LOCUS       NM_001127580            3334 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus 3-oxoacid CoA transferase 1 (Oxct1), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_001127580 XM_001053611 XM_001053666 XM_001073299 XM_001073523
VERSION     NM_001127580.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3334)
  AUTHORS   Cotter,D.G., d'Avignon,D.A., Wentz,A.E., Weber,M.L. and
            Crawford,P.A.
  TITLE     Obligate role for ketone body oxidation in neonatal metabolic
            homeostasis
  JOURNAL   J Biol Chem 286 (9), 6902-6910 (2011)
   PUBMED   21209089
REFERENCE   2  (bases 1 to 3334)
  AUTHORS   Fraser,M.E., Hayakawa,K. and Brown,W.D.
  TITLE     Catalytic role of the conformational change in
            succinyl-CoA:3-oxoacid CoA transferase on binding CoA
  JOURNAL   Biochemistry 49 (48), 10319-10328 (2010)
   PUBMED   20977214
REFERENCE   3  (bases 1 to 3334)
  AUTHORS   Coker,S.F., Lloyd,A.J., Mitchell,E., Lewis,G.R., Coker,A.R. and
            Shoolingin-Jordan,P.M.
  TITLE     The high-resolution structure of pig heart succinyl-CoA:3-oxoacid
            coenzyme A transferase
  JOURNAL   Acta Crystallogr D Biol Crystallogr 66 (Pt 7), 797-805 (2010)
   PUBMED   20606260
REFERENCE   4  (bases 1 to 3334)
  AUTHORS   Hasan,N.M., Longacre,M.J., Seed Ahmed,M., Kendrick,M.A., Gu,H.,
            Ostenson,C.G., Fukao,T. and MacDonald,M.J.
  TITLE     Lower succinyl-CoA:3-ketoacid-CoA transferase (SCOT) and ATP
            citrate lyase in pancreatic islets of a rat model of type 2
            diabetes: knockdown of SCOT inhibits insulin release in rat
            insulinoma cells
  JOURNAL   Arch Biochem Biophys 499 (1-2), 62-68 (2010)
   PUBMED   20460097
  REMARK    GeneRIF: mRNAs of SCOT and ATP citrate lyase were decreased 55% and
            58% and enzyme activities were decreased >70% in pancreatic islets
            of the GK rat, a model of type 2 diabetes.
REFERENCE   5  (bases 1 to 3334)
  AUTHORS   Bregere,C., Rebrin,I., Gallaher,T.K. and Sohal,R.S.
  TITLE     Effects of age and calorie restriction on tryptophan nitration,
            protein content, and activity of succinyl-CoA:3-ketoacid CoA
            transferase in rat kidney mitochondria
  JOURNAL   Free Radic Biol Med 48 (4), 609-618 (2010)
   PUBMED   20025965
REFERENCE   6  (bases 1 to 3334)
  AUTHORS   Grinblat,L., Pacheco Bolanos,L.F. and Stoppani,A.O.
  TITLE     Decreased rate of ketone-body oxidation and decreased activity of
            D-3-hydroxybutyrate dehydrogenase and succinyl-CoA:3-oxo-acid
            CoA-transferase in heart mitochondria of diabetic rats
  JOURNAL   Biochem J 240 (1), 49-56 (1986)
   PUBMED   3548709
REFERENCE   7  (bases 1 to 3334)
  AUTHORS   Williamson,D.H. and Ilic,V.
  TITLE     Activities of enzymes of acetoacetate metabolism in rat brown
            adipose tissue during development
  JOURNAL   Biochem J 231 (3), 773-775 (1985)
   PUBMED   2866764
REFERENCE   8  (bases 1 to 3334)
  AUTHORS   Escriva,F., Rodriguez,C. and Pascual-Leone,A.M.
  TITLE     Glycemia, ketonemia, and brain enzymes of ketone body utilization
            in suckling and adult rats undernourished from intrauterine life
  JOURNAL   J Neurochem 44 (5), 1358-1362 (1985)
   PUBMED   2985752
REFERENCE   9  (bases 1 to 3334)
  AUTHORS   Pacanis,A. and Rogulski,J.
  TITLE     Substrate specificity of succinyl-CoA transferase from rat kidney
            mitochondria
  JOURNAL   Acta Biochim Pol 24 (1), 3-11 (1977)
   PUBMED   868435
REFERENCE   10 (bases 1 to 3334)
  AUTHORS   Askew,E.W., Dohm,G.L. and Huston,R.L.
  TITLE     Fatty acid and ketone body metabolism in the rat: response to diet
            and exercise
  JOURNAL   J Nutr 105 (11), 1422-1432 (1975)
   PUBMED   475
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC166478.1.
