LOCUS       NP_112337                397 aa            linear   ROD 13-DEC-2024
DEFINITION  P2X purinoceptor 3 isoform 1 [Rattus norvegicus].
ACCESSION   NP_112337 XP_346662
VERSION     NP_112337.2
DBSOURCE    REFSEQ: accession NM_031075.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 397)
  AUTHORS   Yeh,T.Y., Chang,M.F., Kan,Y.Y., Chiang,H. and Hsieh,S.T.
  TITLE     HSP27 Modulates Neuropathic Pain by Inhibiting P2X3 Degradation
  JOURNAL   Mol Neurobiol 61 (2), 707-724 (2024)
   PUBMED   37656312
  REMARK    GeneRIF: HSP27 Modulates Neuropathic Pain by Inhibiting P2X3
            Degradation.
REFERENCE   2  (residues 1 to 397)
  AUTHORS   Wu,Y.Y., Wang,Q., Zhang,P.A., Zhu,C. and Xu,G.Y.
  TITLE     miR-1306-3p directly activates P2X3 receptors in primary sensory
            neurons to induce visceral pain in rats
  JOURNAL   Pain 164 (7), 1555-1565 (2023)
   PUBMED   36633528
  REMARK    GeneRIF: miR-1306-3p directly activates P2X3 receptors in primary
            sensory neurons to induce visceral pain in rats.
REFERENCE   3  (residues 1 to 397)
  AUTHORS   Li,Z.H., Zhao,X.D., Li,W. and Han,W.J.
  TITLE     [Effect of electroacupuncture on the expressions of TRPV1, P2X3
            receptors in bladder of rats with interstitial cystitis]
  JOURNAL   Zhongguo Zhen Jiu 42 (11), 1263-1268 (2022)
   PUBMED   36397224
  REMARK    GeneRIF: [Effect of electroacupuncture on the expressions of TRPV1,
            P2X3 receptors in bladder of rats with interstitial cystitis].
REFERENCE   4  (residues 1 to 397)
  AUTHORS   Liu,X., Yang,Y., Gao,Y., Zhang,H., Zhu,J., Dong,X. and Xu,J.
  TITLE     Estrogen inhibits bladder overactivity in rats with
            cyclophosphamide-induced cystitis via downregulating the expression
            of P2X3 receptors in bladder epithelium cells
  JOURNAL   Neurourol Urodyn 41 (1), 174-187 (2022)
   PUBMED   34622458
  REMARK    GeneRIF: Estrogen inhibits bladder overactivity in rats with
            cyclophosphamide-induced cystitis via downregulating the expression
            of P2X3 receptors in bladder epithelium cells.
REFERENCE   5  (residues 1 to 397)
  AUTHORS   Koizumi,M., Asano,S., Furukawa,A., Hayashi,Y., Hitomi,S.,
            Shibuta,I., Hayashi,K., Kato,F., Iwata,K. and Shinoda,M.
  TITLE     P2X3 receptor upregulation in trigeminal ganglion neurons through
            TNFalpha production in macrophages contributes to trigeminal
            neuropathic pain in rats
  JOURNAL   J Headache Pain 22 (1), 31 (2021)
   PUBMED   33902429
  REMARK    GeneRIF: P2X3 receptor upregulation in trigeminal ganglion neurons
            through TNFalpha production in macrophages contributes to
            trigeminal neuropathic pain in rats.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 397)
  AUTHORS   Cockayne,D.A., Hamilton,S.G., Zhu,Q.M., Dunn,P.M., Zhong,Y.,
            Novakovic,S., Malmberg,A.B., Cain,G., Berson,A., Kassotakis,L.,
            Hedley,L., Lachnit,W.G., Burnstock,G., McMahon,S.B. and Ford,A.P.
  TITLE     Urinary bladder hyporeflexia and reduced pain-related behaviour in
            P2X3-deficient mice
  JOURNAL   Nature 407 (6807), 1011-1015 (2000)
   PUBMED   11069181
REFERENCE   7  (residues 1 to 397)
  AUTHORS   Llewellyn-Smith,I.J. and Burnstock,G.
  TITLE     Ultrastructural localization of P2X3 receptors in rat sensory
            neurons
  JOURNAL   Neuroreport 9 (11), 2545-2550 (1998)
   PUBMED   9721930
REFERENCE   8  (residues 1 to 397)
  AUTHORS   Evans,R.J., Lewis,C., Virginio,C., Lundstrom,K., Buell,G.,
            Surprenant,A. and North,R.A.
  TITLE     Ionic permeability of, and divalent cation effects on, two
            ATP-gated cation channels (P2X receptors) expressed in mammalian
            cells
  JOURNAL   J Physiol 497 (Pt 2) (Pt 2), 413-422 (1996)
   PUBMED   8961184
REFERENCE   9  (residues 1 to 397)
  AUTHORS   Lewis,C., Neidhart,S., Holy,C., North,R.A., Buell,G. and
            Surprenant,A.
  TITLE     Coexpression of P2X2 and P2X3 receptor subunits can account for
            ATP-gated currents in sensory neurons
  JOURNAL   Nature 377 (6548), 432-435 (1995)
   PUBMED   7566120
REFERENCE   10 (residues 1 to 397)
  AUTHORS   Chen,C.C., Akopian,A.N., Sivilotti,L., Colquhoun,D., Burnstock,G.
            and Wood,J.N.
  TITLE     A P2X purinoceptor expressed by a subset of sensory neurons
  JOURNAL   Nature 377 (6548), 428-431 (1995)
   PUBMED   7566119
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Jul 21, 2012 this sequence version replaced NP_112337.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X91167.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..397
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     Protein         1..397
                     /product="P2X purinoceptor 3 isoform 1"
                     /note="P2X purinoceptor 3; P2X3; ATP receptor; purinergic
                     receptor P2X, ligand-gated ion channel, 3"
                     /calculated_mol_wt=44261
     Region          1..358
                     /region_name="P2X_receptor"
                     /note="ATP P2X receptor; cl02993"
                     /db_xref="CDD:470714"
     Site            21..43
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P49654.1)"
     Site            139
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000250|UniProtKB:P56373; propagated from
                     UniProtKB/Swiss-Prot (P49654.1)"
     Site            170
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000250|UniProtKB:P56373; propagated from
                     UniProtKB/Swiss-Prot (P49654.1)"
     Site            194
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000250|UniProtKB:P56373; propagated from
                     UniProtKB/Swiss-Prot (P49654.1)"
     Site            290
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000250|UniProtKB:P56373; propagated from
                     UniProtKB/Swiss-Prot (P49654.1)"
     Site            323..341
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P49654.1)"
     CDS             1..397
                     /gene="P2rx3"
                     /coded_by="NM_031075.3:202..1395"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:81739"
                     /db_xref="RGD:620253"
ORIGIN      
        1 mncisdffty ettksvvvks wtigiinrav qlliisyfvg wvflhekayq vrdtaiessv
       61 vtkvkgfgry anrvmdvsdy vtppqgtsvf viitkmivte nqmqgfcpen eekyrcvsds
      121 qcgperfpgg giltgrcvny ssvlrtceiq gwcptevdtv empimmeaen ftifiknsir
      181 fplfnfekgn llpnltdkdi krcrfhpeka pfcpilrvgd vvkfagqdfa klartggvlg
      241 ikigwvcdld kawdqcipky sftrldgvse kssvspgynf rfakyykmen gseyrtllka
      301 fgirfdvlvy gnagkfniip tiissvaaft svgvgtvlcd iillnflkga dhykarkfee
      361 vtettlkgta stnpvfasdq atvekqstds gaysigh
//
