LOCUS       NM_001025627            2387 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus prolyl 3-hydroxylase 2 (P3h2), mRNA.
ACCESSION   NM_001025627 XM_213603
VERSION     NM_001025627.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2387)
  AUTHORS   Fernandes,R.J., Farnand,A.W., Traeger,G.R., Weis,M.A. and Eyre,D.R.
  TITLE     A role for prolyl 3-hydroxylase 2 in post-translational
            modification of fibril-forming collagens
  JOURNAL   J Biol Chem 286 (35), 30662-30669 (2011)
   PUBMED   21757687
  REMARK    GeneRIF: P3H2 has preferred substrate sequences among the classes
            of 3Hyp sites in clade A collagen chains
REFERENCE   2  (bases 1 to 2387)
  AUTHORS   Shah,R., Smith,P., Purdie,C., Quinlan,P., Baker,L., Aman,P.,
            Thompson,A.M. and Crook,T.
  TITLE     The prolyl 3-hydroxylases P3H2 and P3H3 are novel targets for
            epigenetic silencing in breast cancer
  JOURNAL   Br J Cancer 100 (10), 1687-1696 (2009)
   PUBMED   19436308
REFERENCE   3  (bases 1 to 2387)
  AUTHORS   Tiainen,P., Pasanen,A., Sormunen,R. and Myllyharju,J.
  TITLE     Characterization of recombinant human prolyl 3-hydroxylase
            isoenzyme 2, an enzyme modifying the basement membrane collagen IV
  JOURNAL   J Biol Chem 283 (28), 19432-19439 (2008)
   PUBMED   18487197
REFERENCE   4  (bases 1 to 2387)
  AUTHORS   Jarnum,S., Kjellman,C., Darabi,A., Nilsson,I., Edvardsen,K. and
            Aman,P.
  TITLE     LEPREL1, a novel ER and Golgi resident member of the Leprecan
            family
  JOURNAL   Biochem Biophys Res Commun 317 (2), 342-351 (2004)
   PUBMED   15063763
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC099107.1.
            
            On Jul 22, 2005 this sequence version replaced XM_213603.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099107.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760384, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2387
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q22"
     gene            1..2387
                     /gene="P3h2"
                     /gene_synonym="Leprel1"
                     /note="prolyl 3-hydroxylase 2"
                     /db_xref="GeneID:288016"
                     /db_xref="RGD:1304568"
     exon            1..621
                     /gene="P3h2"
                     /gene_synonym="Leprel1"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..2265
                     /gene="P3h2"
                     /gene_synonym="Leprel1"
                     /EC_number="1.14.11.7"
                     /note="leprecan-like protein 1; leprecan-like 1"
                     /codon_start=1
                     /product="prolyl 3-hydroxylase 2 precursor"
                     /protein_id="NP_001020798.1"
                     /db_xref="GeneID:288016"
                     /db_xref="RGD:1304568"
                     /translation="MRESTWVSLLLLLLLPAPQRGGPQDGRGSPEPEPERGPLQPFDL
                     LYASGVAAYYSGDYEGAVRDLEAALRSHRRLRDIRTRCARHCAARRPLAPPGAGPGAE
                     LPFFRAVLERARCSRSCQSQRLGGPASRHRVSEDVRSDFQRRVPYNYLQRAYIKLNQL
                     DKAMEAAHTFFMANPEHMEMQQNIEDYKATARVEAPLVDREAKPHLESYNAGVKHYEA
                     DDFEAAIKYFEQALREYFNEDMVCRALCEGPQRFEEYEYLGSKGSLYEAIADHYMQVL
                     VCQHECVRELATRPGRLSPIENFLPLHYDYLQFAYYRVGEYVKALECAKAYLMFHPDD
                     QDVLDNVDFYESLLDDSTDPASIEAREDLTAFVKRHKLEAELIKSAAEGLGFSYSEPN
                     YWISYGGRQDENRVPSGVNMDGAEVHGLSMGKKSPPKIGRDLREGGPLLYENITFVYN
                     SEQLNGTQRVLLDNVLSEEQCRELHSVASGIMLVGDGYRGKTSPHTPNEKFEGATVLK
                     ALKFGYEGRVPLKSARLFYDISEKARKIVESYFMLNSTLYFSYTHMVCRTALSGQQDR
                     RNDLSHPIHADNCLLDPEANECWKEPPAYTFRDYSALLYMNDDFEGGEFIFTEMDAKT
                     VTASIKPKCGRMISFSSGGENPHGVKAVTRGQRCAVALWFTLDPLYRELERIQADEVI
                     AILDQEQHGKHGLNINPKDEL"
     exon            622..771
                     /gene="P3h2"
                     /gene_synonym="Leprel1"
                     /inference="alignment:Splign:2.1.0"
     exon            772..961
                     /gene="P3h2"
                     /gene_synonym="Leprel1"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1093
                     /gene="P3h2"
                     /gene_synonym="Leprel1"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1236
                     /gene="P3h2"
                     /gene_synonym="Leprel1"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1326
