LOCUS       NM_012871               4584 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Rattus norvegicus oxytocin receptor (Oxtr), mRNA.
ACCESSION   NM_012871
VERSION     NM_012871.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4584)
  AUTHORS   El Heni,H., Kemenesi-Gedei,P.B., Palvolgyi,L., Kozma-Szeredi,I.D.
            and Kis,G.
  TITLE     Peripheral Branch Injury Induces Oxytocin Receptor Expression at
            the Central Axon Terminals of Primary Sensory Neurons
  JOURNAL   Int J Mol Sci 25 (1), 7 (2023)
   PUBMED   38203176
  REMARK    GeneRIF: Peripheral Branch Injury Induces Oxytocin Receptor
            Expression at the Central Axon Terminals of Primary Sensory
            Neurons.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4584)
  AUTHORS   Shen,G., Yang,S., Wu,L., Chen,Y., Hu,Y., Zhou,F., Wang,W., Liu,P.,
            Wu,F., Liu,Y., Wang,F. and Chen,L.
  TITLE     The oxytocin receptor rs2254298 polymorphism and alcohol withdrawal
            symptoms: a gene-environment interaction in mood disorders
  JOURNAL   Front Psychiatry 14, 1085429 (2023)
   PUBMED   37520225
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4584)
  AUTHORS   Demarchi,L., Sanson,A. and Bosch,O.J.
  TITLE     Brief versus long maternal separation in lactating rats:
            Consequences on maternal behavior, emotionality, and brain oxytocin
            receptor binding
  JOURNAL   J Neuroendocrinol 35 (7), e13252 (2023)
   PUBMED   37002874
  REMARK    GeneRIF: Brief versus long maternal separation in lactating rats:
            Consequences on maternal behavior, emotionality, and brain oxytocin
            receptor binding.
REFERENCE   4  (bases 1 to 4584)
  AUTHORS   Suzuki,J., Nagase,M., Sato,N., Takahashi,Y., Okamoto,A. and Kato,F.
  TITLE     Delivery-Dependent Shift in Oxytocin-Responsive Cell Population in
            the Central Amygdala of the Female Rat
  JOURNAL   Neuroendocrinology 113 (1), 48-63 (2023)
   PUBMED   35785764
  REMARK    GeneRIF: Delivery-Dependent Shift in Oxytocin-Responsive Cell
            Population in the Central Amygdala of the Female Rat.
REFERENCE   5  (bases 1 to 4584)
  AUTHORS   D'Addario,C., Pucci,M., Bellia,F., Girella,A., Sabatucci,A.,
            Fanti,F., Vismara,M., Benatti,B., Ferrara,L., Fasciana,F.,
            Celebre,L., Vigano,C., Elli,L., Sergi,M., Maccarrone,M.,
            Buzzelli,V., Trezza,V. and Dell'Osso,B.
  TITLE     Regulation of oxytocin receptor gene expression in
            obsessive-compulsive disorder: a possible role for the
            microbiota-host epigenetic axis
  JOURNAL   Clin Epigenetics 14 (1), 47 (2022)
   PUBMED   35361281
  REMARK    GeneRIF: Regulation of oxytocin receptor gene expression in
            obsessive-compulsive disorder: a possible role for the
            microbiota-host epigenetic axis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4584)
  AUTHORS   Hoare,S., Copland,J.A., Strakova,Z., Ives,K., Jeng,Y.J.,
            Hellmich,M.R. and Soloff,M.S.
  TITLE     The proximal portion of the COOH terminus of the oxytocin receptor
            is required for coupling to g(q), but not g(i). Independent
            mechanisms for elevating intracellular calcium concentrations from
            intracellular stores
  JOURNAL   J Biol Chem 274 (40), 28682-28689 (1999)
   PUBMED   10497238
REFERENCE   7  (bases 1 to 4584)
  AUTHORS   Strakova,Z., Copland,J.A., Lolait,S.J. and Soloff,M.S.
