LOCUS       NM_012800               3888 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Rattus norvegicus purinergic receptor P2Y1 (P2ry1), mRNA.
ACCESSION   NM_012800
VERSION     NM_012800.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3888)
  AUTHORS   Zaripova,K.A., Belova,S.P., Kostrominova,T.Y., Shenkman,B.S. and
            Nemirovskaya,T.L.
  TITLE     P2Y1 and P2Y2 receptors differ in their role in the regulation of
            signaling pathways during unloading-induced rat soleus muscle
            atrophy
  JOURNAL   Arch Biochem Biophys 751, 109844 (2024)
   PUBMED   38043889
  REMARK    GeneRIF: P2Y1 and P2Y2 receptors differ in their role in the
            regulation of signaling pathways during unloading-induced rat
            soleus muscle atrophy.
REFERENCE   2  (bases 1 to 3888)
  AUTHORS   Dias,L., Madeira,D., Dias,R., Tome,A.R., Cunha,R.A. and
            Agostinho,P.
  TITLE     Abeta1-42 peptides blunt the adenosine A2A receptor-mediated
            control of the interplay between P2X7 and P2Y1 receptors mediated
            calcium responses in astrocytes
  JOURNAL   Cell Mol Life Sci 79 (8), 457 (2022)
   PUBMED   35907034
  REMARK    GeneRIF: Abeta1-42 peptides blunt the adenosine A2A
            receptor-mediated control of the interplay between P2X7 and P2Y1
            receptors mediated calcium responses in astrocytes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3888)
  AUTHORS   Su,L., Bai,X., Niu,T., Zhuang,X., Dong,B., Li,Y., Yu,Y. and Wang,G.
  TITLE     P2Y1 Purinergic Receptor Contributes to Remifentanil-Induced Cold
            Hyperalgesia via Transient Receptor Potential Melastatin
            8-Dependent Regulation of N-methyl-d-aspartate Receptor
            Phosphorylation in Dorsal Root Ganglion
  JOURNAL   Anesth Analg 133 (3), 794-810 (2021)
   PUBMED   34166321
  REMARK    GeneRIF: P2Y1 Purinergic Receptor Contributes to
            Remifentanil-Induced Cold Hyperalgesia via Transient Receptor
            Potential Melastatin 8-Dependent Regulation of N-methyl-d-aspartate
            Receptor Phosphorylation in Dorsal Root Ganglion.
REFERENCE   4  (bases 1 to 3888)
  AUTHORS   Yu,Y., He,X., Zhang,J., Tang,C. and Rong,P.
  TITLE     Transcutaneous auricular vagal nerve stimulation inhibits
            hypothalamic P2Y1R expression and attenuates weight gain without
            decreasing food intake in Zucker diabetic fatty rats
  JOURNAL   Sci Prog 104 (2), 368504211009669 (2021)
   PUBMED   33848220
  REMARK    GeneRIF: Transcutaneous auricular vagal nerve stimulation inhibits
            hypothalamic P2Y1R expression and attenuates weight gain without
            decreasing food intake in Zucker diabetic fatty rats.
REFERENCE   5  (bases 1 to 3888)
  AUTHORS   Carvalho,G.B., Mulpuri,Y., Damasio,A. and Spigelman,I.
  TITLE     A Role for The P2Y1 Receptor in Nonsynaptic Cross-depolarization in
            the Rat Dorsal Root Ganglia
  JOURNAL   Neuroscience 423, 98-108 (2019)
   PUBMED   31689490
  REMARK    GeneRIF: A Role for The P2Y1 Receptor in Nonsynaptic
            Cross-depolarization in the Rat Dorsal Root Ganglia.
REFERENCE   6  (bases 1 to 3888)
  AUTHORS   Dranoff,J.A., Masyuk,A.I., Kruglov,E.A., LaRusso,N.F. and
            Nathanson,M.H.
  TITLE     Polarized expression and function of P2Y ATP receptors in rat bile
            duct epithelia
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 281 (4), G1059-G1067 (2001)
   PUBMED   11557527
REFERENCE   7  (bases 1 to 3888)
  AUTHORS   Yoshioka,K., Saitoh,O. and Nakata,H.
  TITLE     Heteromeric association creates a P2Y-like adenosine receptor
  JOURNAL   Proc Natl Acad Sci U S A 98 (13), 7617-7622 (2001)
   PUBMED   11390975
REFERENCE   8  (bases 1 to 3888)
  AUTHORS   Honda,S., Sasaki,Y., Ohsawa,K., Imai,Y., Nakamura,Y., Inoue,K. and
            Kohsaka,S.
  TITLE     Extracellular ATP or ADP induce chemotaxis of cultured microglia
            through Gi/o-coupled P2Y receptors
  JOURNAL   J Neurosci 21 (6), 1975-1982 (2001)
   PUBMED   11245682
REFERENCE   9  (bases 1 to 3888)
  AUTHORS   Jin,J., Daniel,J.L. and Kunapuli,S.P.
