LOCUS       NM_012998               2571 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus prolyl 4-hydroxylase subunit beta (P4hb), mRNA.
ACCESSION   NM_012998
VERSION     NM_012998.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2571)
  AUTHORS   Aiello,F.B., Guszczynski,T., Li,W., Hixon,J.A., Jiang,Q.,
            Hodge,D.L., Massignan,T., Di Lisio,C., Merchant,A., Procopio,A.D.,
            Bonetto,V. and Durum,S.K.
  TITLE     IL-7-induced phosphorylation of the adaptor Crk-like and other
            targets
  JOURNAL   Cell Signal 47, 131-141 (2018)
   PUBMED   29581031
REFERENCE   2  (bases 1 to 2571)
  AUTHORS   Kim,J.Y., Ko,A.R., Hyun,H.W., Min,S.J. and Kim,J.E.
  TITLE     PDI regulates seizure activity via NMDA receptor redox in rats
  JOURNAL   Sci Rep 7, 42491 (2017)
   PUBMED   28198441
  REMARK    GeneRIF: PDI knockdown inhibited the reduction of disulfide bonds
            on NMDAR subunits, resulting in decreased seizure susceptibility in
            response to PILO.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2571)
  AUTHORS   Sobierajska,K., Skurzynski,S., Stasiak,M., Kryczka,J.,
            Cierniewski,C.S. and Swiatkowska,M.
  TITLE     Protein disulfide isomerase directly interacts with beta-actin
            Cys374 and regulates cytoskeleton reorganization
  JOURNAL   J Biol Chem 289 (9), 5758-5773 (2014)
   PUBMED   24415753
REFERENCE   4  (bases 1 to 2571)
  AUTHORS   Franca,L.M., Freitas,L.N., Chagas,V.T., Coelho,C.F., Barroso,W.A.,
            Costa,G.C., Silva,L.A., Debbas,V., Laurindo,F.R. and Paes,A.M.
  TITLE     Mechanisms underlying hypertriglyceridemia in rats with monosodium
            L-glutamate-induced obesity: evidence of XBP-1/PDI/MTP axis
            activation
  JOURNAL   Biochem Biophys Res Commun 443 (2), 725-730 (2014)
   PUBMED   24333444
  REMARK    GeneRIF: As the XBP-1/PDI/MTP axis has been suggested to represent
            a significant lipogenic mechanism in the liver response to ER
            stress, our data indicate that hypertriglyceridemia and liver
            steatosis occurring MSG rats are associated with increased MTP.
REFERENCE   5  (bases 1 to 2571)
  AUTHORS   Zanivan,S., Maione,F., Hein,M.Y., Hernandez-Fernaud,J.R.,
            Ostasiewicz,P., Giraudo,E. and Mann,M.
  TITLE     SILAC-based proteomics of human primary endothelial cell
            morphogenesis unveils tumor angiogenic markers
  JOURNAL   Mol Cell Proteomics 12 (12), 3599-3611 (2013)
   PUBMED   23979707
REFERENCE   6  (bases 1 to 2571)
  AUTHORS   Helaakoski,T., Annunen,P., Vuori,K., MacNeil,I.A., Pihlajaniemi,T.
            and Kivirikko,K.I.
  TITLE     Cloning, baculovirus expression, and characterization of a second
            mouse prolyl 4-hydroxylase alpha-subunit isoform: formation of an
            alpha 2 beta 2 tetramer with the protein disulfide-isomerase/beta
            subunit
  JOURNAL   Proc Natl Acad Sci U S A 92 (10), 4427-4431 (1995)
   PUBMED   7753822
REFERENCE   7  (bases 1 to 2571)
  AUTHORS   Schoenmakers,C.H., Pigmans,I.G., Hawkins,H.C., Freedman,R.B. and
            Visser,T.J.
  TITLE     Rat liver type I iodothyronine deiodinase is not identical to
            protein disulfide isomerase
  JOURNAL   Biochem Biophys Res Commun 162 (2), 857-868 (1989)
   PUBMED   2757644
REFERENCE   8  (bases 1 to 2571)
  AUTHORS   Boado,R.J., Campbell,D.A. and Chopra,I.J.
  TITLE     Nucleotide sequence of rat liver iodothyronine 5'-monodeiodinase
            (5' MD): its identity with the protein disulfide isomerase
  JOURNAL   Biochem Biophys Res Commun 155 (3), 1297-1304 (1988)
   PUBMED   3178809
REFERENCE   9  (bases 1 to 2571)
  AUTHORS   Boado,R.J., Chopra,I.J., Flink,I.L. and Campbell,D.A.
