LOCUS       NM_053667               2562 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus prolyl 3-hydroxylase 1 (P3h1), mRNA.
ACCESSION   NM_053667
VERSION     NM_053667.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2562)
  AUTHORS   Roet,K.C., Franssen,E.H., de Bree,F.M., Essing,A.H., Zijlstra,S.J.,
            Fagoe,N.D., Eggink,H.M., Eggers,R., Smit,A.B., van Kesteren,R.E.
            and Verhaagen,J.
  TITLE     A multilevel screening strategy defines a molecular fingerprint of
            proregenerative olfactory ensheathing cells and identifies SCARB2,
            a protein that improves regenerative sprouting of injured sensory
            spinal axons
  JOURNAL   J Neurosci 33 (27), 11116-11135 (2013)
   PUBMED   23825416
REFERENCE   2  (bases 1 to 2562)
  AUTHORS   Takagi,M., Ishii,T., Barnes,A.M., Weis,M., Amano,N., Tanaka,M.,
            Fukuzawa,R., Nishimura,G., Eyre,D.R., Marini,J.C. and Hasegawa,T.
  TITLE     A novel mutation in LEPRE1 that eliminates only the KDEL ER-
            retrieval sequence causes non-lethal osteogenesis imperfecta
  JOURNAL   PLoS One 7 (5), e36809 (2012)
   PUBMED   22615817
REFERENCE   3  (bases 1 to 2562)
  AUTHORS   Vranka,J.A., Pokidysheva,E., Hayashi,L., Zientek,K., Mizuno,K.,
            Ishikawa,Y., Maddox,K., Tufa,S., Keene,D.R., Klein,R. and
            Bachinger,H.P.
  TITLE     Prolyl 3-hydroxylase 1 null mice display abnormalities in fibrillar
            collagen-rich tissues such as tendons, skin, and bones
  JOURNAL   J Biol Chem 285 (22), 17253-17262 (2010)
   PUBMED   20363744
  REMARK    Erratum:[J Biol Chem. 2010 Jun 25;285(26):20421]
REFERENCE   4  (bases 1 to 2562)
  AUTHORS   Barnes,A.M., Carter,E.M., Cabral,W.A., Weis,M., Chang,W.,
            Makareeva,E., Leikin,S., Rotimi,C.N., Eyre,D.R., Raggio,C.L. and
            Marini,J.C.
  TITLE     Lack of cyclophilin B in osteogenesis imperfecta with normal
            collagen folding
  JOURNAL   N Engl J Med 362 (6), 521-528 (2010)
   PUBMED   20089953
REFERENCE   5  (bases 1 to 2562)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 2562)
  AUTHORS   Lauer,M., Scruggs,B., Chen,S., Wassenhove-McCarthy,D. and
            McCarthy,K.J.
  TITLE     Leprecan distribution in the developing and adult kidney
  JOURNAL   Kidney Int 72 (1), 82-91 (2007)
   PUBMED   17495866
  REMARK    GeneRIF: Regulated expression of leprecan during glomerular
            development or hypertrophy coupled with its reported prolyl
            hydroxylase activity plays a role during basement membrane
            assembly.
REFERENCE   7  (bases 1 to 2562)
  AUTHORS   Cabral,W.A., Chang,W., Barnes,A.M., Weis,M., Scott,M.A., Leikin,S.,
            Makareeva,E., Kuznetsova,N.V., Rosenbaum,K.N., Tifft,C.J.,
            Bulas,D.I., Kozma,C., Smith,P.A., Eyre,D.R. and Marini,J.C.
  TITLE     Prolyl 3-hydroxylase 1 deficiency causes a recessive metabolic bone
            disorder resembling lethal/severe osteogenesis imperfecta
  JOURNAL   Nat Genet 39 (3), 359-365 (2007)
   PUBMED   17277775
  REMARK    Erratum:[Nat Genet. 2008 Jul;40(7):927]
REFERENCE   8  (bases 1 to 2562)
  AUTHORS   Kaul,S.C., Sugihara,T., Yoshida,A., Nomura,H. and Wadhwa,R.
  TITLE     Gros1, a potential growth suppressor on chromosome 1: its identity
            to basement membrane-associated proteoglycan, leprecan
  JOURNAL   Oncogene 19 (32), 3576-3583 (2000)
   PUBMED   10951563
REFERENCE   9  (bases 1 to 2562)
  AUTHORS   Wassenhove-McCarthy,D.J. and McCarthy,K.J.
  TITLE     Molecular characterization of a novel basement membrane-associated
            proteoglycan, leprecan
  JOURNAL   J Biol Chem 274 (35), 25004-25017 (1999)
   PUBMED   10455179
REFERENCE   10 (bases 1 to 2562)
  AUTHORS   Valent,M., Janoska,A., Catar,G. and Scholz,W.
