LOCUS       NM_001197907            4653 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus oxidation resistance 1 (Oxr1), transcript variant
            1, mRNA.
ACCESSION   NM_001197907
VERSION     NM_001197907.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4653)
  AUTHORS   Dianat,M., Radan,M., Mard,S.A., Sohrabi,F. and Saryazdi,S.S.N.
  TITLE     Contribution of reactive oxygen species via the OXR1 signaling
            pathway in the pathogenesis of monocrotaline-induced pulmonary
            arterial hypertension: The protective role of Crocin
  JOURNAL   Life Sci 256, 117848 (2020)
   PUBMED   32585243
  REMARK    GeneRIF: Contribution of reactive oxygen species via the OXR1
            signaling pathway in the pathogenesis of monocrotaline-induced
            pulmonary arterial hypertension: The protective role of Crocin.
REFERENCE   2  (bases 1 to 4653)
  AUTHORS   Rezaei,Z., Kourosh-Arami,M., Azizi,H. and Semnanian,S.
  TITLE     Orexin type-1 receptor inhibition in the rat lateral
            paragigantocellularis nucleus attenuates development of morphine
            dependence
  JOURNAL   Neurosci Lett 724, 134875 (2020)
   PUBMED   32114118
  REMARK    GeneRIF: Orexin type-1 receptor inhibition in the rat lateral
            paragigantocellularis nucleus attenuates development of morphine
            dependence.
REFERENCE   3  (bases 1 to 4653)
  AUTHORS   Mo,J.L., Pan,Z.G., Chen,X., Lei,Y., Lv,L.L., Qian,C. and Sun,F.Y.
  TITLE     MicroRNA-365 Knockdown Prevents Ischemic Neuronal Injury by
            Activating Oxidation Resistance 1-Mediated Antioxidant Signals
  JOURNAL   Neurosci Bull 35 (5), 815-825 (2019)
   PUBMED   30977043
  REMARK    GeneRIF: MicroRNA-365 up-regulation increases oxidative injury by
            inhibiting OXR1 expression, while its down-regulation protects
            neurons from oxidative death by enhancing OXR1-mediated antioxidant
            signals.
REFERENCE   4  (bases 1 to 4653)
  AUTHORS   Garcia-Brito,S., Aldavert-Vera,L., Huguet,G., Alvarez,A., Kadar,E.
            and Segura-Torres,P.
  TITLE     Increased training compensates for OX1R blockage-impairment of
            spatial memory and c-Fos expression in different cortical and
            subcortical areas
  JOURNAL   Behav Brain Res 353, 21-31 (2018)
   PUBMED   29953904
  REMARK    GeneRIF: Results showed a deteriorating effect of OXR1 blockade on
            spatial memory consolidation in the Morris Water Maze, and that
            increased training is able to counteract such an effect.
            Additionally, although c-Fos expression cannot be linked to
            specific neuronal function, the c-Fos data seem to reproduce the
            behavioural results in a set of regions which have been linked to
            spatial memory.
REFERENCE   5  (bases 1 to 4653)
  AUTHORS   Finelli,M.J., Sanchez-Pulido,L., Liu,K.X., Davies,K.E. and
            Oliver,P.L.
  TITLE     The Evolutionarily Conserved Tre2/Bub2/Cdc16 (TBC), Lysin Motif
            (LysM), Domain Catalytic (TLDc) Domain Is Neuroprotective against
            Oxidative Stress
  JOURNAL   J Biol Chem 291 (6), 2751-2763 (2016)
   PUBMED   26668325
REFERENCE   6  (bases 1 to 4653)
  AUTHORS   Oliver,P.L., Finelli,M.J., Edwards,B., Bitoun,E., Butts,D.L.,
            Becker,E.B., Cheeseman,M.T., Davies,B. and Davies,K.E.
  TITLE     Oxr1 is essential for protection against oxidative stress-induced
            neurodegeneration
  JOURNAL   PLoS Genet 7 (10), e1002338 (2011)
   PUBMED   22028674
REFERENCE   7  (bases 1 to 4653)
  AUTHORS   Hoffert,J.D., Pisitkun,T., Wang,G., Shen,R.F. and Knepper,M.A.
  TITLE     Quantitative phosphoproteomics of vasopressin-sensitive renal
            cells: regulation of aquaporin-2 phosphorylation at two sites
  JOURNAL   Proc Natl Acad Sci U S A 103 (18), 7159-7164 (2006)
   PUBMED   16641100
REFERENCE   8  (bases 1 to 4653)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   9  (bases 1 to 4653)
  AUTHORS   Fischer,H., Zhang,X.U., O'Brien,K.P., Kylsten,P. and Engvall,E.
