LOCUS       NM_001135008            1788 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus poly(A) binding protein, nuclear 1 (Pabpn1),
            mRNA.
ACCESSION   NM_001135008 XM_214172
VERSION     NM_001135008.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1788)
  AUTHORS   Zhang,L., Wang,D., Han,X., Guo,X., Cao,Y., Xia,Y. and Gao,D.
  TITLE     Novel read-through fusion transcript Bcl2l2-Pabpn1 in glioblastoma
            cells
  JOURNAL   J Cell Mol Med 26 (17), 4686-4697 (2022)
   PUBMED   35894779
  REMARK    GeneRIF: Novel read-through fusion transcript Bcl2l2-Pabpn1 in
            glioblastoma cells.
REFERENCE   2  (bases 1 to 1788)
  AUTHORS   Matsubara,S., Shimizu,T., Komori,T., Mori-Yoshimura,M., Minami,N.
            and Hayashi,Y.K.
  TITLE     Nuclear inclusions mimicking poly(A)-binding protein nuclear 1
            inclusions in a case of inclusion body myopathy associated with
            Paget disease of bone and frontotemporal dementia with a novel
            mutation in the valosin-containing protein gene
  JOURNAL   Neuromuscul Disord 26 (7), 436-440 (2016)
   PUBMED   27209344
REFERENCE   3  (bases 1 to 1788)
  AUTHORS   Gruber,A.R., Martin,G., Keller,W. and Zavolan,M.
  TITLE     Means to an end: mechanisms of alternative polyadenylation of
            messenger RNA precursors
  JOURNAL   Wiley Interdiscip Rev RNA 5 (2), 183-196 (2014)
   PUBMED   24243805
  REMARK    Review article
REFERENCE   4  (bases 1 to 1788)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 1788)
  AUTHORS   Su,Y.L., Wang,S.C., Chiang,P.Y., Lin,N.Y., Shen,Y.F., Chang,G.D.
            and Chang,C.J.
  TITLE     Tristetraprolin inhibits poly(A)-tail synthesis in nuclear mRNA
            that contains AU-rich elements by interacting with poly(A)-binding
            protein nuclear 1
  JOURNAL   PLoS One 7 (7), e41313 (2012)
   PUBMED   22844456
REFERENCE   6  (bases 1 to 1788)
  AUTHORS   Hurt,J.A., Obar,R.A., Zhai,B., Farny,N.G., Gygi,S.P. and
            Silver,P.A.
  TITLE     A conserved CCCH-type zinc finger protein regulates mRNA nuclear
            adenylation and export
  JOURNAL   J Cell Biol 185 (2), 265-277 (2009)
   PUBMED   19364924
REFERENCE   7  (bases 1 to 1788)
  AUTHORS   Villagra,N.T., Bengoechea,R., Vaque,J.P., Llorca,J., Berciano,M.T.
            and Lafarga,M.
  TITLE     Nuclear compartmentalization and dynamics of the poly(A)-binding
            protein nuclear 1 (PABPN1) inclusions in supraoptic neurons under
            physiological and osmotic stress conditions
  JOURNAL   Mol Cell Neurosci 37 (3), 622-633 (2008)
   PUBMED   18255312
REFERENCE   8  (bases 1 to 1788)
  AUTHORS   Jonson,L., Vikesaa,J., Krogh,A., Nielsen,L.K., Hansen,Tv.,
            Borup,R., Johnsen,A.H., Christiansen,J. and Nielsen,F.C.
  TITLE     Molecular composition of IMP1 ribonucleoprotein granules
  JOURNAL   Mol Cell Proteomics 6 (5), 798-811 (2007)
   PUBMED   17289661
REFERENCE   9  (bases 1 to 1788)
  AUTHORS   Berciano,M.T., Villagra,N.T., Ojeda,J.L., Navascues,J., Gomes,A.,
            Lafarga,M. and Carmo-Fonseca,M.
  TITLE     Oculopharyngeal muscular dystrophy-like nuclear inclusions are
            present in normal magnocellular neurosecretory neurons of the
            hypothalamus
  JOURNAL   Hum Mol Genet 13 (8), 829-838 (2004)
   PUBMED   14976164
REFERENCE   10 (bases 1 to 1788)
  AUTHORS   Okamura,T., Imai,Y., Kon,Y., Goto,M., Yamamoto,M. and Watanabe,T.
