LOCUS       NM_012996                534 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Rattus norvegicus oxytocin/neurophysin I prepropeptide (Oxt), mRNA.
ACCESSION   NM_012996
VERSION     NM_012996.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 534)
  AUTHORS   P Graf,A., Hansson,A.C. and Spanagel,R.
  TITLE     Isolated during adolescence: long-term impact on social behavior,
            pain sensitivity, and the oxytocin system in male and female rats
  JOURNAL   Biol Sex Differ 15 (1), 78 (2024)
   PUBMED   39407302
  REMARK    GeneRIF: Isolated during adolescence: long-term impact on social
            behavior, pain sensitivity, and the oxytocin system in male and
            female rats.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 534)
  AUTHORS   Inada,K.
  TITLE     Neurobiological mechanisms underlying oxytocin-mediated parental
            behavior in rodents
  JOURNAL   Neurosci Res 207, 1-12 (2024)
   PUBMED   38642676
  REMARK    GeneRIF: Neurobiological mechanisms underlying oxytocin-mediated
            parental behavior in rodents.
            Review article
REFERENCE   3  (bases 1 to 534)
  AUTHORS   Li,T., Jiang,Y.H., Wang,X., Hou,D., Jia,S.W. and Wang,Y.F.
  TITLE     Immune-regulating effect of oxytocin and its association with the
            hypothalamic-pituitary axes
  JOURNAL   J Neuroimmunol 394, 578419 (2024)
   PUBMED   39088908
  REMARK    GeneRIF: Immune-regulating effect of oxytocin and its association
            with the hypothalamic-pituitary axes.
REFERENCE   4  (bases 1 to 534)
  AUTHORS   Liu,Y., Shan,L., Liu,T., Li,J., Chen,Y., Sun,C., Yang,C., Bian,X.,
            Niu,Y., Zhang,C., Xi,J. and Rao,Y.
  TITLE     Molecular and cellular mechanisms of the first social relationship:
            A conserved role of 5-HT from mice to monkeys, upstream of oxytocin
  JOURNAL   Neuron 111 (9), 1468-1485 (2023)
   PUBMED   36868221
  REMARK    GeneRIF: Molecular and cellular mechanisms of the first social
            relationship: A conserved role of 5-HT from mice to monkeys,
            upstream of oxytocin.
REFERENCE   5  (bases 1 to 534)
  AUTHORS   Fukushima,A., Kataoka,N. and Nakamura,K.
  TITLE     An oxytocinergic neural pathway that stimulates thermogenic and
            cardiac sympathetic outflow
  JOURNAL   Cell Rep 40 (12), 111380 (2022)
   PUBMED   36130511
  REMARK    GeneRIF: An oxytocinergic neural pathway that stimulates
            thermogenic and cardiac sympathetic outflow.
REFERENCE   6  (bases 1 to 534)
  AUTHORS   Schmitz,E., Mohr,E. and Richter,D.
  TITLE     Rat vasopressin and oxytocin genes are linked by a long
            interspersed repeated DNA element (LINE): sequence and
            transcriptional analysis of LINE
  JOURNAL   DNA Cell Biol 10 (2), 81-91 (1991)
   PUBMED   1706187
REFERENCE   7  (bases 1 to 534)
  AUTHORS   Zierer,R.
  TITLE     Impact of ether anesthesia on the hypophyseal content of oxytocin
            neurophysin I and II: a comparative study with ketamine in the rat
  JOURNAL   Life Sci 49 (19), 1391-1397 (1991)
   PUBMED   1943445
REFERENCE   8  (bases 1 to 534)
  AUTHORS   Mohr,E., Bahnsen,U., Kiessling,C. and Richter,D.
  TITLE     Expression of the vasopressin and oxytocin genes in rats occurs in
            mutually exclusive sets of hypothalamic neurons
  JOURNAL   FEBS Lett 242 (1), 144-148 (1988)
   PUBMED   3203740
REFERENCE   9  (bases 1 to 534)
  AUTHORS   Wood,S.P., Tickle,I.J., Treharne,A.M., Pitts,J.E., Mascarenhas,Y.,
            Li,J.Y., Husain,J., Cooper,S., Blundell,T.L., Hruby,V.J. et al.
  TITLE     Crystal structure analysis of deamino-oxytocin: conformational
            flexibility and receptor binding
  JOURNAL   Science 232 (4750), 633-636 (1986)
   PUBMED   3008332
REFERENCE   10 (bases 1 to 534)
  AUTHORS   Schlesinger,D.H., Pickering,B.T., Watkins,W.B., Peek,J.C.,
            Moore,L.G., Audhya,T.K. and Walter,R.
  TITLE     A comparative study of partial neurophysin protein sequences of
            cod, guinea pig, rat and sheep
  JOURNAL   FEBS Lett 80 (2), 371-373 (1977)
   PUBMED   891987
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Mar 25, 2010 this sequence version replaced NM_012996.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M25649.1, CB791489.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               JAXUCZ010000003.1  138235754-138235909
            157-358             JAXUCZ010000003.1  138236133-138236334
            359-534             JAXUCZ010000003.1  138236419-138236594
FEATURES             Location/Qualifiers
     source          1..534
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..534
                     /gene="Oxt"
                     /note="oxytocin/neurophysin I prepropeptide"
                     /db_xref="GeneID:25504"
                     /db_xref="RGD:3238"
     exon            1..156
                     /gene="Oxt"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..414
                     /gene="Oxt"
                     /note="oxytocin-neurophysin 1; OT-NPI;
                     oxytocin/neurophysin (Oxt) gene, complete gene, complete
                     cds; oxcytocin; oxytocin/neurophysin 1 prepropeptide;
                     oxytocin, prepropeptide"
                     /codon_start=1
                     /product="oxytocin-neurophysin 1 preproprotein"
                     /protein_id="NP_037128.1"
                     /db_xref="GeneID:25504"
                     /db_xref="RGD:3238"
                     /translation="MACPSLACCLLGLLALTSACYIQNCPLGGKRAALDLDMRKCLPC
                     GPGGKGRCFGPSICCADELGCFVGTAEALRCQEENYLPSPCQSGQKPCGSGGRCATAG
                     ICCSPDGCRTDPACDPESAFSER"
     exon            157..358
                     /gene="Oxt"
                     /inference="alignment:Splign:2.1.0"
     exon            359..534
                     /gene="Oxt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcaccgacgg tggatctcgg actgaacacc aacgccatgg cctgccccag tcttgcttgc
       61 tgcctgcttg gcctactggc tctgacctcc gcctgctaca tccagaactg ccccctgggc
      121 ggcaagaggg ctgcgctaga cctggatatg cgcaagtgtc ttccctgcgg acccggcggc
      181 aaagggcgct gcttcgggcc gagcatctgc tgcgcggacg agctgggctg cttcgtgggc
      241 accgccgagg cgctgcgctg ccaggaggag aactacctgc cctcgccctg ccagtctggc
      301 cagaagcctt gcggaagcgg aggccgctgc gccaccgcgg gcatctgctg tagcccggat
      361 ggctgccgca ccgaccccgc ctgcgaccct gagtctgcct tctccgagcg ctgagcccgc
      421 tttgtgatga tacctttagg gcgcttcctt cattccccat ggccactacc agaaaaaatt
      481 aaaaaaaaaa cataaataaa taaataaata aataaagcag atttcctctt caaa
//