  TITLE     Molecular basis for ADP-induced platelet activation. II. The P2Y1
            receptor mediates ADP-induced intracellular calcium mobilization
            and shape change in platelets
  JOURNAL   J Biol Chem 273 (4), 2030-2034 (1998)
   PUBMED   9442040
REFERENCE   10 (bases 1 to 3888)
  AUTHORS   Tokuyama,Y., Hara,M., Jones,E.M., Fan,Z. and Bell,G.I.
  TITLE     Cloning of rat and mouse P2Y purinoceptors
  JOURNAL   Biochem Biophys Res Commun 211 (1), 211-218 (1995)
   PUBMED   7779087
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Feb 10, 2021 this sequence version replaced NM_012800.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.9884.1,
                                           SRR26643296.6240.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1797              JAXUCZ010000002.1  147391661-147393457
            1798-3888           JAXUCZ010000002.1  147395780-147397870
FEATURES             Location/Qualifiers
     source          1..3888
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q31"
     gene            1..3888
                     /gene="P2ry1"
                     /gene_synonym="P2y; P2y1"
                     /note="purinergic receptor P2Y1"
                     /db_xref="GeneID:25265"
                     /db_xref="RGD:3242"
     exon            1..1797
                     /gene="P2ry1"
                     /gene_synonym="P2y; P2y1"
                     /inference="alignment:Splign:2.1.0"
     CDS             641..1762
                     /gene="P2ry1"
                     /gene_synonym="P2y; P2y1"
                     /note="ATP receptor; P2 purinoreceptor subclass 2Y; P2Y
                     ATP receptor 1; purinergic receptor P2Y, G-protein
                     coupled, 1"
                     /codon_start=1
                     /product="P2Y purinoceptor 1"
                     /protein_id="NP_036932.1"
                     /db_xref="GeneID:25265"
                     /db_xref="RGD:3242"
                     /translation="MTEVPWSAVPNGTDAAFLAGLGSLWGNSTIASTAAVSSSFRCAL
                     IKTGFQFYYLPAVYILVFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVL
                     TLPALIFYYFNKTDWIFGDVMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSL
                     GRLKKKNAIYVSVLVWLIVVVAISPILFYSGTGIRKNKTVTCYDSTSDEYLRSYFIYS
                     MCTTVAMFCIPLVLILGCYGLIVRALIYKDLDNSPLRRKSIYLVIIVLTVFAVSYIPF
                     HVMKTMNLRARLDFQTPEMCDFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRR
                     LSRATRKASRRSEANLQSKSEEMTLNILSEFKQNGDTSL"
     exon            1798..3888
                     /gene="P2ry1"
                     /gene_synonym="P2y; P2y1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcgagacc cagcagagca ccgaggagag ctgctgactt catggactgc gagcggggtg
       61 aagggtagct ccagggtccg cggccaagag ctctcccaag gctgagtgcg ggctgagaat
      121 gcggccggaa gaagagtcgc ggcgtccccg gtgacggtcc ggagttgcaa ggtagggagt
      181 aggcagatgg ccaggcaaag ttgatcggag cgaggaggtg gttggcctgc gcccttcggc
      241 cgctgagaac cgcggagcta cttggacttg accctactgc gccccaggcg ctttgagcag
      301 cgcctatctg tcgccctgcg cgggagcgca cttgcaaact tggtggaggt gccctgcgcg
      361 tcctgttgtg taacctccgt gccgccagct ggaccgggaa gttgcccgcc cgtccttcag
      421 cttggatcgg tcgcagcccc gggcgaattt catggcccgc gacaaacgcg cggccagagc
      481 cggtgtgggc gagcccccgc gcgctccgac ccgtagggaa ctcccgcacg cggtccctgc
      541 ccctggcccg cgcctccgat gcgcgctgag cctctcgccg cagctgccct ctcgtcgcgg
      601 tctgtccttt cgagtagctg cctgagttgg aaagaagagg atgaccgagg tgccttggtc
      661 ggctgtcccc aacgggacag atgctgcctt cctggctggc ctgggctccc tttggggaaa
      721 cagtacaatc gcctcgactg cagcagtttc ctcttcattc cgatgtgccc tgatcaagac
      781 cggcttccag ttctactacc tgcctgcggt ctacatctta gtgttcatca taggcttcct
      841 tggcaacagc gtggcaatct ggatgtttgt tttccacatg aagccttgga gcggcatctc
