LOCUS       NM_031594               1973 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Rattus norvegicus purinergic receptor P2X 4 (P2rx4), mRNA.
ACCESSION   NM_031594
VERSION     NM_031594.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1973)
  AUTHORS   Wei,L., Yu,X., Chen,H. and Du,Y.
  TITLE     The role of P2X4R in regulating CA1 hippocampal synaptic impairment
            in LPS-induced depression
  JOURNAL   J Affect Disord 362, 595-605 (2024)
   PUBMED   39019229
  REMARK    GeneRIF: The role of P2X4R in regulating CA1 hippocampal synaptic
            impairment in LPS-induced depression.
REFERENCE   2  (bases 1 to 1973)
  AUTHORS   Hu,Q.Q., He,X.F., Ma,Y.Q., Ma,L.Q., Qu,S.Y., Wang,H.Z., Kang,Y.R.,
            Chen,L.H., Li,X., Liu,B.Y., Shao,X.M., Fang,J.F., Liang,Y.,
            Fang,J.Q. and Jiang,Y.L.
  TITLE     Dorsal root ganglia P2X4 and P2X7 receptors contribute to
            diabetes-induced hyperalgesia and the downregulation of
            electroacupuncture on P2X4 and P2X7
  JOURNAL   Purinergic Signal 19 (1), 29-41 (2023)
   PUBMED   35218450
  REMARK    GeneRIF: Dorsal root ganglia P2X4 and P2X7 receptors contribute to
            diabetes-induced hyperalgesia and the downregulation of
            electroacupuncture on P2X4 and P2X7.
REFERENCE   3  (bases 1 to 1973)
  AUTHORS   Manzoor,S., Khalid,M. and Idrees,M.
  TITLE     P2X4 receptors mediate induction of antioxidants, fibrogenic
            cytokines and ECM transcripts; in presence of replicating HCV in in
            vitro setting: An insight into role of P2X4 in fibrosis
  JOURNAL   PLoS One 17 (5), e0259727 (2022)
   PUBMED   35594248
  REMARK    GeneRIF: P2X4 receptors mediate induction of antioxidants,
            fibrogenic cytokines and ECM transcripts; in presence of
            replicating HCV in in vitro setting: An insight into role of P2X4
            in fibrosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1973)
  AUTHORS   He,W., Wang,Q., Sha,W., Wang,L., Li,D. and Chen,G.
  TITLE     P2X4 Inhibition reduces microglia inflammation and apoptosis by
            NLRP3 and improves nervous system defects in rat brain trauma model
  JOURNAL   J Clin Neurosci 99, 224-232 (2022)
   PUBMED   35290938
  REMARK    GeneRIF: P2X4 Inhibition reduces microglia inflammation and
            apoptosis by NLRP3 and improves nervous system defects in rat brain
            trauma model.
REFERENCE   5  (bases 1 to 1973)
  AUTHORS   Tan,S.L., Barri,M., Atakpa-Adaji,P., Taylor,C.W., St John Smith,E.
            and Murrell-Lagnado,R.D.
  TITLE     P2X4 Receptors Mediate Ca2+ Release from Lysosomes in Response to
            Stimulation of P2X7 and H1 Histamine Receptors
  JOURNAL   Int J Mol Sci 22 (19), 10492 (2021)
   PUBMED   34638832
  REMARK    GeneRIF: P2X4 Receptors Mediate Ca(2+) Release from Lysosomes in
            Response to Stimulation of P2X7 and H1 Histamine Receptors.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1973)
  AUTHORS   Soto,F., Garcia-Guzman,M., Gomez-Hernandez,J.M., Hollmann,M.,
            Karschin,C. and Stuhmer,W.
  TITLE     P2X4: an ATP-activated ionotropic receptor cloned from rat brain
  JOURNAL   Proc Natl Acad Sci U S A 93 (8), 3684-3688 (1996)
   PUBMED   8622997
REFERENCE   7  (bases 1 to 1973)
  AUTHORS   Wang,C.Z., Namba,N., Gonoi,T., Inagaki,N. and Seino,S.
