LOCUS       NM_001108194            4525 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus oxidative stress responsive kinase 1 (Oxsr1),
            mRNA.
ACCESSION   NM_001108194 XM_001078098 XM_236687
VERSION     NM_001108194.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4525)
  AUTHORS   Li,R., Wen,Y., Wu,B., He,M., Zhang,P., Zhang,Q. and Chen,Y.
  TITLE     MicroRNA-25-3p suppresses epileptiform discharges through
            inhibiting oxidative stress and apoptosis via targeting OXSR1 in
            neurons
  JOURNAL   Biochem Biophys Res Commun 523 (4), 859-866 (2020)
   PUBMED   31954517
  REMARK    GeneRIF: MicroRNA-25-3p suppresses epileptiform discharges through
            inhibiting oxidative stress and apoptosis via targeting OXSR1 in
            neurons.
REFERENCE   2  (bases 1 to 4525)
  AUTHORS   Qin,Y., Wang,G. and Peng,Z.
  TITLE     MicroRNA-191-5p diminished sepsis-induced acute kidney injury
            through targeting oxidative stress responsive 1 in rat models
  JOURNAL   Biosci Rep 39 (8) (2019)
   PUBMED   31362998
  REMARK    GeneRIF: MicroRNA-191-5p diminished sepsis-induced acute kidney
            injury through targeting oxidative stress responsive 1 in rat
            models.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4525)
  AUTHORS   Kochl,R., Thelen,F., Vanes,L., Brazao,T.F., Fountain,K., Xie,J.,
            Huang,C.L., Lyck,R., Stein,J.V. and Tybulewicz,V.L.
  TITLE     WNK1 kinase balances T cell adhesion versus migration in vivo
  JOURNAL   Nat Immunol 17 (9), 1075-1083 (2016)
   PUBMED   27400149
  REMARK    Erratum:[Nat Immunol. 2017 Jan 19;18(2):246. doi:
            10.1038/ni0217-246a.. PMID: 28102214]
REFERENCE   4  (bases 1 to 4525)
  AUTHORS   Vorontsova,I., Lam,L., Delpire,E., Lim,J. and Donaldson,P.
  TITLE     Identification of the WNK-SPAK/OSR1 signaling pathway in rodent and
            human lenses
  JOURNAL   Invest Ophthalmol Vis Sci 56 (1), 310-321 (2014)
   PUBMED   25515571
  REMARK    GeneRIF: Identification of the WNK-SPAK/OSR1 signaling pathway in
            rodent and human lenses.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4525)
  AUTHORS   de Los Heros,P., Alessi,D.R., Gourlay,R., Campbell,D.G., Deak,M.,
            Macartney,T.J., Kahle,K.T. and Zhang,J.
  TITLE     The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and
            inhibit the K+-Cl- co-transporters
  JOURNAL   Biochem J 458 (3), 559-573 (2014)
   PUBMED   24393035
REFERENCE   6  (bases 1 to 4525)
  AUTHORS   Anselmo,A.N., Earnest,S., Chen,W., Juang,Y.C., Kim,S.C., Zhao,Y.
            and Cobb,M.H.
  TITLE     WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa
            cells
  JOURNAL   Proc Natl Acad Sci U S A 103 (29), 10883-10888 (2006)
   PUBMED   16832045
REFERENCE   7  (bases 1 to 4525)
  AUTHORS   Vitari,A.C., Thastrup,J., Rafiqi,F.H., Deak,M., Morrice,N.A.,
            Karlsson,H.K. and Alessi,D.R.
  TITLE     Functional interactions of the SPAK/OSR1 kinases with their
            upstream activator WNK1 and downstream substrate NKCC1
  JOURNAL   Biochem J 397 (1), 223-231 (2006)
   PUBMED   16669787
REFERENCE   8  (bases 1 to 4525)
  AUTHORS   Vitari,A.C., Deak,M., Morrice,N.A. and Alessi,D.R.