      901 ggtgtacatg ttcaatttgg ctctggccga ctttttgtat gtgctcaccc taccagctct
      961 catcttctac tacttcaaca agactgactg gatcttcggg gatgttatgt gcaagctgca
     1021 gaggttcatc ttccatgtaa acctctatgg cagcatcttg ttcctcacct gcatcagtgc
     1081 acacaggtac agtggcgtgg tgtaccctct caagtctctg ggcaggctca agaagaagaa
     1141 tgccatttat gtcagtgtgc tggtatggct cattgtggtg gtggccatct cccccattct
     1201 cttctactct ggcactggga ttcggaaaaa caaaactgtc acctgctacg actccacgtc
     1261 agatgagtac ctgcgaagtt atttcatcta cagtatgtgc acgactgtgg ccatgttctg
     1321 catccccctg gtgctgatct tgggctgtta tggattaatt gttagagctt tgatctacaa
     1381 agatctggac aactctcctc tccggaggaa atccatttac ctggtgataa ttgtcctgac
     1441 ggtgtttgct gtgtcttaca tccctttcca tgtgatgaaa acgatgaatt tgagggcacg
     1501 gctggatttc cagaccccag aaatgtgtga tttcaacgac agggtttatg ccacctatca
     1561 ggtaacaaga ggtctagcaa gtctcaacag ctgtgtggac cccattcttt atttcttggc
     1621 tggagataca ttcagaagga gactgtcccg agccaccagg aaagcttcca ggaggagtga
     1681 ggccaattta caatccaaga gtgaagaaat gactctcaac attttgtctg agttcaagca
     1741 gaacggagac acaagtttgt gaaggcagga gatccaagct cctcagtttg taacatggtc
     1801 acaagaagtc cctgagatga cctgatgcac aggtcaagaa gaagcaacat tctattggcc
     1861 aaaagaccag tttgtgccac atgagtaggt gttttcatat aatgacagtt atgttgacat
     1921 tttgttgaaa gacacctgaa actgtaagat gtagcaagtg actcttcaca ctacaaagat
     1981 gtcttcattc caagctcaag ggtttgtttt ccttgttgct atctgctgtt tattccttac
     2041 aaagtactgt ctcggactct ttgatggttg ctttgaacct gtattgaacg gaaatgataa
     2101 attaagaaga aacttagcac acaagacaga attcaaaatt aaaaccgtga tgtgaccact
     2161 gagaagacat ttggaagccc attcttcatg aacagaaaaa ggcgacagga caccaactgt
     2221 tgatgccata ggtgctgtgg taagtcttga aaagcagtga gaactgtttg gaatctgctt
     2281 ctgtgcttcc taggactctc cagtctagtc cttggagaaa gttctcaatc tccaccgact
     2341 gtggaacgga caagttgaaa cctgtaaatc tctgctcacc caaccaggac actaatccat
     2401 cttgatatga caaatatcag tactcagtag caactagaat tcaattagtg acaggacata
     2461 gacagtgtga tactagtaaa tgtgtattga agcttttctt ccattggtcg aatgtaatta
     2521 ttgaaatagt atttattgaa gaggtttatg ggccttcaga tgtacagatt gtaaaacttc
     2581 cttgaagata caacatactg gtgtaaactc tatttattgc agtgcataat gttcaaatgt
     2641 cacatgtata ttttacagta atatataagg ctagataaaa atgagaatta tatttaagag
     2701 ttttttttcc agatattagt atctttgaac ctttaggacc agtttgtatt tgaatctgaa
     2761 aagatgaaaa tgtgttttct aacaagggtt ttaattttcc ctagatttga atttgcatgc
     2821 tttccttttg tgtgggttta ttgctaccca gatatgattt ggtgttagac catggtaaga
     2881 tttataacaa gcataggata ttttagacag gttatgtatt atgtacatta tatatgttta
     2941 tacaatagaa agtttgtgtt gtcttttcag aaagtttaga gtattgccct aactatgatc
     3001 gcagcttcca ctgccaaagg ctaatggctt atctcctatt caaaattgat ttagatgtct
     3061 agtgggttgg gtagtgtaga tacaatgtga gaatgtaaaa gacaatcttt agtgatgcag
     3121 ggtgataaag atgcagctga tagttttctg ccagatcttg aagctttaca atgtattttt
     3181 ttcttaaggc cacatagtac aatcttcttt gaggtgggtt tatttttaag taacactaac
     3241 aacaaattga gcattgctat taattttaat ctgttttctt gaggttggta actttaatac
     3301 caacatttca agtgataacc atgtcatttg gctgctaaat tctgtcattt taaaaaatga
     3361 aggtgaattt atgtttcata tcaaaatttg tacatttgag ttatgttgtt ttagcgattt
     3421 tgcaagaaaa agtttatttt tataataatt gtgattttta tgcagatgat ggaagcagat
     3481 ttctttgtgg ttaacagtgc tattgagtta ggtatggaac agtgttactt tggcactttg
     3541 agccttctca ggtttatctc gtcagtggta gcttaacaaa ctctggattg attgtatata
     3601 attgtctttg tattaaaaag aggttcatgg cccataaaag cacagtattg cttgactgta
     3661 gggagctgca gaatcgccca tgtttctgac tttgctcgct cgtgtgtgtg tgtgtgtgtg
     3721 tgtgtgtgtg tgtgtgtgtg cgcgcgcgcg cgcgcgtgtc ctaggcatgg cagccaacct
     3781 tatatctgct atttataata acagcagagc ttcataaatt gtggtcatta gaagtgtact
     3841 ttgcatagaa aattaaaaca gaaagattca ataaagctat gaaacatg
//
