LOCUS       NP_001007680             350 aa            linear   ROD 27-APR-2025
DEFINITION  proton-activated chloride channel [Rattus norvegicus].
ACCESSION   NP_001007680 XP_223071
VERSION     NP_001007680.1
DBSOURCE    REFSEQ: accession NM_001007679.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 350)
  AUTHORS   Ullrich,F., Blin,S., Lazarow,K., Daubitz,T., von Kries,J.P. and
            Jentsch,T.J.
  TITLE     Identification of TMEM206 proteins as pore of PAORAC/ASOR
            acid-sensitive chloride channels
  JOURNAL   Elife 8, e49187 (2019)
   PUBMED   31318332
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 350)
  AUTHORS   Yang,J., Chen,J., Del Carmen Vitery,M., Osei-Owusu,J., Chu,J.,
            Yu,H., Sun,S. and Qiu,Z.
  TITLE     PAC, an evolutionarily conserved membrane protein, is a
            proton-activated chloride channel
  JOURNAL   Science 364 (6438), 395-399 (2019)
   PUBMED   31023925
REFERENCE   3  (residues 1 to 350)
  AUTHORS   Teckchandani,A., Toida,N., Goodchild,J., Henderson,C., Watts,J.,
            Wollscheid,B. and Cooper,J.A.
  TITLE     Quantitative proteomics identifies a Dab2/integrin module
            regulating cell migration
  JOURNAL   J Cell Biol 186 (1), 99-111 (2009)
   PUBMED   19581412
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC082061.1.
            
            On Nov 29, 2004 this sequence version replaced XP_223071.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082061.1, FQ228821.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..350
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q27"
     Protein         1..350
                     /product="proton-activated chloride channel"
                     /note="transmembrane protein 206"
                     /calculated_mol_wt=39942
     Site            9
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H813; propagated from
                     UniProtKB/Swiss-Prot (Q66H28.1)"
     Site            10
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q9D771; propagated from
                     UniProtKB/Swiss-Prot (Q66H28.1)"
     Site            14
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66H28.1)"
     Site            24
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66H28.1)"
     Region          55..349
                     /region_name="TMEM206"
                     /note="TMEM206 protein family; pfam15122"
                     /db_xref="CDD:434477"
     Site            65..85
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66H28.1)"
     Site            155
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q66H28.1)"
     Site            162
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q66H28.1)"
     Site            302..318
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66H28.1)"
     CDS             1..350
                     /gene="Pacc1"
                     /gene_synonym="PAC; RGD1359339; Tmem206"
                     /coded_by="NM_001007679.1:68..1120"
                     /db_xref="GeneID:305070"
                     /db_xref="RGD:1359339"
ORIGIN      
        1 mirqdlstsy qelseeleqv venseqader dkelvqvqgp gvvpgvdnes asssirfska
       61 clknvfsvll iliylllmav avflvyqtit dfreklkhpv msvsykevdr ydapgialyp
      121 gqaqllsckh hyevipplas pgqpgdrnct tqrinythpf snhtmqsali vqgpqevkkr
      181 elvflqfrln qsdedfsaid yllfssfref mqspdkagfm qacesayssw kfsggfrtwv
      241 kmslvktkee dgreavefrq etsvvnyidq rpaaekstql ffvvfewkdp fiqkvqdiit
      301 anpwntiall cgaflalfka aefaklsvkw mikirkrylk rrgqatnhis
//
