LOCUS       NM_022800               1254 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus purinergic receptor P2Y12 (P2ry12), mRNA.
ACCESSION   NM_022800
VERSION     NM_022800.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1254)
  AUTHORS   Zou,L., Liu,S., Li,L., Yang,R., Xu,X., Li,G., Zhang,C., Li,G. and
            Liang,S.
  TITLE     Implication of P2Y12 receptor in uc.48+-mediated abnormal
            sympathoexcitatory reflex via superior cervical ganglia in
            myocardial ischemic rats
  JOURNAL   Eur J Pharmacol 927, 175049 (2022)
   PUBMED   35644421
  REMARK    GeneRIF: Implication of P2Y12 receptor in uc.48+-mediated abnormal
            sympathoexcitatory reflex via superior cervical ganglia in
            myocardial ischemic rats.
REFERENCE   2  (bases 1 to 1254)
  AUTHORS   Wu,G., Xue,P., Jin,H., Zhang,M., Gui,C., Bao,G., Xu,G., Jiang,J.,
            Zhang,J., Cui,S., Cui,Z. and Sun,Y.
  TITLE     Upregulation of P2Y12 inhibits chondrocyte apoptosis in lumbar
            osteoarthritis through the PI3K/AKT signaling pathway
  JOURNAL   Mol Biol Rep 49 (7), 6459-6466 (2022)
   PUBMED   35581507
  REMARK    GeneRIF: Upregulation of P2Y12 inhibits chondrocyte apoptosis in
            lumbar osteoarthritis through the PI3K/AKT signaling pathway.
REFERENCE   3  (bases 1 to 1254)
  AUTHORS   Wang,L., Li,N., Wang,F. and Cui,L.
  TITLE     P2Y12 inhibition in macrophages reduces ventricular arrhythmias in
            rats after myocardial ischemia-reperfusion
  JOURNAL   Adv Clin Exp Med 30 (4), 413-420 (2021)
   PUBMED   33908199
  REMARK    GeneRIF: P2Y12 inhibition in macrophages reduces ventricular
            arrhythmias in rats after myocardial ischemia-reperfusion.
REFERENCE   4  (bases 1 to 1254)
  AUTHORS   Cohen,E.M., Mohammed,S., Kavurma,M., Nedoboy,P.E., Cartland,S.,
            Farnham,M.M.J. and Pilowsky,P.M.
  TITLE     Microglia in the RVLM of SHR have reduced P2Y12R and CX3CR1
            expression, shorter processes, and lower cell density
  JOURNAL   Auton Neurosci 216, 9-16 (2019)
   PUBMED   30598122
  REMARK    GeneRIF: gene expression of the metabotropic purinergic receptor
            P2Y12 and the fractalkine receptor CX3CR1 was downregulated in the
            Medulla oblongata of Spontaneously Hypertensive Rats compared to
            Wistar kyoto rats (by 37.3% and 30.9% respectively).
REFERENCE   5  (bases 1 to 1254)
  AUTHORS   Guo,J., Sheng,X., Dan,Y., Xu,Y., Zhang,Y., Ji,H., Wang,J., Xu,Z.,
            Che,H., Li,G., Liang,S. and Li,G.
  TITLE     Involvement of P2Y12 receptor of stellate ganglion in diabetic
            cardiovascular autonomic neuropathy
  JOURNAL   Purinergic Signal 14 (4), 345-357 (2018)
   PUBMED   30084083
  REMARK    GeneRIF: that P2Y12 receptor in the stellate ganglia may
            participate in developing diabetic autonomic neuropathy
            Erratum:[Purinergic Signal. 2021 Mar;17(1):163. doi:
            10.1007/s11302-020-09741-y.. PMID: 33185789]
REFERENCE   6  (bases 1 to 1254)
  AUTHORS   Cattaneo,M., Zighetti,M.L., Lombardi,R., Martinez,C., Lecchi,A.,
            Conley,P.B., Ware,J. and Ruggeri,Z.M.
  TITLE     Molecular bases of defective signal transduction in the platelet
            P2Y12 receptor of a patient with congenital bleeding
  JOURNAL   Proc Natl Acad Sci U S A 100 (4), 1978-1983 (2003)
   PUBMED   12578987
REFERENCE   7  (bases 1 to 1254)
  AUTHORS   Simon,J., Filippov,A.K., Goransson,S., Wong,Y.H., Frelin,C.,
            Michel,A.D., Brown,D.A. and Barnard,E.A.
  TITLE     Characterization and channel coupling of the P2Y(12) nucleotide
            receptor of brain capillary endothelial cells
  JOURNAL   J Biol Chem 277 (35), 31390-31400 (2002)
   PUBMED   12080041
REFERENCE   8  (bases 1 to 1254)
  AUTHORS   Foster,C.J., Prosser,D.M., Agans,J.M., Zhai,Y., Smith,M.D.,
            Lachowicz,J.E., Zhang,F.L., Gustafson,E., Monsma,F.J. Jr.,
            Wiekowski,M.T., Abbondanzo,S.J., Cook,D.N., Bayne,M.L., Lira,S.A.
            and Chintala,M.S.
