LOCUS       NM_057124               2530 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus pyrimidinergic receptor P2Y6 (P2ry6), mRNA.
ACCESSION   NM_057124
VERSION     NM_057124.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2530)
  AUTHORS   Tian,Y.Q., Li,J.H., Li,Y.C., Xu,Y.C., Zhang,P.A., Wang,Q., Li,R.
            and Xu,G.Y.
  TITLE     Overexpression of GRK6 alleviates chronic visceral hypersensitivity
            through downregulation of P2Y6 receptors in anterior cingulate
            cortex of rats with prenatal maternal stress
  JOURNAL   CNS Neurosci Ther 28 (6), 851-861 (2022)
   PUBMED   35349212
  REMARK    GeneRIF: Overexpression of GRK6 alleviates chronic visceral
            hypersensitivity through downregulation of P2Y6 receptors in
            anterior cingulate cortex of rats with prenatal maternal stress.
REFERENCE   2  (bases 1 to 2530)
  AUTHORS   Cai,H., Zhu,X., Li,Z., Zhu,Y. and Lang,J.
  TITLE     lncRNA/mRNA profiling of endometriosis rat uterine tissues during
            the implantation window
  JOURNAL   Int J Mol Med 44 (6), 2145-2160 (2019)
   PUBMED   31638262
  REMARK    GeneRIF: In conclusion, the changes in the expression of lncRNAs,
            mRNAs and proteins (Adamts7, P2ry6, Dlx3 and TP53) may possibly
            affect endometrial receptivity in rats with endometriosis during
            the implantation window, probably resulting in implantation failure
            of the embryo.
REFERENCE   3  (bases 1 to 2530)
  AUTHORS   Wang,Z., Zhao,W., Shen,X., Wan,H. and Yu,J.M.
  TITLE     The role of P2Y6 receptors in the maintenance of neuropathic pain
            and its improvement of oxidative stress in rats
  JOURNAL   J Cell Biochem 120 (10), 17123-17130 (2019)
   PUBMED   31106899
  REMARK    GeneRIF: The role of P2Y6 receptors in the maintenance of
            neuropathic pain and its improvement of oxidative stress in rats.
REFERENCE   4  (bases 1 to 2530)
  AUTHORS   Wang,S., Tang,L., Zhou,Q., Lu,D., Duan,W., Chen,C., Huang,L. and
            Tan,Y.
  TITLE     miR-185/P2Y6 Axis Inhibits Angiotensin II-Induced Human Aortic
            Vascular Smooth Muscle Cell Proliferation
  JOURNAL   DNA Cell Biol 36 (5), 377-385 (2017)
   PUBMED   28277742
REFERENCE   5  (bases 1 to 2530)
  AUTHORS   Barragan-Iglesias,P., Mendoza-Garces,L., Pineda-Farias,J.B.,
            Solano-Olivares,V., Rodriguez-Silverio,J., Flores-Murrieta,F.J.,
            Granados-Soto,V. and Rocha-Gonzalez,H.I.
  TITLE     Participation of peripheral P2Y1, P2Y6 and P2Y11 receptors in
            formalin-induced inflammatory pain in rats
  JOURNAL   Pharmacol Biochem Behav 128, 23-32 (2015)
   PUBMED   25449358
  REMARK    GeneRIF: Results suggest that peripheral activation of P2Y1, P2Y6
            and P2Y11 receptors plays a pronociceptive role in formalin-induced
            pain.
REFERENCE   6  (bases 1 to 2530)
  AUTHORS   Pillois,X., Chaulet,H., Belloc,I., Dupuch,F., Desgranges,C. and
            Gadeau,A.P.
  TITLE     Nucleotide receptors involved in UTP-induced rat arterial smooth
            muscle cell migration
  JOURNAL   Circ Res 90 (6), 678-681 (2002)
   PUBMED   11934835
  REMARK    GeneRIF: prominent role for the UDP receptor, P2Y(6), in
            UTP-induced rat ASMC migration
REFERENCE   7  (bases 1 to 2530)
  AUTHORS   Dranoff,J.A., Masyuk,A.I., Kruglov,E.A., LaRusso,N.F. and
            Nathanson,M.H.
