LOCUS       NM_012721               2331 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Rattus norvegicus purinergic receptor P2X 6 (P2rx6), mRNA.
ACCESSION   NM_012721
VERSION     NM_012721.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2331)
  AUTHORS   Padilla,K., Gonzalez-Mendoza,D., Berumen,L.C., Escobar,J.E.,
            Miledi,R. and Garcia-Alcocer,G.
  TITLE     Differential gene expression patterns and colocalization of
            ATP-gated P2X6/P2X4 ion channels during rat small intestine
            ontogeny
  JOURNAL   Gene Expr Patterns 21 (2), 81-88 (2016)
   PUBMED   27545450
  REMARK    GeneRIF: P2X4 and P2X6 proteins were expressed in a different way
            during rat small intestine development, showing a higher
            colocalization coefficient at age P30 in both intestine regions.
            Those results suggest that purinergic receptors may play a role in
            intestinal maturation, which is associated with age and intestinal
            region.
REFERENCE   2  (bases 1 to 2331)
  AUTHORS   Liu,Y., Tian,X., Wu,Y., Chen,L., Yi,C.L., Li,Z.W., Zhang,Y. and
            Li,C.Y.
  TITLE     Phenotypes of ATP-activated current associated with their genotypes
            of P2X1-6 subunits in neurons innervating tooth-pulp
  JOURNAL   Biochem Biophys Res Commun 458 (3), 596-600 (2015)
   PUBMED   25680470
  REMARK    GeneRIF: The study explores the association of the phenotype of
            ATP-activated current with the genotype of P2X1-6 subunits in
            neurons innervating tooth-pulp.
REFERENCE   3  (bases 1 to 2331)
  AUTHORS   Antonio,L.S., Stewart,A.P., Varanda,W.A. and Edwardson,J.M.
  TITLE     Identification of P2X2/P2X4/P2X6 heterotrimeric receptors using
            atomic force microscopy (AFM) imaging
  JOURNAL   FEBS Lett 588 (12), 2125-2128 (2014)
   PUBMED   24815693
REFERENCE   4  (bases 1 to 2331)
  AUTHORS   Garcia-Alcocer,G., Padilla,K., Rodriguez,A., Miledi,R. and
            Berumen,L.C.
  TITLE     Distribution of the purinegic receptors P2X(4) and P2X(6) during
            rat gut development
  JOURNAL   Neurosci Lett 509 (2), 92-95 (2012)
   PUBMED   22230887
  REMARK    GeneRIF: P2X(4) and P2X(6) purinoreceptors are present in the gut
            from birth and that they are differentially distributed among
            regions
REFERENCE   5  (bases 1 to 2331)
  AUTHORS   Aoyama,R., Okada,Y., Yokota,S., Yasui,Y., Fukuda,K., Shinozaki,Y.,
            Yoshida,H., Nakamura,M., Chiba,K., Yasui,Y., Kato,F. and Toyama,Y.
  TITLE     Spatiotemporal and anatomical analyses of P2X receptor-mediated
            neuronal and glial processing of sensory signals in the rat dorsal
            horn
  JOURNAL   Pain 152 (9), 2085-2097 (2011)
   PUBMED   21669492
  REMARK    GeneRIF: The P2X6 receptor subunit is widely expressed in neuropils
            in the whole gray matter except for the dorsal superficial layer of
            the dorsal horn.
REFERENCE   6  (bases 1 to 2331)
  AUTHORS   Bobanovic,L.K., Royle,S.J. and Murrell-Lagnado,R.D.
  TITLE     P2X receptor trafficking in neurons is subunit specific
  JOURNAL   J Neurosci 22 (12), 4814-4824 (2002)
   PUBMED   12077178
REFERENCE   7  (bases 1 to 2331)
  AUTHORS   Glass,R., Loesch,A., Bodin,P. and Burnstock,G.
  TITLE     P2X4 and P2X6 receptors associate with VE-cadherin in human
            endothelial cells
  JOURNAL   Cell Mol Life Sci 59 (5), 870-881 (2002)
   PUBMED   12088286
REFERENCE   8  (bases 1 to 2331)
  AUTHORS   Rubio,M.E. and Soto,F.
  TITLE     Distinct Localization of P2X receptors at excitatory postsynaptic
            specializations
  JOURNAL   J Neurosci 21 (2), 641-653 (2001)
   PUBMED   11160443
REFERENCE   9  (bases 1 to 2331)
  AUTHORS   Soto,F., Garcia-Guzman,M., Karschin,C. and Stuhmer,W.
