LOCUS       NM_001002853            1011 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus purinergic receptor P2Y13 (P2ry13), mRNA.
ACCESSION   NM_001002853 XM_227178
VERSION     NM_001002853.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1011)
  AUTHORS   Yin,S., Yang,X., Li,H., Li,C., Li,C., Chen,C., Ye,S., Zou,L.,
            Liang,S. and Liu,S.
  TITLE     P2Y13 receptor involved in HIV-1 gp120 induced neuropathy in
            superior cervical ganglia through NLRP3 inflammasome activation
  JOURNAL   Neuropharmacology 245, 109818 (2024)
   PUBMED   38142931
  REMARK    GeneRIF: P2Y13 receptor involved in HIV-1 gp120 induced neuropathy
            in superior cervical ganglia through NLRP3 inflammasome activation.
            Review article
REFERENCE   2  (bases 1 to 1011)
  AUTHORS   Shen,D., Shen,X., Schwarz,W., Grygorczyk,R. and Wang,L.
  TITLE     P2Y13 and P2X7 receptors modulate mechanically induced adenosine
            triphosphate release from mast cells
  JOURNAL   Exp Dermatol 29 (5), 499-508 (2020)
   PUBMED   32155290
  REMARK    GeneRIF: P2Y13 and P2X7 receptors modulate mechanically induced
            adenosine triphosphate release from mast cells.
REFERENCE   3  (bases 1 to 1011)
  AUTHORS   de Almeida-Pereira,L., Repossi,M.G., Magalhaes,C.F., Azevedo,R.F.,
            Correa-Velloso,J.D.C., Ulrich,H., Ventura,A.L.M. and
            Fragel-Madeira,L.
  TITLE     P2Y12 but not P2Y13 Purinergic Receptor Controls Postnatal Rat
            Retinogenesis In Vivo
  JOURNAL   Mol Neurobiol 55 (11), 8612-8624 (2018)
   PUBMED   29574630
  REMARK    GeneRIF: Gene expression of the purinergic P2Y12 subtype was
            detected in rat retina during early postnatal days (P0 to P5),
            while expression levels of P2Y13 were low.
REFERENCE   4  (bases 1 to 1011)
  AUTHORS   Zeng,J., Wang,G., Liu,X., Wang,C., Tian,H., Liu,A., Jin,H., Luo,X.
            and Chen,Y.
  TITLE     P2Y13 receptor-mediated rapid increase in intracellular calcium
            induced by ADP in cultured dorsal spinal cord microglia
  JOURNAL   Neurochem Res 39 (11), 2240-2250 (2014)
   PUBMED   25186167
  REMARK    GeneRIF: the activation of P2Y13 receptor might be involved in the
            effect of ADP on [Ca(2+)]i in cultured dorsal spinal cord microglia
REFERENCE   5  (bases 1 to 1011)
  AUTHORS   Morente,V., Perez-Sen,R., Ortega,F., Huerta-Cepas,J., Delicado,E.G.
            and Miras-Portugal,M.T.
  TITLE     Neuroprotection elicited by P2Y13 receptors against genotoxic
            stress by inducing DUSP2 expression and MAPK signaling recovery
  JOURNAL   Biochim Biophys Acta 1843 (9), 1886-1898 (2014)
   PUBMED   24851838
  REMARK    GeneRIF: P2Y13 receptors regulate DUSP2 expression and contribute
            to p38 signaling homeostasis and survival in granule neurons.
REFERENCE   6  (bases 1 to 1011)
  AUTHORS   Yano,S., Tsukimoto,M., Harada,H. and Kojima,S.
  TITLE     Involvement of P2Y13 receptor in suppression of neuronal
            differentiation
  JOURNAL   Neurosci Lett 518 (1), 5-9 (2012)
   PUBMED   22521313
  REMARK    GeneRIF: P2Y13 receptor in invloves in suppression of neuronal
            differentiation. P2Y13 receptor antagonists might be candidates for
            treatment of neurodegenerative diseases.
REFERENCE   7  (bases 1 to 1011)
  AUTHORS   Gao,Z.G., Ding,Y. and Jacobson,K.A.
  TITLE     P2Y(13) receptor is responsible for ADP-mediated degranulation in
            RBL-2H3 rat mast cells
  JOURNAL   Pharmacol Res 62 (6), 500-505 (2010)
   PUBMED   20813187
  REMARK    GeneRIF: ADP-mediated intracellular calcium mobilization and Hex
            release in RBL-2H3 cells are via P2Y(1) and P2y13 receptors,
            respectively.
REFERENCE   8  (bases 1 to 1011)
  AUTHORS   Espada,S., Ortega,F., Molina-Jijon,E., Rojo,A.I., Perez-Sen,R.,
            Pedraza-Chaverri,J., Miras-Portugal,M.T. and Cuadrado,A.