  TITLE     Cloning and pharmacological characterization of a fourth P2X
            receptor subtype widely expressed in brain and peripheral tissues
            including various endocrine tissues
  JOURNAL   Biochem Biophys Res Commun 220 (1), 196-202 (1996)
   PUBMED   8602843
REFERENCE   8  (bases 1 to 1973)
  AUTHORS   Seguela,P., Haghighi,A., Soghomonian,J.J. and Cooper,E.
  TITLE     A novel neuronal P2x ATP receptor ion channel with widespread
            distribution in the brain
  JOURNAL   J Neurosci 16 (2), 448-455 (1996)
   PUBMED   8551329
REFERENCE   9  (bases 1 to 1973)
  AUTHORS   Buell,G., Lewis,C., Collo,G., North,R.A. and Surprenant,A.
  TITLE     An antagonist-insensitive P2X receptor expressed in epithelia and
            brain
  JOURNAL   EMBO J 15 (1), 55-62 (1996)
   PUBMED   8598206
REFERENCE   10 (bases 1 to 1973)
  AUTHORS   Bo,X., Zhang,Y., Nassar,M., Burnstock,G. and Schoepfer,R.
  TITLE     A P2X purinoceptor cDNA conferring a novel pharmacological profile
  JOURNAL   FEBS Lett 375 (1-2), 129-133 (1995)
   PUBMED   7498461
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031594.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X87763.1, BC078792.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-234               JAXUCZ010000012.1  39522856-39523089   c
            235-382             JAXUCZ010000012.1  39517319-39517466   c
            383-454             JAXUCZ010000012.1  39514738-39514809   c
            455-527             JAXUCZ010000012.1  39514559-39514631   c
            528-624             JAXUCZ010000012.1  39513993-39514089   c
            625-705             JAXUCZ010000012.1  39509550-39509630   c
            706-847             JAXUCZ010000012.1  39509298-39509439   c
            848-984             JAXUCZ010000012.1  39509067-39509203   c
            985-1078            JAXUCZ010000012.1  39507277-39507370   c
            1079-1144           JAXUCZ010000012.1  39507122-39507187   c
            1145-1240           JAXUCZ010000012.1  39506633-39506728   c
            1241-1973           JAXUCZ010000012.1  39505438-39506170   c
FEATURES             Location/Qualifiers
     source          1..1973
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..1973
                     /gene="P2rx4"
                     /note="purinergic receptor P2X 4"
                     /db_xref="GeneID:29659"
                     /db_xref="RGD:62073"
     exon            1..234
                     /gene="P2rx4"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..1267
                     /gene="P2rx4"
                     /note="P2X4; ATP receptor; purinergic receptor P2X,
                     ligand-gated ion channel 4"
                     /codon_start=1
                     /product="P2X purinoceptor 4"
                     /protein_id="NP_113782.2"
                     /db_xref="GeneID:29659"
                     /db_xref="RGD:62073"
                     /translation="MAGCCSVLGSFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVI
                     GWVFVWEKGYQETDSVVSSVTTKAKGVAVTNTSQLGFRIWDVADYVIPAQEENSLFIM
                     TNMIVTVNQTQSTCPEIPDKTSICNSDADCTPGSVDTHSSGVATGRCVPFNESVKTCE
                     VAAWCPVENDVGVPTPAFLKAAENFTLLVKNNIWYPKFNFSKRNILPNITTSYLKSCI
                     YNAQTDPFCPIFRLGTIVEDAGHSFQEMAVEGGIMGIQIKWDCNLDRAASLCLPRYSF
                     RRLDTRDLEHNVSPGYNFRFAKYYRDLAGKEQRTLTKAYGIRFDIIVFGKAGKFDIIP
                     TMINVGSGLALLGVATVLCDVIVLYCMKKKYYYRDKKYKYVEDYEQGLSGEMNQ"
     exon            235..382
                     /gene="P2rx4"
                     /inference="alignment:Splign:2.1.0"