  TITLE     ERK2 mediates oxytocin-stimulated PGE2 synthesis
  JOURNAL   Am J Physiol 274 (4), E634-E641 (1998)
   PUBMED   9575824
REFERENCE   8  (bases 1 to 4584)
  AUTHORS   Strakova,Z. and Soloff,M.S.
  TITLE     Coupling of oxytocin receptor to G proteins in rat myometrium
            during labor: Gi receptor interaction
  JOURNAL   Am J Physiol 272 (5 Pt 1), E870-E876 (1997)
   PUBMED   9176188
REFERENCE   9  (bases 1 to 4584)
  AUTHORS   Jeng,Y.J., Lolait,S.J., Strakova,Z., Chen,C., Copland,J.A.,
            Mellman,D., Hellmich,M.R. and Soloff,M.S.
  TITLE     Molecular cloning and functional characterization of the oxytocin
            receptor from a rat pancreatic cell line (RINm5F)
  JOURNAL   Neuropeptides 30 (6), 557-565 (1996)
   PUBMED   9004255
REFERENCE   10 (bases 1 to 4584)
  AUTHORS   Rozen,F., Russo,C., Banville,D. and Zingg,H.H.
  TITLE     Structure, characterization, and expression of the rat oxytocin
            receptor gene
  JOURNAL   Proc Natl Acad Sci U S A 92 (1), 200-204 (1995)
   PUBMED   7816817
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1996 Oct 15;93(21):12051]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Mar 11, 2021 this sequence version replaced NM_012871.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.17291.1,
                                           SRR26643290.17297.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1034              JAXUCZ010000004.1  147169466-147170499 c
            1035-4584           JAXUCZ010000004.1  147154374-147157923 c
FEATURES             Location/Qualifiers
     source          1..4584
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q41"
     gene            1..4584
                     /gene="Oxtr"
                     /gene_synonym="OT-R; OTR; OTR1"
                     /note="oxytocin receptor"
                     /db_xref="GeneID:25342"
                     /db_xref="RGD:3239"
     exon            1..1034
                     /gene="Oxtr"
                     /gene_synonym="OT-R; OTR; OTR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..1282
                     /gene="Oxtr"
                     /gene_synonym="OT-R; OTR; OTR1"
                     /note="oxcytocin receptor"
                     /codon_start=1
                     /product="oxytocin receptor"
                     /protein_id="NP_037003.2"
                     /db_xref="GeneID:25342"
                     /db_xref="RGD:3239"
                     /translation="MEGTPAANWSVELDLGSGVPPGEEGNRTAGPPQRNEALARVEVA
                     VLCLILFLALSGNACVLLALRTTRHKHSRLFFFMKHLSIADLVVAVFQVLPQLLWDIT
                     FRFYGPDLLCRLVKYLQVVGMFASTYLLLLMSLDRCLAICQPLRSLRRRTDRLAVLGT
                     WLGCLVASAPQVHIFSLREVADGVFDCWAVFIQPWGPKAYVTWITLAVYIVPVIVLAA
                     CYGLISFKIWQNLRLKTAAAAAAAEGNDAAGGAGRAALARVSSVKLISKAKIRTVKMT
                     FIIVLAFIVCWTPFFFVQMWSVWDVNAPKEASAFIIAMLLASLNSCCNPWIYMLFTGH
                     LFHELVQRFFCCSARYLKGSRPGETSVSKKSNSSTFVLSRRSSSQRSCSQPSSA"