  TITLE     The purinergic P2Y(13) receptor activates the Nrf2/HO-1 axis and
            protects against oxidative stress-induced neuronal death
  JOURNAL   Free Radic Biol Med 49 (3), 416-426 (2010)
   PUBMED   20447456
  REMARK    GeneRIF: results show a previously unrecognized role of the
            purinergic P2Y13 receptor in the induction of the Nrf2/HO-1
            antioxidant response and in protection against oxidative stress
REFERENCE   9  (bases 1 to 1011)
  AUTHORS   Tominaga,M., Kurihara,H., Honda,S., Amakawa,G., Sakai,T. and
            Tomooka,Y.
  TITLE     Molecular characterization of mitocalcin, a novel mitochondrial
            Ca2+-binding protein with EF-hand and coiled-coil domains
  JOURNAL   J Neurochem 96 (1), 292-304 (2006)
   PUBMED   16336229
REFERENCE   10 (bases 1 to 1011)
  AUTHORS   Fumagalli,M., Trincavelli,L., Lecca,D., Martini,C., Ciana,P. and
            Abbracchio,M.P.
  TITLE     Cloning, pharmacological characterisation and distribution of the
            rat G-protein-coupled P2Y(13) receptor
  JOURNAL   Biochem Pharmacol 68 (1), 113-124 (2004)
   PUBMED   15183123
  REMARK    GeneRIF: rat P2rY13 receptor displays several similarities but also
            interesting differences with its human and mouse orthologs
            [P2Y(13)]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY639875.1.
            
            On Aug 30, 2004 this sequence version replaced XM_227178.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AY639875.1 [ECO:0000345]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1011
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q26"
     gene            1..1011
                     /gene="P2ry13"
                     /gene_synonym="P2y13"
                     /note="purinergic receptor P2Y13"
                     /db_xref="GeneID:310444"
                     /db_xref="RGD:1302941"
     CDS             1..1011
                     /gene="P2ry13"
                     /gene_synonym="P2y13"
                     /note="purinergic receptor P2Y, G-protein coupled, 13"
                     /codon_start=1
                     /product="P2Y purinoceptor 13"
                     /protein_id="NP_001002853.1"
                     /db_xref="GeneID:310444"
                     /db_xref="RGD:1302941"
                     /translation="MLGTVNTTGMQGFNKSERCPRDTRMTQLLFPVLYTVVFFTGVLL
                     NTLALWVFIHIPSNSTFIIYLKNTLVADLIMTLMLPFKILSDSRLAPWQLRGFVCTFS
                     SVVFYETMYVGIMMLGLIAFDRFLKIVVPFRKTFVKKTAFAKIVSISIWLLMFLISLP
                     NMILNKEATASTVKKCASLKSPLGLLWHQVVSHTCQFIFWTVFILMLLFYTVIAKKVY
                     DSYRKFKSRDSKHKRLEAKVFIVMAVFFVCFAPFHFVRVPYTHSQTTNKTDCRLENQL
                     FLAKESTLFLATTNICMDPLIYIILCKKFTRKVPCMRWRTKTAASSDEHHSSQTDNIT
                     LS"
     exon            1..1011
                     /gene="P2ry13"
                     /gene_synonym="P2y13"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgctcggga cggtcaacac cactgggatg cagggcttca acaagtctga gaggtgcccc
       61 agggacactc ggatgacaca gctgctgttc ccagtgctct atactgtggt cttcttcaca
      121 ggcgtcctgc tgaacaccct ggccctctgg gtgttcatcc acatccccag caattccacc
      181 tttatcatct acctcaaaaa caccctggtg gcagacttga taatgacact aatgctccct
      241 ttcaaaatcc tttctgactc acgccttgcg ccctggcagc tcaggggttt tgtgtgcact
      301 ttctcatccg tggtctttta cgagacaatg tatgtcggca tcatgatgct gggtctcatc
      361 gcttttgaca gattcctcaa gatcgtcgta ccgtttagga aaacttttgt aaaaaagact
      421 gctttcgcaa aaatagtctc catttccatc tggctcctga tgttcctcat ctccctgccg
      481 aacatgatct tgaacaaaga ggcaacggca tcaaccgtga agaaatgtgc gtccctaaag
      541 agtcccctgg ggctgctgtg gcatcaagta gtcagtcaca catgccagtt cattttctgg
      601 actgtgttta ttctgatgct tctgttttac acggtgattg ccaagaaggt atacgactcc
      661 tataggaagt ttaaaagtag ggacagcaag cacaagcggc tggaggcgaa ggtatttatc
      721 gtcatggctg tcttctttgt ctgctttgcc ccgtttcatt ttgtcagagt accatacacc
      781 cacagtcaaa ccaccaacaa gactgactgt agattagaaa accagctgtt tcttgctaaa
      841 gaatcaactc tcttcctggc aacaactaac atttgtatgg accccttaat atatatcatc
      901 ttgtgtaaga agttcacccg gaaggtacca tgtatgagat ggaggacaaa gacagcggcg
      961 tccagcgatg agcaccacag cagtcagaca gacaacatca ccctatcctg a
//
