LOCUS       NM_080780               2409 bp    mRNA    linear   ROD 15-JUN-2024
DEFINITION  Rattus norvegicus purinergic receptor P2X 5 (P2rx5), mRNA.
ACCESSION   NM_080780
VERSION     NM_080780.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2409)
  AUTHORS   Sun,L.F., Liu,Y., Wang,J., Huang,L.D., Yang,Y., Cheng,X.Y.,
            Fan,Y.Z., Zhu,M.X., Liang,H., Tian,Y., Wang,H.S., Guo,C.R. and
            Yu,Y.
  TITLE     Altered allostery of the left flipper domain underlies the weak ATP
            response of rat P2X5 receptors
  JOURNAL   J Biol Chem 294 (51), 19589-19603 (2019)
   PUBMED   31727741
  REMARK    GeneRIF: analysis of the role of the left flipper domain in the
            weak ATP response of rat P2X5 receptors
REFERENCE   2  (bases 1 to 2409)
  AUTHORS   Liu,Y., Tian,X., Wu,Y., Chen,L., Yi,C.L., Li,Z.W., Zhang,Y. and
            Li,C.Y.
  TITLE     Phenotypes of ATP-activated current associated with their genotypes
            of P2X1-6 subunits in neurons innervating tooth-pulp
  JOURNAL   Biochem Biophys Res Commun 458 (3), 596-600 (2015)
   PUBMED   25680470
  REMARK    GeneRIF: The study explores the association of the phenotype of
            ATP-activated current with the genotype of P2X1-6 subunits in
            neurons innervating tooth-pulp.
REFERENCE   3  (bases 1 to 2409)
  AUTHORS   Aoyama,R., Okada,Y., Yokota,S., Yasui,Y., Fukuda,K., Shinozaki,Y.,
            Yoshida,H., Nakamura,M., Chiba,K., Yasui,Y., Kato,F. and Toyama,Y.
  TITLE     Spatiotemporal and anatomical analyses of P2X receptor-mediated
            neuronal and glial processing of sensory signals in the rat dorsal
            horn
  JOURNAL   Pain 152 (9), 2085-2097 (2011)
   PUBMED   21669492
  REMARK    GeneRIF: The P2X5 receptor subunit is located in neuronal somata.
REFERENCE   4  (bases 1 to 2409)
  AUTHORS   Duckwitz,W., Hausmann,R., Aschrafi,A. and Schmalzing,G.
  TITLE     P2X5 subunit assembly requires scaffolding by the second
            transmembrane domain and a conserved aspartate
  JOURNAL   J Biol Chem 281 (51), 39561-39572 (2006)
   PUBMED   17001079
  REMARK    GeneRIF: analysis of topology, helix-helix interactions, and
            oligomerization of P2X5 subunits
REFERENCE   5  (bases 1 to 2409)
  AUTHORS   Aschrafi,A., Sadtler,S., Niculescu,C., Rettinger,J. and
            Schmalzing,G.
  TITLE     Trimeric architecture of homomeric P2X2 and heteromeric P2X1+2
            receptor subtypes
  JOURNAL   J Mol Biol 342 (1), 333-343 (2004)
   PUBMED   15313628
REFERENCE   6  (bases 1 to 2409)
  AUTHORS   Ryten,M., Dunn,P.M., Neary,J.T. and Burnstock,G.
  TITLE     ATP regulates the differentiation of mammalian skeletal muscle by
            activation of a P2X5 receptor on satellite cells
  JOURNAL   J Cell Biol 158 (2), 345-355 (2002)
   PUBMED   12135987
  REMARK    GeneRIF: activation of a P2X receptor inhibits proliferation,
            stimulates expression of markers of muscle cell differentiation and
            increases the rate of myotube formation
REFERENCE   7  (bases 1 to 2409)
  AUTHORS   Cox,J.A., Barmina,O. and Voigt,M.M.
  TITLE     Gene structure, chromosomal localization, cDNA cloning and
            expression of the mouse ATP-gated ionotropic receptor P2X5 subunit
  JOURNAL   Gene 270 (1-2), 145-152 (2001)
   PUBMED   11404011
REFERENCE   8  (bases 1 to 2409)
  AUTHORS   Torres,G.E., Haines,W.R., Egan,T.M. and Voigt,M.M.
  TITLE     Co-expression of P2X1 and P2X5 receptor subunits reveals a novel
            ATP-gated ion channel
  JOURNAL   Mol Pharmacol 54 (6), 989-993 (1998)
   PUBMED   9855626
REFERENCE   9  (bases 1 to 2409)
  AUTHORS   Garcia-Guzman,M., Soto,F., Laube,B. and Stuhmer,W.
