LOCUS       NM_001004206            1602 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus proliferation-associated 2G4 (Pa2g4), mRNA.
ACCESSION   NM_001004206 XM_213828
VERSION     NM_001004206.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1602)
  AUTHORS   Zhang,Y., Zhang,M., Xu,W., Chen,J. and Zhou,X.
  TITLE     The long non-coding RNA H19 promotes cardiomyocyte apoptosis in
            dilated cardiomyopathy
  JOURNAL   Oncotarget 8 (17), 28588-28594 (2017)
   PUBMED   28430627
REFERENCE   2  (bases 1 to 1602)
  AUTHORS   Liu,Y., Liu,Y., Cao,J., Zhu,X., Nie,X., Yao,L., Chen,M., Cheng,X.
            and Wang,Y.
  TITLE     Upregulated expression of ebp1 contributes to schwann cell
            differentiation and migration after sciatic nerve crush
  JOURNAL   J Mol Neurosci 54 (4), 602-613 (2014)
   PUBMED   24878627
  REMARK    GeneRIF: Ebp1 was upregulated in Schwann cells following sciatic
            nerve crush.
REFERENCE   3  (bases 1 to 1602)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 1602)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   5  (bases 1 to 1602)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 1602)
  AUTHORS   Liu,Z., Liu,X., Nakayama,K.I., Nakayama,K. and Ye,K.
  TITLE     Protein kinase C-delta phosphorylates Ebp1 and prevents its
            proteolytic degradation, enhancing cell survival
  JOURNAL   J Neurochem 100 (5), 1278-1288 (2007)
   PUBMED   17316401
  REMARK    GeneRIF: PKC-delta antagonizes apoptosis through phosphorylating
            Ebp1 and protects it from apoptotic degradation.
REFERENCE   7  (bases 1 to 1602)
  AUTHORS   Liu,Z., Ahn,J.Y., Liu,X. and Ye,K.
  TITLE     Ebp1 isoforms distinctively regulate cell survival and
            differentiation
  JOURNAL   Proc Natl Acad Sci U S A 103 (29), 10917-10922 (2006)
   PUBMED   16832058
  REMARK    GeneRIF: Ebp1 might regulate cell survival and differentiation
            through two distinctive p48 and p42 isoforms.
REFERENCE   8  (bases 1 to 1602)
  AUTHORS   Ahn,J.Y., Liu,X., Liu,Z., Pereira,L., Cheng,D., Peng,J., Wade,P.A.,
            Hamburger,A.W. and Ye,K.
  TITLE     Nuclear Akt associates with PKC-phosphorylated Ebp1, preventing DNA
            fragmentation by inhibition of caspase-activated DNase
  JOURNAL   EMBO J 25 (10), 2083-2095 (2006)
   PUBMED   16642037
  REMARK    GeneRIF: Results suggest that Ebp1 contributes to inhibition of DNA
            fragmentation by caspase-activated DNase, and that nuclear Akt
            might contribute to suppressing apoptosis through interaction with
            Ebp1.
REFERENCE   9  (bases 1 to 1602)
  AUTHORS   Zhang,Y. and Hamburger,A.W.
  TITLE     Heregulin regulates the ability of the ErbB3-binding protein Ebp1
            to bind E2F promoter elements and repress E2F-mediated
            transcription
  JOURNAL   J Biol Chem 279 (25), 26126-26133 (2004)
   PUBMED   15073182
REFERENCE   10 (bases 1 to 1602)
  AUTHORS   Squatrito,M., Mancino,M., Donzelli,M., Areces,L.B. and Draetta,G.F.
  TITLE     EBP1 is a nucleolar growth-regulating protein that is part of
            pre-ribosomal ribonucleoprotein complexes
  JOURNAL   Oncogene 23 (25), 4454-4465 (2004)
   PUBMED   15064750
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079095.1.
