LOCUS       NM_031075               3770 bp    mRNA    linear   ROD 13-DEC-2024
DEFINITION  Rattus norvegicus purinergic receptor P2X 3 (P2rx3), transcript
            variant 1, mRNA.
ACCESSION   NM_031075 XM_346661
VERSION     NM_031075.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3770)
  AUTHORS   Yeh,T.Y., Chang,M.F., Kan,Y.Y., Chiang,H. and Hsieh,S.T.
  TITLE     HSP27 Modulates Neuropathic Pain by Inhibiting P2X3 Degradation
  JOURNAL   Mol Neurobiol 61 (2), 707-724 (2024)
   PUBMED   37656312
  REMARK    GeneRIF: HSP27 Modulates Neuropathic Pain by Inhibiting P2X3
            Degradation.
REFERENCE   2  (bases 1 to 3770)
  AUTHORS   Wu,Y.Y., Wang,Q., Zhang,P.A., Zhu,C. and Xu,G.Y.
  TITLE     miR-1306-3p directly activates P2X3 receptors in primary sensory
            neurons to induce visceral pain in rats
  JOURNAL   Pain 164 (7), 1555-1565 (2023)
   PUBMED   36633528
  REMARK    GeneRIF: miR-1306-3p directly activates P2X3 receptors in primary
            sensory neurons to induce visceral pain in rats.
REFERENCE   3  (bases 1 to 3770)
  AUTHORS   Li,Z.H., Zhao,X.D., Li,W. and Han,W.J.
  TITLE     [Effect of electroacupuncture on the expressions of TRPV1, P2X3
            receptors in bladder of rats with interstitial cystitis]
  JOURNAL   Zhongguo Zhen Jiu 42 (11), 1263-1268 (2022)
   PUBMED   36397224
  REMARK    GeneRIF: [Effect of electroacupuncture on the expressions of TRPV1,
            P2X3 receptors in bladder of rats with interstitial cystitis].
REFERENCE   4  (bases 1 to 3770)
  AUTHORS   Liu,X., Yang,Y., Gao,Y., Zhang,H., Zhu,J., Dong,X. and Xu,J.
  TITLE     Estrogen inhibits bladder overactivity in rats with
            cyclophosphamide-induced cystitis via downregulating the expression
            of P2X3 receptors in bladder epithelium cells
  JOURNAL   Neurourol Urodyn 41 (1), 174-187 (2022)
   PUBMED   34622458
  REMARK    GeneRIF: Estrogen inhibits bladder overactivity in rats with
            cyclophosphamide-induced cystitis via downregulating the expression
            of P2X3 receptors in bladder epithelium cells.
REFERENCE   5  (bases 1 to 3770)
  AUTHORS   Koizumi,M., Asano,S., Furukawa,A., Hayashi,Y., Hitomi,S.,
            Shibuta,I., Hayashi,K., Kato,F., Iwata,K. and Shinoda,M.
  TITLE     P2X3 receptor upregulation in trigeminal ganglion neurons through
            TNFalpha production in macrophages contributes to trigeminal
            neuropathic pain in rats
  JOURNAL   J Headache Pain 22 (1), 31 (2021)
   PUBMED   33902429
  REMARK    GeneRIF: P2X3 receptor upregulation in trigeminal ganglion neurons
            through TNFalpha production in macrophages contributes to
            trigeminal neuropathic pain in rats.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3770)
  AUTHORS   Cockayne,D.A., Hamilton,S.G., Zhu,Q.M., Dunn,P.M., Zhong,Y.,
            Novakovic,S., Malmberg,A.B., Cain,G., Berson,A., Kassotakis,L.,
            Hedley,L., Lachnit,W.G., Burnstock,G., McMahon,S.B. and Ford,A.P.
  TITLE     Urinary bladder hyporeflexia and reduced pain-related behaviour in
            P2X3-deficient mice
  JOURNAL   Nature 407 (6807), 1011-1015 (2000)
   PUBMED   11069181
REFERENCE   7  (bases 1 to 3770)
  AUTHORS   Llewellyn-Smith,I.J. and Burnstock,G.