  TITLE     Molecular cloning and functional expression of a novel rat heart
            P2X purinoceptor
  JOURNAL   FEBS Lett 388 (2-3), 123-127 (1996)
   PUBMED   8690069
REFERENCE   10 (bases 1 to 2409)
  AUTHORS   Collo,G., North,R.A., Kawashima,E., Merlo-Pich,E., Neidhart,S.,
            Surprenant,A. and Buell,G.
  TITLE     Cloning OF P2X5 and P2X6 receptors and the distribution and
            properties of an extended family of ATP-gated ion channels
  JOURNAL   J Neurosci 16 (8), 2495-2507 (1996)
   PUBMED   8786426
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 27, 2020 this sequence version replaced NM_080780.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X92069.1, X97328.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-319               JAXUCZ010000010.1  58276329-58276647
            320-470             JAXUCZ010000010.1  58280325-58280475
            471-542             JAXUCZ010000010.1  58281020-58281091
            543-618             JAXUCZ010000010.1  58281556-58281631
            619-715             JAXUCZ010000010.1  58281717-58281813
            716-796             JAXUCZ010000010.1  58281968-58282048
            797-935             JAXUCZ010000010.1  58282314-58282452
            936-1069            JAXUCZ010000010.1  58282822-58282955
            1070-1163           JAXUCZ010000010.1  58283220-58283313
            1164-1229           JAXUCZ010000010.1  58283430-58283495
            1230-1312           JAXUCZ010000010.1  58285571-58285653
            1313-1480           JAXUCZ010000010.1  58286307-58286474
            1481-2409           JAXUCZ010000010.1  58287010-58287938
FEATURES             Location/Qualifiers
     source          1..2409
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..2409
                     /gene="P2rx5"
                     /gene_synonym="P2x5"
                     /note="purinergic receptor P2X 5"
                     /db_xref="GeneID:113995"
                     /db_xref="RGD:620256"
     exon            1..319
                     /gene="P2rx5"
                     /gene_synonym="P2x5"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..1550
                     /gene="P2rx5"
                     /gene_synonym="P2x5"
                     /note="ATP receptor; purinergic receptor P2X, ligand-gated
                     ion channel, 5"
                     /codon_start=1
                     /product="P2X purinoceptor 5"
                     /protein_id="NP_542958.3"
                     /db_xref="GeneID:113995"
                     /db_xref="RGD:620256"
                     /translation="MGQAAWKGFVLSLFDYKTAKFVVAKSKKVGLLYRVLQLIILLYL
                     LIWVFLIKKSYQDIDTSLQSAVVTKVKGVAYTNTTMLGERLWDVADFVIPSQGENVFF
                     VVTNLIVTPNQRQGICAEREGIPDGECSEDDDCHAGESVVAGHGLKTGRCLRVGNSTR
                     GTCEIFAWCPVETKSMPTDPLLKDAESFTIFIKNFIRFPKFNFSKANVLETDNKHFLK
                     TCHFSSTNLYCPIFRLGSIVRWAGADFQDIALKGGVIGIYIEWDCDLDKAASKCNPHY
                     YFNRLDNKHTHSISSGYNFRFARYYRDPNGVEFRDLMKAYGIRFDVIVNGKAGKFSII
                     PTVINIGSGLALMGAGAFFCDLVLIYLIRKSEFYRDKKFEKVRGQKEDANVEVEANEM
                     EQERPEDEPLERVRQDEQSQELAQSGRKQNSNCQVLLEPARFGLRENAIVNVKQSQIL
                     HPVKT"
     exon            320..470
                     /gene="P2rx5"
                     /gene_synonym="P2x5"
                     /inference="alignment:Splign:2.1.0"
     exon            471..542
                     /gene="P2rx5"
                     /gene_synonym="P2x5"
                     /inference="alignment:Splign:2.1.0"
     exon            543..618
                     /gene="P2rx5"
                     /gene_synonym="P2x5"
                     /inference="alignment:Splign:2.1.0"
     exon            619..715
                     /gene="P2rx5"
                     /gene_synonym="P2x5"
                     /inference="alignment:Splign:2.1.0"
     exon            716..796
                     /gene="P2rx5"
                     /gene_synonym="P2x5"
                     /inference="alignment:Splign:2.1.0"
