LOCUS       NM_001302889            3311 bp    mRNA    linear   ROD 08-OCT-2024
DEFINITION  Rattus norvegicus OTU deubiquitinase with linear linkage
            specificity (Otulin), mRNA.
ACCESSION   NM_001302889 XM_002725921 XM_002729016
VERSION     NM_001302889.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3311)
  AUTHORS   Wang,Y., Wan,Y., Zhou,X., Zhang,P. and Zhang,J.
  TITLE     OTULIN of exosomes derived from Schwann cells promotes peripheral
            nerve injury repair by regulating macrophage polarization via
            deubiquitination of ERBB2
  JOURNAL   Neurosci Lett 833, 137813 (2024)
   PUBMED   38723761
  REMARK    GeneRIF: OTULIN of exosomes derived from Schwann cells promotes
            peripheral nerve injury repair by regulating macrophage
            polarization via deubiquitination of ERBB2.
REFERENCE   2  (bases 1 to 3311)
  AUTHORS   Xu,H., Wang,Y. and Luo,Y.
  TITLE     OTULIN is a new target of EA treatment in the alleviation of brain
            injury and glial cell activation via suppression of the NF-kappaB
            signalling pathway in acute ischaemic stroke rats
  JOURNAL   Mol Med 27 (1), 37 (2021)
   PUBMED   33836646
  REMARK    GeneRIF: OTULIN is a new target of EA treatment in the alleviation
            of brain injury and glial cell activation via suppression of the
            NF-kappaB signalling pathway in acute ischaemic stroke rats.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3311)
  AUTHORS   Heger,K., Wickliffe,K.E., Ndoja,A., Zhang,J., Murthy,A.,
            Dugger,D.L., Maltzman,A., de Sousa E Melo,F., Hung,J., Zeng,Y.,
            Verschueren,E., Kirkpatrick,D.S., Vucic,D., Lee,W.P.,
            Roose-Girma,M., Newman,R.J., Warming,S., Hsiao,Y.C., Komuves,L.G.,
            Webster,J.D., Newton,K. and Dixit,V.M.
  TITLE     OTULIN limits cell death and inflammation by deubiquitinating LUBAC
  JOURNAL   Nature 559 (7712), 120-124 (2018)
   PUBMED   29950720
REFERENCE   4  (bases 1 to 3311)
  AUTHORS   Zhou,Q., Yu,X., Demirkaya,E., Deuitch,N., Stone,D., Tsai,W.L.,
            Kuehn,H.S., Wang,H., Yang,D., Park,Y.H., Ombrello,A.K., Blake,M.,
            Romeo,T., Remmers,E.F., Chae,J.J., Mullikin,J.C., Guzel,F.,
            Milner,J.D., Boehm,M., Rosenzweig,S.D., Gadina,M., Welch,S.B.,
            Ozen,S., Topaloglu,R., Abinun,M., Kastner,D.L. and Aksentijevich,I.
  TITLE     Biallelic hypomorphic mutations in a linear deubiquitinase define
            otulipenia, an early-onset autoinflammatory disease
  JOURNAL   Proc Natl Acad Sci U S A 113 (36), 10127-10132 (2016)
   PUBMED   27559085
REFERENCE   5  (bases 1 to 3311)
  AUTHORS   Damgaard,R.B., Walker,J.A., Marco-Casanova,P., Morgan,N.V.,
            Titheradge,H.L., Elliott,P.R., McHale,D., Maher,E.R.,
            McKenzie,A.N.J. and Komander,D.
  TITLE     The Deubiquitinase OTULIN Is an Essential Negative Regulator of
            Inflammation and Autoimmunity
  JOURNAL   Cell 166 (5), 1215-1230 (2016)
   PUBMED   27523608
REFERENCE   6  (bases 1 to 3311)
  AUTHORS   Elliott,P.R., Nielsen,S.V., Marco-Casanova,P., Fiil,B.K.,
            Keusekotten,K., Mailand,N., Freund,S.M., Gyrd-Hansen,M. and
            Komander,D.
  TITLE     Molecular basis and regulation of OTULIN-LUBAC interaction
  JOURNAL   Mol Cell 54 (3), 335-348 (2014)
   PUBMED   24726323
REFERENCE   7  (bases 1 to 3311)
  AUTHORS   Mevissen,T.E., Hospenthal,M.K., Geurink,P.P., Elliott,P.R.,
            Akutsu,M., Arnaudo,N., Ekkebus,R., Kulathu,Y., Wauer,T., El
            Oualid,F., Freund,S.M., Ovaa,H. and Komander,D.
  TITLE     OTU deubiquitinases reveal mechanisms of linkage specificity and
            enable ubiquitin chain restriction analysis
  JOURNAL   Cell 154 (1), 169-184 (2013)
   PUBMED   23827681
REFERENCE   8  (bases 1 to 3311)
  AUTHORS   Fiil,B.K., Damgaard,R.B., Wagner,S.A., Keusekotten,K., Fritsch,M.,
            Bekker-Jensen,S., Mailand,N., Choudhary,C., Komander,D. and
            Gyrd-Hansen,M.
  TITLE     OTULIN restricts Met1-linked ubiquitination to control innate
            immune signaling
  JOURNAL   Mol Cell 50 (6), 818-830 (2013)
   PUBMED   23806334
REFERENCE   9  (bases 1 to 3311)
  AUTHORS   Rivkin,E., Almeida,S.M., Ceccarelli,D.F., Juang,Y.C., MacLean,T.A.,
            Srikumar,T., Huang,H., Dunham,W.H., Fukumura,R., Xie,G., Gondo,Y.,
            Raught,B., Gingras,A.C., Sicheri,F. and Cordes,S.P.
