LOCUS       NM_017255               3178 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus purinergic receptor P2Y2 (P2ry2), mRNA.
ACCESSION   NM_017255 XM_346560
VERSION     NM_017255.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3178)
  AUTHORS   Zaripova,K.A., Belova,S.P., Kostrominova,T.Y., Shenkman,B.S. and
            Nemirovskaya,T.L.
  TITLE     P2Y1 and P2Y2 receptors differ in their role in the regulation of
            signaling pathways during unloading-induced rat soleus muscle
            atrophy
  JOURNAL   Arch Biochem Biophys 751, 109844 (2024)
   PUBMED   38043889
  REMARK    GeneRIF: P2Y1 and P2Y2 receptors differ in their role in the
            regulation of signaling pathways during unloading-induced rat
            soleus muscle atrophy.
REFERENCE   2  (bases 1 to 3178)
  AUTHORS   Cheng,R., Zhu,G., Ni,C., Wang,R., Sun,P., Tian,L., Zhang,L.,
            Zhang,J., Ye,X. and Luo,B.
  TITLE     P2Y2 Receptor Mediated Neuronal Regeneration and Angiogenesis to
            Affect Functional Recovery in Rats with Spinal Cord Injury
  JOURNAL   Neural Plast 2022, 2191011 (2022)
   PUBMED   35154311
  REMARK    GeneRIF: P2Y2 Receptor Mediated Neuronal Regeneration and
            Angiogenesis to Affect Functional Recovery in Rats with Spinal Cord
            Injury.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3178)
  AUTHORS   Xue,L.X., Chen,S.F., Xue,S.X., Zhang,X.Z. and Lian,Y.J.
  TITLE     P2RY2 Alleviates Cerebral Ischemia-Reperfusion Injury by Inhibiting
            YAP Phosphorylation and Reducing Mitochondrial Fission
  JOURNAL   Neuroscience 480, 155-166 (2022)
   PUBMED   34780922
  REMARK    GeneRIF: P2RY2 Alleviates Cerebral Ischemia-Reperfusion Injury by
            Inhibiting YAP Phosphorylation and Reducing Mitochondrial Fission.
REFERENCE   4  (bases 1 to 3178)
  AUTHORS   Leonard,E.M. and Nurse,C.A.
  TITLE     Expanding Role of Dopaminergic Inhibition in Hypercapnic Responses
            of Cultured Rat Carotid Body Cells: Involvement of Type II Glial
            Cells
  JOURNAL   Int J Mol Sci 21 (15), 5434 (2020)
   PUBMED   32751703
  REMARK    GeneRIF: Expanding Role of Dopaminergic Inhibition in Hypercapnic
            Responses of Cultured Rat Carotid Body Cells: Involvement of Type
            II Glial Cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3178)
  AUTHORS   Zheng,Z., Chen,B., Jin,Z., Gao,M., Tang,C., Mao,Y., Qu,Y. and
            Liu,Y.
  TITLE     Downregulation of P2Y2 and HuD during the development of the
            enteric nervous system in fetal rats with anorectal malformations
  JOURNAL   Mol Med Rep 20 (2), 1297-1305 (2019)
   PUBMED   31173231
  REMARK    GeneRIF: downregulation of P2Y2 and HuD may partly be related to
            the development of the enteric nervous system in anorectal
            malformations embryos.
REFERENCE   6  (bases 1 to 3178)
  AUTHORS   Yoshioka,K., Saitoh,O. and Nakata,H.
  TITLE     Heteromeric association creates a P2Y-like adenosine receptor
  JOURNAL   Proc Natl Acad Sci U S A 98 (13), 7617-7622 (2001)
   PUBMED   11390975
REFERENCE   7  (bases 1 to 3178)
  AUTHORS   Honda,S., Sasaki,Y., Ohsawa,K., Imai,Y., Nakamura,Y., Inoue,K. and
            Kohsaka,S.
  TITLE     Extracellular ATP or ADP induce chemotaxis of cultured microglia
            through Gi/o-coupled P2Y receptors
  JOURNAL   J Neurosci 21 (6), 1975-1982 (2001)
   PUBMED   11245682
REFERENCE   8  (bases 1 to 3178)
  AUTHORS   Seye,C.I., Gadeau,A.P., Daret,D., Dupuch,F., Alzieu,P., Capron,L.
            and Desgranges,C.
  TITLE     Overexpression of P2Y2 purinoceptor in intimal lesions of the rat
            aorta
  JOURNAL   Arterioscler Thromb Vasc Biol 17 (12), 3602-3610 (1997)
   PUBMED   9437211
REFERENCE   9  (bases 1 to 3178)
  AUTHORS   Chen,Z.P., Krull,N., Xu,S., Levy,A. and Lightman,S.L.