  TITLE     [Treatment of trichomoniasis with a single dose of Metronidazol
            SPOFA (author's transl)]
  JOURNAL   Bratisl Lek Listy 63 (6), 680-683 (1975)
   PUBMED   1095156
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Dec 1, 2020 this sequence version replaced NM_053667.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF087433.1, SRR26643290.20220.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-488               JAXUCZ010000005.1  138127240-138127727
            489-641             JAXUCZ010000005.1  138129495-138129647
            642-831             JAXUCZ010000005.1  138130836-138131025
            832-963             JAXUCZ010000005.1  138132018-138132149
            964-1103            JAXUCZ010000005.1  138132765-138132904
            1104-1193           JAXUCZ010000005.1  138134956-138135045
            1194-1246           JAXUCZ010000005.1  138135497-138135549
            1247-1368           JAXUCZ010000005.1  138135706-138135827
            1369-1496           JAXUCZ010000005.1  138137630-138137757
            1497-1592           JAXUCZ010000005.1  138138031-138138126
            1593-1743           JAXUCZ010000005.1  138138588-138138738
            1744-1861           JAXUCZ010000005.1  138140260-138140377
            1862-1937           JAXUCZ010000005.1  138140748-138140823
            1938-2078           JAXUCZ010000005.1  138141080-138141220
            2079-2562           JAXUCZ010000005.1  138141491-138141974
FEATURES             Location/Qualifiers
     source          1..2562
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2562
                     /gene="P3h1"
                     /gene_synonym="Gros1; Lepre1"
                     /note="prolyl 3-hydroxylase 1"
                     /db_xref="GeneID:114200"
                     /db_xref="RGD:628823"
     exon            1..488
                     /gene="P3h1"
                     /gene_synonym="Gros1; Lepre1"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..2234
                     /gene="P3h1"
                     /gene_synonym="Gros1; Lepre1"
                     /EC_number="1.14.11.7"
                     /note="leprecan-1; leucine- and proline-enriched
                     proteoglycan 1; growth supressor 1; leucine
                     proline-enriched proteoglycan (leprecan) 1"
                     /codon_start=1
                     /product="prolyl 3-hydroxylase 1 precursor"
                     /protein_id="NP_446119.2"
                     /db_xref="GeneID:114200"
                     /db_xref="RGD:628823"
                     /translation="MAVSVRRLLAAMVAVAAAAASRATAESEPGWNVAAPDLLYAEGT
                     AAYVRGDWPGVVLNMERALRSRAALRALRLRCRTRCATELPWAPDLDLGPASSLNHDP
                     GAAALHDLRFFGALLRRAACLRRCLGPPSAHLLSEELDLEFNKRSPYNYLQVAYFKIN
                     KLEKAVAAAHTFFVGNPEHMEMRQNLDYYQTMSGVKEEDFKDLEAKPHMHEFRLGVRL
                     YSEEKPLEAVPHLEAALQEYFVADEECRALCEGPYDYDGYNYLDYSADLFQAITDHYV
                     QVLSCKQNCVTELASHPSREKPFEDFLPSHYNYLQFAYYNIGNYTQAIECAKTYLLFF
                     PNDEVMSQNLAYYTAVLGEEEASSISPRENAQEYRHRSLLEKELLFFAYDIFGIPFVD
                     PDSWTPEEVIPKRLQEKQKSERETAVRISQEIGNLMKEIETLVEEKTKESLDVSRLTR
                     EGGPLLYEGINLTMNSKVLNGSQRVVMDGVISDDECQELQRLTNAAATSGDGYRGQTS
                     PHTPNEKFYGVTVLKALKLGQEGKVPLQSAHMYYNVTEKVRRVMESYFRLDTPLYFSY
                     SHLVCRTAIEESQAERKDSSHPVHVDNCILNAESLVCIKEPPAYTFRDYSAILYLNGD
                     FDGGNFYFTELDAKTVTAEVQPQCGRAVGFSSGTENPHGVKAVTRGQRCAIALWFTLD
                     PRHSERDRVQADDLVKMLFSPEEVDLPQEQPLPDQQGSPKPGEESLSDRESQPKDEL"
     exon            489..641
                     /gene="P3h1"
                     /gene_synonym="Gros1; Lepre1"
                     /inference="alignment:Splign:2.1.0"
     exon            642..831
                     /gene="P3h1"
                     /gene_synonym="Gros1; Lepre1"
                     /inference="alignment:Splign:2.1.0"
     exon            832..963
                     /gene="P3h1"
                     /gene_synonym="Gros1; Lepre1"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1103
                     /gene="P3h1"
                     /gene_synonym="Gros1; Lepre1"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1193
                     /gene="P3h1"
                     /gene_synonym="Gros1; Lepre1"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1246
                     /gene="P3h1"