     exon            1035..4584
                     /gene="Oxtr"
                     /gene_synonym="OT-R; OTR; OTR1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagaggaca ggcaggtaga cacctggacc gagcaccagg ccccgcccca cgtgccacgc
       61 tttaaagaat cgtaagactt agtgctccct ggaggtcgcg gtcgcggtcg cggacatgga
      121 gggcacgcca gcagccaact ggagtgtcga gttggacctc gggagtggag tgccaccagg
      181 ggaggagggc aaccgcacgg ccgggccacc acaacgcaac gaggccctgg cgcgcgtgga
      241 ggtggcggtc ctgtgcctca ttctgttcct ggctctgagt ggcaacgcgt gtgtgctgct
      301 ggcgctgcgc accacgcgcc acaagcactc gcgcctcttc tttttcatga agcacctgag
      361 catcgctgac ctggtggtgg ctgtgtttca ggtgcttccg cagctgctgt gggacatcac
      421 cttccgcttc tatgggcccg acctgctgtg tcgtctggtc aaatacttgc aggtggtggg
      481 catgttcgcc tccacctacc tgctgctgct gatgtcgctc gaccgctgtc tggccatctg
      541 ccagccgctg cgctccctgc gccgccgaac cgaccgcctg gcggtgctgg ggacgtggct
      601 tggctgcctg gtggccagtg ctccgcaggt gcacattttc tcgctgcgcg aagtggcgga
      661 cggagtcttc gattgctggg cggtcttcat ccaaccctgg ggacccaagg cctacgtcac
      721 atggatcacg ctcgccgtct acattgtacc ggtcatcgtg ctggccgcct gctacggcct
      781 catcagcttc aagatctggc agaatctgag actcaagacg gcagcggcgg cggcggctgc
      841 cgaggggaat gacgcggcgg gtggagctgg gcgtgcggcg ttggcacggg tcagtagtgt
      901 caagcttatc tccaaggcca aaatccgcac ggtgaagatg accttcatca tcgtactggc
      961 cttcatcgtg tgctggacac ctttcttctt cgtgcagatg tggagcgttt gggacgtcaa
     1021 tgcgcccaag gaagcttctg ccttcatcat tgccatgctc ttggccagcc tcaacagctg
     1081 ctgcaacccg tggatctaca tgctcttcac aggtcacctc ttccacgaac tcgtgcagcg
     1141 cttcttctgc tgctctgctc gttacctgaa gggcagccgg cccggcgaga cgagtgtcag
     1201 caagaagagc aactcatcca cctttgtcct gagccgtcgc agctcaagcc agaggagctg
     1261 ctctcagcca tcttcagcat gagccatagg cctggcccac cgggccagcc gcagggttgg
     1321 tggtgtggac tccagtcttc ccccgtggtg gctgtgcatg aagctgcatt aggtgtctat
     1381 tggtttgcat cccttctctc cttgagttgg ctagagcgtg tgtcatattc tgacgtgggg
     1441 tggggaaatg tctctatggg ggatgatcgg gtcactcagc catcagaggg tcacctgaac
     1501 tcccacctgt gtttctacta ccctgactca agtgctcctg ggtggtgggt ggactcttgg
     1561 acacctggct tttgtccctt tccctcttgt ttatcctggt atcttgtgaa agacagcacg
     1621 cctaggatag gtgacttgaa gcccagtggg ctgacaagga gtgggaaatg aggctgcgga
     1681 cgcagagtgg tgctaatttc cccctgacct gagtcgtgtg gacagatctt agcatcctta
     1741 gggcatcctg gaaagcactg ggaaccggaa actgagctgg gaggctgcct ggctctgaaa
     1801 ggtgatgaga acgaggccaa aatgttgaag atgctgctgc ttggcaaaca tttaggaagg
     1861 aaaaggagag tcatccagga caggtgaggg aggggagctg tttgtacatg acactgaccc
     1921 gtgcatatgt gatctaggag cactcacata catatgcgta cgtgcacaca catgcaagta
     1981 gcccttctct cccccctcct ctccctctct cctttcccct taccccgtct ctccccagag
     2041 ctgacagaga agtagcaagg ttagtgtcag atcaatgtta caaagtttgt tcatatttcc
     2101 ttatactgct ggtgaccaat gggaaagtga aggggcgtcc atccataaaa gtcccagaat
     2161 gaggaaagga gggttaggga taacaaggga aatgtaaccc tgcgccctca aagctgcaaa
