LOCUS       NM_001415680            1483 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ovo-like zinc finger 2 (Ovol2), transcript
            variant 1, mRNA.
ACCESSION   NM_001415680 XM_039104597
VERSION     NM_001415680.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1483)
  AUTHORS   Wu,R.S., Hong,J.J., Wu,J.F., Yan,S., Wu,D., Liu,N., Liu,Q.F.,
            Wu,Q.W., Xie,Y.Y., Liu,Y.J., Zheng,Z.Z., Chan,E.C., Zhang,Z.M. and
            Li,B.A.
  TITLE     OVOL2 antagonizes TGF-beta signaling to regulate epithelial to
            mesenchymal transition during mammary tumor metastasis
  JOURNAL   Oncotarget 8 (24), 39401-39416 (2017)
   PUBMED   28455959
REFERENCE   2  (bases 1 to 1483)
  AUTHORS   Watanabe,K., Villarreal-Ponce,A., Sun,P., Salmans,M.L., Fallahi,M.,
            Andersen,B. and Dai,X.
  TITLE     Mammary morphogenesis and regeneration require the inhibition of
            EMT at terminal end buds by Ovol2 transcriptional repressor
  JOURNAL   Dev Cell 29 (1), 59-74 (2014)
   PUBMED   24735879
REFERENCE   3  (bases 1 to 1483)
  AUTHORS   Lee,B., Villarreal-Ponce,A., Fallahi,M., Ovadia,J., Sun,P.,
            Yu,Q.C., Ito,S., Sinha,S., Nie,Q. and Dai,X.
  TITLE     Transcriptional mechanisms link epithelial plasticity to adhesion
            and differentiation of epidermal progenitor cells
  JOURNAL   Dev Cell 29 (1), 47-58 (2014)
   PUBMED   24735878
REFERENCE   4  (bases 1 to 1483)
  AUTHORS   Wells,J., Lee,B., Cai,A.Q., Karapetyan,A., Lee,W.J., Rugg,E.,
            Sinha,S., Nie,Q. and Dai,X.
  TITLE     Ovol2 suppresses cell cycling and terminal differentiation of
            keratinocytes by directly repressing c-Myc and Notch1
  JOURNAL   J Biol Chem 284 (42), 29125-29135 (2009)
   PUBMED   19700410
REFERENCE   5  (bases 1 to 1483)
  AUTHORS   Unezaki,S., Horai,R., Sudo,K., Iwakura,Y. and Ito,S.
  TITLE     Ovol2/Movo, a homologue of Drosophila ovo, is required for
            angiogenesis, heart formation and placental development in mice
  JOURNAL   Genes Cells 12 (6), 773-785 (2007)
   PUBMED   17573777
REFERENCE   6  (bases 1 to 1483)
  AUTHORS   Teng,A., Nair,M., Wells,J., Segre,J.A. and Dai,X.
  TITLE     Strain-dependent perinatal lethality of Ovol1-deficient mice and
            identification of Ovol2 as a downstream target of Ovol1 in skin
            epidermis
  JOURNAL   Biochim Biophys Acta 1772 (1), 89-95 (2007)
   PUBMED   17049212
REFERENCE   7  (bases 1 to 1483)
  AUTHORS   Mackay,D.R., Hu,M., Li,B., Rheaume,C. and Dai,X.
  TITLE     The mouse Ovol2 gene is required for cranial neural tube
            development
  JOURNAL   Dev Biol 291 (1), 38-52 (2006)
   PUBMED   16423343
REFERENCE   8  (bases 1 to 1483)
  AUTHORS   Unezaki,S., Nishizawa,M., Okuda-Ashitaka,E., Masu,Y., Mukai,M.,
            Kobayashi,S., Sawamoto,K., Okano,H. and Ito,S.
  TITLE     Characterization of the isoforms of MOVO zinc finger protein, a
            mouse homologue of Drosophila Ovo, as transcription factors
  JOURNAL   Gene 336 (1), 47-58 (2004)
   PUBMED   15225875
REFERENCE   9  (bases 1 to 1483)
  AUTHORS   Masu,Y., Ikeda,S., Okuda-Ashitaka,E., Sato,E. and Ito,S.