  TITLE     Molecular identification and characterization of the platelet ADP
            receptor targeted by thienopyridine antithrombotic drugs
  JOURNAL   J Clin Invest 107 (12), 1591-1598 (2001)
   PUBMED   11413167
REFERENCE   9  (bases 1 to 1254)
  AUTHORS   Zhang,F.L., Luo,L., Gustafson,E., Lachowicz,J., Smith,M., Qiao,X.,
            Liu,Y.H., Chen,G., Pramanik,B., Laz,T.M., Palmer,K., Bayne,M. and
            Monsma,F.J. Jr.
  TITLE     ADP is the cognate ligand for the orphan G protein-coupled receptor
            SP1999
  JOURNAL   J Biol Chem 276 (11), 8608-8615 (2001)
   PUBMED   11104774
REFERENCE   10 (bases 1 to 1254)
  AUTHORS   Hollopeter,G., Jantzen,H.M., Vincent,D., Li,G., England,L.,
            Ramakrishnan,V., Yang,R.B., Nurden,P., Nurden,A., Julius,D. and
            Conley,P.B.
  TITLE     Identification of the platelet ADP receptor targeted by
            antithrombotic drugs
  JOURNAL   Nature 409 (6817), 202-207 (2001)
   PUBMED   11196645
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF313450.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF313450.1, H31419.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1254
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q26"
     gene            1..1254
                     /gene="P2ry12"
                     /gene_synonym="P2y12"
                     /note="purinergic receptor P2Y12"
                     /db_xref="GeneID:64803"
                     /db_xref="RGD:621681"
     exon            1..119
                     /gene="P2ry12"
                     /gene_synonym="P2y12"
                     /inference="alignment:Splign:2.1.0"
     exon            120..1254
                     /gene="P2ry12"
                     /gene_synonym="P2y12"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..1155
                     /gene="P2ry12"
                     /gene_synonym="P2y12"
                     /note="P2Y12 platelet ADP receptor; purinergic receptor
                     P2Y, G-protein coupled, 12"
                     /codon_start=1
                     /product="P2Y purinoceptor 12"
                     /protein_id="NP_073637.1"
                     /db_xref="GeneID:64803"
                     /db_xref="RGD:621681"
                     /translation="MEVPGANATSANTTSIPGTSTLCSRDYKITQVLFPLLYTVLFFA
                     GLITNSLAMRIFFQIRSKSNFIIFLKNTVISDLLMILTFPFKILSDAKLGAGHLRTLV
                     CQVTSVTFYFTMYISISFLGLITIDRYLKTTRPFKTSSPSNLLGAKILSVAIWAFMFL
                     LSLPNMILTNRRPKDKDITKCSFLKSEFGLVWHEIVNYICQVIFWINFLIVIVCYSLI
                     TKELYRSYVRTRGSAKAPKKRVNIKVFIIIAVFFICFVPFHFARIPYTLSQTRAVFDC
                     NAENTLFYVKESTLWLTSLNACLDPFIYFFLCKSFRNSLMSMLRCSTSGANKKKGQEG
                     GDPSEETPM"
ORIGIN      
        1 gagggctttg gcaacgaaac caagtcactg agaggaaagc accagatgcc agtctgcaag
       61 ttctactaac tagtattacc ggagacactc atttccttcc gagtcaacag aataaccagg
      121 accatggagg tgcctggtgc caacgccacc tcagccaaca ccacctccat tcctgggacc
      181 agcaccctgt gcagcagaga ctacaagatc acccaggttc tcttcccatt gctctacact
      241 gtcctgtttt ttgctgggct catcacgaac agcttggcga tgaggatttt cttccagatc
      301 cgcagtaaat cgaacttcat catttttctt aagaacacgg tcatctctga tcttcttatg
      361 atcctaactt ttcctttcaa aattctcagt gatgccaaac tgggagctgg gcacctgaga
      421 accctggtgt gccaagtcac ttcagtcacg ttttacttca caatgtacat cagtatctcg
      481 ttcctcggat tgataaccat tgaccgatac ctgaagacca ccagaccatt taaaacttcc
      541 agccccagca atcttttggg tgcgaagatt ctttctgttg ccatctgggc cttcatgttc
      601 ctgctgtcac tgcctaacat gattctcacc aacaggaggc caaaagataa ggacataacg
      661 aaatgttctt tcttgaagtc ggagtttggt ctggtctggc acgagatagt caattacatc
      721 tgccaagtca ttttctggat taatttttta attgttattg tttgttacag cctcattaca
      781 aaagagctct ataggtccta cgtcagaacg aggggttcag ccaaagctcc caagaaaagg
      841 gtgaacatca aggttttcat catcattgct gtgttcttca tttgcttcgt tcccttccac
      901 tttgcacgga ttccctacac cctgagccag acacgggccg tctttgactg caatgccgag
      961 aacactctgt tctacgtgaa ggagagcacc ctgtggctga cgtccttgaa cgcctgcctt
     1021 gatccattca tctatttctt tctttgcaag tctttcagaa attccttgat gagcatgctg
     1081 aggtgctcaa catccggggc aaataagaag aaaggacagg aaggtgggga cccaagcgag
     1141 gagaccccaa tgtagaatgt tacagggggg gaggacggga gggttgcttc agtctttagt
     1201 gtccagactc ctccaaggaa atcaccacat aaatatatta tcagtctcta aaaa
//
