LOCUS       NM_001168583            1531 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus OXA1L, mitochondrial inner membrane protein
            (Oxa1l), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001168583 XM_001053801 XM_001078039
VERSION     NM_001168583.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1531)
  AUTHORS   Wenz,L.S., Opalinski,L., Wiedemann,N. and Becker,T.
  TITLE     Cooperation of protein machineries in mitochondrial protein sorting
  JOURNAL   Biochim Biophys Acta 1853 (5), 1119-1129 (2015)
   PUBMED   25633533
  REMARK    Review article
REFERENCE   2  (bases 1 to 1531)
  AUTHORS   Haque,M.E., Spremulli,L.L. and Fecko,C.J.
  TITLE     Identification of protein-protein and protein-ribosome interacting
            regions of the C-terminal tail of human mitochondrial inner
            membrane protein Oxa1L
  JOURNAL   J Biol Chem 285 (45), 34991-34998 (2010)
   PUBMED   20739282
REFERENCE   3  (bases 1 to 1531)
  AUTHORS   Haque,M.E., Elmore,K.B., Tripathy,A., Koc,H., Koc,E.C. and
            Spremulli,L.L.
  TITLE     Properties of the C-terminal tail of human mitochondrial inner
            membrane protein Oxa1L and its interactions with mammalian
            mitochondrial ribosomes
  JOURNAL   J Biol Chem 285 (36), 28353-28362 (2010)
   PUBMED   20601428
REFERENCE   4  (bases 1 to 1531)
  AUTHORS   Sato,T. and Mihara,K.
  TITLE     Topogenesis of mammalian Oxa1, a component of the mitochondrial
            inner membrane protein export machinery
  JOURNAL   J Biol Chem 284 (22), 14819-14827 (2009)
   PUBMED   19349278
  REMARK    GeneRIF: Topogenesis of Oxa1 is a cooperative event of all five
            transmembrane segments (TM), and hexapeptide GLPWWG followed
            immediately by TM1 is essential for correct Oxa1 topogenesis.
REFERENCE   5  (bases 1 to 1531)
  AUTHORS   Stiburek,L., Fornuskova,D., Wenchich,L., Pejznochova,M.,
            Hansikova,H. and Zeman,J.
  TITLE     Knockdown of human Oxa1l impairs the biogenesis of F1Fo-ATP
            synthase and NADH:ubiquinone oxidoreductase
  JOURNAL   J Mol Biol 374 (2), 506-516 (2007)
   PUBMED   17936786
REFERENCE   6  (bases 1 to 1531)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   7  (bases 1 to 1531)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   8  (bases 1 to 1531)
  AUTHORS   Bonnefoy,N., Kermorgant,M., Groudinsky,O., Minet,M., Slonimski,P.P.
            and Dujardin,G.
  TITLE     Cloning of a human gene involved in cytochrome oxidase assembly by
            functional complementation of an oxa1- mutation in Saccharomyces
            cerevisiae
  JOURNAL   Proc Natl Acad Sci U S A 91 (25), 11978-11982 (1994)
   PUBMED   7991568
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On or before Dec 13, 2009 this sequence version replaced
            XM_001053801.1, XM_001078039.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ228721.1, FQ218860.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                JAXUCZ010000015.1  31783725-31783804
            81-227              JAXUCZ010000015.1  31784209-31784355
            228-441             JAXUCZ010000015.1  31785869-31786082
            442-585             JAXUCZ010000015.1  31789273-31789416
            586-671             JAXUCZ010000015.1  31789611-31789696
            672-836             JAXUCZ010000015.1  31789870-31790034
            837-941             JAXUCZ010000015.1  31790193-31790297
            942-1104            JAXUCZ010000015.1  31790402-31790564
            1105-1185           JAXUCZ010000015.1  31790845-31790925
            1186-1531           JAXUCZ010000015.1  31791008-31791353
FEATURES             Location/Qualifiers
     source          1..1531
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p13"
     gene            1..1531
                     /gene="Oxa1l"
                     /note="OXA1L, mitochondrial inner membrane protein"
                     /db_xref="GeneID:691393"
                     /db_xref="RGD:1585024"
     exon            1..80