            
            On Sep 10, 2004 this sequence version replaced XM_213828.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079095.1, SRR8487227.94434.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1602
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..1602
                     /gene="Pa2g4"
                     /gene_synonym="Ebp1"
                     /note="proliferation-associated 2G4"
                     /db_xref="GeneID:288778"
                     /db_xref="RGD:1302994"
     exon            1..208
                     /gene="Pa2g4"
                     /gene_synonym="Ebp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..1305
                     /gene="Pa2g4"
                     /gene_synonym="Ebp1"
                     /note="proliferation-associated 2G4, 38kDa; ErbB3-binding
                     protein 1"
                     /codon_start=1
                     /product="proliferation-associated protein 2G4"
                     /protein_id="NP_001004206.1"
                     /db_xref="GeneID:288778"
                     /db_xref="RGD:1302994"
                     /translation="MSGEDEQQEQTIAEDLVVTKYKMGGDIANRVLRSLVEASSSGVS
                     VLSLCEKGDAMIMEETGKIFKKEKEMKKGIAFPTSISVNNCVCHFSPLKSDQDYILKE
                     GDLVKIDLGVHVDGFIANVAHTFVIGVAQGSQVTGRKADVIKAAHLCAEAALRLVKPG
                     NQNTQVTEAWNKVAHSFNCTPIEGMLSHQLKQHVIDGEKTIIQNPTDQQKKDHEKAEF
                     EVHEVYAVDVLVSSGEGKAKDAGQRTTIYKRDPSKQYGLKMKTSRAFFSEVERRFDAM
                     PFTLRAFEDEKKARMGVVECAKHELLQPFNVLYEKEGEFVAQFKFTVLLMPNGPMRIT
                     SGPFEPDLYKSEMEVQDAELKALLQSSASRKTQKKKKKKASKTAENATSGETLEENGA
                     GD"
     exon            209..337
                     /gene="Pa2g4"
                     /gene_synonym="Ebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            338..443
                     /gene="Pa2g4"
                     /gene_synonym="Ebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            444..513
                     /gene="Pa2g4"
                     /gene_synonym="Ebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            514..606
                     /gene="Pa2g4"
                     /gene_synonym="Ebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            607..670
                     /gene="Pa2g4"
                     /gene_synonym="Ebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            671..749
                     /gene="Pa2g4"
                     /gene_synonym="Ebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            750..828
                     /gene="Pa2g4"
                     /gene_synonym="Ebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            829..962
                     /gene="Pa2g4"
                     /gene_synonym="Ebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1057
                     /gene="Pa2g4"
                     /gene_synonym="Ebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1185
                     /gene="Pa2g4"
                     /gene_synonym="Ebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1239
                     /gene="Pa2g4"
                     /gene_synonym="Ebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1574
                     /gene="Pa2g4"
                     /gene_synonym="Ebp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccttgctag ctcgcgcttt cctcgcggat cgaagagact ccggctacag cttgtggctg
       61 ggaagggaga cggaggccgc agctcaggga aagtgaagct gcagtagtgg cagtaggaag
      121 atgtcgggcg aagacgagca gcaggagcaa actatcgccg aggacctggt cgtgaccaag
      181 tataagatgg ggggcgacat cgccaaccgg gtgcttcgat ctttggtgga agcttctagc
      241 tcaggtgtgt ctgtactgag cttgtgtgag aaaggtgacg ccatgattat ggaagagaca
      301 gggaagatct tcaagaagga gaaggagatg aagaaaggta ttgcctttcc taccagcatt
      361 tccgtaaata actgtgtgtg tcacttctcc cctttgaaga gtgaccagga ctatatactc
      421 aaggaaggcg acttggtaaa aattgacctt ggggttcatg tggatggctt cattgccaac
      481 gtggctcaca cttttgtaat tggtgtagct caggggtccc aggtaacagg tcggaaagca
      541 gatgtcatta aggctgctca cttatgtgcc gaagctgctt tacgactggt caaacctgga
      601 aaccagaaca cacaagtgac agaagcctgg aacaaagtcg ctcattcatt taactgcacg
      661 ccaatagaag gtatgctgtc acaccagttg aagcagcatg tgattgatgg agagaaaacc
      721 attatccaga atcctacaga ccagcagaag aaggaccacg aaaaggcaga atttgaagtg
      781 catgaggttt atgctgtgga tgtcctcgtc agctcaggag aaggcaaggc caaagatgca
      841 ggacagagaa ccaccattta caagcgagac ccctctaaac aatatggcct gaaaatgaaa
      901 acttcacgtg cctttttcag tgaggtggaa aggcgttttg atgctatgcc ctttacttta
      961 agagcatttg aggatgagaa gaaggctcga atgggtgtgg tggagtgcgc caagcatgag
     1021 ttactacagc cattcaacgt tctctatgag aaggagggtg agtttgttgc ccagtttaaa
     1081 tttacagttc tactcatgcc caatggcccc atgcggataa ccagtggtcc ctttgagccc
     1141 gacctgtaca agtctgagat ggaggttcag gatgcagagc tgaaggctct tctccagagc
     1201 tctgcaagtc gaaaaaccca gaaaaagaag aaaaagaagg cctccaagac tgcagagaac
     1261 gccaccagtg gagagacatt agaggagaat ggagctgggg actgaggtgg gtcccctccc
     1321 cagcttgtca ctcctgcctc accccctccc accgcacccc aggctctgtc aagtgcagtt
     1381 cgtcttctcc acccaagact accagcagag cggggttctg ccctcatccc ggtcccccac
     1441 ccacccgccc actcctttca acaaaaaaac cagctccgac tgactctggt gttgggaggc
     1501 caggcttccc aaccaccgaa gactactttt agtagaaaaa gaaattgaat aataaaatca
     1561 ggagtcaaaa tccaaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