     exon            797..935
                     /gene="P2rx5"
                     /gene_synonym="P2x5"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1069
                     /gene="P2rx5"
                     /gene_synonym="P2x5"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1163
                     /gene="P2rx5"
                     /gene_synonym="P2x5"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1229
                     /gene="P2rx5"
                     /gene_synonym="P2x5"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1312
                     /gene="P2rx5"
                     /gene_synonym="P2x5"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1480
                     /gene="P2rx5"
                     /gene_synonym="P2x5"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..2409
                     /gene="P2rx5"
                     /gene_synonym="P2x5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccagttctcc tcggcagtgg gatccgccgg gccgccccgt gctcgcgccc gggtctgcgc
       61 gtctgctctc tccagctcat gccctttgga gccgcgcgcc ccgggactgc ggcagcgcac
      121 acagagtgct cggttggctg cagggcagcg ggaggaggcg gccgccagag tgagctggag
      181 gcatgggcca ggcggcctgg aaggggtttg tgctgtctct gttcgactat aagactgcaa
      241 agttcgtggt cgccaagagc aagaaggtgg ggctgctcta ccgggtgctg cagctcatca
      301 tcctgttgta cttgctcata tgggtgtttc tgataaagaa gagttatcag gacattgaca
      361 cttccctgca gagtgctgtg gtcaccaaag tcaagggggt ggcctatact aacaccacga
      421 tgcttgggga acggctctgg gatgtagcag actttgtcat tccatctcag ggggagaacg
      481 ttttcttcgt ggtcaccaac ctgatcgtga ctcctaacca gcggcagggc atctgcgctg
      541 agcgtgaagg catccctgat ggcgagtgtt ctgaggatga tgactgtcac gctggggagt
      601 ctgttgtagc tgggcacgga ctgaaaactg gccgctgtct ccgggtgggg aactctaccc
      661 ggggaacctg tgagatcttt gcttggtgcc cagtggagac aaagtccatg ccaacggatc
      721 cccttctaaa ggatgccgaa agcttcacca ttttcataaa gaacttcatt cgcttcccca
      781 agttcaactt ctccaaagcc aatgtactag aaacagacaa caaacatttc ctgaaaacct
      841 gtcacttcag ctccacaaat ctctactgtc ccatcttccg actggggtct attgtccgct
      901 gggcaggggc agacttccag gacatagccc tgaagggtgg tgtgatagga atctatattg
      961 aatgggactg tgaccttgat aaagctgcct ctaaatgcaa cccacactac tacttcaacc
     1021 gcctggacaa caaacacaca cactccatct cctctgggta caacttcagg ttcgccaggt
     1081 attaccgtga ccctaatggg gtagagttcc gtgacctgat gaaagcctac ggcatccgct
     1141 ttgatgtgat agttaatggc aaggcaggaa aattcagcat catccccaca gtcatcaaca
     1201 ttggttctgg gctggcgctc atgggtgctg gggctttctt ctgcgacctg gtacttatct
     1261 acctcatcag gaagagtgag ttttaccgag acaagaagtt tgagaaagtg aggggtcaga
     1321 aggaggatgc caatgttgag gttgaggcca acgagatgga gcaggagcgg cctgaggacg
     1381 aaccactgga gagggttcgt caggatgagc agtcccaaga actggcccag agtggcagga
     1441 agcagaatag caactgccag gtgcttttgg agcctgccag gtttggcctc cgggagaatg
     1501 ccattgtgaa cgtgaagcag tcacagatct tgcatccagt gaagacgtag ccagagctct
     1561 cggcagagaa cagattcgat gattgggcca ggacaggcca cagctctgaa ctgacgagag
     1621 gcatctcggt ggggcctgct caggatgagg cttctgagaa aagcccctca actccacaaa
     1681 gttagggtgg gatcctgctg caaacttttt tgtttcacgg aaggtctcct ggtggcctaa
     1741 gtggctcagg atgcaggaag gagaccctgg ggcaggccct cagggaaggg gcaggcctgg
     1801 ggtttcagtt ggtttccgtt cctgactctg agcccgctgg acatgcgttt atttacacag
     1861 gcgtttacac atgcgtttat ttacacactt actggtgcat gcagcacttt agcccgacct
     1921 gagaggcttg agatgctgac ctggccccag ggtagaaggc acacatgtta actctcacca
     1981 gagacatcat agtcagcccc accggcctgg cttcctccag cctctagccc agactttttg
     2041 acaggtcccc gccaagaatg atggttgctc agtaaaagct gttggatgac atccaggaga
     2101 cacttagctt cgcccccaga tgtaagatgt aaagctggcc aaggaggcac ctggaaaaca
     2161 acttagggaa gagcaaactc ccggggctct taggtaagat tggagagggg aggcaagtaa
     2221 gccactagcc tgctccagcc actacccaaa gcctagagta gctctggaaa actgacttgc
     2281 ccaggtcaga tggacttgtg cagttcagct cttgctgctt ggtggtgctg ggggtctctg
     2341 tctgacttcc ttcctgctcc cagaagctca gccttgatat gctgagataa aggatgattt
     2401 tcactgaaa
//
