LOCUS       NM_021581               2440 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus prolyl 3-hydroxylase family member 4 (P3h4),
            mRNA.
ACCESSION   NM_021581 XM_006247414
VERSION     NM_021581.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2440)
  AUTHORS   Heard,M.E., Besio,R., Weis,M., Rai,J., Hudson,D.M., Dimori,M.,
            Zimmerman,S.M., Kamykowski,J.A., Hogue,W.R., Swain,F.L.,
            Burdine,M.S., Mackintosh,S.G., Tackett,A.J., Suva,L.J., Eyre,D.R.
            and Morello,R.
  TITLE     Sc65-Null Mice Provide Evidence for a Novel Endoplasmic Reticulum
            Complex Regulating Collagen Lysyl Hydroxylation
  JOURNAL   PLoS Genet 12 (4), e1006002 (2016)
   PUBMED   27119146
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2440)
  AUTHORS   Gruenwald,K., Castagnola,P., Besio,R., Dimori,M., Chen,Y.,
            Akel,N.S., Swain,F.L., Skinner,R.A., Eyre,D.R., Gaddy,D., Suva,L.J.
            and Morello,R.
  TITLE     Sc65 is a novel endoplasmic reticulum protein that regulates bone
            mass homeostasis
  JOURNAL   J Bone Miner Res 29 (3), 666-675 (2014)
   PUBMED   23959653
REFERENCE   3  (bases 1 to 2440)
  AUTHORS   Chen,Q., Pearlman,R.E. and Moens,P.B.
  TITLE     Isolation and characterization of a cDNA encoding a synaptonemal
            complex protein
  JOURNAL   Biochem Cell Biol 70 (10-11), 1030-1038 (1992)
   PUBMED   1363622
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On or before May 5, 2015 this sequence version replaced
            XM_006247414.2, NM_021581.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ227296.1, BC107672.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-506               JAXUCZ010000010.1  85844971-85845476   c
            507-659             JAXUCZ010000010.1  85844722-85844874   c
            660-831             JAXUCZ010000010.1  85844425-85844596   c
            832-960             JAXUCZ010000010.1  85843160-85843288   c
            961-1106            JAXUCZ010000010.1  85842212-85842357   c
            1107-1190           JAXUCZ010000010.1  85841597-85841680   c
            1191-1335           JAXUCZ010000010.1  85839840-85839984   c
            1336-2440           JAXUCZ010000010.1  85838528-85839632   c
FEATURES             Location/Qualifiers
     source          1..2440
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..2440
                     /gene="P3h4"
                     /gene_synonym="Leprel4; Sc65"
                     /note="prolyl 3-hydroxylase family member 4"
                     /db_xref="GeneID:59101"
                     /db_xref="RGD:620767"
     exon            1..506
                     /gene="P3h4"
                     /gene_synonym="Leprel4; Sc65"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1358
                     /gene="P3h4"
                     /gene_synonym="Leprel4; Sc65"
                     /note="leprecan-like protein 4; SC65 synaptonemal complex
                     protein; synaptonemal complex protein SC65; leprecan-like
                     4; endoplasmic reticulum protein SC65; prolyl
                     3-hydroxylase family member 4 (non-enzymatic)"
                     /codon_start=1
                     /product="endoplasmic reticulum protein SC65 precursor"
                     /protein_id="NP_067592.2"
                     /db_xref="GeneID:59101"
                     /db_xref="RGD:620767"
                     /translation="MARAAWGLLWLLLGSAGAQYEKYSFRGFPPEDLMPLATAYGHAL
                     EQYEGESWRESARYLEAALRLHRLLRDSEAFCHANCSGPATSQPRPAPGPDGDNEGDG
                     EDWARELRLFGHVLERAACLRRCKRTLPAFQVPYPSRQLLRDFQNRLPYQYLHYAHFK
                     ANRLEKAVAAAYTFLQRNPKHELTAKYLNYYRGMLDIGDESLTDLEAQPYEAVFLQAV
                     KLYNSGDFRSSTEHMERALADYMTVFARCLAGCEGAHEQVDFKDFYPAIADLFAESLQ
                     CKVDCEANLTPNVGGFFVDKFVATMYHYLQFAYYKLNDVHQAARSAASYMLFDPKDSV
                     MQQNLVYYRFHRARWGLEEEDFQPREEAVLYHNQTSELRELLDFTHMYLQSDDEMELE
                     ETESLPEPEKPLSDAEFEGEGDYEEGLYADWWQEPDAKGDEDEAEPEPELA"
     exon            507..659
                     /gene="P3h4"
