LOCUS       NM_001106620            2598 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus prolyl 3-hydroxylase 3 (P3h3), mRNA.
ACCESSION   NM_001106620 XM_001062610 XM_006237343 XM_216278
VERSION     NM_001106620.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2598)
  AUTHORS   Hudson,D.M., Weis,M., Rai,J., Joeng,K.S., Dimori,M., Lee,B.H.,
            Morello,R. and Eyre,D.R.
  TITLE     P3h3-null and Sc65-null Mice Phenocopy the Collagen Lysine
            Under-hydroxylation and Cross-linking Abnormality of Ehlers-Danlos
            Syndrome Type VIA
  JOURNAL   J Biol Chem 292 (9), 3877-3887 (2017)
   PUBMED   28115524
REFERENCE   2  (bases 1 to 2598)
  AUTHORS   Heard,M.E., Besio,R., Weis,M., Rai,J., Hudson,D.M., Dimori,M.,
            Zimmerman,S.M., Kamykowski,J.A., Hogue,W.R., Swain,F.L.,
            Burdine,M.S., Mackintosh,S.G., Tackett,A.J., Suva,L.J., Eyre,D.R.
            and Morello,R.
  TITLE     Sc65-Null Mice Provide Evidence for a Novel Endoplasmic Reticulum
            Complex Regulating Collagen Lysyl Hydroxylation
  JOURNAL   PLoS Genet 12 (4), e1006002 (2016)
   PUBMED   27119146
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2598)
  AUTHORS   Shah,R., Smith,P., Purdie,C., Quinlan,P., Baker,L., Aman,P.,
            Thompson,A.M. and Crook,T.
  TITLE     The prolyl 3-hydroxylases P3H2 and P3H3 are novel targets for
            epigenetic silencing in breast cancer
  JOURNAL   Br J Cancer 100 (10), 1687-1696 (2009)
   PUBMED   19436308
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On or before Jan 4, 2023 this sequence version replaced
            XM_006237343.4, NM_001106620.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22399481.873119.1,
                                           SRR21887623.2938501.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMN09345329 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-524               JAXUCZ010000004.1  159347481-159348004 c
            525-677             JAXUCZ010000004.1  159346043-159346195 c
            678-876             JAXUCZ010000004.1  159345196-159345394 c
            877-1008            JAXUCZ010000004.1  159344860-159344991 c
            1009-1145           JAXUCZ010000004.1  159344336-159344472 c
            1146-1235           JAXUCZ010000004.1  159342998-159343087 c
            1236-1288           JAXUCZ010000004.1  159342380-159342432 c
            1289-1356           JAXUCZ010000004.1  159342218-159342285 c
            1357-1481           JAXUCZ010000004.1  159341904-159342028 c
            1482-1583           JAXUCZ010000004.1  159337099-159337200 c
            1584-1734           JAXUCZ010000004.1  159336675-159336825 c
            1735-1852           JAXUCZ010000004.1  159336356-159336473 c
            1853-1928           JAXUCZ010000004.1  159336165-159336240 c
            1929-2069           JAXUCZ010000004.1  159333203-159333343 c
            2070-2598           JAXUCZ010000004.1  159332514-159333042 c
FEATURES             Location/Qualifiers
     source          1..2598
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..2598
                     /gene="P3h3"
                     /gene_synonym="Leprel2"
                     /note="prolyl 3-hydroxylase 3"
                     /db_xref="GeneID:297595"
                     /db_xref="RGD:1305699"
     exon            1..524
                     /gene="P3h3"