  TITLE     Cloning and tissue distribution of a novel P2X receptor from rat
            brain
  JOURNAL   Biochem Biophys Res Commun 223 (2), 456-460 (1996)
   PUBMED   8670303
REFERENCE   10 (bases 1 to 2331)
  AUTHORS   Collo,G., North,R.A., Kawashima,E., Merlo-Pich,E., Neidhart,S.,
            Surprenant,A. and Buell,G.
  TITLE     Cloning OF P2X5 and P2X6 receptors and the distribution and
            properties of an extended family of ATP-gated ion channels
  JOURNAL   J Neurosci 16 (8), 2495-2507 (1996)
   PUBMED   8786426
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            X97376.1, CO554543.1 and X92070.1.
            
            On Apr 21, 2009 this sequence version replaced NM_012721.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X92070.1, X97376.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1446              X97376.1           12-1457
            1447-1821           CO554543.1         298-672
            1822-2331           X92070.1           1703-2212
FEATURES             Location/Qualifiers
     source          1..2331
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..2331
                     /gene="P2rx6"
                     /gene_synonym="P2rxl1; P2x6; Rnap2x6"
                     /note="purinergic receptor P2X 6"
                     /db_xref="GeneID:25041"
                     /db_xref="RGD:3243"
     exon            1..272
                     /gene="P2rx6"
                     /gene_synonym="P2rxl1; P2x6; Rnap2x6"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1272
                     /gene="P2rx6"
                     /gene_synonym="P2rxl1; P2x6; Rnap2x6"
                     /note="purinergic receptor P2X6; P2XM; ATP receptor;
                     purinergic receptor P2X-like 1 orphan receptor; P2X6
                     receptor; purinergic receptor P2X, ligand-gated ion
                     channel, 6"
                     /codon_start=1
                     /product="P2X purinoceptor 6"
                     /protein_id="NP_036853.2"
                     /db_xref="GeneID:25041"
                     /db_xref="RGD:3243"
                     /translation="MQLQPAGTGSMASAVAAALVSWGFLDYKTEKYVMTRNCWVGISQ
                     RLLQLGVVVYVIGWALLAKKGYQEWDMDPQISVITKLKGVSVTQVKELEKRLWDVADF
                     VRPSQGENVFFLVTNFLVTPAQVQGRCPEHPSVPLANCWADEDCPEGEMGTYSHGIKT
                     GQCVAFNGTHRTCEIWSWCPVESSAVPRKPLLAQAKNFTLFIKNTVTFNKFNFSRTNA
                     LDTWDNTYFKYCLYDSLSSPYCPVFRIGDLVAMTGGDFEDLALLGGAVGINIHWDCNL
                     DTKGSDCSPQYSFQLQERGYNFRTANYWWAASGVESRSLLKLYGIRFDILVTGQAGKF
                     ALIPTAITVGTGAAWLGMVTFLCDLLLLYVDREAGFYWRTKYEEARAPKATTNSA"
     exon            273..423
                     /gene="P2rx6"
                     /gene_synonym="P2rxl1; P2x6; Rnap2x6"
                     /inference="alignment:Splign:2.1.0"
     exon            424..495
                     /gene="P2rx6"
                     /gene_synonym="P2rxl1; P2x6; Rnap2x6"
                     /inference="alignment:Splign:2.1.0"
     exon            496..571
                     /gene="P2rx6"
                     /gene_synonym="P2rxl1; P2x6; Rnap2x6"
                     /inference="alignment:Splign:2.1.0"
     exon            572..665
                     /gene="P2rx6"
                     /gene_synonym="P2rxl1; P2x6; Rnap2x6"
                     /inference="alignment:Splign:2.1.0"
     exon            666..746
                     /gene="P2rx6"
                     /gene_synonym="P2rxl1; P2x6; Rnap2x6"
                     /inference="alignment:Splign:2.1.0"
     exon            747..888
                     /gene="P2rx6"
                     /gene_synonym="P2rxl1; P2x6; Rnap2x6"
                     /inference="alignment:Splign:2.1.0"