                     /gene_synonym="Leprel4; Sc65"
                     /inference="alignment:Splign:2.1.0"
     exon            660..831
                     /gene="P3h4"
                     /gene_synonym="Leprel4; Sc65"
                     /inference="alignment:Splign:2.1.0"
     exon            832..960
                     /gene="P3h4"
                     /gene_synonym="Leprel4; Sc65"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1106
                     /gene="P3h4"
                     /gene_synonym="Leprel4; Sc65"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1190
                     /gene="P3h4"
                     /gene_synonym="Leprel4; Sc65"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1335
                     /gene="P3h4"
                     /gene_synonym="Leprel4; Sc65"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..2440
                     /gene="P3h4"
                     /gene_synonym="Leprel4; Sc65"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttgagcctc cgggcgcggc gcgggcatgg ctcgcgcggc gtgggggctg ctgtggctgc
       61 tgctgggtag cgccggcgcg cagtatgaga agtacagctt ccgaggattc cccccggagg
      121 acctgatgcc tctggccacg gcctacggcc acgctctgga gcagtatgaa ggggagagct
      181 ggcgcgagag cgcgcgctac ctggaggcgg cgctgcggct gcatcggctg ctgcgcgaca
      241 gtgaggcctt ctgccacgcc aactgcagcg gccccgccac ctcgcagccc cggcccgctc
      301 ccggccccga cggcgacaac gagggtgatg gcgaggattg ggcgcgcgag ctgcggctct
      361 tcggccacgt cctggagcgt gccgcctgtt tgcggcgctg caagcggact ctgcccgcct
      421 tccaagtccc ctacccgtcg cggcagctac tgcgcgactt ccagaaccgc ctgccctacc
      481 agtacctgca ctacgcgcac ttcaaggcga accgactaga gaaggcggtg gctgcagcct
      541 acaccttcct ccagaggaac cccaagcacg agctgaccgc caagtatctc aactactaca
      601 ggggaatgct ggatatcgga gatgagtccc tcactgatct ggaggcccag ccctacgagg
      661 ctgtgttcct tcaggctgtg aagctctaca acagcgggga ctttcgcagc agcacagaac
      721 acatggagcg ggccttggct gattatatga ccgtctttgc tcggtgtcta gctggctgtg
      781 aaggggccca cgagcaggta gacttcaagg acttctaccc agccatagca gatctctttg
      841 cagaatccct gcagtgcaag gtggattgtg aagccaatct cacccccaac gtaggtggct
      901 tctttgtgga caagttcgtg gccaccatgt atcactacct gcagtttgcc tactacaaat
      961 tgaacgatgt gcaccaggct gcccgcagcg ctgctagcta catgctcttt gaccccaagg
     1021 acagtgtcat gcagcagaac ctggtatatt accgcttcca ccgggctcgc tggggccttg
     1081 aagaggagga cttccagccc cgggaggaag ctgtgctcta ccacaaccag acctctgaac
     1141 ttcgggagtt gctagacttc acacacatgt accttcagtc agatgatgag atggaactgg
     1201 aggagacgga atcacttccg gagcctgaaa aacctctgtc tgatgccgag ttcgaaggcg
     1261 agggcgacta tgaggagggc ctctatgcgg actggtggca ggagccggat gccaagggtg
     1321 atgaggatga ggctgagcca gagcctgaac tggcctaaga cagtgacatg gtgcactctt
     1381 caagctcagg acacctggct gggggcagga actatttatt aaaacttaaa atcggggttg
     1441 gggatttagc tcagtggtag agcacttgcc tagcaaccac aaggccctgg gttcggtccc
     1501 tagctccgaa agaaaaaaaa aaacaaaaaa aaacttaaaa tcgccaggtg tggtagcaca
     1561 cacctttcac cctggcacgc gggggaagca gaagcaggag gatctcttga cttcccggcc
     1621 agaccggttt acagtgagaa cctggtcagt tcgggctaca cagcgagatc ttgtttcaaa
     1681 acaaaaacaa ctgcgtgtgg catcgcacgc cttcaattcc agcagttggg atgcaggggc
     1741 agggggatct ctgcgggttc caggctagcc tcatgtagtg agttccaggc cagtcgaggc
     1801 tatgttgtaa gagcctgtct caaaataaaa caaaagggaa aacctcaaaa gggacacggt
     1861 tggcctagtt cccacccaga ctctacctta cctctctctg tgtgtccttg aacctgcaga
     1921 ctggtggcca tattgctggt tggcaagtga gctattgggg gtcctaaccc cccctttctg
     1981 ctcctgtgga actcctcagc ttccggcttg agtctcacag gaccaaggcc tgtctgagct
     2041 gcagagtggg ttgtgaagaa cgtcgggctt agagctctgg tgctcagtaa atgtttattg
     2101 ttgaatgaat cataacgcct gaggctagtc ggcaagactg agatttgtgg gtgcagggcc
     2161 ttgcctcact ctcgctgcta atctcccctt atctgtgcaa tgccagttgg tgtactctat
     2221 ggccttggca ggtcctttac tggcatccaa ttgagagctg cagaatccct gttagctggg
     2281 aggaacctca gacctaccac cagggggcgt gaagacacag tattccatga agatggtggt
     2341 ttcagatttc taatcaggga tgtctgtatt tttctcgtcc caggccactc ttctcgggac
     2401 ttagagggat atgaagaggg aattaaagac atttactaca
//