  TITLE     The WNK1 and WNK4 protein kinases that are mutated in Gordon's
            hypertension syndrome phosphorylate and activate SPAK and OSR1
            protein kinases
  JOURNAL   Biochem J 391 (Pt 1), 17-24 (2005)
   PUBMED   16083423
  REMARK    GeneRIF: WNK1 and WNK4 both interacted with SPAK as well as a
            closely related kinase, termed oxidative stress response kinase-1.
REFERENCE   9  (bases 1 to 4525)
  AUTHORS   Chen,W., Yazicioglu,M. and Cobb,M.H.
  TITLE     Characterization of OSR1, a member of the mammalian Ste20p/germinal
            center kinase subfamily
  JOURNAL   J Biol Chem 279 (12), 11129-11136 (2004)
   PUBMED   14707132
REFERENCE   10 (bases 1 to 4525)
  AUTHORS   Piechotta,K., Lu,J. and Delpire,E.
  TITLE     Cation chloride cotransporters interact with the stress-related
            kinases Ste20-related proline-alanine-rich kinase (SPAK) and
            oxidative stress response 1 (OSR1)
  JOURNAL   J Biol Chem 277 (52), 50812-50819 (2002)
   PUBMED   12386165
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473954.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_236687.4, XM_001078098.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4525
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..4525
                     /gene="Oxsr1"
                     /note="oxidative stress responsive kinase 1"
                     /db_xref="GeneID:316064"
                     /db_xref="RGD:1310466"
     exon            1..364
                     /gene="Oxsr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             295..1878
                     /gene="Oxsr1"
                     /EC_number="2.7.11.1"
                     /note="oxidative-stress responsive 1; oxidative
                     stress-responsive 1 protein"
                     /codon_start=1
                     /product="serine/threonine-protein kinase OSR1"
                     /protein_id="NP_001101664.1"
                     /db_xref="GeneID:316064"
                     /db_xref="RGD:1310466"
                     /translation="MSEDSSALPWSINRDDYELQEVIGSGATAVVQAAYCAPKKERVA
                     IKRINLEKCQTSMDELLKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLD
                     IIKHIVAKGEHKGGVLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSV
                     QIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAI
                     ELATGAAPYHKYPPMKVLMLTLQNDPPSLDTGVQDKEMLKKYGKSFRKMISLCLQKDP
                     EKRPTAAELLRHKFFQKAKNKEFLQEKILQRAPTISERSKKVRRVPGSSGRLHKTEDG
                     GWEWSDDEFDEESEEGKAAISQLRSPRVKDSLSNSELFSAADPMGTLLQVPEQISAHL
                     PQPASQMPTQPAQVSLLPPAEPAKPAQARSSGERSQETKVPISLVLRLRNSKKELNDI
                     RFEFTPGRDTAEGVSQELISAGLVDGRDLVIVAANLQKIVEEPQSNRSVTFKLASGVE
                     GSDIPDDGKLIGFAQLSIS"
     exon            365..477
                     /gene="Oxsr1"
                     /inference="alignment:Splign:2.1.0"
     exon            478..586
                     /gene="Oxsr1"
                     /inference="alignment:Splign:2.1.0"
     exon            587..728
                     /gene="Oxsr1"
                     /inference="alignment:Splign:2.1.0"
     exon            729..784
                     /gene="Oxsr1"
                     /inference="alignment:Splign:2.1.0"
     exon            785..894
                     /gene="Oxsr1"
                     /inference="alignment:Splign:2.1.0"