  TITLE     Ultrastructural localization of P2X3 receptors in rat sensory
            neurons
  JOURNAL   Neuroreport 9 (11), 2545-2550 (1998)
   PUBMED   9721930
REFERENCE   8  (bases 1 to 3770)
  AUTHORS   Evans,R.J., Lewis,C., Virginio,C., Lundstrom,K., Buell,G.,
            Surprenant,A. and North,R.A.
  TITLE     Ionic permeability of, and divalent cation effects on, two
            ATP-gated cation channels (P2X receptors) expressed in mammalian
            cells
  JOURNAL   J Physiol 497 (Pt 2) (Pt 2), 413-422 (1996)
   PUBMED   8961184
REFERENCE   9  (bases 1 to 3770)
  AUTHORS   Lewis,C., Neidhart,S., Holy,C., North,R.A., Buell,G. and
            Surprenant,A.
  TITLE     Coexpression of P2X2 and P2X3 receptor subunits can account for
            ATP-gated currents in sensory neurons
  JOURNAL   Nature 377 (6548), 432-435 (1995)
   PUBMED   7566120
REFERENCE   10 (bases 1 to 3770)
  AUTHORS   Chen,C.C., Akopian,A.N., Sivilotti,L., Colquhoun,D., Burnstock,G.
            and Wood,J.N.
  TITLE     A P2X purinoceptor expressed by a subset of sensory neurons
  JOURNAL   Nature 377 (6548), 428-431 (1995)
   PUBMED   7566119
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Dec 21, 2022 this sequence version replaced NM_031075.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X91167.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-320               JAXUCZ010000003.1  90528990-90529309   c
            321-456             JAXUCZ010000003.1  90516777-90516912   c
            457-528             JAXUCZ010000003.1  90516347-90516418   c
            529-592             JAXUCZ010000003.1  90516086-90516149   c
            593-686             JAXUCZ010000003.1  90515451-90515544   c
            687-764             JAXUCZ010000003.1  90515152-90515229   c
            765-906             JAXUCZ010000003.1  90514340-90514481   c
            907-1043            JAXUCZ010000003.1  90513729-90513865   c
            1044-1137           JAXUCZ010000003.1  90491547-90491640   c
            1138-1203           JAXUCZ010000003.1  90491209-90491274   c
            1204-1281           JAXUCZ010000003.1  90490496-90490573   c
            1282-3770           JAXUCZ010000003.1  90487506-90489994   c
FEATURES             Location/Qualifiers
     source          1..3770
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     gene            1..3770
                     /gene="P2rx3"
                     /note="purinergic receptor P2X 3"
                     /db_xref="GeneID:81739"
                     /db_xref="RGD:620253"
     exon            1..320
                     /gene="P2rx3"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..1395
                     /gene="P2rx3"
                     /note="isoform 1 is encoded by transcript variant 1; P2X
                     purinoceptor 3; P2X3; ATP receptor; purinergic receptor
                     P2X, ligand-gated ion channel, 3"
                     /codon_start=1
                     /product="P2X purinoceptor 3 isoform 1"
                     /protein_id="NP_112337.2"
                     /db_xref="GeneID:81739"
                     /db_xref="RGD:620253"
                     /translation="MNCISDFFTYETTKSVVVKSWTIGIINRAVQLLIISYFVGWVFL
