LOCUS       NM_012997               2547 bp    mRNA    linear   ROD 04-APR-2024
DEFINITION  Rattus norvegicus purinergic receptor P2X 1 (P2rx1), transcript
            variant 1, mRNA.
ACCESSION   NM_012997
VERSION     NM_012997.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2547)
  AUTHORS   Franco,M., Bautista-Perez,R., Cano-Martinez,A., Pacheco,U.,
            Santamaria,J., Del Valle Mondragon,L., Perez-Mendez,O. and
            Navar,L.G.
  TITLE     Physiopathological implications of P2X1 and P2X7 receptors in
            regulation of glomerular hemodynamics in angiotensin II-induced
            hypertension
  JOURNAL   Am J Physiol Renal Physiol 313 (1), F9-F19 (2017)
   PUBMED   28404593
  REMARK    GeneRIF: Indicate a predominant role for P2X1R and P2X7R in the
            control of glomerular hemodynamics in ANG II hypertension.
REFERENCE   2  (bases 1 to 2547)
  AUTHORS   Back,M.J., Lee,H.K., Lee,J.H., Fu,Z., Son,M.W., Choi,S.Z., Go,H.S.,
            Yoo,S., Hwang,S.W. and Kim,D.K.
  TITLE     P2X1 Receptor-Mediated Ca2+ Influx Triggered by DA-9801 Potentiates
            Nerve Growth Factor-Induced Neurite Outgrowth
  JOURNAL   ACS Chem Neurosci 7 (11), 1488-1498 (2016)
   PUBMED   27442785
  REMARK    GeneRIF: Study demonstrated that P2X1 receptor-mediated calcium ion
            influx triggered by DA-9801 potentiated the Nerve Growth
            Factor-induced neurite outgrowth. The results obtained in this
            study imply a possible relationship between P2X1 and
            neuroregeneration.
REFERENCE   3  (bases 1 to 2547)
  AUTHORS   Rodrigues,R.J., Almeida,T., Diaz-Hernandez,M., Marques,J.M.,
            Franco,R., Solsona,C., Miras-Portugal,M.T., Ciruela,F. and
            Cunha,R.A.
  TITLE     Presynaptic P2X1-3 and alpha3-containing nicotinic receptors
            assemble into functionally interacting ion channels in the rat
            hippocampus
  JOURNAL   Neuropharmacology 105, 241-257 (2016)
   PUBMED   26801076
REFERENCE   4  (bases 1 to 2547)
  AUTHORS   Harhun,M.I., Sukhanova,K., Gordienko,D. and Dyskina,Y.
  TITLE     Molecular identification of P2X receptors in vascular smooth muscle
            cells from rat anterior, posterior, and basilar arteries
  JOURNAL   Pharmacol Rep 67 (6), 1055-1060 (2015)
   PUBMED   26481522
  REMARK    GeneRIF: work identified that in major arteries of rat cerebral
            circulation Vascular Smooth Muscle Cells express only P2X1 and P2X4
            receptors subunits.
REFERENCE   5  (bases 1 to 2547)
  AUTHORS   Liu,Y., Tian,X., Wu,Y., Chen,L., Yi,C.L., Li,Z.W., Zhang,Y. and
            Li,C.Y.
  TITLE     Phenotypes of ATP-activated current associated with their genotypes
            of P2X1-6 subunits in neurons innervating tooth-pulp
  JOURNAL   Biochem Biophys Res Commun 458 (3), 596-600 (2015)
   PUBMED   25680470
  REMARK    GeneRIF: The study explores the association of the phenotype of
            ATP-activated current with the genotype of P2X1-6 subunits in
            neurons innervating tooth-pulp.
REFERENCE   6  (bases 1 to 2547)
  AUTHORS   Mulryan,K., Gitterman,D.P., Lewis,C.J., Vial,C., Leckie,B.J.,
            Cobb,A.L., Brown,J.E., Conley,E.C., Buell,G., Pritchard,C.A. and
            Evans,R.J.
  TITLE     Reduced vas deferens contraction and male infertility in mice
            lacking P2X1 receptors
  JOURNAL   Nature 403 (6765), 86-89 (2000)
   PUBMED   10638758
REFERENCE   7  (bases 1 to 2547)
  AUTHORS   Torres,G.E., Haines,W.R., Egan,T.M. and Voigt,M.M.
  TITLE     Co-expression of P2X1 and P2X5 receptor subunits reveals a novel
            ATP-gated ion channel
  JOURNAL   Mol Pharmacol 54 (6), 989-993 (1998)
   PUBMED   9855626
REFERENCE   8  (bases 1 to 2547)
  AUTHORS   Valera,S., Talabot,F., Evans,R.J., Gos,A., Antonarakis,S.E.,
            Morris,M.A. and Buell,G.N.