  TITLE     C7, a novel nucleolar protein, is the mouse homologue of the
            Drosophila late puff product L82 and an isoform of human OXR1
  JOURNAL   Biochem Biophys Res Commun 281 (3), 795-803 (2001)
   PUBMED   11237729
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Dec 14, 2022 this sequence version replaced NM_001197907.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.20813.1,
                                           SRR26643296.19901.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               JAXUCZ010000007.1  74413609-74413751
            144-300             JAXUCZ010000007.1  74489545-74489701
            301-497             JAXUCZ010000007.1  74615909-74616105
            498-580             JAXUCZ010000007.1  74784204-74784286
            581-688             JAXUCZ010000007.1  74787901-74788008
            689-802             JAXUCZ010000007.1  74788938-74789051
            803-955             JAXUCZ010000007.1  74795237-74795389
            956-1140            JAXUCZ010000007.1  74798871-74799055
            1141-1901           JAXUCZ010000007.1  74801692-74802452
            1902-2070           JAXUCZ010000007.1  74805469-74805637
            2071-2233           JAXUCZ010000007.1  74807969-74808131
            2234-2314           JAXUCZ010000007.1  74838258-74838338
            2315-2440           JAXUCZ010000007.1  74840130-74840255
            2441-2593           JAXUCZ010000007.1  74841055-74841207
            2594-2689           JAXUCZ010000007.1  74842974-74843069
            2690-2763           JAXUCZ010000007.1  74844627-74844700
            2764-4653           JAXUCZ010000007.1  74848598-74850487
FEATURES             Location/Qualifiers
     source          1..4653
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q31"
     gene            1..4653
                     /gene="Oxr1"
                     /note="oxidation resistance 1"
                     /db_xref="GeneID:117520"
                     /db_xref="RGD:621857"
     exon            1..143
                     /gene="Oxr1"
                     /inference="alignment:Splign:2.1.0"
     exon            144..300
                     /gene="Oxr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             278..2899
                     /gene="Oxr1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     oxidation resistance protein 1; protein C7"
                     /codon_start=1
                     /product="oxidation resistance protein 1 isoform 1"
                     /protein_id="NP_001184836.1"
                     /db_xref="GeneID:117520"
                     /db_xref="RGD:621857"
                     /translation="MSVSNLSWLKKKSQSVDITAPGFNPLGGAGKQAPQASKPPAPKT
                     PIIEEEQNNSANTQKHPSRKSELKRFYTIDTGQKKTLDKKDGRRMSFQKPKGTIEYTV
                     ESRDSLNSIALKFDTTPNELVQLNKLFSRAVVTGQVLYVPDPEYVSSVESSPSLSPVS
                     PLSPTSSEAEFDKTTTPDVVHPKEAPPSSTESSIRPARVVSSTSEEEEAFTEKFLKIN
                     CKYITNGKGTVSGVLLVTPNNIMFDPHKTDPLVQENGCEEYGIMCPMEEVMSAAMYKE
                     ILDSKLKESLPIEVDQLSGRGFCHSKKMTGVPAEETDSRSRDQGNDSVSTAPRSTEES
                     LSEDVFTESELSPIREELPSSELRQEKSSDASSESVQTVSQIEVESLTAASESADVPD
                     HTNANSGRSSSEVGALSHETGLSSLEIATKEGDKATGNLQEVSGPKEQSTDIKGQDNQ
                     DSFHHENSLQQEAGEDSLSSGETVELTEKPTVLKDQQGKELKRDSETEVEELRKLWKT
                     HSMQQAKQQRDTIQQVAQRESKHRGAPADAHGEGSSLLKEKRRHRLHKFLCLRVGKPM
                     RKTFVSQASATMQQYAQRDKKHEYWFAVPQERTDHLYAFFIQWSPEIYAEDTGEYTRE
                     PGFIVVKKMAESGPDEAPAGEAAAREWEVVSVAEYHRRIDALNTEELRTLCRRLQITT
                     REDINSKQAAPAKADLEPESFRPNLSDPSELLLPDQIEKLTKHLPPRTIGYPWTLVYG
                     TGKHGTSLKTLYRTMTGLDTPVLMVIKDSDGQVFGALASEPFKVSDGFYGTGETFVFT