  TITLE     Enzyme binding-inhibiting assay for iodothyronine 5'-monodeiodinase
            (5'-MD) and its application to isolation of complementary
            deoxyribonucleic acid clones for the 5'-MD in rat liver
  JOURNAL   Endocrinology 123 (3), 1264-1273 (1988)
   PUBMED   2841089
REFERENCE   10 (bases 1 to 2571)
  AUTHORS   Edman,J.C., Ellis,L., Blacher,R.W., Roth,R.A. and Rutter,W.J.
  TITLE     Sequence of protein disulphide isomerase and implications of its
            relationship to thioredoxin
  JOURNAL   Nature 317 (6034), 267-270 (1985)
   PUBMED   3840230
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB583787.1, FM060266.1, JAXUCZ010000010.1 and FM067812.1.
            
            On Apr 28, 2015 this sequence version replaced NM_012998.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061857.1, X02918.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840115, SAMN16676785
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-590               CB583787.1         1-590
            591-1055            FM060266.1         186-650
            1056-1081           JAXUCZ010000010.1  106338438-106338463 c
            1082-1579           FM067812.1         1-498
            1580-2526           JAXUCZ010000010.1  106335300-106336246 c
            2527-2570           FM067812.1         500-543
            2571-3517           JAXUCZ010000010.1  106335300-106336246 c
FEATURES             Location/Qualifiers
     source          1..2571
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.3"
     gene            1..2571
                     /gene="P4hb"
                     /gene_synonym="PDI; PDIR"
                     /note="prolyl 4-hydroxylase subunit beta"
                     /db_xref="GeneID:25506"
                     /db_xref="RGD:3244"
     exon            1..300
                     /gene="P4hb"
                     /gene_synonym="PDI; PDIR"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..1679
                     /gene="P4hb"
                     /gene_synonym="PDI; PDIR"
                     /EC_number="5.3.4.1"
                     /note="protein disulfide-isomerase; cellular thyroid
                     hormone-binding protein; prolyl 4-hydroxylase, beta
                     polypeptide; Protein disulfide isomerase (Prolyl
                     4-hydroxylase, beta polypeptide)"
                     /codon_start=1
                     /product="protein disulfide-isomerase precursor"
                     /protein_id="NP_037130.2"
                     /db_xref="GeneID:25506"
                     /db_xref="RGD:3244"
                     /translation="MLSRALLCLALAWAARVGADALEEEDNVLVLKKSNFAEALAAHN
                     YLLVEFYAPWCGHCKALAPEYAKAAAKLKAEGSEIRLAKVDATEESDLAQQYGVRGYP
                     TIKFFKNGDTASPKEYTAGREADDIVNWLKKRTGPAATTLSDTAAAESLVDSSEVTVI
                     GFFKDAGSDSAKQFLLAAEAVDDIPFGITSNSDVFSKYQLDKDGVVLFKKFDEGRNNF
                     EGEITKEKLLDFIKHNQLPLVIEFTEQTAPKIFGGEIKTHILLFLPKSVSDYDGKLSN
                     FKKAAEGFKGKILFIFIDSDHTDNQRILEFFGLKKEECPAVRLITLEEEMTKYKPESD
                     ELTAEKITQFCHHFLEGKIKPHLMSQELPEDWDKQPVKVLVGKNFEEVAFDEKKNVFV
                     EFYAPWCGHCKQLAPIWDKLGETYKDHENIVIAKMDSTANEVEAVKVHSFPTLKFFPA
                     SADRTVIDYNGERTLDGFKKFLESGGQDGAGDNDDLDLEEALEPDMEEDDDQKAVKDE
                     L"
     exon            301..507
                     /gene="P4hb"
                     /gene_synonym="PDI; PDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            508..641
                     /gene="P4hb"
                     /gene_synonym="PDI; PDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            642..779
                     /gene="P4hb"
                     /gene_synonym="PDI; PDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            780..884
                     /gene="P4hb"
                     /gene_synonym="PDI; PDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1010
                     /gene="P4hb"