                     /gene_synonym="Leprel2"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..2240
                     /gene="P3h3"
                     /gene_synonym="Leprel2"
                     /EC_number="1.14.11.7"
                     /note="leprecan-like 2"
                     /codon_start=1
                     /product="prolyl 3-hydroxylase 3 precursor"
                     /protein_id="NP_001100090.3"
                     /db_xref="GeneID:297595"
                     /db_xref="RGD:1305699"
                     /translation="MLRLLRLLLLLLLPPPGSPEPSEPPGLAQLSPGAPPQAPDLLYA
                     DGLRAYSAGAWAPAVALLREALRSREVLGRARQDCGASCAAEPGAALPAQILGAPQPV
                     SGPGAWEPLLLRATLRRAECLTQCAAGRLGPGGAARFRVVSALRDAFRRREPYNYLQR
                     AYYQLKKLDLAASAAHTFFVANPTHLQMREDMAKYRRMSAIRPQSFQDLVTPLYWAAY
                     DTGLELLKQQEAALALPKLEEALQGSLAQMESCRAGCEGPEEHQGAEEEEEKGTQGGL
                     YEAIAGHWIRVLQCRQHCVAETATRPGRSFPVRDFLPSQLRRLHEAYAQVGNVSQAVE
                     NVLSVLLFYPEDEAAKRALNQYQTQLGELRPDLGPREDVQRFILRSLGEKRQLYYAME
                     HLGTSFKDPDSWTPEAFIPKALREKLREDQEKKPWDSEPPQQKPPTYWKDALLLEGVT
                     LTQDAQQLNGSERAVLDGLLTPAECGLLLQLAKDAAEAGARSGYRGRRSPHSPHERFE
                     GLTVLKAAQLARAGTVGRPGAKLLLEVSERVRTLTQAYFSPERPLHLSFTHLVCRSAI
                     EGEQEQRMDLSHPVHADNCFLDPDTGECWREPPAYTYRDYSGLLYLNDDFKGGDLFFT
                     QPNALTVTAQVRPRCGRLVAFSSGGENPHGVWAVTRGRRCALALWHTWAPEHREQEWT
                     EAKELLREEEEEEEENEEEEEILSRDPSPEPPSHKLQRVQDKAGKPLRVREEL"
     exon            525..677
                     /gene="P3h3"
                     /gene_synonym="Leprel2"
                     /inference="alignment:Splign:2.1.0"
     exon            678..876
                     /gene="P3h3"
                     /gene_synonym="Leprel2"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1008
                     /gene="P3h3"
                     /gene_synonym="Leprel2"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1145
                     /gene="P3h3"
                     /gene_synonym="Leprel2"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1235
                     /gene="P3h3"
                     /gene_synonym="Leprel2"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1288
                     /gene="P3h3"
                     /gene_synonym="Leprel2"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1356
                     /gene="P3h3"
                     /gene_synonym="Leprel2"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1481
                     /gene="P3h3"
                     /gene_synonym="Leprel2"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1583
                     /gene="P3h3"
                     /gene_synonym="Leprel2"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1734
                     /gene="P3h3"
                     /gene_synonym="Leprel2"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1852
                     /gene="P3h3"
                     /gene_synonym="Leprel2"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..1928
                     /gene="P3h3"
                     /gene_synonym="Leprel2"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2069
                     /gene="P3h3"
                     /gene_synonym="Leprel2"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2598
                     /gene="P3h3"