                     HEKAYQVRDTAIESSVVTKVKGFGRYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQ
                     MQGFCPENEEKYRCVSDSQCGPERFPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTV
                     EMPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTDKDIKRCRFHPEKAPFCPILRV
                     GDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDGVSEKSSVSP
                     GYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGV
                     GTVLCDIILLNFLKGADHYKARKFEEVTETTLKGTASTNPVFASDQATVEKQSTDSGA
                     YSIGH"
     exon            321..456
                     /gene="P2rx3"
                     /inference="alignment:Splign:2.1.0"
     exon            457..528
                     /gene="P2rx3"
                     /inference="alignment:Splign:2.1.0"
     exon            529..592
                     /gene="P2rx3"
                     /inference="alignment:Splign:2.1.0"
     exon            593..686
                     /gene="P2rx3"
                     /inference="alignment:Splign:2.1.0"
     exon            687..764
                     /gene="P2rx3"
                     /inference="alignment:Splign:2.1.0"
     exon            765..906
                     /gene="P2rx3"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1043
                     /gene="P2rx3"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1137
                     /gene="P2rx3"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1203
                     /gene="P2rx3"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1281
                     /gene="P2rx3"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..3770
                     /gene="P2rx3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaccgttgg cttccagagt atcaagggga gagactaggc actgggctac agttgcctgg
       61 cttacaggaa ctggctcttt tcctcaagcc tcattaagca gcccactcca gttcttgatc
      121 tttgtctccc agtcctgaag tcctttctct ccttaggctg catccacagc ccttctaagt
      181 ggctgtgagc agtttctcag tatgaactgt atatcagact tcttcaccta cgagactacc
      241 aagtcggtgg ttgtgaagag ctggaccatt gggatcatca accgagccgt ccagctgctg
      301 attatctcct actttgtggg gtgggttttc ttgcatgaga aggcctacca agtgagggac
      361 accgccattg agtcctcagt agttacaaag gtgaaaggct tcgggcgcta tgccaacaga
      421 gtcatggacg tgtcggatta tgtgacccca ccccagggca cctctgtctt tgtcatcatc
      481 accaaaatga tcgttactga aaatcaaatg caaggattct gtccagagaa tgaagagaag
      541 taccgctgtg tgtctgacag ccagtgtggg cctgaacgct tcccaggtgg ggggatcctc
      601 accggccgct gcgtgaacta cagctctgtt ctccggacct gtgagatcca gggctggtgc
      661 cccactgagg tggacaccgt ggagatgcct atcatgatgg aggctgagaa cttcaccatt
      721 ttcatcaaga acagcatccg tttccctctc ttcaactttg agaagggaaa cctcctgcct
      781 aacctcaccg acaaggacat aaagaggtgc cgcttccacc ctgaaaaggc cccattttgc
      841 cccatcttga gggtagggga tgtggttaag tttgctggac aggattttgc caagctggcc
      901 cgcacgggtg gcgttctggg tattaagatc ggctgggtgt gcgatctaga caaggcctgg
      961 gaccagtgca tccctaaata ttccttcact cggctggatg gagtttctga gaaaagcagt
     1021 gtttcccctg gctacaactt caggtttgcc aaatactata agatggagaa cggcagcgag
     1081 taccgcacac tcctgaaggc ttttggcatc cgctttgatg tgctggtata tgggaacgct
     1141 ggcaagttca acatcatccc caccattatc agctcggtgg cggccttcac ttctgtggga
