.J.
  TITLE     Identification of TMEM206 proteins as pore of PAORAC/ASOR
            acid-sensitive chloride channels
  JOURNAL   Elife 8, e49187 (2019)
   PUBMED   31318332
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1419)
  AUTHORS   Yang,J., Chen,J., Del Carmen Vitery,M., Osei-Owusu,J., Chu,J.,
            Yu,H., Sun,S. and Qiu,Z.
  TITLE     PAC, an evolutionarily conserved membrane protein, is a
            proton-activated chloride channel
  JOURNAL   Science 364 (6438), 395-399 (2019)
   PUBMED   31023925
REFERENCE   3  (bases 1 to 1419)
  AUTHORS   Teckchandani,A., Toida,N., Goodchild,J., Henderson,C., Watts,J.,
            Wollscheid,B. and Cooper,J.A.
  TITLE     Quantitative proteomics identifies a Dab2/integrin module
            regulating cell migration
  JOURNAL   J Cell Biol 186 (1), 99-111 (2009)
   PUBMED   19581412
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC082061.1.
            
            On Nov 29, 2004 this sequence version replaced XM_223071.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082061.1, FQ228821.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1419
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q27"
     gene            1..1419
                     /gene="Pacc1"
                     /gene_synonym="PAC; RGD1359339; Tmem206"
                     /note="proton activated chloride channel 1"
                     /db_xref="GeneID:305070"
                     /db_xref="RGD:1359339"
     exon            1..103
                     /gene="Pacc1"
                     /gene_synonym="PAC; RGD1359339; Tmem206"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..1120
                     /gene="Pacc1"
                     /gene_synonym="PAC; RGD1359339; Tmem206"
                     /note="transmembrane protein 206"
                     /codon_start=1
                     /product="proton-activated chloride channel"
                     /protein_id="NP_001007680.1"
                     /db_xref="GeneID:305070"
                     /db_xref="RGD:1359339"
                     /translation="MIRQDLSTSYQELSEELEQVVENSEQADERDKELVQVQGPGVVP
                     GVDNESASSSIRFSKACLKNVFSVLLILIYLLLMAVAVFLVYQTITDFREKLKHPVMS
                     VSYKEVDRYDAPGIALYPGQAQLLSCKHHYEVIPPLASPGQPGDRNCTTQRINYTHPF
                     SNHTMQSALIVQGPQEVKKRELVFLQFRLNQSDEDFSAIDYLLFSSFREFMQSPDKAG
                     FMQACESAYSSWKFSGGFRTWVKMSLVKTKEEDGREAVEFRQETSVVNYIDQRPAAEK
                     STQLFFVVFEWKDPFIQKVQDIITANPWNTIALLCGAFLALFKAAEFAKLSVKWMIKI
                     RKRYLKRRGQATNHIS"
     exon            104..200
                     /gene="Pacc1"
                     /gene_synonym="PAC; RGD1359339; Tmem206"
                     /inference="alignment:Splign:2.1.0"
     exon            201..410
                     /gene="Pacc1"
                     /gene_synonym="PAC; RGD1359339; Tmem206"
                     /inference="alignment:Splign:2.1.0"
     exon            411..562
                     /gene="Pacc1"
                     /gene_synonym="PAC; RGD1359339; Tmem206"
                     /inference="alignment:Splign:2.1.0"
     exon            563..705
                     /gene="Pacc1"
                     /gene_synonym="PAC; RGD1359339; Tmem206"
                     /inference="alignment:Splign:2.1.0"
     exon            706..850
                     /gene="Pacc1"
                     /gene_synonym="PAC; RGD1359339; Tmem206"
                     /inference="alignment:Splign:2.1.0"
     exon            851..958
                     /gene="Pacc1"
                     /gene_synonym="PAC; RGD1359339; Tmem206"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1396
                     /gene="Pacc1"
                     /gene_synonym="PAC; RGD1359339; Tmem206"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtagacctc ggagctccta cctcccgcag cgtcgcggtc cctagtgagc cgcagccggc
       61 cagtgccatg atccgacaag acctctccac atcctaccag gagctcagtg aagagttgga
      121 gcaggtggtt gagaactcgg agcaggcaga tgaacgggac aaggagctgg tccaagttca
      181 aggtccaggt gttgtgccag gtgtggacaa tgagtctgca tccagcagca tccgcttcag
      241 caaggcctgc ctgaagaatg tcttctcggt cctcctcatt ctcatctacc tgctgctcat
      301 ggcagtggcc gtcttcctgg tctaccagac catcacggac ttccgagaaa agctcaagca
      361 ccctgtcatg tctgtgtctt acaaggaggt ggatcgctac gatgctccag ggattgcctt
      421 ataccccggt caggctcagc tgctcagctg taagcaccac tatgaggtca tcccacctct
      481 tgccagccct ggccagcccg gagacaggaa ctgcaccact cagaggatca attacaccca
      541 ccccttctcc aatcacacca tgcagtcagc cctgattgtc caggggcccc aggaagtgaa
      601 gaagcgggag ctggtgttcc tccagttccg cctgaaccag agcgacgagg acttcagtgc
      661 cattgactat ctcctcttct cctctttccg ggagttcatg caaagcccgg acaaggcggg
      721 cttcatgcag gcctgtgaga gtgcctactc cagctggaag ttctccggag gcttccgcac
      781 ctgggtcaag atgtcactgg tgaagaccaa agaagaggat gggcgagaag ccgttgagtt
      841 ccggcaagag accagcgtgg tcaattatat tgaccagagg ccggcagccg agaagagtac
      901 tcagttgttc tttgtggtct ttgaatggaa ggatcccttc atccagaaag tccaggatat
      961 aatcacggcc aatccttgga acaccatcgc cctactctgc ggggcgttcc tggcattatt
     1021 taaagcagca gagtttgcca aactaagtgt gaaatggatg atcaaaatca ggaaacgata
     1081 ccttaaacgg agaggccagg cgacaaacca cataagctga agtgcctgtg ccccagcact
     1141 ccgacaaacc gagccaccag cactcctgta ctcacttgaa gggacctcgc agggaaggac
     1201 ggcctgtcgc attggatgct caaccctggc ccaggaggac actgtcctgg gcccaaaggg
     1261 aaacacccag tggataaccc gaaacttatt taagtactta aattattaac ggacatttgc
     1321 agagctgcct agtgccttgg agaggtttgc ggaaggcggc ttcctcctat ttggtcatta
     1381 aatagttaag ctccaaaaaa aaaaaaaaaa aaaaaaaaa
//