     exon            889..998
                     /gene="P2rx6"
                     /gene_synonym="P2rxl1; P2x6; Rnap2x6"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1092
                     /gene="P2rx6"
                     /gene_synonym="P2rxl1; P2x6; Rnap2x6"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1158
                     /gene="P2rx6"
                     /gene_synonym="P2rxl1; P2x6; Rnap2x6"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1236
                     /gene="P2rx6"
                     /gene_synonym="P2rxl1; P2x6; Rnap2x6"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..2288
                     /gene="P2rx6"
                     /gene_synonym="P2rxl1; P2x6; Rnap2x6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaggagcca gatcctactg aattcgagat gtccctttaa cgacactggc ctgaatccca
       61 tgcacgtcca gtacagccgt ggctgaagtt gcctgctgac tcatgcagtt gcagccagcg
      121 ggaactggga gcatggcttc tgcagtcgca gcagcactag tgagctgggg gtttctggat
      181 tacaagacag agaaatatgt gatgaccagg aactgctggg tgggcatctc ccagaggctg
      241 ctgcagctcg gagtggtagt ctacgtgatt gggtgggccc tcttggccaa aaaaggctac
      301 caggaatggg acatggaccc ccagatttct gtcatcacca aactcaaggg ggtttctgta
      361 acccaggtta aggaactgga gaaacggctg tgggatgtgg ctgacttcgt gaggccatca
      421 cagggagaga atgtgttctt cctggtaacc aacttccttg tgacaccagc tcaagtccag
      481 ggcagatgcc cagagcatcc ttctgttcct ctggctaact gctgggctga tgaggactgt
      541 cctgaagggg agatggggac atacagccac ggcataaaga ctggtcagtg tgtggcgttc
      601 aacggaaccc acaggacctg tgagatctgg agctggtgcc cagtggagag tagtgctgtg
      661 cccaggaaac ccctgctagc tcaggccaag aacttcacgc tcttcatcaa aaatactgta
      721 accttcaaca agttcaactt ctccagaacc aatgccttag atacctggga caacacctat
      781 ttcaagtact gtctctacga ttcactctcc agtccgtact gcccagtgtt ccgcatcggg
      841 gaccttgtgg ctatgactgg aggggacttt gaggaccttg cattgctggg tggtgctgtg
      901 ggcatcaaca tccactggga ttgcaacctg gacacgaaag gctctgactg ctctccccag
      961 tactccttcc agctgcagga gagggggtac aatttcagga cagctaatta ctggtgggca
     1021 gcctcaggcg tggagtcccg gagcctgctc aaactctatg ggatccgctt tgacattctt
     1081 gtcactgggc aggcaggaaa gtttgcactc atccctacgg ccatcacagt gggcacagga
     1141 gcagcttggc tgggcatggt caccttcctc tgtgatctgc tgctactgta cgtggataga
     1201 gaggccggtt tctactggag gaccaagtat gaagaggcaa gagccccaaa ggcaactacc
     1261 aacagtgcat agacagagcc ggctttctca cctgctaacc ctgctgccca ggtgtctcag
     1321 gagtggtttg cacctgcccc acgtctgctg atgccgggat ccaagcattc atgcaccagt
     1381 ggcctgtctg gatggtgtca gcctatccat tcctgaggca tacaccctct ccctgctagt
     1441 taaagttagg gcttgggaac atcgaggaca aagccccaca ggactggaga gggggttggg
     1501 gtaattccac cagactctgc atgcaaactc cctcctaggt tcacccagag agagagagag
     1561 agagagagag agagagagag agagagagag cgcaatgcgg ttgaatgaat ggtggctggt
     1621 atccttggaa ctctctttat gtctgctggg gcactctgcc atctagttca aggcccctgg
     1681 tcctggctac caggtttctc gggagcctaa ggaatgagag aagctgcatg tctaggattt
     1741 cctgttatca aatcagtcct ggcaacctca acctattctg aagcacctgc ctgccagagg
     1801 ccctgactct ggccccagtc agagtgccat agttttgagg tatggtctca tgaagggcac
     1861 tggggttcct taggactggc tggttctgta actatccttc cttgattctt cccttagtaa
     1921 gactttcccc atgaaccata gaaagaaggg caaggacagg ctacataaac tttcctggtc
     1981 caagtgtggg gtggtgtaga aagtgcatcc cgggaagtga agaggcagtt tggctgtgga
     2041 tgtgcagtca cggagggaat accaaggcta gggtgaaagc aacagtcaca gctgggacct
     2101 ccaggcttcc acggcctcca aaacccttta gaattcctgg tgccactcag ccctcaaggc
     2161 tgtagcctga aaagggctag agtgcagagg cgggggtccc ggaggtggct cacatggaca
     2221 cagtagttct gggggtaggg gaaccaaaga acctgatatt cctgctgaag taaagcttgc
     2281 caaagcaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