     exon            895..996
                     /gene="Oxsr1"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1130
                     /gene="Oxsr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1179
                     /gene="Oxsr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1245
                     /gene="Oxsr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1368
                     /gene="Oxsr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1404
                     /gene="Oxsr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1551
                     /gene="Oxsr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1616
                     /gene="Oxsr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1669
                     /gene="Oxsr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1738
                     /gene="Oxsr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..1803
                     /gene="Oxsr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..4525
                     /gene="Oxsr1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agggcgggac ggaggggcag ggccgggaag aagctctctt cgcggtgccg cggaggctga
       61 ggccggctcg tgggctgggc cggggactgc gggacacgga gccgcaggag gcgagttcgg
      121 ccgcagccgc gcgtccccgc ctcgggcccg cgcttgaccc gcgcgccccg gcgttgtgcg
      181 ccccaaggct gggccaagcg gcgggttggg ggcggctggg cgtggggagg cgcgcggcga
      241 ggtgacccga gagccccaag cgtgagaagc acggagccag gcgctgcagc cgtcatgtcc
      301 gaggactcga gcgccctgcc ctggtccatc aacagggacg actacgagct gcaggaggtg
      361 atcgggagtg gagcaactgc tgtggtccaa gcagcttact gtgcccccaa aaaggagaga
      421 gtggcaatca aacggataaa cctggagaag tgtcagacga gcatggatga gctcctgaaa
      481 gaaatccaag ctatgagtca atgccatcat cctaacattg tgtcttacta cacatccttt
      541 gtggtaaaag atgagctgtg gctggtcatg aagctgctaa gtggaggttc cgttctggat
      601 attattaaac acattgtggc aaagggggaa cataagggcg gagttttgga tgagtcgacc
      661 atcgctacaa tcctccgaga agtcttagaa ggactggagt acctgcacaa gaacgggcag
      721 atccacagag atgtgaaagc tgggaacatt cttctaggag aagacggctc tgtgcagatt
      781 gcagatttcg gtgttagtgc ttttttagcc actggtggtg acattaccag aaataaagta
      841 agaaagacgt ttgttggcac cccgtgctgg atggcacctg aagttatgga gcaggttcga
      901 ggttatgatt ttaaagctga tatctggagt tttggaatca cagcgattga actagccaca
      961 ggggcagctc cttatcataa atatcctcca atgaaggttt taatgctgac actccagaac
     1021 gatcctcctt ctttggatac tggtgttcaa gataaagaaa tgctgaaaaa atatggaaaa
     1081 tcatttagaa aaatgatttc attgtgcctt caaaaggatc cagaaaaaag accaacagca
     1141 gcagaactgt tgaggcacaa gtttttccag aaggcaaaga ataaagaatt tcttcaagaa
     1201 aaaatactac agagagcacc taccatctct gaaagatcta aaaaggtccg gagagtgccc
     1261 ggctccagcg gccgtctcca taagacagag gatggaggct gggagtggag cgacgatgag
     1321 tttgatgagg agagcgagga agggaaagct gcgatttctc agctcaggtc tccccgagta
     1381 aaagactcat tgtcaaattc tgagctcttc tcggccgctg atcccatggg gactttgctt
     1441 caagttccag aacaaatttc tgcacatcta cctcagccag ctagccagat gcccacacag
     1501 ccagctcaag tctctctcct gccccctgca gagccagcaa agccagcaca ggctcgatct
     1561 tcaggagagc ggtcccagga gaccaaggtc cctatcagtc tagtgctaag attaaggaat
     1621 tccaaaaaag aactaaatga tattcgattt gaatttactc ctgggagaga tacagcagag
     1681 ggtgtttctc aggagctcat ttctgctggc ctggtcgacg gaagggattt agtgatagtg
     1741 gcagctaatt tgcagaaaat tgtggaagaa cctcagtcaa atcgatctgt cactttcaaa