  TITLE     Molecular cloning and functional characterization of a rat
            pituitary G protein-coupled adenosine triphosphate (ATP) receptor
  JOURNAL   Endocrinology 137 (5), 1833-1840 (1996)
   PUBMED   8612522
REFERENCE   10 (bases 1 to 3178)
  AUTHORS   Rice,W.R., Burton,F.M. and Fiedeldey,D.T.
  TITLE     Cloning and expression of the alveolar type II cell P2u-purinergic
            receptor
  JOURNAL   Am J Respir Cell Mol Biol 12 (1), 27-32 (1995)
   PUBMED   7811468
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Dec 5, 2020 this sequence version replaced NM_017255.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.2150.1,
                                           SRR26643285.3019.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676806 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-269               JAXUCZ010000001.1  164779220-164779488 c
            270-460             JAXUCZ010000001.1  164771266-164771456 c
            461-3178            JAXUCZ010000001.1  164764119-164766836 c
FEATURES             Location/Qualifiers
     source          1..3178
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..3178
                     /gene="P2ry2"
                     /gene_synonym="P2Y2"
                     /note="purinergic receptor P2Y2"
                     /db_xref="GeneID:29597"
                     /db_xref="RGD:62088"
     exon            1..269
                     /gene="P2ry2"
                     /gene_synonym="P2Y2"
                     /inference="alignment:Splign:2.1.0"
     exon            270..460
                     /gene="P2ry2"
                     /gene_synonym="P2Y2"
                     /inference="alignment:Splign:2.1.0"
     exon            461..3178
                     /gene="P2ry2"
                     /gene_synonym="P2Y2"
                     /inference="alignment:Splign:2.1.0"
     CDS             465..1589
                     /gene="P2ry2"
                     /gene_synonym="P2Y2"
                     /note="P2U1; ATP receptor; P2U purinoceptor 1; P2Y ATP
                     receptor 2; purinergic receptor P2Y, G-protein coupled, 2"
                     /codon_start=1
                     /product="P2Y purinoceptor 2"
                     /protein_id="NP_058951.2"
                     /db_xref="GeneID:29597"
                     /db_xref="RGD:62088"
                     /translation="MAAGLDSWNSTINGTWEGDELGYKCRFNEDFKYVLLPVSYGVVC
                     VLGLCLNVVALYIFLCRLKTWNASTTYMFHLAVSDSLYAASLPLLVYYYAQGDHWPFS
                     TVLCKLVRFLFYTNLYCSILFLTCISVHRCLGVLRPLHSLSWGHARYARRVAAVVWVL
                     VLACQAPVLYFVTTSVRGTRITCHDTSARELFSHFVAYSSVMLGLLFAVPFSIILVCY
                     VLMARRLLKPAYGTTGLPRAKRKSVRTIALVLAVFALCFLPFHVTRTLYYSFRSLDLS
                     CHTLNAINMAYKITRPLASANSCLDPVLYFLAGQRLVRFARDAKPATEPTPSPQARRK
                     LGLHRPNRTDTVRKDLSISSDDSRRTESTPAGSETKDICL"
ORIGIN      
        1 ccaggaaccg cggcggcggc ggcgcctgga ggggaccagt gcggcgggga gatgacgggg
       61 acctaaagag gaacgaacac cgggagaggc cgccaagtgc ggcctgagga caggcgcgcc
      121 tgtcgactca gcgccaaaca gggagagccc attacgtgac tctgtcccga gggcctgggc
      181 tcccagccct tgtactgcgc aaaactgggc ggtgagagcc ggctgccggc gcgctgttga
      241 actttgtttt ctctagagcg tggacctcgg agccctccag gcagctgctt gccttgaaaa
      301 atgctggagg ctgggcgggg gcccaggccc gggaacctgt tcttcctgtt tcctgcctca
      361 gtcccagtag ctggtccagg cctgtgcaca tgcgagtgaa gaactggaac ggacgctgag