                     /gene_synonym="Gros1; Lepre1"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1368
                     /gene="P3h1"
                     /gene_synonym="Gros1; Lepre1"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1496
                     /gene="P3h1"
                     /gene_synonym="Gros1; Lepre1"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1592
                     /gene="P3h1"
                     /gene_synonym="Gros1; Lepre1"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1743
                     /gene="P3h1"
                     /gene_synonym="Gros1; Lepre1"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1861
                     /gene="P3h1"
                     /gene_synonym="Gros1; Lepre1"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..1937
                     /gene="P3h1"
                     /gene_synonym="Gros1; Lepre1"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2078
                     /gene="P3h1"
                     /gene_synonym="Gros1; Lepre1"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..2562
                     /gene="P3h1"
                     /gene_synonym="Gros1; Lepre1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaggagcaa gaccatggcg gtgagtgtta ggaggctgct ggccgcgatg gtagcggtcg
       61 ccgcagccgc cgcctcgcgg gctaccgcgg agtctgagcc gggatggaac gtggcagccc
      121 ctgacctact ttacgcagag gggacggcgg cctacgtgcg cggggactgg cccggggtgg
      181 tactgaacat ggagcgggct ctgcgctcgc gggccgctct gcgcgccctc cgcctgcgct
      241 gccgcacacg ctgcgccacc gagctgccgt gggcgccgga cctcgatctc ggtccggcct
      301 cgagtctgaa ccacgacccg ggcgctgccg ccttgcacga ccttcgcttc ttcggagccc
      361 tgctgcgccg tgccgcctgc ctgcgtcgct gcctcgggcc gccttctgcc cacttgttga
      421 gtgaagagct ggacctggag ttcaacaagc ggagcccgta caactacctg caggtcgcct
      481 atttcaagat aaacaagctg gaaaaagccg tggcagcagc acacaccttc tttgtgggca
      541 atcctgagca catggaaatg cggcagaacc tcgactacta ccaaaccatg tctggggtaa
      601 aggaggaaga cttcaaggac ctcgaggcca agccccacat gcatgagttt cggctagggg
      661 tgcgactcta ctctgaggag aagccactgg aagctgtgcc ccacctggag gcggcgttgc
      721 aagagtactt tgtggcagat gaggagtgcc gtgccctctg cgaagggccc tatgactacg
      781 acggctacaa ctacctagac tacagcgctg acctcttcca ggccatcaca gatcattacg
      841 tccaggtcct cagctgtaag cagaactgtg tcaccgagct ggcttcccac ccaagtcgag
      901 aaaagccttt tgaagacttc ctcccctcac actataatta cctacagttt gcctactata
      961 acattgggaa ctatacacaa gctattgaat gtgccaagac ctacctcctc ttcttcccca
     1021 atgatgaggt gatgagtcag aacctggctt actatacagc cgtgcttgga gaagaggagg
     1081 ccagctccat cagtccccgg gagaatgccc aggaataccg acatcgaagc ctgctggaga
     1141 aagaactgct tttcttcgct tatgacattt tcggaattcc ctttgtggat ccggactcat
     1201 ggacaccaga agaggtgatt cccaagagac tgcaagagaa acaaaagtca gaacgcgaaa
     1261 ccgcagtccg catctcccag gagataggca acctcatgaa ggagatcgag accctcgtgg
     1321 aggagaagac gaaggagtcg ctggatgtga gcagactgac acgggaaggt ggtcccttac
     1381 tgtatgaagg catcaatctc actatgaact ccaaagtctt gaacggctcc cagcgagtgg
     1441 tgatggatgg tgtgatctct gatgacgagt gccaggaact gcagagactg accaacgcag
     1501 cagcaacttc aggagatggc tatcgaggtc agacctcccc acacacccca aatgaaaagt
     1561 tctatggtgt cactgtcctc aaagctctca agcttgggca ggaagggaaa gttcctctgc
     1621 agagcgccca catgtactac aacgtgacag agaaggttcg gcgtgtcatg gagtcctact
     1681 tccgcctgga cacacccctc tacttctcct actcccacct agtgtgccgc actgcaatag
     1741 aagagtcaca ggctgagagg aaggacagta gccaccctgt ccatgtggat aactgcattc
     1801 tgaatgccga atccctcgtg tgtatcaagg agcccccagc ctatacgttc cgggactaca
     1861 gcgccatcct ctacctcaat ggggacttcg atggaggaaa cttctacttc acagaactag
     1921 atgccaagac tgtgacggca gaggtgcagc cccagtgtgg aagggctgtg ggattctctt
     1981 ccggcaccga gaacccacat ggagtgaagg ctgtcaccag ggggcagcgc tgcgccatcg
     2041 ccctgtggtt cacgctggat cctcggcaca gtgagagaga cagggtacag gcagatgacc
     2101 tggtgaagat gctcttcagc ccagaagagg tggacctccc ccaggagcag cccctgcctg
     2161 accaacaggg ctccccgaaa cctggagaag agtctctgtc cgacagagag tcacagccca
     2221 aggatgagct atgacagcag ctaggtcgca gttgatgtcg ctggacccat ggggggaact
     2281 cagtcctgca gcctggactt cccagaccct gaaggctgca gagtaagggg cacttctgtt
     2341 tgctgcccgg cccgaggacc ctgcccacag ccttcttcat ggtgctgctg ttctcggagg
     2401 agtgggcatg gcaggacaca ctcttctctg ggcttcactg aaggctcagg atgtaggccc
     2461 agaaccacct ggggcctatg gaggcagctg cctgtcggca gcatgatgta tttaagcgtc
     2521 tgtagagaca gccaaagaat aaatgatttg ttttttcatt ta
//