            
            On or before May 31, 2008 this sequence version replaced
            XM_001073299.1, XM_001073523.1, XM_001053666.1, XM_001053611.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166478.1, AY724483.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3334
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q16"
     gene            1..3334
                     /gene="Oxct1"
                     /gene_synonym="SCOT"
                     /note="3-oxoacid CoA transferase 1"
                     /db_xref="GeneID:690163"
                     /db_xref="RGD:1584008"
     exon            1..176
                     /gene="Oxct1"
                     /gene_synonym="SCOT"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..1661
                     /gene="Oxct1"
                     /gene_synonym="SCOT"
                     /EC_number="2.8.3.5"
                     /note="scot-S; somatic-type succinyl-CoA:3-oxoacid
                     CoA-transferase; succinyl-CoA:3-ketoacid CoA transferase;
                     succinyl-CoA:3-ketoacid coenzyme A transferase 1,
                     mitochondrial; succinyl-CoA:3-ketoacid-coenzyme A
                     transferase 1, mitochondrial-like; succinyl-CoA:3-oxoacid
                     CoA transferase"
                     /codon_start=1
                     /product="succinyl-CoA:3-ketoacid coenzyme A transferase
                     1, mitochondrial precursor"
                     /protein_id="NP_001121052.1"
                     /db_xref="GeneID:690163"
                     /db_xref="RGD:1584008"
                     /translation="MAALKLLSSGLRLCASARNSRGALHKGCACYFSVSTRHHTKFYT
                     DPVEAVKDIPNGATLLVGGFGLCGIPENLIGALLKTGVKDLTAVSNNAGVDNFGLGLL
                     LRSKQIKRMISSYVGENAEFERQFLSGELEVELTPQGTLAERIRAGGAGVPAFYTSTG
                     YGTLVQEGGSPIKYNKDGSVAIASKPREVREFRGQHFILEEAITGDFALVKAWKADRA
                     GNVIFRKSARNFNLPMCKAAGTTVVEVEEIVDIGSFAPEDIHIPKIYVHRLIKGEKYE
                     KRIERLSLRKEGEGKAKSGKPGEDVRERIIKRAALEFEDGMYANLGIGIPLLASNFIS
                     PNMTVHLQSENGVLGLGPYPLKDEADADLINAGKETVTVLPGASFFSSDESFAMIRGG
                     HVNLTMLGAMQVSKYGDLANWMIPGKMVKGMGGAMDLVSSSKTKVVVTMEHSAKGNAH
                     KIMEKCTLPLTGKQCVNRIITEKGVFDVDKKNGLTLIELWEGLTVDDIRKSTGCDFAV
                     SPNLMPMQQIST"
     exon            177..285
                     /gene="Oxct1"
                     /gene_synonym="SCOT"
                     /inference="alignment:Splign:2.1.0"
     exon            286..376
                     /gene="Oxct1"
                     /gene_synonym="SCOT"
                     /inference="alignment:Splign:2.1.0"
     exon            377..512
                     /gene="Oxct1"
                     /gene_synonym="SCOT"
                     /inference="alignment:Splign:2.1.0"
     exon            513..662
                     /gene="Oxct1"
                     /gene_synonym="SCOT"
                     /inference="alignment:Splign:2.1.0"
     exon            663..769
                     /gene="Oxct1"
                     /gene_synonym="SCOT"
                     /inference="alignment:Splign:2.1.0"
     exon            770..830
                     /gene="Oxct1"
                     /gene_synonym="SCOT"
                     /inference="alignment:Splign:2.1.0"
     exon            831..938
                     /gene="Oxct1"
                     /gene_synonym="SCOT"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1053
                     /gene="Oxct1"
                     /gene_synonym="SCOT"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1148
                     /gene="Oxct1"
                     /gene_synonym="SCOT"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1197
                     /gene="Oxct1"
                     /gene_synonym="SCOT"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1270
                     /gene="Oxct1"
                     /gene_synonym="SCOT"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1346
                     /gene="Oxct1"
                     /gene_synonym="SCOT"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1436
                     /gene="Oxct1"
                     /gene_synonym="SCOT"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1517
                     /gene="Oxct1"
                     /gene_synonym="SCOT"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1619
                     /gene="Oxct1"