                     /gene_synonym="PDI; PDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1211
                     /gene="P4hb"
                     /gene_synonym="PDI; PDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1332
                     /gene="P4hb"
                     /gene_synonym="PDI; PDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1514
                     /gene="P4hb"
                     /gene_synonym="PDI; PDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1601
                     /gene="P4hb"
                     /gene_synonym="PDI; PDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..2571
                     /gene="P4hb"
                     /gene_synonym="PDI; PDIR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcaggtgac gcgcgcagta agggggaggc gtgggcgcgt ccccgaccca ggatttataa
       61 aggcgaggtc tggaccgacg cgcgctctcg tcgccttggc tgtcccggcg gcgccaacct
      121 agctgccccg cccgctgccg acgtccgaca tgctgagccg tgctttgctg tgcctggccc
      181 tggcctgggc ggctagggtg ggcgccgacg ctctggagga ggaggacaac gtcctggtgc
      241 tgaagaagag caacttcgca gaggcgctgg cggcgcacaa ctacctgctg gtggagttct
      301 atgccccatg gtgtggccac tgcaaagcac tggccccaga gtatgccaaa gctgctgcaa
      361 aactgaaggc agaaggctct gagatccgac tagcaaaggt ggacgccaca gaagagtctg
      421 acctggccca gcagtatggt gtccgtggct accccacaat caagttcttc aagaatggag
      481 acacagcctc cccaaaggaa tatacagctg gcagggaagc tgacgacatt gtgaactggc
      541 tgaagaaacg cacaggccca gcagccacaa ccctgtctga cactgcagct gcagagtcct
      601 tggtggactc aagcgaagtg acggtcatcg gcttcttcaa ggacgcaggg tcagactccg
      661 ccaagcagtt cttgctggca gcagaggctg ttgatgacat accttttgga atcacttcca
      721 atagcgatgt gttttccaag taccagctgg acaaggatgg ggtggtcctc tttaagaagt
      781 ttgatgaagg ccgcaacaat tttgaaggtg agatcaccaa ggagaagctg ttagacttca
      841 tcaagcacaa ccagctgcct ttggtcatcg agttcactga acagacagct ccaaagattt
      901 tcggaggtga aatcaaaaca catattctgc tgttcctgcc caagagtgtg tctgactacg
      961 atggcaaatt gagcaacttt aagaaagcgg ccgagggctt taagggcaag atcctgttca
     1021 tcttcatcga tagtgaccac actgacaacc agcgcatact tgagttcttt ggcctgaaga
     1081 aggaggaatg tccagctgtg cggcttatta ccctggagga agagatgacc aagtacaaac
     1141 cggagtcaga cgagctgaca gctgagaaga tcacacaatt ttgccaccac ttcctggagg
     1201 gcaagatcaa gccccacctg atgagccagg aactgcctga agactgggac aagcagccag
     1261 tgaaagtgct agttgggaaa aactttgagg aggttgcttt tgatgagaaa aagaacgtgt
     1321 ttgttgaatt ctatgctccc tggtgtggtc actgcaagca gctagccccg atttgggata
     1381 aactgggaga gacatacaaa gaccatgaga atatcgtcat cgctaagatg gactcaacag
     1441 ccaatgaggt ggaagctgtg aaggtgcaca gctttcccac actcaagttc ttcccagcaa
     1501 gtgcagacag aacggtcatt gattacaacg gtgagcggac actagatggt tttaagaaat
     1561 tcttggagag cggtggccag gatggagcgg gggacaatga cgacctcgac ctagaagaag
     1621 ctttagagcc agatatggaa gaagacgacg atcagaaagc cgtgaaggat gaactgtagt
     1681 gcagaagcca gatctgggcg cctgaaccca aaacctcggt gggccatgtc ccagcagccc
     1741 acatctccgg agcctgagcc tcaccccagg agggagcgcc atcagaaccc agggaatctt
     1801 tctgaagcca cactcatctg acacacgtac acttaaacct gtctcttctt tttttgcttt
     1861 tcaattttgg aaagggatct ctgtccaggc cagcccatct tgaagggcta cgttttgttt
     1921 taattggtgg tgtacttttt tgtacgtgga ttttgtccca agtgcttgct accatatttg
     1981 gggatttcac actggtaatg tctttcctgt tagagaggtt tatgctatca cttcagattt
     2041 cgtctgtgag atgtttcatc ttcctgacat gtctccatgt cgaggtactt gttccaccac
     2101 gcagacctcc ctgagacccc ttcctgccct gcgcaggagg cgatggttct gggtcgtatg
     2161 ctctctctct ctccaccttg tactagtgtt gccatgacag catggctttt gtagtttgca
     2221 tttaacctgg ggatttctgc atcctgtcag agggtgggtc cccacgtgtg gaaaagagac
     2281 agtgtggctt gctgccaggc tcaggccagg cctggacagc tctcactctt cttaagccag
     2341 aactaccgac cagccggccg gctgtgggca cattactctg gctgctggat cctcttccag
     2401 catggcatgt ggcctgtgtg aggcagaacc gggacccttg attcccagac tgggagtcag
     2461 ctaaggacac tggggctgaa tgaaatgccc attctcaagg catttctaaa ccataatgtt
     2521 ggaattgaac acattggcta aataaagttg aaattttact acccattgtc a
//