                     /gene="P3h2"
                     /gene_synonym="Leprel1"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1367
                     /gene="P3h2"
                     /gene_synonym="Leprel1"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1462
                     /gene="P3h2"
                     /gene_synonym="Leprel1"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1590
                     /gene="P3h2"
                     /gene_synonym="Leprel1"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1686
                     /gene="P3h2"
                     /gene_synonym="Leprel1"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1837
                     /gene="P3h2"
                     /gene_synonym="Leprel1"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..1955
                     /gene="P3h2"
                     /gene_synonym="Leprel1"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..2031
                     /gene="P3h2"
                     /gene_synonym="Leprel1"
                     /inference="alignment:Splign:2.1.0"
     exon            2032..2172
                     /gene="P3h2"
                     /gene_synonym="Leprel1"
                     /inference="alignment:Splign:2.1.0"
     exon            2173..2363
                     /gene="P3h2"
                     /gene_synonym="Leprel1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgcagcgct gccggcggtc acctgggact gtcgtgcagc aggaccgcgg caaggcaggc
       61 gcgctagctc tcggagccag agcggggctc gaactcgagg tgcggggggc aggcaaggag
      121 cgcgactgtc cccctccacg ggtccggcgg aggatgcggg agagcacgtg ggtgtcgctg
      181 ctgttgctgc tgctgctgcc cgcgccacag cggggcggcc cccaggacgg tcgcgggtcg
      241 ccggagccgg agccagagcg cggcccgctg cagcccttcg acctgctcta cgctagcggc
      301 gtggctgcct actacagcgg cgactacgaa ggtgcggtgc gggacctaga agccgcgctg
      361 cgcagccacc ggcgcctgcg agacatccgc acgcgctgcg cccgccactg cgccgcgcgc
      421 cgcccgctcg cgcccccagg cgccggcccg ggagccgagc tgcccttctt ccgcgcggtg
      481 ctcgaacgag cgcgctgctc ccgcagctgc cagagccagc gtctgggcgg ccccgcgtcc
      541 cgccaccgtg tcagcgaaga cgtgcgcagc gacttccagc gcagagtgcc ctacaactac
      601 ctgcagaggg cctacatcaa gctcaaccag ctcgataaag ccatggaagc agctcacaca
      661 ttcttcatgg ccaaccccga gcacatggaa atgcagcaga acatagaaga ctataaagcc
      721 acagcaagag tggaagcccc gttagtagac agagaagcca agccacacct ggaaagctat
      781 aatgctggag ttaaacatta tgaggcggat gactttgaag cagccatcaa gtactttgaa
      841 caagctttaa gagaatattt caatgaagat atggtgtgcc gcgctctgtg tgaggggcct
      901 cagagatttg aggaatatga gtatttagga tctaagggca gtctttatga ggcaatcgca
      961 gatcactaca tgcaggttct ggtctgtcag catgagtgtg tgagggaact tgccacccgc
     1021 ccaggccgcc tctcaccaat cgagaacttt cttcccttgc attatgacta cctccagttt
     1081 gcctactaca gagttggtga gtatgtgaaa gccttggagt gtgccaaagc ctacctgatg
     1141 ttccacccag acgaccagga tgtcctggac aatgtagact tctatgagag tctgctggat
     1201 gacagcactg acccagcatc cattgaggcc cgagaggatt taacagcatt tgtcaaacgt
     1261 cataaacttg aagctgaact gatcaagtca gctgcagagg gcctgggatt ttcatattct
     1321 gaaccaaatt actggatcag ttatggagga cggcaggatg agaaccgagt cccttcggga
     1381 gtgaatatgg atggggcaga agttcacgga ttgtccatgg ggaagaagtc accacccaag
     1441 ataggtcgag atcttagaga aggtggccct ctgctctatg agaacatcac cttcgtctac
     1501 aactccgagc agctgaacgg gactcagcgg gttctcctag ataacgtcct gtcggaagaa
     1561 cagtgccggg agctgcacag tgtggccagt ggaatcatgc tggttggtga tggataccga
     1621 gggaaaacgt caccccacac acccaatgag aagtttgaag gagcaactgt tttgaaagca
     1681 ctcaaatttg gttatgaagg ccgggtgcca ctgaagagtg cacggctgtt ctatgacatc
     1741 agcgagaagg ctcggaagat tgtggagtcc tatttcatgc tgaactcaac cctgtatttt
     1801 tcctatacac acatggtctg cagaacagcc ctgtctgggc agcaggatcg aagaaatgac
     1861 ctcagtcacc ccattcatgc ggacaactgc ttgctggatc cagaagccaa cgaatgctgg
     1921 aaggagcctc ctgcttacac ctttcgggac tatagtgctc tcctgtatat gaatgacgac
     1981 tttgaaggag gagaattcat cttcacggaa atggatgcta aaactgtgac tgcctctata
     2041 aagccaaaat gtgggcgaat gatcagcttc tcatctggtg gcgagaaccc tcacggggtg
     2101 aaggcagtca ccagaggcca gcgctgtgct gtggcactgt ggttcaccct agaccctctc
     2161 taccgagaat tggagcggat acaggctgat gaagtgattg ccatcttgga tcaagaacaa
     2221 cacgggaagc atggactgaa tattaacccc aaagacgagc tatagaaaag agagtattct
     2281 attgaatatt tatttaaata gataatctta tgagaacgtt tttatttttg tacagagccg
     2341 tggtataaat taacaggata ctaaaaaaaa aaaaaaaaaa aaaaaaa
//
