LOCUS       NM_001399277            1742 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus prolyl 4-hydroxylase, transmembrane (P4htm),
            mRNA.
ACCESSION   NM_001399277 XM_217285
VERSION     NM_001399277.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1742)
  AUTHORS   Laitala,A., Aro,E., Walkinshaw,G., Maki,J.M., Rossi,M.,
            Heikkila,M., Savolainen,E.R., Arend,M., Kivirikko,K.I., Koivunen,P.
            and Myllyharju,J.
  TITLE     Transmembrane prolyl 4-hydroxylase is a fourth prolyl 4-hydroxylase
            regulating EPO production and erythropoiesis
  JOURNAL   Blood 120 (16), 3336-3344 (2012)
   PUBMED   22955912
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Jan 5, 2022 this sequence version replaced XM_217285.10.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.3152389.1,
                                           SRR26360176.583815.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760433,
                                           SAMEA5760475 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-381               JAXUCZ010000008.1  118170622-118171002 c
            382-463             JAXUCZ010000008.1  118170299-118170380 c
            464-654             JAXUCZ010000008.1  118158858-118159048 c
            655-751             JAXUCZ010000008.1  118158020-118158116 c
            752-914             JAXUCZ010000008.1  118156883-118157045 c
            915-1100            JAXUCZ010000008.1  118154951-118155136 c
            1101-1191           JAXUCZ010000008.1  118154271-118154361 c
            1192-1315           JAXUCZ010000008.1  118153981-118154104 c
            1316-1742           JAXUCZ010000008.1  118153158-118153584 c
FEATURES             Location/Qualifiers
     source          1..1742
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..1742
                     /gene="P4htm"
                     /gene_synonym="Ph-4; RGD1311848"
                     /note="prolyl 4-hydroxylase, transmembrane"
                     /db_xref="GeneID:301008"
                     /db_xref="RGD:1311848"
     exon            1..381
                     /gene="P4htm"
                     /gene_synonym="Ph-4; RGD1311848"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..1536
                     /gene="P4htm"
                     /gene_synonym="Ph-4; RGD1311848"
                     /EC_number="1.14.11.29"
                     /note="hypoxia-inducible factor prolyl 4-hydroxylase"
                     /codon_start=1
                     /product="transmembrane prolyl 4-hydroxylase"
                     /protein_id="NP_001386206.1"
                     /db_xref="GeneID:301008"
                     /db_xref="RGD:1311848"
                     /translation="MAAAVATVQRPVAETIEEASNLQWPLPPEHRPSGAATRPGDGEE
                     APVRPLCKPRGICSRAYFLVLMVFVHLYLGNVLALLLFVHYSNGDESTDPGPQRREQS
                     PQPVPTLGPLTRLEGIKVGYERKVQVVAGRDHFIRTLSLKPLLFEIPGFLSDEECRLI
                     IHLAQMKGLQRSQILPTEEYEEAMSAMRVSQLDLFQLLDQNHDGRLQLREVLAQTRLG
                     NGRWMTPENIQEMYSAIKADPDGDGVLSLQEFSNMDLRDFHKYMRSHKAESSELVRNS
                     HHTWLHQGEGAHHVMRAIRQRVLRLTRLSPEIVELSEPLQVVRYGEGGHYHAHVDSGP
                     VYPETVCSHTKLVANESVPFETSCRYMTVLFYLNNVTGGGETVFPVADNRTYDEMSLI
                     QDNVDLRDTRRHCDKGNLRVKPQQGTAVFWYNYLPDGQGWVGEVDDYSLHGGCLVTRG
                     TKWIANNWINVDPSRARQALFQQEMARLAREGGADSQPEWALDRAYSDARAEL"
     exon            382..463