  TITLE     Polarized expression and function of P2Y ATP receptors in rat bile
            duct epithelia
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 281 (4), G1059-G1067 (2001)
   PUBMED   11557527
REFERENCE   8  (bases 1 to 2530)
  AUTHORS   Lazarowski,E.R., Rochelle,L.G., O'Neal,W.K., Ribeiro,C.M.,
            Grubb,B.R., Zhang,V., Harden,T.K. and Boucher,R.C.
  TITLE     Cloning and functional characterization of two murine uridine
            nucleotide receptors reveal a potential target for correcting ion
            transport deficiency in cystic fibrosis gallbladder
  JOURNAL   J Pharmacol Exp Ther 297 (1), 43-49 (2001)
   PUBMED   11259526
REFERENCE   9  (bases 1 to 2530)
  AUTHORS   Communi,D., Parmentier,M. and Boeynaems,J.M.
  TITLE     Cloning, functional expression and tissue distribution of the human
            P2Y6 receptor
  JOURNAL   Biochem Biophys Res Commun 222 (2), 303-308 (1996)
   PUBMED   8670200
REFERENCE   10 (bases 1 to 2530)
  AUTHORS   Chang,K., Hanaoka,K., Kumada,M. and Takuwa,Y.
  TITLE     Molecular cloning and functional analysis of a novel P2 nucleotide
            receptor
  JOURNAL   J Biol Chem 270 (44), 26152-26158 (1995)
   PUBMED   7592819
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC072520.1.
            
            On Jun 13, 2004 this sequence version replaced NM_057124.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072520.1, DN930791.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840119, SAMN13663594
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2530
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..2530
                     /gene="P2ry6"
                     /gene_synonym="P2y6"
                     /note="pyrimidinergic receptor P2Y6"
                     /db_xref="GeneID:117264"
                     /db_xref="RGD:620269"
     exon            1..92
                     /gene="P2ry6"
                     /gene_synonym="P2y6"
                     /inference="alignment:Splign:2.1.0"
     exon            93..181
                     /gene="P2ry6"
                     /gene_synonym="P2y6"
                     /inference="alignment:Splign:2.1.0"
     exon            182..2466
                     /gene="P2ry6"
                     /gene_synonym="P2y6"
                     /inference="alignment:Splign:2.1.0"
     CDS             216..1202
                     /gene="P2ry6"
                     /gene_synonym="P2y6"
                     /note="P2Y ATP receptor 6; pyrimidinergic receptor P2Y,
                     G-protein coupled, 6"
                     /codon_start=1
                     /product="P2Y purinoceptor 6"
                     /protein_id="NP_476465.1"
                     /db_xref="GeneID:117264"
                     /db_xref="RGD:620269"
                     /translation="MERDNGTIQAPGLPPTTCVYREDFKRLLLPPVYSVVLVVGLPLN
                     VCVIAQICASRRTLTRSAVYTLNLALADLLYACSLPLLIYNYARGDHWPFGDLACRLV
                     RFLFYANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWVVCGVVWLVVTAQCL
                     PTAVFAATGIQRNRTVCYDLSPPILSTRYLPYGMALTVIGFLLPFTALLACYCRMARR
                     LCRQDGPAGPVAQERRSKAARMAVVVAAVFVISFLPFHITKTAYLAVRSTPGVSCPVL
                     ETFAAAYKGTRPFASANSVLDPILFYFTQQKFRRQPHDLLQKLTAKWQRQRV"