                     /gene_synonym="SCOT"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..3307
                     /gene="Oxct1"
                     /gene_synonym="SCOT"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctttagcggg tgacgccgcc gcgggcccgg gcaaccagca cttacacgca ctcccgcgcg
       61 cgccaccttg ctacccactc ctgcacccgg gtccgaagat ggcggctctt aaactcttgt
      121 cctccgggct tcggctctgc gcctccgccc gcaactcgcg gggcgccctg cacaaggggt
      181 gtgcctgcta cttttccgtc agtactcgtc accacaccaa attttacaca gatcccgtgg
      241 aagctgtaaa agatattcct aatggtgcaa ccttgctggt tggtggtttc gggttgtgtg
      301 gtattccaga gaatctcata ggagctttgc tgaagaccgg agtgaaggat ctaactgcag
      361 tcagcaacaa tgcaggggtt gacaacttcg gcctgggcct tttacttcga tctaagcaga
      421 taaaacgcat gatctcctca tatgtgggag aaaacgcaga gtttgagcga cagttcttat
      481 cgggtgaact agaagtagag ctgacacctc agggcactct tgcagagagg atccgtgcag
      541 gtggggctgg cgtccctgcc ttctacacca gcacagggta tgggaccctg gtgcaagagg
      601 gaggatcacc catcaaatat aacaaagatg gcagtgttgc cattgccagc aagccacgag
      661 aggtgaggga gttccgcggt cagcacttta ttttggagga agccatcacg ggagactttg
      721 ctttggtgaa ggcctggaaa gcagaccggg caggaaatgt gattttcagg aaaagtgcaa
      781 gaaacttcaa tttgccaatg tgcaaagctg caggaaccac agtggtggag gttgaagaaa
      841 ttgtagacat tggctcgttt gctccagaag atatccacat tcccaagatt tatgtgcacc
      901 gccttataaa gggagagaaa tatgagaaga gaatcgagcg tttatcactg cgaaaggaag
      961 gtgaaggaaa agccaagtct ggtaagcccg gagaagacgt cagggagcgg atcatcaaga
     1021 gagccgctct tgagtttgag gatggcatgt atgctaacct gggtataggg atacctcttc
     1081 tggccagcaa ctttatcagc ccaaacatga ctgttcatct ccaaagtgaa aatggagtct
     1141 tgggcttggg cccataccca ctaaaagacg aagctgatgc tgacctcatc aatgcaggaa
     1201 aggaaacggt tactgttctc ccaggagcct ctttcttctc cagcgatgaa tcattcgcca
     1261 tgattagagg gggacacgtc aatctaacga tgttaggagc catgcaggtt tctaaatatg
     1321 gtgacttggc caactggatg atacctggga aaatggtgaa aggaatggga ggagctatgg
     1381 atttagtgtc cagttccaaa accaaagtgg tggtcaccat ggaacactcc gcaaagggga
     1441 atgcgcataa aatcatggag aagtgtacac taccactgac aggaaagcag tgcgtcaacc
     1501 gcatcattac agaaaagggt gtgtttgacg tggacaagaa aaacgggttg acattgatcg
     1561 agctttggga aggcctgact gttgatgaca tcaggaagag cacaggctgt gactttgcag
     1621 tttcaccaaa cctcatgcca atgcagcaga tctcaacttg aagtgtcaat tggacatttg
     1681 ccccaggctg ctaagatttc attttcaaca aataggattt aattgaaagg atgtcagtaa
     1741 tcaacagtta cacatttaac aagacgtttc gactagtttt cttctagtat ttctggattt
     1801 gtgcagccat agactttgct ctctccagtg tgatgtatca gttccatgaa aaacaaaagg
     1861 aaaacgtttc attgtggtct tgcttcatga gtgctaagaa ggttgtcttt gtcattggtg
     1921 ctcacagtgg ataaatgttc atcttttttg ctgtatatat taaacatgac ttagcagccg
     1981 tgaaggaaaa ttttcatgtg catttgtgat taggtagaat actttttttg atgactatgt
     2041 atttttatct tcctctgttt ttgagaaatg ctggttatgc ttgcctcctt agaacattca
     2101 ccttccccac acacttctta tagatacctg agacggcaaa caggagcatc cctgagaaaa
     2161 gtaatcagaa gaaagaacag ggcataggct ctaccagtgc tggcatccca ccaaatattg
     2221 cctttaaaga caaccaacca tctacctatg tgtgaaaaca gctgaagcta aggatgggaa
     2281 gaggatggga aacctactga catacttacc tagttctcct attataaaag ggtgtgctat
     2341 atctttgtat tctgaagact ctgtttctgc attgagctcc agtgtttact taatacaaca
     2401 tctcttgagc aaaaaagaac catgggcaat tcatcatggg tcttcaatct tgaatgacag
     2461 tagtacttaa aaagatgata ttccaagaga tccccctttt aggatctcca ttctgctcag
     2521 caaagattgt aaacactttt tctacactac aatgggtatt ctgcataggc tagttctctt
     2581 aacaaagtgc tattacttta gccttatctg tgctgggaat gatgggaaag gctcagatcg
     2641 gagtagtcag ttagcaggct ttgtgtgaca gagtaaacac agtagcttgt gtttatcagc
     2701 gatgcttcct cagaagtggc cacaatatag acagttgcca ggggccatca ctccagaagc
     2761 accctttgta tcagatgtct gaaagcctag gtgtcctgaa gctagactgg acagctggtg
     2821 tctatacagt gaaacatatt gtccttctgg cactaattat aggaatttat gcacgtctta
     2881 ggtgatggtt gtcactggaa ctcactcttc aagtatagcc acagttgacc tatacatgat
     2941 gtgaaaggaa gataagctct tcctccatag tacactctat gtaggactgc tttttctgga
     3001 tggccacagg gttgaaagca tcctctgcca gtgttggtaa gaagaaccca tcttagaagg
     3061 tccaaggccc atgagagtac atatgtctat gttagagtgc acagttgaaa aacgttccta
     3121 ttgttggtat ggatatgtct tcacatgcac ttgcttatca ttccagtctg ttactttaag
     3181 acaaggaggt tcttagaaca ttttaaacct caaaacctga atagacaact taagattcaa
     3241 agagtgtcat gacattttaa aaaaaaatgt gttaagtgat acaataaaaa ttgcagattg
     3301 atagagaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