                     /gene="P4htm"
                     /gene_synonym="Ph-4; RGD1311848"
                     /inference="alignment:Splign:2.1.0"
     exon            464..654
                     /gene="P4htm"
                     /gene_synonym="Ph-4; RGD1311848"
                     /inference="alignment:Splign:2.1.0"
     exon            655..751
                     /gene="P4htm"
                     /gene_synonym="Ph-4; RGD1311848"
                     /inference="alignment:Splign:2.1.0"
     exon            752..914
                     /gene="P4htm"
                     /gene_synonym="Ph-4; RGD1311848"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1100
                     /gene="P4htm"
                     /gene_synonym="Ph-4; RGD1311848"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1191
                     /gene="P4htm"
                     /gene_synonym="Ph-4; RGD1311848"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1315
                     /gene="P4htm"
                     /gene_synonym="Ph-4; RGD1311848"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1742
                     /gene="P4htm"
                     /gene_synonym="Ph-4; RGD1311848"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcgcgcgc gcgacctggg cgccatggcg gcagcggtgg cgaccgtgca gcggcctgtg
       61 gctgagacga tcgaggaggc ctcaaatctt cagtggccgc tgccaccgga gcatcgccct
      121 tccggggcag cgaccagacc aggcgatggt gaagaagcac cggtgcggcc actgtgcaag
      181 ccacggggca tctgttcccg tgcctacttc ttggtactga tggtgttcgt gcacctgtac
      241 ttgggcaatg tgctggccct gctgctcttc gtgcactaca gcaacgggga cgaaagcaca
      301 gacccgggac cccagcgccg tgagcagagc ccccagccag tgccaacctt aggtcccctc
      361 acccggctgg agggcatcaa ggtgggatat gagcggaaag tccaggtggt cgcgggcagg
      421 gatcacttca tccgaaccct cagcctcaag ccattgctct tcgaaatccc aggcttcctg
      481 agtgacgagg agtgccgcct tatcatccac ctggcacaga tgaaagggtt acagcgaagc
      541 cagatcctgc ctactgagga gtatgaggag gccatgagcg ccatgcgagt cagccagctg
      601 gacctcttcc agctgttgga tcagaaccac gacggtcgcc tgcaactccg agaggtgctg
      661 gcccagactc gcctgggaaa tggacggtgg atgactccgg agaacattca ggagatgtac
      721 tctgctatca aggcagaccc cgatggtgac ggagtgctga gtctgcagga attttccaac
      781 atggaccttc gagacttcca caagtacatg aggagccata aggcagaatc cagcgagctg
      841 gtgaggaaca gccaccacac atggctccac cagggcgagg gagcccatca cgtcatgcgt
      901 gccatccgcc agagggtgct gcgcctcact cgcctctcgc cagagatcgt ggagctcagc
      961 gagcctctac aggttgtacg atacggtgag ggaggccact accatgccca tgtggacagc
     1021 ggacctgtgt acccagagac cgtctgctct cataccaagc tggtagccaa tgaatctgta
     1081 cccttcgaga cctcctgtcg ctacatgaca gtgctgtttt atttgaacaa tgtcaccggt
     1141 gggggcgaga ctgtcttccc tgtagcagac aacaggacct acgatgaaat gagtctgatt
     1201 caggacaacg ttgatctccg agacactcga aggcactgtg acaaggggaa ccttcgggtc
     1261 aagccccagc aaggaactgc agtcttttgg tacaactatc ttcctgatgg gcaaggctgg
     1321 gtgggtgaag tggatgacta ctcgttgcat gggggatgcc tggtcacccg cggaaccaaa
     1381 tggatcgcta acaactggat caatgtggac ccaagccgag cacggcaagc cttgttccag
     1441 caggagatgg ctcgtctggc tcgggaaggt ggtgctgact cgcagcccga gtgggccttg
     1501 gaccgggcct acagtgatgc ccgcgcggag ctctgacacg aggccctgat gcgagtcacc
     1561 cgctgcccaa cgtcaaagac cctgcaggtc ctctgtccta ctgcagactg aagttctggc
     1621 tgacctcttg ccctatccct ccctgcctgc agccgcgatg aaaggcgcag ttcctacatt
     1681 cacgttattt attggtgtac agcctccatg ctgctccgtt aaataaaact acagggcttc
     1741 ca
//