      421 catcctcgtc acaccaagag caggagctga tcgggtccag ggcaatggca gcaggcctgg
      481 actcctggaa tagtaccatc aatggcacct gggaggggga cgaactgggt tacaaatgtc
      541 gcttcaacga ggacttcaag tatgtgctgc tgcccgtgtc ctatggcgtg gtgtgcgtgc
      601 tcgggctgtg cctgaacgtc gtggccctct acatcttcct gtgccgcctc aagacctgga
      661 acgcctccac cacctacatg tttcacctgg cagtttctga ctctctctac gcagcctccc
      721 tgccgctgct ggtttattac tacgcccagg gtgaccactg gccatttagc acagtgctct
      781 gcaagctggt gcgtttcctt ttctacacta acctctactg cagcatcctc ttcctcacct
      841 gcatcagcgt gcaccggtgc ctgggggtcc tgcgccctct gcactccctg agctggggcc
      901 atgcccgcta tgcccgccga gtggctgcgg ttgtgtgggt gctagtgctg gcctgccagg
      961 cacccgtgct ctactttgtc accaccagcg tgagagggac ccgaatcacc tgccacgaca
     1021 cctcggcccg agagctcttt agccattttg tggcttacag ctctgtcatg ctgggtctgc
     1081 tttttgctgt gcccttttcc atcatcctgg tctgttacgt gctcatggcc cgacggctgc
     1141 tcaaaccggc ttatgggacc acaggtctgc ctcgggccaa gcgcaagtct gtgcgcacca
     1201 tcgccttagt actggccgtc ttcgccctct gcttcctgcc tttccacgtc acccgcaccc
     1261 tctattactc cttccgatca cttgacctca gttgccacac cctcaacgcc atcaacatgg
     1321 cgtataagat cacccggcca ctggccagcg ccaacagttg ccttgaccct gtgctctact
     1381 tcctggcagg gcagagactg gtccgctttg cccgagatgc caagcccgcc acagagccta
     1441 cacccagccc acaggctcgt cgcaagctgg ggctgcacag gcctaacaga actgacactg
     1501 tgaggaaaga tttgtcgatc agcagtgatg actcaagaag gacagagtcc acaccagctg
     1561 gaagtgagac taaggacatt tgtctatagc agctcagtca ggtgtcagtt catgtagggg
     1621 agagctgtag gggaccaagg cttgttcaaa ggggctgata tcctctgata tgatatcaac
     1681 ggctctcatt tggcagggac tcaggatact catcctgtgg tcccaagagt gacaggaccc
     1741 caaagtcccc aatcatttgt atgtgtgagt tggggaatcg tatctaaggc aacgccacct
     1801 gactcccatg caaacagctg ccattcctgc caaggtacct aggccgagct tcagcctctt
     1861 aaatccaagg gagaagcagg cccagggaga acacagcaga gtccagacta gctacctgga
     1921 ttagaagtag aatcgcgggg ttggggattt agctcagcgg tagagcgctt gcctagcgag
     1981 cgcaaggccc tgggttcagt ccccagctcc ggaaaaaaaa agaaaaaaag aaaaaaaaaa
     2041 gattctaact ttaggggttg ggaatttagc tcagcggtag agcgattgcc tagcaagcgc
     2101 aaggccctgg gttcgatccc cagctccgga aaaaaaaaaa aaaaagagag aagtagaatc
     2161 gcaaggtgac tggagggctt ttgttcccat ggtgatgtag gatgtacctg ggcactagac
     2221 tcagctcaga ggaggacact caggccaaga gacaagaatc tgagagctat tgtcaggacc
     2281 atctggagac tcccctgggc tagcagcagg tggaaaccgt aacttttatg agaggctgtg
     2341 ccacccattg ggctgtgctc tggggcacgg cctagtaagc tagcaccacc cacacgaagg
     2401 cctgttatct ctgccatctg ccttccttca gtagtaggaa ggttcggatc agggatccct
     2461 cctcagaccc cccaggtcaa tcctgctttt aaggatggta ccataccagg cacggagaag
     2521 actcaaatag ggttctagtt cttggggtcc ccagttgaca aaacttcacg taagctcgta
     2581 aacatcgaac catttaactg aactggggtg gggaggggtt ttttatttat aacactgcca
     2641 acccttgtgg tacaagcaat cccactgtgg ccaatcctat ttcaatttta aattactaac
     2701 acaatggcaa gcccattgca aaattcctga aaatcaacaa ctggttctcc cctccccaac
     2761 ccccggggct tgtgggggag ggcagtgcgg ctgattaggc aagatctggg gtaaccaaag
     2821 gcggcctttg aatttgccac gtagctgagg ctggccttga actccttacc ctcttgcctc
     2881 tatagagaaa gtgctgggat tgcaggcaga tgacacacct gtccaacaac tggttcataa
     2941 aggcagatgc agggtacttc acacacaccc gtgctgggca gctgggactg ccagggagag
     3001 gtccttagca tacatgaaag tggacaggga cagctctggg gtttaggcag gaatagacaa
     3061 aggtgacaag cctcacgacc tcagggacag gaggtccctg tgagggccct gcctacctcc
     3121 tgtatctccc ctctcccctg tcagccatta aagatgaggc atcctcagtt gccctctg
//