  TITLE     Molecular cloning and characterization of mouse testis poly(A)
            binding protein II encoded by the Pabp3 gene, which
            transcomplements meiotic mutant sme2 of S. pombe
  JOURNAL   Biochem Genet 38 (1-2), 1-11 (2000)
   PUBMED   10862355
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Sep 16, 2008 this sequence version replaced XM_214172.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.973405.1, CK479333.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-352               JAXUCZ010000015.1  32338089-32338440
            353-467             JAXUCZ010000015.1  32338799-32338913
            468-535             JAXUCZ010000015.1  32339571-32339638
            536-642             JAXUCZ010000015.1  32339737-32339843
            643-730             JAXUCZ010000015.1  32340745-32340832
            731-882             JAXUCZ010000015.1  32340917-32341068
            883-1788            JAXUCZ010000015.1  32341795-32342700
FEATURES             Location/Qualifiers
     source          1..1788
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p13"
     gene            1..1788
                     /gene="Pabpn1"
                     /note="poly(A) binding protein, nuclear 1"
                     /db_xref="GeneID:116697"
                     /db_xref="RGD:619928"
     exon            1..352
                     /gene="Pabpn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..922
                     /gene="Pabpn1"
                     /codon_start=1
                     /product="polyadenylate-binding protein 2"
                     /protein_id="NP_001128480.1"
                     /db_xref="GeneID:116697"
                     /db_xref="RGD:619928"
                     /translation="MAAAAAAAAAAGAAGGRGSGPGRRRHLVPGAGGEAGEGDPGGAG
                     DYGNGLESEELEPGELLPEPEPEEEPPRPRAPPGAPGPGPGSGAPGSQEEEEEPGLVE
                     TDPGDGAIEDPELEAIKARVREMEEEAEKLKELQNEVEKQMNMSPPPGNAGPVIMSLE
                     EKMEADARSIYVGNVDYGATAEELEAHFHGCGSVNRVTILCDKFSGHPKGFAYIEFSD
                     KESVRTSLALDESLFRGRQIKVIPKRTNRPGISTTDRGFPRARYRARTTNYNSSRSRF
                     YSGFNSRPRGRIYRGRARATSWYSPY"
     exon            353..467
                     /gene="Pabpn1"
                     /inference="alignment:Splign:2.1.0"
     exon            468..535
                     /gene="Pabpn1"
                     /inference="alignment:Splign:2.1.0"
     exon            536..642
                     /gene="Pabpn1"
                     /inference="alignment:Splign:2.1.0"
     exon            643..730
                     /gene="Pabpn1"
                     /inference="alignment:Splign:2.1.0"
     exon            731..882
                     /gene="Pabpn1"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1788
                     /gene="Pabpn1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtctgagcg gcgatggcgg cggcggcggc ggcggcagca gcagcggggg ctgcgggcgg
       61 tcggggctcc gggccggggc ggcggcgcca tcttgtgccc ggggccggtg gggaggccgg
      121 ggagggggac ccggggggcg caggggacta cgggaacggc ctggagtctg aggagctgga
      181 gcctggggag ctgctgccag agcccgagcc cgaagaggag ccgccccggc cccgcgcccc
      241 tccgggagct ccgggtcctg ggcccggctc gggagccccc ggcagccagg aggaggagga
      301 agagccggga ctggttgaga ccgaccccgg ggacggcgcc attgaggacc cggagctaga
      361 agcgatcaaa gctcgagtca gggagatgga ggaagaggct gagaagctaa aggagctaca
      421 aaacgaggta gagaaacaga tgaatatgag tccaccccca ggcaatgctg gcccagtgat
      481 catgtctctt gaggagaaga tggaggctga tgcccgttcc atctacgttg gcaatgtgga
      541 ctatggtgcg acagcagaag agctggaggc ccattttcac ggctgcggtt cagtcaaccg
      601 ggtgactata ctctgtgaca aatttagtgg ccatcccaaa gggtttgcat atatagagtt
      661 ctcagacaaa gagtcagtga ggacgtccct ggccttagat gagtccctgt ttagaggaag
      721 acaaatcaag gtgattccca agcgaaccaa cagaccaggc atcagcacaa cagaccgggg
      781 cttcccgcgt gcccgatacc gcgcccggac taccaattac aacagctcca gatctcgatt
      841 ctacagtggt tttaacagca ggccccgggg tcgaatctac aggggccggg ctagagcgac
      901 atcatggtat tccccttact aaaaaaagtg tgtattagga ggagagagag gaaaaaagag
      961 gaaagaagga aaaaaaagaa ttaaaaaaaa aaaaagaaaa acagaagatg accttgatgg
     1021 aaaaaaaata tttaaaaaaa aaaaaagata tactgtggaa ggggggagaa tcccataact
     1081 aactgtgagg agggacctgc tttggggagt aggggaaggc ccagggagtg gggcaggggc
     1141 tacatattcc ctctggggat tcgccatgga cacatctcaa ctgtgcaagc tgctccctgt
     1201 ttccctgctc cccttcatcc tctttgggcc tgctcaaggg taggtgggca cgggtggtag
     1261 gagggctttt ttttacccag ggctctggaa ggacaccaaa ctgttcggct tgtttccttc
     1321 cctcgtctct ccctgccttt tgcagcccct gccttcctgc tcctgtccta ccaggtctcc
     1381 gcccacccta ccctctttcc tccggctccc tgcccctcca gtttgcctgg tgatctattt
     1441 tgtttccttt tgtgtttctt tttctgtttt gagtgtcttt ctttgcaggt ttctgtagcc
     1501 ggaagatctc gctcccagcg gctccagtgt aaattcccct ctccctgggg aatgcactac
     1561 tttgttttgg ggagtttggg ggtgtttttg tttttcaggt gtttttgttt tgttttattt
     1621 tttttttcct ttaccttttt ttttcccttt tatttggagg gaatgggagg aagtgggaac
     1681 agggtggtgg gggtggcttt tgtttttatt tttttaactc atttccaggg gatgggaatt
     1741 ttttttttaa ataatgtgtc atgaataaag ttgtttatga aaaaagtg
//