                     /gene_synonym="Leprel2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccttcggcgg tgggcccgcg gctctgggca ccatgctccg gctcctgcgg ttgttgcttt
       61 tgctgctgct gcctcccccg gggtcccccg agccttccga gcctccaggt ctggcccagt
      121 tgtcgcccgg ggcgcctcct caggccccgg acttgcttta cgcggacggc ctgagagcct
      181 actcggccgg ggcttgggcg cccgcagtgg ctctgctgcg agaggcgctg cggagccggg
      241 aagtgctggg ccgcgcgcgc caggactgcg gggcgagctg cgcggccgag ccgggcgccg
      301 cgctccccgc ccagatcctg ggagccccgc agcctgtctc ggggcccggg gcctgggaac
      361 ccctgctcct gcgcgccacg ctccgccgcg ccgagtgcct gacccagtgc gcggcgggga
      421 ggctgggccc ggggggcgcg gcgcggttcc gcgtggtgag cgcgctgcgg gatgccttcc
      481 gccggcggga gccctacaac tacctgcaga gggcctacta ccagttgaag aagttggacc
      541 tggcagcttc agcagcacac accttctttg tggcgaaccc aacgcacttg cagatgcggg
      601 aagacatggc taagtatagg agaatgtctg caatacgacc ccagagtttc caggacctgg
      661 tgacgcccct gtattgggca gcttatgaca ctggcctgga gctactgaag caacaggaag
      721 cagctttggc tctacccaaa ctagaggagg ccctccaggg gagcctggcc cagatggaga
      781 gctgtcgtgc tggctgtgag ggacctgagg agcaccaagg ggctgaagaa gaggaggaga
      841 aagggaccca ggggggcctg tatgaagcca ttgcaggaca ctggattcgg gttctgcagt
      901 gccggcagca ctgtgtagca gagacagcca cacgtcctgg tcgcagcttc cctgtccggg
      961 acttcctccc aagccagctg agacggctgc acgaggccta tgctcaggtg gggaatgtgt
     1021 ctcaggccgt ggaaaatgtc ctgagcgtcc tgctcttcta tccagaggat gaggctgcca
     1081 aaagggctct gaaccagtac caaactcagc tgggagagct gagacctgac ctgggaccac
     1141 gagaggacgt ccagcgtttc atccttcgct ccctcgggga gaagagacag ctatattacg
     1201 ccatggagca tctgggcacc agcttcaagg acccggattc ttggacccca gaggctttca
     1261 tccctaaagc actgagagag aagctcagag aggatcaaga gaagaagccc tgggacagtg
     1321 agccgccaca gcagaagccc ccgacttact ggaaggatgc ccttctcctg gagggtgtga
     1381 ctctcaccca ggatgcccag cagctgaatg gatccgagcg ggctgtgtta gatgggctgc
     1441 taactccagc cgagtgtggg cttctactgc agctggccaa ggatgcagct gaggctggag
     1501 ccaggtcagg ctaccgtggg cgccgctccc ctcatagtcc tcacgaacgg tttgagggac
     1561 tcacggtgct caaggctgct cagctggccc gggctgggac ggtgggcagg ccaggcgcta
     1621 agctgcttct ggaggtgagt gagcgagtac gcaccttgac ccaggcctac ttctccccgg
     1681 aacggccact gcatctttct ttcacgcacc tggtgtgtag aagtgccata gaaggtgagc
     1741 aagaacagcg tatggacctg agtcacccgg ttcacgcaga caactgcttc ctggaccctg
     1801 acaccgggga atgctggcgg gagcccccag cctacaccta tcgagactat agtggactcc
     1861 tctacctcaa tgatgacttc aagggaggcg acctgttctt cacgcagccc aacgccctca
     1921 ctgtcacggc tcaggtccgt cctcgatgtg gacgcctcgt ggccttcagc tctgggggtg
     1981 agaatcccca tggcgtatgg gctgtgactc ggggacggcg ttgtgcccta gctctgtggc
     2041 acacctgggc acctgagcac agggagcagg agtggacaga agccaaagag ctgttgcggg
     2101 aggaagagga ggaggaagag gaaaatgagg aagaggaaga aatcctgagt agagaccctt
     2161 ccccagaacc cccaagtcac aagcttcagc gggtccaaga caaagccggg aaaccactcc
     2221 gggtccgaga ggaactgtga acggccagct tctttggata tggccactca gcttgggaag
     2281 agaccaatga gaatgccctg atgacattgg ggacatagta gcatgccgag tctaccatct
     2341 cggggaccta caagggccac caaaccctgg cctcacaagc ttgcaacaca gactcagcct
     2401 agagaacatc aggccttggg agctagggct ggccccgact gcggggcctg caaactccct
     2461 aggacaggca aagatcactg tgcctctctg aagggcatgg cgaggattga gggccaagtg
     2521 cttctcataa gaaacacaca gagaggaaag acagtctcac cttctcccaa cctgtgcaat
     2581 aaaggatgtg actaccca
//