                     FCPEFEVFKWTGDNMFFIKGDMDSLAFGGGGGEFALWLDGDLYHGRSHSCKTFGNHTL
                     SKKEDFFIQDIEIWAFE"
     exon            301..497
                     /gene="Oxr1"
                     /inference="alignment:Splign:2.1.0"
     exon            498..580
                     /gene="Oxr1"
                     /inference="alignment:Splign:2.1.0"
     exon            581..688
                     /gene="Oxr1"
                     /inference="alignment:Splign:2.1.0"
     exon            689..802
                     /gene="Oxr1"
                     /inference="alignment:Splign:2.1.0"
     exon            803..955
                     /gene="Oxr1"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1140
                     /gene="Oxr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1901
                     /gene="Oxr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..2070
                     /gene="Oxr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2071..2233
                     /gene="Oxr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2234..2314
                     /gene="Oxr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2315..2440
                     /gene="Oxr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2441..2593
                     /gene="Oxr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2594..2689
                     /gene="Oxr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2690..2763
                     /gene="Oxr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2764..4653
                     /gene="Oxr1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagccggct gcgtcaggct gagcgcagtc cgcgcgcggc cgcgggagcg cagtgccagc
       61 gccgcccggc cccaccgaga ggggcgcact cgccgctgcg gggctcgcac cgctcaccgc
      121 agccccctcc cgccgacccg caagtcctct caaaccctga ataagtaagt ggtctgtgcc
      181 tgttccaagg gcagagtgga aagtggcagt ggtcctgtcc agtggacata ctgcttccct
      241 acttggactc tccaggattc catcacagat tgctgcaatg tctgtatcta atctatcatg
      301 gttgaagaaa aagtcccagt cagtggatat tactgctcca gggttcaacc ctttgggtgg
      361 tgcagggaag caagcaccac aagccagcaa gcccccagca cccaagactc ccatcataga
      421 agaagaacag aacaactcgg caaacaccca gaagcatcct tccaggaaaa gtgagctgaa
      481 gaggttctat accattgata ctggccaaaa gaagacccta gacaagaaag atgggcgaag
      541 gatgtctttt cagaagccta agggaactat tgaatatact gttgaatcaa gggattcttt
      601 gaatagcata gccctgaaat ttgataccac acccaatgaa cttgttcagt taaataagtt
      661 attctccaga gcagtcgtga ctggacaggt tttatacgtt cctgatcctg agtatgtctc
      721 tagtgttgaa agttccccat ccctaagccc tgtaagtcct ctgtcaccaa catcatcaga
      781 agctgaattt gataaaacca ctactcctga tgtagtccat ccaaaagaag cgcctccttc
      841 atctacagag agcagtattc ggcctgcaag agttgtatct tcaacttctg aagaagaaga
      901 agcatttact gagaaatttc ttaaaattaa ttgcaaatat atcaccaatg gcaagggcac
      961 agttagtggc gtcctgctag ttacaccgaa taacataatg tttgatccac ataagacaga
     1021 ccccctggtt caagagaacg gttgtgagga atatggcatc atgtgtccga tggaagaggt
     1081 gatgtcagct gccatgtaca aagagatttt ggacagcaaa ttaaaggagt cactgcccat
     1141 agaagtagat cagttgtcag gaagggggtt ctgccattca aagaaaatga caggagtccc
     1201 tgctgaggaa acagactcga gaagccgcga tcagggaaac gacagtgtca gcactgctcc
     1261 caggagcact gaggagtctc tctcagaaga tgttttcacg gagtcagaac tctctcctat
     1321 ccgagaggag ctgccctcct cagagctgag acaagagaag tcatctgacg cctcgtcaga
     1381 atctgtgcaa accgtcagtc agatcgaagt agagtccttg acagccgcgt cagagtctgc
     1441 tgatgttcct gaccacacta acgcgaatag tggacgttct tcaagcgaag ttggggcttt
     1501 atctcatgaa actggtttaa gtagtcttga aatagccact aaggaaggag ataaagctac
     1561 aggaaacctc caagaagtct caggccctaa agaacaaagc acagatataa aaggtcagga
     1621 taaccaagat tctttccacc acgaaaattc actgcagcaa gaggcaggtg aagacagtct