     exon            383..454
                     /gene="P2rx4"
                     /inference="alignment:Splign:2.1.0"
     exon            455..527
                     /gene="P2rx4"
                     /inference="alignment:Splign:2.1.0"
     exon            528..624
                     /gene="P2rx4"
                     /inference="alignment:Splign:2.1.0"
     exon            625..705
                     /gene="P2rx4"
                     /inference="alignment:Splign:2.1.0"
     exon            706..847
                     /gene="P2rx4"
                     /inference="alignment:Splign:2.1.0"
     exon            848..984
                     /gene="P2rx4"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1078
                     /gene="P2rx4"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1144
                     /gene="P2rx4"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1240
                     /gene="P2rx4"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1973
                     /gene="P2rx4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcagcgagc ctgccggagc tggtgggtgg agctgcggcc gggagccggc ggtggcgagg
       61 ggacccacag tggccaaggc gcggagcggt cggcggagcc atggcgggct gctgctccgt
      121 gctcgggtcc ttcctgttcg agtacgacac gccgcgcatc gtgctcatcc gcagccgtaa
      181 agtggggctc atgaaccgcg cggtgcagct gctcatcctg gcttacgtca tcgggtgggt
      241 gttcgtgtgg gaaaagggct accaggaaac ggactccgtg gtcagctcgg tgacaaccaa
      301 agccaaaggt gtggctgtga ccaacacctc tcagcttgga ttccggatct gggacgtggc
      361 ggactatgtg attccagctc aggaggaaaa ctccctcttc atcatgacca acatgatcgt
      421 caccgtgaac cagacacaga gcacctgtcc agagattcct gataagacca gcatttgtaa
      481 ttcagacgcc gactgcactc ctggctccgt ggacacccac agcagtggag ttgcgactgg
      541 aagatgtgtt cctttcaatg agtctgtgaa gacctgtgag gtggctgcat ggtgcccggt
      601 ggagaacgac gttggcgtgc caacgccggc tttcttaaag gctgcagaaa acttcaccct
      661 cttggtaaag aacaacatct ggtaccccaa gtttaacttc agcaagagga acatcctccc
      721 caacatcacc acgtcctacc tcaaatcgtg catttacaat gctcaaacgg atcccttctg
      781 ccccatattc cgtcttggca caatcgtgga ggacgcggga catagcttcc aggagatggc
      841 agttgaggga ggcatcatgg gtatccagat caagtgggac tgcaacctgg atagagccgc
      901 ctccctttgc ctgcccagat attccttccg gcgcctggac acccgggacc tggaacacaa
      961 tgtgtctcct ggctacaatt tcaggtttgc caagtactac agggacctgg ccggcaaaga
     1021 gcagcgcaca ctcaccaagg cgtacggcat ccgctttgac atcatcgtgt ttggaaaggc
     1081 tgggaagttt gacatcatcc ctaccatgat caatgttggc tctggcttgg cgctcctcgg
     1141 ggtggcgacg gtgctctgtg acgtcatagt cctctactgc atgaagaaga aatactacta
     1201 ccgggacaag aaatataagt atgtggaaga ctacgagcag ggtctttcgg gggagatgaa
     1261 ccagtgacgc ctaaagttac atttccaccc cgctcagccc gcgaagcaga aagatgggga
     1321 gagatggcta ctgcgtctgt cactctagag aaagctccag agtttcagct cagttctcca
     1381 ctccacaaat actcagggtt gcccaagcac gtcttgttga gcccggttct tgctctgctg
     1441 ctcagatggg cttcagatac aagatcctcc tgcttctgcc tctaggaatg ctgggatcat
     1501 acatgttcac tgcaatgccc atttcccatg ggagttttgg cattttttac attttacctt
     1561 tcctttgtat acatctaagg ctggcctcag acgcaagacg ttcttccacc ctatacaccc
     1621 ttttaatctc actgtgtgtg ggaggggggt cgtttgcaca cgacgcacgg tggatgtctg
     1681 gtgtgctgtt ggctgggcca cctgtggctt atacagtgtg agcgtatgga ggtaggaagg
     1741 gtctgagagc agagacactg ctgtggctta cggacaggcc caggctctgt ccacgcactt
     1801 tatttctaag gaaggaggct ctctcaggtg ctgtcagcag gcctgggaca ccattcctct
     1861 tccctataat cagagaagtt gtccttgtag caaaggcagg gttagctttt ccttttataa
     1921 gggctgtgtt gaaatgacct aggaccaaac attaaaagaa ataatttttt aaa
//