     2221 caagaactgg agggaaataa aggagaatag ataaatgggg ccaccttgcg cttatgggtc
     2281 agagacataa tattgttgaa cagatttgat gtaatcctca ccaagatcct agctggcttc
     2341 tgaagaaatt gataaagtgg tcctaaaatt cccaaggaga tgggaattgg ggtggttagg
     2401 atgccttgga atttgtgatg ggcgcacggt tctgagaacg tattaaaagt taataaacaa
     2461 ccccccggag gctgaggagc tgcctcactc agagaagcgt gtgctgagca agtgtgagaa
     2521 cccaacttga gcacctcagc gtccatgtag aagccaggct cagtgcatct taacctcagc
     2581 cctggggtgg gggcttacag gtggatccca gacacttaca gggcagccag cctagcagac
     2641 tgatcaactt tgagttcagc aaaagactct atctcaagat taactaagta aataaaaata
     2701 aggtggagag tgatggagga aaacctttgg tctctacatg tatctgtgga tagacaacat
     2761 acacgaatgc acgtatacac acacacacac acacacacac acacacacac acactaaaac
     2821 actaaactat atacacttaa aaatgagaaa aaaatttaag agctgagttc tgggaaaacc
     2881 caaatgatgg atgactttct tggcctattt tcctctagtg cagtttcccc tgtgacccac
     2941 caagtgtctg caggagaggc gggtcctatg ctggcctgtg aatgcagtgc tcatccccgt
     3001 ctggcattaa cgaaggccag agagggatgt tccgaggctc catgccctgt cttctttaga
     3061 gcagcatttc cccaggaggc ttaaaggctt tgtttatcgg atacacatgc cctcaagtgt
     3121 cctctcagcc ttgagggcag gatatgactc tgtctcagaa ataccattgg ctattaaata
     3181 taggacacga ttgaatattg gctctctgtc tgtggctggt tactgtgcat tctggagtcc
     3241 ctttgaaata cccagacgta attctggact tactgaaatg tatcaagggc gcttccaaaa
     3301 tacctagaat ctgtagatcc actttgtcaa ccaccctact gcccctcccc cacttctgag
     3361 cacattttct tctgctacac tgcaatattt gcccagccca tacacatacc tgtatgcaca
     3421 catgcacaca agaatatgaa ccagtaccgt ccaatgttca gggaggaggg aagcgtgtgc
     3481 cacactgtcc atgttcaaca ctcacaattt agggcaagct gaagacagga ggcaatgccg
     3541 tttttggacc cagggacact gaccctcatg catgcagtgt cccacctgct agtccctgct
     3601 ctttgagaag ctaacaagat tctgctttgg ggtgtctgtg cctgtgttct agaccatcct
     3661 gctcgcttgg gtgcagacat gacagtaggg tgggagcctg ttagcatcag tgccttgcag
     3721 atgttccgag tccctggagt tcatagagaa gttgctaacc ttagagtcaa gaggagtcac
     3781 taggagtcaa gggaagcaat gactcagata ttctgaccac gggcagtgtt cccgagagcc
     3841 ccagagggca tagaaaccta ctagggtgct gctgccagtc tatgtgaaag ctctagctgg
     3901 ttccttgggt tttgtactga caccgtatct gttacataag tgacaattga cttcaccagc
     3961 aacattggat tgacaccgta ctgtcccgat ctcacgcgtg aatattttta acatttctcc
     4021 aatttttgtt tacccaatga aagccaagga tctctagggc ttccaaacac actccctccc
     4081 aatcttgcgg cctgcattct ccttcctcgg accccatact agacatctcc aatgtctctt
     4141 cctactttcc aacctgttta aaatctgtgt gtagggttgg aggttgtatt aaattggagc
     4201 atgctgaatg ttctggaatg ttttgtcgtt ctgaccacaa ggagtcagtg tgcaaactgt
     4261 gagagttatt taggccctgc aagaaaagag tcctacattt agaaatctgt agcccctttt
     4321 ttgggacaaa tctgagccat catttcaggg agcacaatgg ggtgtgggtg taggctgccg
     4381 gatgatggtc ctggcttcca gtctgtaact tttgtattca cttgcaatga gatgcccctc
     4441 atcacacagt gtgaattcct tgatattgtg atttcatgga catttgtgtg atgcccagtg
     4501 tcccctgcat ctggtgagtg acacagcctc ctgctttacc agctgcttga taaatggtgc
     4561 acttaataaa cgttcttttc tgta
//