     1801 ctggcatctg gtgttgaagg ctcggatatt cctgatgatg gcaaactgat aggatttgcc
     1861 cagctcagca tcagctaaac cacagccccg gaagagtcag cctaggagac gccacacatg
     1921 cacatgtctg ttgcttctgt tggcctgaac ctacaactgc caaagaaccc agcaaggaac
     1981 ctcccagctc ggagctttag tttttctctt tgtttttctt gcctccgccc ttctgccccc
     2041 cttttcctac aaggaaagaa aagttggatc acctgtggcc agcatcccct cagagagttc
     2101 cgttggtaga cacgttgctc atgtgccctc tccctccacg tgagaggcag aagtggccag
     2161 tgtgcctcga ggcccaggat ggaagtctct cagctcattc ttgccttact aagttgttgg
     2221 ccccagtgga tcgagcagcc gcactgggca gcctcatctt gcctgctctc ccacacctgc
     2281 tgggacatga gcatcttggg ataactctct aacactcaag tagcaattaa aagttgattg
     2341 ttcagctgga gcccagagaa tttaattact tttttttttc tttgtacctg gtgtgaattc
     2401 tagcaacctt tgttagaaaa aaagcacagc ctcgaatgga ggcagcctaa actcttgtct
     2461 gtctccttca tggtgtctct tacatgtttt gctgagctgt tctcaggctg ttctcaggca
     2521 cccccttcac tgctccctcc agaaagggtt gctagcctta acttcagctg gtgcgaaaca
     2581 tctgactgtc gtcagacttc agccatctcc ttcagagtgc acctttggat cgtttacgca
     2641 gaaaacatca agcaatggct tataaatctt atcttgccag aggtagtttt tgaacaagaa
     2701 gagaactttg taaatcttat cattgggaaa gtattttcga tatttaaaaa aattaaactg
     2761 aagaaaaact gatctttgac cctcctatga agatggattt gcctggcctc taagtcatga
     2821 ggaaatggtg tacaccgctg agagttttac agcaataaag gagactcaca cgaggctaga
     2881 ggcctgcctc tgctcctctc tcgcactgac tctgcagggc ttcttcattc gctcaactgc
     2941 ccaagacgga acctgaagcc acccgtgctg taaccttagg ctcatgagta gacggtgttc
     3001 atttgatgtt ctagaaatta tgtgacttat tctttagggt aaaaagtgag ctcaatgcaa
     3061 tatggttata atcagtgaag ttggcttttc ttttttccta tcgttaaata gcatttgtct
     3121 aattgctaat aagcctacca agttaccaga ttgtatatga gagtggaata gtcaagtctg
     3181 gccttaaaga gacaaagatg ggctgtgagc ccctagagtg ggactagttc gttgcctttt
     3241 atagaattcc ttgcacccgc cattgttggt ttgatgaaca agattagtac ccagtttgtt
     3301 tccaccctca ccccacctca cccagttgag gatcacagtg ctgctcctat gagcagctcc
     3361 gttgactttt ttcttggaac acacctgaga gctttcccca tctctgactt gtgccacctc
     3421 atgtttcatt catactgagc ctatagtttc agtcatggac tttcatactg cagagtgcaa
     3481 aggcatgttg ggaaaggtgt tggagaggaa gagaagatgg atttgagaag ggaattgaga
     3541 gaatagagag tccaaggtcc cagcaggttg gtaaaaggag gaacctgttg agctaggagg
     3601 gagaaaaaag attgagcagc tagttggaaa ccattttttt tctttcttct ttccccactt
     3661 gttagaggta gggttgtgag gaagcaaaga aggggaggtg ggatggagtc taggaagcag
     3721 gcagtgttgc ctttggcaga aggctcatgg cctgctgtag aattcaatct ggtttcagca
     3781 gcttgactta attcacttaa gggctcagga aggaatggat atcactgttc tggctttcga
     3841 cttagggggt gctccagtgc caggttggaa gtaagcagca gcctatctct tgttctctag
     3901 accatcatca cctttgcctt gctgtgaggg gacagacatg acagtaaaag tggcctgggg
     3961 ctctttttct gttcatggtt tgcttttttg gcaaggagga ggtcggcact aagacccagg
     4021 acaatgttac ttctccgtga tgtgtggtga cttccttctg ctggcttatg cagtgatggc
     4081 gagagaacca gtcagcggcg gaaactgcag agatgggaca gctcagaagc cagggagcta
     4141 gagcagagct tccaggggac tctgccatta agtcctcaag atgcccgtgt ccctggagta
     4201 gggactgact atagcacaag atagtgtgtg ccaatatagc caagagaatg tgtgaaatag
     4261 tctttctaaa tgataaaggc atcatttggg ttggttcttg ttttttgtgt tttcccttct
     4321 gttttcaacc aaatcctaga gccagctgag actgatacgt aacctgaagg ctaacacaag
     4381 aatgaaccag gaatgtcagt tcctccttgg gaggtttgct gggtggtgaa agatgtaaaa
     4441 tattaccttc tccctcttct cttgacttgt attttactgc atgttttttt ttttcatttt
     4501 taatcaataa agagtaaatt gtcct
//