     1681 gtcttccgga gaaacagtgg aactgacaga aaagccaact gttcttaagg atcaacaagg
     1741 gaaggaacta aaacgggact cagagacaga agtagaggaa ctgcgcaaac tctggaaaac
     1801 ccactctatg cagcaagcca aacagcaaag ggacaccatt cagcaggtgg cacagaggga
     1861 gagtaaacac agaggcgcac ctgcagatgc acatggagag ggctcctcgt tgttaaagga
     1921 aaagagaagg catcgattac ataagttctt atgtctccga gtcggaaaac caatgaggaa
     1981 gacatttgta tctcaagcca gtgctacgat gcagcagtat gcacagagag ataaaaaaca
     2041 cgagtattgg tttgcagtgc cacaagaaag gacagaccac ttgtatgcct tcttcattca
     2101 gtggagtcca gaaatctacg cagaagacac tggggagtac accagagagc ccggatttat
     2161 agtggtcaag aagatggcag agtctggacc agatgaagcc cctgccggcg aagccgcagc
     2221 cagggagtgg gaggtagtgt cggtggctga gtatcaccgc aggatcgatg ctctaaacac
     2281 tgaagaactg cgcacactct gcagacgtct ccagatcacc acacgggagg acatcaactc
     2341 aaagcaggct gctccagcaa aagcagacct ggagccagaa tctttccgac caaacctaag
     2401 tgaccccagt gaactcttac tgcctgatca gatcgaaaag cttactaagc accttccacc
     2461 gagaaccatt ggctacccat ggactcttgt gtacggtact gggaagcatg gcaccagttt
     2521 gaagaccctt taccgaacaa tgacaggtct agacactccg gtgctgatgg tgattaaaga
     2581 cagtgatggg caggtttttg gtgcattagc atcagagccg tttaaagtaa gtgatggctt
     2641 ttacggtact ggagaaacat ttgtttttac attctgtcca gaatttgagg tcttcaagtg
     2701 gacaggagat aatatgtttt ttatcaaagg agacatggat tcgttagcgt ttggtggtgg
     2761 aggaggagaa tttgctcttt ggcttgacgg agatctctac catggaagaa gccattcctg
     2821 taaaacgttt gggaatcata cactgtctaa gaaggaagac ttcttcatcc aagacattga
     2881 aatctgggct tttgaatgaa tacagtgctc ttggttgtag caggacatca gcccaaacct
     2941 gaatggacaa acgcatcgtt tggaatgttc aagaagcaat acaattaatg tcacttgtgc
     3001 tttaaagtca gtctgtttgg ccatttactg caactataat tttggagttt atttttcaaa
     3061 tcatgtttct gtcccagagt tcttttgttt acaccatggc ctgggttcca gtagtttaac
     3121 agccaggtgg gatctgtcag cccagtgtag cacttggatc acaaaggcca ccaccttttc
     3181 agttgatgtc atctcagtcc taactggatg gtgctctgtt caactttttt taacctgtgt
     3241 taattctttt tatagagcag tgtacttggg gcattgagga aatggggcct agatacttct
     3301 gtatctggtg aagctgacac aggtaacaat tgggcctact tacattttcg tctaaatgag
     3361 aaaccacatg ccaaaataac acatgcttca tagacctctt ctagttctaa ttcagtgcag
     3421 cattctctta ttcattttgt aagcattctc gatttcattt gaagacagtg aaattggagg
     3481 agcagtctga ttggcataga cagcagcaca cacagtcggc aggtttgggc gcatgttttc
     3541 atcactgaat tttcagatag agttacaaat tgacagagga gaatgggaat tcaatgattc
     3601 tattggattt aatatattaa gcaagtaata ctatttacat atttgtagct taatagggca
     3661 ttatcataag tacaaaacta aaacttgcat atttcttcaa cattgtgtca tatacactgt
     3721 tttacagttc tcttgtttta gcctcgttgc ataccaactc ccccaataca ttttagtttt
     3781 gttttgtttt ctgctcaaaa ggaagcaaat tgttttgaaa taaaaacgtg tttttttcta
     3841 agtggtatat gttattagtt accattagca tctgctctta ccggagggca gtgactatcg
     3901 tagacaatac tgtaactcag tagacttggc gaatgtgcaa gcttactgtc aagtggcctc
     3961 caaaatgaaa agatagaata aactagcact tgtattcttt cttgtaggaa accaacaata
     4021 agccatgtgg caacaattca tcaattaaat ttcagagctt catgtaatgc aaaaaaaaaa
     4081 aaaaaaaaag tcctgctgtt atacatgtga cagtgacttt gtgctgaaaa ttcagctgtt
     4141 ccacacaaac gttgtatatc ttgtaaattg atgtttaaag atagttttgt tcttatagaa
     4201 agtgttgact gccaggttgc ttatagcact ttaaattatt ctgaagatga aattaccagc
     4261 caagtatgtt ggcttaagta gttttagtta tataactctt aaaaatacct agttcttttg
     4321 ggaacagttt aaataattat ctaaagaaag cataatatta atcagaatct ctggtgttct
     4381 atgacacgct gttgctgaag atgaatagaa acggcatcgt ttcctcgtct gtgtaaagct
     4441 ctcattacaa gttaggtaat agtgtctagg atagatgttt ataacataag gaactgtaaa
     4501 taaatgtacc cttcccccat tggtcttcca cagcagtatt attgtcttcg tggaggtgac
     4561 taattgcaaa actttaaaca tcctgtaatg gattccagct acaacaaggt catagggatg
     4621 tataccaaat aaaattaaat gcataagtgc aaa
//