  TITLE     Characterization and chromosomal localization of a human P2X
            receptor from the urinary bladder
  JOURNAL   Recept Channels 3 (4), 283-289 (1995)
   PUBMED   8834001
REFERENCE   9  (bases 1 to 2547)
  AUTHORS   Valera,S., Hussy,N., Evans,R.J., Adami,N., North,R.A.,
            Surprenant,A. and Buell,G.
  TITLE     A new class of ligand-gated ion channel defined by P2x receptor for
            extracellular ATP
  JOURNAL   Nature 371 (6497), 516-519 (1994)
   PUBMED   7523951
REFERENCE   10 (bases 1 to 2547)
  AUTHORS   Owens,G.P., Hahn,W.E. and Cohen,J.J.
  TITLE     Identification of mRNAs associated with programmed cell death in
            immature thymocytes
  JOURNAL   Mol Cell Biol 11 (8), 4177-4188 (1991)
   PUBMED   2072913
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            X80477.1 and BC061742.1.
            
            On Oct 18, 2013 this sequence version replaced NM_012997.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061742.1, X80477.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-838               X80477.1           1-838
            839-2547            BC061742.1         831-2539
FEATURES             Location/Qualifiers
     source          1..2547
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..2547
                     /gene="P2rx1"
                     /gene_synonym="P2XMR"
                     /note="purinergic receptor P2X 1"
                     /db_xref="GeneID:25505"
                     /db_xref="RGD:3240"
     exon            1..346
                     /gene="P2rx1"
                     /gene_synonym="P2XMR"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..1409
                     /gene="P2rx1"
                     /gene_synonym="P2XMR"
                     /note="isoform 1 is encoded by transcript variant 1; P2X
                     purinoceptor 1; P2X1; ATP receptor; RP-2 protein;
                     purinergic receptor P2X, ligand-gated ion channel, 1"
                     /codon_start=1
                     /product="P2X purinoceptor 1 isoform 1"
                     /protein_id="NP_037129.1"
                     /db_xref="GeneID:25505"
                     /db_xref="RGD:3240"
                     /translation="MARRLQDELSAFFFEYDTPRMVLVRNKKVGVIFRLIQLVVLVYV
                     IGWVFVYEKGYQTSSDLISSVSVKLKGLAVTQLQGLGPQVWDVADYVFPAHGDSSFVV
                     MTNFIVTPQQTQGHCAENPEGGICQDDSGCTPGKAERKAQGIRTGNCVPFNGTVKTCE
                     IFGWCPVEVDDKIPSPALLREAENFTLFIKNSISFPRFKVNRRNLVEEVNGTYMKKCL
                     YHKIQHPLCPVFNLGYVVRESGQDFRSLAEKGGVVGITIDWKCDLDWHVRHCKPIYQF
                     HGLYGEKNLSPGFNFRFARHFVQNGTNRRHLFKVFGIHFDILVDGKAGKFDIIPTMTT
                     IGSGIGIFGVATVLCDLLLLHILPKRHYYKQKKFKYAEDMGPGEGEHDPVATSSTLGL
                     QENMRTS"
     exon            347..494
                     /gene="P2rx1"
                     /gene_synonym="P2XMR"
                     /inference="alignment:Splign:2.1.0"
     exon            495..566
                     /gene="P2rx1"
                     /gene_synonym="P2XMR"
                     /inference="alignment:Splign:2.1.0"
     exon            567..636
                     /gene="P2rx1"
                     /gene_synonym="P2XMR"
                     /inference="alignment:Splign:2.1.0"
     exon            637..733
                     /gene="P2rx1"
                     /gene_synonym="P2XMR"
                     /inference="alignment:Splign:2.1.0"
     exon            734..814
                     /gene="P2rx1"
                     /gene_synonym="P2XMR"
                     /inference="alignment:Splign:2.1.0"
     exon            815..956
                     /gene="P2rx1"
                     /gene_synonym="P2XMR"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1084
                     /gene="P2rx1"
