LOCUS       NM_133577               1794 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus purinergic receptor P2Y14 (P2ry14), mRNA.
ACCESSION   NM_133577 XM_008760984
VERSION     NM_133577.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1794)
  AUTHORS   Lin,J., Liu,F., Zhang,Y.Y., Song,N., Liu,M.K., Fang,X.Y.,
            Liao,D.Q., Zhou,C., Wang,H. and Shen,J.F.
  TITLE     P2Y14 receptor is functionally expressed in satellite glial cells
            and mediates interleukin-1beta and chemokine CCL2 secretion
  JOURNAL   J Cell Physiol 234 (11), 21199-21210 (2019)
   PUBMED   31032956
  REMARK    GeneRIF: Our findings directly proved the functional presence of
            P2Y14 receptor in satellite glial cells. It was also verified that
            P2Y14 receptor activation was involved in activating satellite
            glial cells
REFERENCE   2  (bases 1 to 1794)
  AUTHORS   Li,F., Li,W., Li,X., Li,F., Zhang,L., Wang,B., Huang,G., Guo,X.,
            Wan,L., Liu,Y., Zhang,S., Kang,S. and Ma,J.
  TITLE     Geniposide attenuates inflammatory response by suppressing P2Y14
            receptor and downstream ERK1/2 signaling pathway in oxygen and
            glucose deprivation-induced brain microvascular endothelial cells
  JOURNAL   J Ethnopharmacol 185, 77-86 (2016)
   PUBMED   26976766
  REMARK    GeneRIF: Geniposide exerted anti-inflammatory effects by
            interfering with the expression of P2Y14 receptor, which
            subsequently inhibits the downstream ERK1/2 signaling pathways and
            the release of the pro-inflammatory cytokines IL-8, MCP-1,
            IL-1beta.
REFERENCE   3  (bases 1 to 1794)
  AUTHORS   Kinoshita,M., Nasu-Tada,K., Fujishita,K., Sato,K. and Koizumi,S.
  TITLE     Secretion of matrix metalloproteinase-9 from astrocytes by
            inhibition of tonic P2Y14-receptor-mediated signal(s)
  JOURNAL   Cell Mol Neurobiol 33 (1), 47-58 (2013)
   PUBMED   22872320
  REMARK    GeneRIF: When Gi-coupled signaling is removed from astrocyte P2Y14
            receptors, the cells start to release TNF-alpha, boosting MMP-9
            secretion.
REFERENCE   4  (bases 1 to 1794)
  AUTHORS   Gao,Z.G., Ding,Y. and Jacobson,K.A.
  TITLE     UDP-glucose acting at P2Y14 receptors is a mediator of mast cell
            degranulation
  JOURNAL   Biochem Pharmacol 79 (6), 873-879 (2010)
   PUBMED   19896471
  REMARK    GeneRIF: Mast cells express an endogenous P2Y(14) receptor, which
            mediates G(i)-dependent degranulation and is therefore a potential
            novel therapeutic target for allergic conditions.
REFERENCE   5  (bases 1 to 1794)
  AUTHORS   Bassil,A.K., Bourdu,S., Townson,K.A., Wheeldon,A., Jarvie,E.M.,
            Zebda,N., Abuin,A., Grau,E., Livi,G.P., Punter,L., Latcham,J.,
            Grimes,A.M., Hurp,D.P., Downham,K.M., Sanger,G.J., Winchester,W.J.,
            Morrison,A.D. and Moore,G.B.
  TITLE     UDP-glucose modulates gastric function through P2Y14
            receptor-dependent and -independent mechanisms
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 296 (4), G923-G930 (2009)
   PUBMED   19164486
  REMARK    GeneRIF: These results demonstrate a novel function of the P2Y14
            receptor in the rodent stomach and an ability of UDP-glucose to
            delay gastric emptying without involving the P2Y14 receptor.
REFERENCE   6  (bases 1 to 1794)
  AUTHORS   Krzeminski,P., Pomorski,P. and Baranska,J.
  TITLE     The P2Y14 receptor activity in glioma C6 cells
  JOURNAL   Eur J Pharmacol 594 (1-3), 49-54 (2008)
   PUBMED   18638471
  REMARK    GeneRIF: we demonstrated the presence and the activity of the P2Y14
            receptor in glioma C6 cells
REFERENCE   7  (bases 1 to 1794)
  AUTHORS   Chambers,J.K., Macdonald,L.E., Sarau,H.M., Ames,R.S., Freeman,K.,
            Foley,J.J., Zhu,Y., McLaughlin,M.M., Murdock,P., McMillan,L.,
            Trill,J., Swift,A., Aiyar,N., Taylor,P., Vawter,L., Naheed,S.,
            Szekeres,P., Hervieu,G., Scott,C., Watson,J.M., Murphy,A.J.,
            Duzic,E., Klein,C., Bergsma,D.J., Wilson,S. and Livi,G.P.
  TITLE     A G protein-coupled receptor for UDP-glucose
  JOURNAL   J Biol Chem 275 (15), 10767-10771 (2000)
   PUBMED   10753868
REFERENCE   8  (bases 1 to 1794)
  AUTHORS   Charlton,M.E., Williams,A.S., Fogliano,M., Sweetnam,P.M. and
            Duman,R.S.
  TITLE     The isolation and characterization of a novel G protein-coupled
            receptor regulated by immunologic challenge
  JOURNAL   Brain Res 764 (1-2), 141-148 (1997)
   PUBMED   9295203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1 and FM071543.1.