                     /gene="Oxa1l"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..1319
                     /gene="Oxa1l"
                     /note="oxidase assembly 1-like; oxidase (cytochrome c)
                     assembly 1-like"
                     /codon_start=1
                     /product="mitochondrial inner membrane protein OXA1L"
                     /protein_id="NP_001162055.1"
                     /db_xref="GeneID:691393"
                     /db_xref="RGD:1585024"
                     /translation="MAMGSVCRRWQLLRLLQPPRSFHSVAGSLKPLATKLLAARSGSG
                     RPHYALLAVLTPRCISTSAALFAEAQVQVPPVVPAASAPAAVPEVASAGPADVVQCAT
                     EQSFAELGLGSYTPVGLIQNLLEYIHVDLGLPWWGAIATCTVLARCLVFPLIVKGQRE
                     AAKIHNHMPEMQKFSARIREAKLSGDQAEFYKATIEMTHYQKKHDIKFFRPLILPLTQ
                     APIFISFFIALREMANLPVPSLQTGGLWWFQDLTVSDPIYVLPLVVTATMWGVLELGA
                     ETGMQSSDLQLMRNVIRVMPLAVLPVTIHFPSAVFMYWLSSNVFSLCQVACLRFPAVR
                     TALKIPQRVVHDPSKLPPREGFLKSFKKGWKNAEIAHRLREREERMQKHLDLAARGPL
                     RQTFTHNPLLQHDPSRSPNTPNSSTNSVKANTKKPWQDTLG"
     exon            81..227
                     /gene="Oxa1l"
                     /inference="alignment:Splign:2.1.0"
     exon            228..441
                     /gene="Oxa1l"
                     /inference="alignment:Splign:2.1.0"
     exon            442..585
                     /gene="Oxa1l"
                     /inference="alignment:Splign:2.1.0"
     exon            586..671
                     /gene="Oxa1l"
                     /inference="alignment:Splign:2.1.0"
     exon            672..836
                     /gene="Oxa1l"
                     /inference="alignment:Splign:2.1.0"
     exon            837..941
                     /gene="Oxa1l"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1104
                     /gene="Oxa1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1185
                     /gene="Oxa1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1531
                     /gene="Oxa1l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttctcttcc cggcaagatg gcgatgggtt cagtttgccg tcgctggcag cttctgcgac
       61 tcctacagcc cccgcgttcg ttccacagcg tcgcagggtc cctgaaaccg ctggcaacca
      121 agctcctcgc agcccgctcg ggtagtgggc ggccacacta cgctcttctc gccgtcctaa
      181 cccctcgctg catcagtaca tctgctgccc tctttgcaga agcccaggtc caggtacctc
      241 ctgttgttcc tgctgcctca gcccctgctg cagtaccaga ggtagcttct gcaggacctg
      301 cagatgtcgt ccagtgtgca acagaacaga gcttcgcaga actggggctt ggctcttaca
      361 ccccagtggg actcatccag aacctcttgg aatatataca tgtggacctg ggcctgcctt
      421 ggtggggggc cattgccacg tgtactgtcc ttgcccgctg ccttgttttc cctctcattg
      481 tgaagggcca gcgagaagca gccaagatcc acaaccacat gccggagatg cagaagtttt
      541 ccgctcgaat cagagaggcc aagttgtcag gagaccaggc tgagttttac aaggccacca
      601 tagagatgac ccactatcag aaaaagcatg acattaaatt cttcaggccg ctcatcctac
      661 ctctcactca ggcccccatc ttcatctcct tctttattgc cttgagagag atggccaacc
      721 tgcctgtgcc cagcctccag acaggtgggc tctggtggtt tcaagatctc acggtatctg
      781 atcccatcta cgtcttgcca ctggtagtca ctgccacaat gtggggtgtc cttgagctag
      841 gcgctgagac aggtatgcag agctctgacc tccagctcat gaggaacgtc atcagggtga
      901 tgcctctagc agtcttgccc gtgactatcc acttcccctc ggcggtgttc atgtactggc
      961 tgtcctccaa cgtgttctcc ctgtgccaag tagcctgcct ccggtttcca gctgtgcgca
     1021 cagcactcaa gatcccccag cgagttgtgc atgaccctag caagttacct cccagggaag
     1081 gcttcttgaa gagcttcaaa aaaggctgga agaatgctga aattgcacat cggctccgag
     1141 agcgggagga gcggatgcag aaacacttgg acctagctgc cagaggaccc ttacgacaga
     1201 cttttaccca caaccctctg ctacagcatg atccaagtcg ctcccccaac acccccaaca
     1261 gcagcaccaa cagcgtcaaa gcaaacacaa agaagccgtg gcaggacaca ctcggctgat
     1321 gcgttctgtg ctcaccggga cgagagccct gcctctgcac agactcctcg gaacagaggt
     1381 gatgctgtcc tcgccccagc cctgggcact gcagcatttg gaagtgttca ttttaaacat
     1441 agtttccact atagactctt acttgtgtgt gttaaaaggg ccctggagag ccacctggat
     1501 agagttagta aacctctgtc ttatctgggc t
//