                     /gene_synonym="P2XMR"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1175
                     /gene="P2rx1"
                     /gene_synonym="P2XMR"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1241
                     /gene="P2rx1"
                     /gene_synonym="P2XMR"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1343
                     /gene="P2rx1"
                     /gene_synonym="P2XMR"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..2479
                     /gene="P2rx1"
                     /gene_synonym="P2XMR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccaaaagct gttctgatca cccagggttt ttcctcccaa cccagacccc accatcgaac
       61 ctccaactct ggtcccacct agcctgctct gtccttaagg ggccgggaag ccccagtcac
      121 tccactgcta ttgtagatgc agatggtggc ctgcccttga ccatagaggc cgtgtggggt
      181 gttcatctct gagccccttc tggcccacca tggctcggcg gctgcaagat gagctgtcag
      241 ccttcttctt tgaatatgac actccccgga tggtgctggt acgaaacaag aaggtgggag
      301 tcattttccg tctgatccag ttggtggttc tggtctacgt cattgggtgg gtgtttgtct
      361 atgaaaaagg ataccagacc tcaagtgacc tcatcagcag tgtgtccgtg aagctcaagg
      421 gcttggctgt gacccagctc cagggcctgg gaccccaggt ctgggacgtg gctgactatg
      481 tcttcccagc acacggggac agctcctttg tagttatgac caacttcatc gtgacccctc
      541 agcagactca aggccattgt gcagagaacc cagaaggtgg catatgccag gatgacagtg
      601 gctgcactcc aggaaaagca gaaaggaaag cccaaggtat tcgcacaggc aactgtgtgc
      661 ccttcaatgg cactgtgaag acatgtgaga tctttggttg gtgtcctgta gaggtggatg
      721 acaagatccc aagccctgct cttcttcgtg aggctgagaa cttcaccctc ttcatcaaaa
      781 acagcatcag ctttccacgc ttcaaggtca acaggcgcaa cctggtagag gaggtgaatg
      841 gcacctacat gaagaagtgc ctctatcaca agattcaaca ccccctgtgc ccagtcttca
      901 accttggcta tgtggtgcga gagtcaggcc aggacttccg cagccttgct gagaagggtg
      961 gggtggttgg tatcaccatt gactggaagt gtgatctgga ctggcacgtt cggcactgca
     1021 aacccatcta ccagttccac ggactgtatg gggagaagaa cctgtctcca ggcttcaact
     1081 tcagatttgc caggcatttc gtgcagaatg ggacaaaccg tcgtcacctc ttcaaggtgt
     1141 ttgggattca ctttgatatc cttgtggatg gcaaggctgg gaagtttgac atcatcccta
     1201 ctatgactac tatcggttct gggattggca tctttggagt ggccacagtg ctttgtgatc
     1261 tcttattgct ccacatcctg cctaagaggc actactacaa gcagaagaag ttcaaatatg
     1321 ccgaggacat ggggccggga gagggtgaac atgaccccgt ggccaccagc tccactctgg
     1381 gcctgcagga gaacatgagg acctcctgac cttagtcttg agatccggac ttgacgcagt
     1441 gtgtggcttc cggcaagggc tgatggcttt gagccagggc agagggcatt cccagaggct
     1501 ttcctgcaag gcagacacca gtggccctct ggttcagcat gaagacaggc aagactttgg
     1561 atttcagagc tctggtttca gttccacatg tcccttcctg agggatgcct cctccagttt
     1621 tcaccaattt gggttcatat ggctgggccc ctcacacatc tatactctag ctttgtgctt
     1681 aaggctcagg ctgtcattgt ctttcccaca gccttacctg cctagatttg ggctcttcca
     1741 catggtagcc actagccaga tgtgtcagtt tgaactttaa ttaaaatata ataaaaagat
     1801 ggctgggttg aactagttac ggggacactt ttggcccgtg gctgccacac tggataacaa
     1861 tggatgctgt cattgtaaga agttccgaaa gaattcctgg ggaggctcat caacagtgca
     1921 ggtgcctgat acacaccccc accccctaaa ccagaaacgc aggccatttt gtagctgagg
     1981 cttaagaatt gctctcccag agctttctga ttcttaagct cccagtcagc cttgggtcag
     2041 caccaactgg caggtgtagg cactgagcag ggtctcaaac acccacagca tttgtgtgga
     2101 cagcaagtgt gtcgtgtgtt cttgtgccac aaagagattc acgaaccccc atgtgcacac
     2161 acacctctac acataccacc ctccgccccc actgtgggag ggaacagctt gggcactgca
     2221 agcacagcca tctgaacaca cccacactgc aaggcaggga cacacagtct ccatacagtg
     2281 tcatcccaag ggagtcacac cagaccagcc cttctagccc ctgaacctga ctcagctacc
     2341 tcaggtggag atgtaaccct ggtgaatcct ggctccttgc ctgtggccca gtcccagttt
     2401 ccatagcctg tccagcttgg ccggaacatg agggctgagg aggcaagggg tgggccacaa
     2461 taaaaagaat gaggacaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2521 aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