            
            On or before Nov 30, 2020 this sequence version replaced
            XM_008760984.2, NM_133577.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083545.1, FQ112152.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                JAXUCZ010000002.1  145538442-145538510 c
            70-102              FM071543.1         1-33
            103-1188            JAXUCZ010000002.1  145522598-145523683 c
            1189-1793           FM071543.1         34-638
            1794-2879           JAXUCZ010000002.1  145522598-145523683 c
FEATURES             Location/Qualifiers
     source          1..1794
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q26"
     gene            1..1794
                     /gene="P2ry14"
                     /gene_synonym="Gpr105"
                     /note="purinergic receptor P2Y14"
                     /db_xref="GeneID:171108"
                     /db_xref="RGD:70912"
     exon            1..137
                     /gene="P2ry14"
                     /gene_synonym="Gpr105"
                     /inference="alignment:Splign:2.1.0"
     exon            138..1794
                     /gene="P2ry14"
                     /gene_synonym="Gpr105"
                     /inference="alignment:Splign:2.1.0"
     CDS             383..1399
                     /gene="P2ry14"
                     /gene_synonym="Gpr105"
                     /note="G protein-coupled receptor 105; P2Y14; VTR 15-20;
                     UDP-glucose receptor; G protein-coupled receptor VTR
                     15-20; purinergic receptor P2Y, G-protein coupled, 14"
                     /codon_start=1
                     /product="P2Y purinoceptor 14"
                     /protein_id="NP_598261.2"
                     /db_xref="GeneID:171108"
                     /db_xref="RGD:70912"
                     /translation="MDNTTTTEPPKQPCTRNTLITQQIIPMLYCVVFITGVLLNGISG
                     WIFFYVPSSKSFIIYLKNIVVADFLMGLTFPFKVLSDSGLGPWQLNVFVCRVSAVIFY
                     VNMYVSIAFFGLISFDRYYKIVKPLLVSIVQSVNYSKVLSVLVWVLMLLLAVPNIILT
                     NQSVKDVTNIQCMELKNELGRKWHKASNYVFVSIFWIVFLLLTVFYMAITRKIFKSHL
                     KSRKNSISVKRKSSRNIFSIVLVFVVCFVPYHIARIPYTKSQTEGHYSCQAKETLLYT
                     KEFTLLLSAANVCLDPIIYFFLCQPFREVLNKKLRMSLTVQNDLETSKTRRGNMIQES
                     TDTL"
ORIGIN      
        1 aggaaagaaa acaaatgcag agcatgaagg ccacaacccc accgggacta acgccagacg
       61 tgaaggactt catgtgagga agtcctcgta ttcttctccg aaacactaat gcctaggcta
      121 ctgaggtggg cgtactgcat ctggaattct ctcttccgca ccctgggttc tgtggatgaa
      181 acttgcctct gagaatcctg aacatggaga aatagagata aataccccag aagaggggga
      241 gtaagtgttc acaaccttgg tgggtttcgc ctcatgtctg tccctccact ttaagagatg
      301 ccggtcacct gagggccaca aactgcgctc taagtaacca gcctgccttt ctacccagat
      361 ctttgtctcc agaagtgaga agatggacaa cacaacaacc acagaacctc caaagcagcc
      421 ctgcacccgg aacaccctga tcacacagca gatcatcccc atgttgtact gtgtggtctt
      481 catcacaggg gtcctcctca acggaatatc gggatggata ttcttttacg tgcccagctc
      541 taagagtttt atcatctatc tcaagaacat agttgtggct gactttctca tgggcctcac
      601 tttccctttc aaagtcctca gcgactcagg cctcggtccc tggcagctga atgtgtttgt
      661 atgcagggtg tctgccgtga tcttctacgt caacatgtac gtcagcatcg cgttcttcgg
      721 gctcatcagc tttgacaggt actataaaat cgtgaagccc cttctggtgt ctatcgtcca
      781 gtcagtgaac tacagcaaag tgctgtccgt gcttgtgtgg gtgctcatgc ttctcctcgc
      841 tgtccccaac atcattctga caaaccagag tgtcaaggat gtcactaaca tacagtgcat
      901 ggaactcaaa aacgagctgg ggcggaagtg gcacaaggcg tctaactatg tcttcgtgag
      961 cattttctgg atcgtgttcc ttctgctgac cgtcttctac atggccataa cgaggaagat
     1021 cttcaagtct cacctcaagt ccagaaagaa ttccatctcc gtcaaaagga agtccagccg
     1081 caatatattc agcattgtgc tcgtatttgt cgtctgtttc gtgccttacc acattgccag
     1141 gatcccctac accaagagcc agacggaagg acactacagc tgccaggcca aggagaccct
     1201 gctctatacg aaagaattca ccctgctgct ctcggctgcc aatgtgtgtc tggaccccat
     1261 tatctatttc ttcttatgcc agccgtttag agaagtcttg aataagaagt taagaatgtc
     1321 actaacagtc cagaatgacc tagagacttc caaaaccaga aggggaaata tgattcagga
     1381 aagcacagat actttgtaaa ttctcacccc tttccaagta ttatggacct tgttacacgg
     1441 taattaagat gtatgaagtg aaaagcaggc ctgcggcggt aaatacctta gctagctata
     1501 ttgtccaata acatgtataa aagtccagaa aagtataata aaaatgaaag gtaagttccc
     1561 atgtaaagtg aaagtctaca gcacgtcaca tctttttaga aatcgaatgg agaagtggca
     1621 tgtgggtgct agtctgcgag ttaccaaaac taaactctct cttctattaa cgggcttctt
     1681 agaagacacc caccctttca gaagttcctc ctgagtatcc ttctaagtaa tgctcacctc
     1741 tgtttcatgc tttgttctgt gtatgtgcca ataaacaagt tgtctttaaa acca
//
