LOCUS       NM_031680               1177 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus pyrimidinergic receptor P2Y4 (P2ry4), mRNA.
ACCESSION   NM_031680
VERSION     NM_031680.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1177)
  AUTHORS   Dosh,R.H., Khalfa,H.M., Al-Rehemi,S.M., Almsaid,H.L. and Hadi,N.
  TITLE     IN VIVO ACTIVATION OF P2Y4 PURINERGIC RECEPTORS USING ATP IN RAT
            EPIDERMAL TISSUE
  JOURNAL   Wiad Lek 75 (11 pt 2), 2729-2733 (2022)
   PUBMED   36591760
  REMARK    GeneRIF: IN VIVO ACTIVATION OF P2Y4 PURINERGIC RECEPTORS USING ATP
            IN RAT EPIDERMAL TISSUE.
REFERENCE   2  (bases 1 to 1177)
  AUTHORS   Szrejder,M., Rachubik,P., Rogacka,D., Audzeyenka,I., Rychlowski,M.,
            Angielski,S. and Piwkowska,A.
  TITLE     Extracellular ATP modulates podocyte function through P2Y
            purinergic receptors and pleiotropic effects on AMPK and cAMP/PKA
            signaling pathways
  JOURNAL   Arch Biochem Biophys 695, 108649 (2020)
   PUBMED   33122160
  REMARK    GeneRIF: Extracellular ATP modulates podocyte function through P2Y
            purinergic receptors and pleiotropic effects on AMPK and cAMP/PKA
            signaling pathways.
REFERENCE   3  (bases 1 to 1177)
  AUTHORS   Gohar,E.Y., Kasztan,M., Becker,B.K., Speed,J.S. and Pollock,D.M.
  TITLE     Ovariectomy uncovers purinergic receptor activation of
            endothelin-dependent natriuresis
  JOURNAL   Am J Physiol Renal Physiol 313 (2), F361-F369 (2017)
   PUBMED   28468962
  REMARK    GeneRIF: Activation of renal medullary P2Y2/P2Y4 receptors promotes
            ET-1-dependent natriuresis in ovariectomized rats.
REFERENCE   4  (bases 1 to 1177)
  AUTHORS   Anikina,T.A., Anisimova,I.N., Zverev,A.A., Sitdikov,F.G. and
            Zefirov,T.L.
  TITLE     Involvement of P2Y(2,4) receptors in the regulation of myocardial
            contractility in growing rats
  JOURNAL   Bull Exp Biol Med 156 (3), 299-302 (2014)
   PUBMED   24771361
  REMARK    GeneRIF: in 100-day-old animals, the myocardial inotropic response
            to the administration of uridine triphosphate was mediated by R2Y2
            receptors. R2Y4 receptors took part in the realization of negative
            inotropic response to uridine triphosphate in all age groups
REFERENCE   5  (bases 1 to 1177)
  AUTHORS   Traves,P.G., Pimentel-Santillana,M., Carrasquero,L.M.,
            Perez-Sen,R., Delicado,E.G., Luque,A., Izquierdo,M.,
            Martin-Sanz,P., Miras-Portugal,M.T. and Bosca,L.
  TITLE     Selective impairment of P2Y signaling by prostaglandin E2 in
            macrophages: implications for Ca2+-dependent responses
  JOURNAL   J Immunol 190 (8), 4226-4235 (2013)
   PUBMED   23479225
REFERENCE   6  (bases 1 to 1177)
  AUTHORS   Dranoff,J.A., Masyuk,A.I., Kruglov,E.A., LaRusso,N.F. and
            Nathanson,M.H.
  TITLE     Polarized expression and function of P2Y ATP receptors in rat bile
            duct epithelia
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 281 (4), G1059-G1067 (2001)
   PUBMED   11557527
REFERENCE   7  (bases 1 to 1177)
  AUTHORS   Lazarowski,E.R., Rochelle,L.G., O'Neal,W.K., Ribeiro,C.M.,
            Grubb,B.R., Zhang,V., Harden,T.K. and Boucher,R.C.
  TITLE     Cloning and functional characterization of two murine uridine
            nucleotide receptors reveal a potential target for correcting ion
            transport deficiency in cystic fibrosis gallbladder
  JOURNAL   J Pharmacol Exp Ther 297 (1), 43-49 (2001)
   PUBMED   11259526
REFERENCE   8  (bases 1 to 1177)
  AUTHORS   Suarez-Huerta,N., Pouillon,V., Boeynaems,J. and Robaye,B.
  TITLE     Molecular cloning and characterization of the mouse P2Y4 nucleotide
            receptor
  JOURNAL   Eur J Pharmacol 416 (3), 197-202 (2001)
   PUBMED   11290369
REFERENCE   9  (bases 1 to 1177)
  AUTHORS   Webb,T.E., Henderson,D.J., Roberts,J.A. and Barnard,E.A.