     1201 gtgggcactg ttctctgtga catcatcctg ctcaatttcc tcaaaggggc tgatcactac
     1261 aaagccagga agtttgagga ggtgactgag acaacactga agggtactgc gtcaaccaac
     1321 ccagtgttcg ccagtgacca ggccactgtg gagaagcagt ctacagactc aggggcctat
     1381 tctattggtc actagggcct cttcccaggg ttccatgctc acccttaggc tgcagaacct
     1441 gcaaacaggc cactctatct aagcagtcag gggtgggagg gggagaagaa gggctgctat
     1501 ttctgctgtt caccccaaag actagatcca gatatctagg ccctcactgt tcaacagata
     1561 ggcaatgctt cccactaaga cttgaatctt gcctttaccc cttgcatgcc tcccacctgc
     1621 ttccctggat cccaggacag cagcatccac ccctttccaa aggattgaga aaatggtagc
     1681 taaggttaca cccataggac ctaccacgta ccaagcactt ccacacatat tatccctttt
     1741 cacccttaaa ataatcctat aaggtagatt tcttgggttg tttgtttgtt ttgttattaa
     1801 gagaagcaaa ggcccaggga gaccgaggcg tttgccccag gccatgtagc taggaagtga
     1861 gatctacacc ctggctagcc cttctgccca catctgtaat ggaagaatga actctctagg
     1921 catctaccct tctgtgtcag ttgcctttcc ctgccttccc atgatgccca acagtgagct
     1981 ttttcaggaa tgcagcccta ctttagggga gcccacggaa atgcagaagg aaatagctgt
     2041 gactatcagt gatttttcct tgcctcaccc catatcgcaa gctcaagctg aggaagagac
     2101 ctttattctc caatgaggtc ctcacacatc cacacatctg ggccctcact ccggaatcta
     2161 gacagaaaac acacacatac atgaccgaca agaggcaatt tctaacccta gcaccatgtc
     2221 ccagtacatc agctgtctta gtttatagca ctgttgggaa agccatggtt aggggctggg
     2281 gatgtagttg ggtaggtaga gtgtttgtct agtatgttag ccctaagacc aacctgcagc
     2341 acttcataaa ccaggcacac ttgtaatccc agcactcggg aggtaggcat ggaggatcaa
     2401 aagttcgagt ttatccttgc caacgcaata agtgtgaacc ttgcctggaa cccatgaaac
     2461 tgtttcaaaa tagaagtggg gagacccagt aagacccaat accttgtgag cattcagcca
     2521 gggcagcaag gcctgttttc acaggatcct aacaggtgat caggtagaag ctaaaggagc
     2581 ctcagaaacc atcatgtcta ggcctcttgc ttactgatca ttaaccctga ggccaaaaat
     2641 gaaaaatttc ttgccttgtg ccattgtgag gggccaagag aggacacagg tgtcctgtgc
     2701 attataagct gaagacaagt tcacattgtc tccatagccc agatgtccca tctcctttct
     2761 gagtttttaa agaaaacaag agatgttgag gaagctctaa atgtagcgga caaaactcaa
     2821 ggacagatca aggtgtagga aagaagcagg ttgagaggct cttttggttt ggtttgttta
     2881 tttggttggt tggttggttg gttggttggt tggttggttg gttggttggt tggttggttt
     2941 tgatgaaaag actttcctgt gcattcctgg ctggcctcaa tttacagatc tcctctctca
     3001 actcaacttt tccccagtat ttggatctgc aggcaagcgc cattatacag ctgggggcat
     3061 ctcttttaaa agaatatatg attaagtatc agaaaagttc atgcaaatca gtgggcctga
     3121 ggtatacatt taattaatat cagggccaat ctgcctctta aacatgggct tgatgctgag
     3181 agcttagaag agatgagcat tcatgtggac agagggctgg cccctcaccg gacggtgcaa
     3241 agagatgtgg gagagggaga gtctaggagg accacaggag tgctcacaca gacccaacct
     3301 caatgatgcc caccccaggg ggagaagggg taagagtcct cccactagct tcatcaatcc
     3361 tttcttccct ctgcttgccc acagccccat cataatgtgt gatggggtac tgtctcccta
     3421 acaccagtgt caattcctgg gtagtatcca gagacctggc caggcttcat ctctccaata
     3481 gagacatcag caaaggaaag agcacagcct ccaagaagga agcttatagc ccctcattgg
     3541 gccaaggctg agttcaccaa gatgctccct agaagaagat ggagacactg tgtcctaaga
     3601 ggatctcata ccccagacta gaataattct tccccacatg cctggacctc ttctgggcct
     3661 tcagtaagtg tgtaaactcc atgctgtact ctccttgtct gaaccaagtc cacttcgatg
     3721 tgctagatgt cagctaatca tagaaattac aacgaccagc ttgtatctga
//