ORIGIN      
        1 gaactgaact gcagcggctg cttcagaagt ctagcttgct ccagctctca agatggcttg
       61 caagtggttg ctgcatcagg gggagttttc aggggtaaac taagacccaa cctgccttga
      121 caacgagcaa caccagagct ggtacatcct cctaagacat cgtccatctt gcatgagaca
      181 gattctccaa gcataggaaa agcaggccgc cagttatgga gcgggacaat ggcaccatcc
      241 aggctccagg cttgccgccc accacctgcg tctaccgtga ggatttcaag cgactgctgc
      301 tacccccagt ttactcagtg gtgctggtgg tcggcctgcc actgaacgtc tgtgtcatcg
      361 cccagatatg cgcatcccgc cggaccctga cccgttccgc tgtgtacacc ctgaacttgg
      421 cactggcgga cctgctgtat gcctgttcac tgcccctact tatctataac tacgccagag
      481 gggaccactg gcccttcgga gaccttgcct gccgcctggt acgcttcctc ttctatgcca
      541 acctacacgg cagcatcctg ttcctcacct gcattagctt ccagcgatac ctaggcatct
      601 gccatcccct ggccccctgg cacaagcgtg gaggtcgccg tgctgcttgg gtggtatgtg
      661 gagtcgtttg gctggttgtg acagcccagt gcctgcccac agcagtcttt gccgccacgg
      721 gcatccagcg caaccgcact gtctgctacg acctgagccc acccatcctg tccacccgct
      781 acctgccgta tggcatggcc ctcacggtca tcggcttctt gcttcccttc acagccttac
      841 tggcctgcta ctgtcgcatg gcccgccgcc tgtgtcgcca ggatggccca gcaggtcctg
      901 tggcccaaga gcgtcgcagc aaggcggccc gtatggctgt cgtggtagca gctgtctttg
      961 ttatcagctt cctgcctttc cacatcacca agacagccta cttggctgtg cgctccacgc
     1021 ccggcgtctc ttgcccggta ctggagacct tcgctgcagc ctacaaaggc acccggccct
     1081 tcgccagtgc taacagcgtt ctggacccta tcctcttcta cttcacacaa cagaagttcc
     1141 ggcggcaacc acacgatctc ctacagaagc tcacagccaa gtggcagagg cagagagtct
     1201 gagaccccag gggaggccct gaagcactgg ctgcaatgtg tttgcccact ggggtcatgg
     1261 tgcctgaagc tttctcccaa tcggaaacca taccgagaag aagcaaaact tggcccaaca
     1321 tgcctggccc tccaaaattt ctatgtcaac cacaaaacta agacacctgt gtttcgggga
     1381 ctggtcagtt catgcttgtt ataccagaat tcaggatgtc atgacaggat aacaagctct
     1441 aagccagcct ggtctacatg gtgaaacccc atctcagaca atcaagggtt gagctaggtc
     1501 ctggaatagc actgcaaatt ctaacaaagg tcttcccgcc tgaccgttct tgtgtttaca
     1561 aggtagaggg gaccactggt acaccatcac gaacgtgagg gcaaggcccc tcctgtagag
     1621 gaagaagctg ggaaagctca cattcccatc catttgccaa gacttttgca caggagagag
     1681 aaataaatgt gttcttgtgt ttgttgtttt gtttttgtta atttttaagc cattgtacgc
     1741 atgagctttc aagcacacac acacacacac acacacacac acacacacac agccaagcca
     1801 aatgagtcct ttagtcagat tccatcaacg ctaggtgaaa gcaggcaacg acttaactgg
     1861 gataggggac aggatgtctg ctggaacctg acgggaacta agaacaaggg ttggaaatac
     1921 ccaggaggca tcttaaagat ggctgaccac ctggggaggt cagccctagg gtagcttgag
     1981 gctgagaggg agtatatcca tgtcatataa cagatgacac agatgacaga acgggatact
     2041 ccaccttggc ttcacggtgc ctcctaattt tgtaatgccg tacacacttc tgtcacgaaa
     2101 actttgtcca cgagtcccaa agtcaagttc atgacgccca tcaaaactga tatcaccatt
     2161 acctgattat ccactaaaac aatggatcaa cacagtagat acacacacat ctagaattat
     2221 tacaccaaca tgaaacactt caacttagca gtatgatatt aaggaacaag aactccttcc
     2281 gaattatttg taggcagtgt cctttctatg aggttaggaa gaactaaagc agagatgctg
     2341 gcccatgggg gtagccatag catgtggaag gccaactcag gctcaatagt tggaggtgag
     2401 cctggactgt ggactttgtt cattgccttt aaaaatattt taaattatat tttatataca
     2461 attttaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2521 aaaaaaaaaa
//