  TITLE     Molecular cloning and characterization of the rat P2Y4 receptor
  JOURNAL   J Neurochem 71 (4), 1348-1357 (1998)
   PUBMED   9751165
REFERENCE   10 (bases 1 to 1177)
  AUTHORS   Bogdanov,Y.D., Wildman,S.S., Clements,M.P., King,B.F. and
            Burnstock,G.
  TITLE     Molecular cloning and characterization of rat P2Y4 nucleotide
            receptor
  JOURNAL   Br J Pharmacol 124 (3), 428-430 (1998)
   PUBMED   9647463
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from Y11433.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y11433.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132268, SAMD00132274
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1177
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq22"
     gene            1..1177
                     /gene="P2ry4"
                     /gene_synonym="P2Y4"
                     /note="pyrimidinergic receptor P2Y4"
                     /db_xref="GeneID:63843"
                     /db_xref="RGD:61798"
     exon            1..48
                     /gene="P2ry4"
                     /gene_synonym="P2Y4"
                     /inference="alignment:Splign:2.1.0"
     exon            49..1177
                     /gene="P2ry4"
                     /gene_synonym="P2Y4"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1140
                     /gene="P2ry4"
                     /gene_synonym="P2Y4"
                     /note="pyrimidinergic receptor P2Y, G-protein coupled, 4;
                     purinergic receptor P2Y, G-protein coupled 4; P2Y ATP
                     receptor 4"
                     /codon_start=1
                     /product="P2Y purinoceptor 4"
                     /protein_id="NP_113868.1"
                     /db_xref="GeneID:63843"
                     /db_xref="RGD:61798"
                     /translation="MTSAESLLFTSLGPSPSSGDGDCRFNEEFKFILLPMSYAVVFVL
                     GLALNAPTLWLFLFRLRPWDATATYMFHLALSDTLYVLSLPTLVYYYAARNHWPFGTG
                     LCKFVRFLFYWNLYCSVLFLTCISVHRYLGICHPLRAIRWGRPRFASLLCLGVWLVVA
                     GCLVPNLFFVTTNANGTTILCHDTTLPEEFDHYVYFSSAVMVLLFGLPFLITLVCYGL
                     MARRLYRPLPGAGQSSSRLRSLRTIAVVLTVFAVCFVPFHITRTIYYQARLLQADCHV
                     LNIVNVVYKVTRPLASANSCLDPVLYLFTGDKYRNQLQQLCRGSKPKPRTAASSLALV
                     TLHEESISRWADTHQDSTFSAYEGDRL"
ORIGIN      
        1 aagctctgtc tgatgccatc agtccctggg ctggactaag gaagctaggg ggccatgacc
       61 agtgcagaat ccttgctatt cacatcacta ggtcccagcc caagttctgg agatggtgat
      121 tgtaggttta atgaggagtt caagttcatc ctgttgccta tgagctatgc agttgtgttt
      181 gtgctgggcc tggccctcaa tgctccaacc ctctggctgt tcctcttccg ccttcgaccc
      241 tgggatgcaa cagccaccta catgttccac ctggcattgt cagacacctt gtatgtgctg
      301 tcactgccca ccctcgtcta ctactatgct gccagaaacc actggccctt tggcactggc
      361 ctttgcaagt ttgtccgctt tctcttctat tggaacctct actgtagtgt ccttttcctc
      421 acctgcatca gtgtgcaccg atacctgggt atctgccacc cactgcgggc aatccgctgg
      481 ggccgccctc gatttgcaag ccttctctgc ctgggtgttt ggttggtagt agctggctgc
      541 ctcgtgccca atcttttctt tgtgacaacc aatgccaatg gaactaccat cctgtgccat
      601 gacactactc tgccagagga gtttgaccac tacgtctact tcagttcggc agtcatggtg
      661 ctgctctttg gtttgccctt cttgatcacc ctggtctgct atggactcat ggcccggcga
      721 ctgtatcgac ctttgccagg agctggacag tcatcttctc ggctccgttc cctccgtacc
      781 attgctgtgg tgctgactgt ctttgctgtc tgcttcgtgc ccttccacat cacccgcaca
      841 atttattacc aggcaagact gttgcaagct gactgtcatg tgctgaacat tgtcaatgtg
      901 gtttacaagg tgactcgacc cctggccagt gctaatagct gtcttgatcc agtgctctat
      961 ctcttcacgg gggacaagta tcgaaaccag ctccagcagc tatgccgagg cagcaaaccc
     1021 aagccccgaa cagctgcctc ctccctggcc ttggtgactc tacatgagga aagcatcagc
     1081 aggtgggcgg acacccacca agacagcacc ttctctgctt atgagggaga tcgattgtaa
     1141 ccctgctgct ggatatgaag ggaactaact gcagggc
//