  TITLE     Expression of murine novel zinc finger proteins highly homologous
            to Drosophila ovo gene product in testis
  JOURNAL   FEBS Lett 421 (3), 224-228 (1998)
   PUBMED   9468311
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Dec 22, 2022 this sequence version replaced XM_039104597.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.16249.1,
                                           SRR26643297.13227.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-320               JAXUCZ010000003.1  152160168-152160487 c
            321-538             JAXUCZ010000003.1  152159302-152159519 c
            539-728             JAXUCZ010000003.1  152145779-152145968 c
            729-1483            JAXUCZ010000003.1  152130767-152131521 c
FEATURES             Location/Qualifiers
     source          1..1483
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..1483
                     /gene="Ovol2"
                     /gene_synonym="Zfp339"
                     /note="ovo-like zinc finger 2"
                     /db_xref="GeneID:296201"
                     /db_xref="RGD:1306130"
     exon            1..320
                     /gene="Ovol2"
                     /gene_synonym="Zfp339"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..1045
                     /gene="Ovol2"
                     /gene_synonym="Zfp339"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein 339; transcription factor Ovo-like 2;
                     ovo-like 2"
                     /codon_start=1
                     /product="transcription factor Ovo-like 2 isoform 1"
                     /protein_id="NP_001402609.1"
                     /db_xref="GeneID:296201"
                     /db_xref="RGD:1306130"
                     /translation="MPKVFLVKRRSPGASVRSWDELPDDKRADTYIPVSLGCLLRDPP
                     EDCRSDGGSSSGCSCSAGEPGGAESSSSPRAPEPETPELHDAEGTDGHLAAMQRPVAR
                     SKIKFTTGTCNDSVIHNCDLCGKSFRLQRMLNRHLKCHNQVKRHLCTFCGKGFNDTFD
                     LKRHVRTHTGIRPYKCEVCYKAFTQRCSLESHLKKIHGVQQQYAYKQRRDKLYVCEDC
                     GYTGPTQEDLYLHVNSAHPGSTFLKKTSKKLAALMQNKLTSPLQENSTLSEEEEKK"
     exon            321..538
                     /gene="Ovol2"
                     /gene_synonym="Zfp339"
                     /inference="alignment:Splign:2.1.0"
     exon            539..728
                     /gene="Ovol2"
                     /gene_synonym="Zfp339"
                     /inference="alignment:Splign:2.1.0"
     exon            729..1483
                     /gene="Ovol2"
                     /gene_synonym="Zfp339"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgcgattt aaggcatagg tgtcgccgag cccggaggct gcgagtagcc gggagtgaag
       61 ggagaggacc aggcagcgcg gcgcggggtg caggaagaag gcaggcgagg cgggaaggtg
      121 ggctccggac tccaggagcg gggggaccca ggcgccaccg ccgccactag cggggagcag
      181 ccgggaggag ggggccgcag tcgggagaga agatcccacc atgcccaaag tctttctggt
      241 gaagaggagg agcccgggag cctctgtccg cagctgggat gagctcccgg atgacaaaag
      301 ggcagacact tacatcccag tgagcctggg ctgtctgctc cgcgaccccc ccgaagactg
      361 ccgcagcgac ggtggcagta gcagcggctg cagctgcagc gccggggagc ccggaggggc
      421 cgaaagcagc tcgtccccgc gcgcgccgga gcctgaaact ccagagcttc acgacgccga
      481 aggcacggat ggacatctgg cagcgatgca gcgcccggtt gccaggtcaa aaatcaagtt
      541 taccactggc acgtgcaacg actccgtgat tcacaactgt gacctgtgtg gcaagagttt
      601 ccgtctgcag cgcatgctca accgtcacct taagtgccac aaccaggtaa agaggcacct
      661 gtgcaccttc tgcggcaagg gcttcaacga caccttcgac ctgaagaggc atgtacgcac
      721 acacacaggc attcgcccct acaaatgcga ggtgtgttac aaagccttca cccagcgatg
      781 ttccttggag tcccacctga agaagatcca tggggtacag cagcagtatg cctacaagca
      841 acgtcgggac aaactctatg tgtgtgagga ttgcggctac acgggcccca cccaggagga
      901 cctgtacctg catgtgaaca gtgcccatcc aggtagcacg tttctcaaaa agacttccaa
      961 aaagttggcg gcccttatgc agaacaagct gacatcccca ctgcaggaga attccaccct
     1021 gagcgaagag gaggaaaaaa agtgaagctc gaggaaagac agaggagaga cgagacgccg
     1081 gtgccacatt tacttggact tttggtctga ggcgtgcccc tctgctcccc tggatctttt
     1141 tatagtgacg agtattcagt ccacctctct tttcttttgc aacagtaagg agcaccccaa
     1201 agttgtcagt cattctgcca aacaggccct gtaccctgtg ttattgtttt cttggtggtt
     1261 gaggtcacat acgggttcgt gagtgtgagt gtgtgtgtgt gtgtctctgt gtgttatgtg
     1321 tgtttttttt cctaatagaa ttttcacata tgaatagaga gaggggtgtt cttaaagaga
     1381 cagtcatctt atggtgcctt gaaacacttc ccgaacaagg aaaatgtata ttctttctga
     1441 aagagtttac agaaattatt ttaataaatg aaatgttcgt gtg
//