  TITLE     The linear ubiquitin-specific deubiquitinase gumby regulates
            angiogenesis
  JOURNAL   Nature 498 (7454), 318-324 (2013)
   PUBMED   23708998
REFERENCE   10 (bases 1 to 3311)
  AUTHORS   Keusekotten,K., Elliott,P.R., Glockner,L., Fiil,B.K.,
            Damgaard,R.B., Kulathu,Y., Wauer,T., Hospenthal,M.K.,
            Gyrd-Hansen,M., Krappmann,D., Hofmann,K. and Komander,D.
  TITLE     OTULIN antagonizes LUBAC signaling by specifically hydrolyzing
            Met1-linked polyubiquitin
  JOURNAL   Cell 153 (6), 1312-1326 (2013)
   PUBMED   23746843
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1, BC158613.1, FM089678.1, BC158827.1 and
            FM122033.1.
            
            On or before Nov 27, 2014 this sequence version replaced
            XM_002725921.4, XM_002729016.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158613.1, SRR26643297.7068.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 JAXUCZ010000002.1  80046839-80046843   c
            6-211               BC158613.1         1-206
            212-901             FM089678.1         6-695
            902-1453            BC158613.1         897-1448
            1454-2610           BC158827.1         306-1462
            2611-2777           FM122033.1         409-575
            2778-3311           JAXUCZ010000002.1  80021381-80021914   c
FEATURES             Location/Qualifiers
     source          1..3311
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q22"
     gene            1..3311
                     /gene="Otulin"
                     /gene_synonym="Fam105b"
                     /note="OTU deubiquitinase with linear linkage specificity"
                     /db_xref="GeneID:100362554"
                     /db_xref="RGD:2324500"
     exon            1..224
                     /gene="Otulin"
                     /gene_synonym="Fam105b"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..1134
                     /gene="Otulin"
                     /gene_synonym="Fam105b"
                     /EC_number="3.4.19.12"
                     /note="family with sequence similarity 105, member B"
                     /codon_start=1
                     /product="ubiquitin thioesterase otulin"
                     /protein_id="NP_001289818.1"
                     /db_xref="GeneID:100362554"
                     /db_xref="RGD:2324500"
                     /translation="MSRGIMPQPGAWPGAGCAETPAREAGAAARDGGKVTVGAQPRAA
                     TRCPAEHEEDMYRAADEIEKEKELLIHERGISAEPRLSVAPEMDIMDYCKKEWRGNTE
                     KAMCMRKGYEEVSQKFTSIRRVRGDNYCALRATLFQAMSQLAELPPWLQDLELILLPE
                     KLINKYTWIKQWKLGLKFDGKSEDLVERIKESLALLRKKWVSLAAMEAAEARQTACDE
                     LFTNEEEEYSLYEAMKFLMLARAIQLYDDKEKGKEVPFFSVLLFARDTSNDPEQLLRN
                     HLNQVGHTGGLEQVEMFLLAYAVRHTIQVYRLSKYNTEEFITVYPTDPPKDWPMVTLI
                     AEDDRHYNIPVRVCEETSL"
     exon            225..301
                     /gene="Otulin"
                     /gene_synonym="Fam105b"
                     /inference="alignment:Splign:2.1.0"
     exon            302..399
                     /gene="Otulin"
                     /gene_synonym="Fam105b"
                     /inference="alignment:Splign:2.1.0"
     exon            400..543
                     /gene="Otulin"
                     /gene_synonym="Fam105b"
                     /inference="alignment:Splign:2.1.0"
     exon            544..669
                     /gene="Otulin"
                     /gene_synonym="Fam105b"
                     /inference="alignment:Splign:2.1.0"
     exon            670..939
                     /gene="Otulin"
                     /gene_synonym="Fam105b"
                     /inference="alignment:Splign:2.1.0"
     exon            940..3311
                     /gene="Otulin"
                     /gene_synonym="Fam105b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacctcgcga ggtgcggggc agagcaatca cggctccaga cggcgggacc gcagggccct
       61 gcgtggccgc gaatgagtcg gggaatcatg ccccaacccg gagcgtggcc gggagcgggc
      121 tgcgcggaga cgccggcgcg cgaggcaggg gctgcggcgc gggacggcgg gaaggtgacg
      181 gtcggcgcgc agccccgggc cgcgacgcga tgcccggccg agcacgagga ggacatgtac
      241 cgtgctgcag atgaaataga aaaggagaaa gaattgctaa tacatgaaag agggatatca
      301 gcagaaccca ggttaagtgt ggctcctgaa atggatatta tggactactg caaaaaggaa
      361 tggagaggaa ataccgagaa agccatgtgc atgagaaagg gctatgagga agtttctcag
      421 aagttcactt ccataaggcg agtccgtggc gataattact gtgcactgcg ggccacactg
      481 ttccaggcta tgagccagct ggctgagctg cccccctggc tgcaggacct ggagctcata
      541 ctgttaccgg aaaagctgat aaacaaatat acctggatca agcagtggaa acttggactg
      601 aaatttgatg ggaagagtga ggacctggtt gaaagaatca aggaatccct tgccctgcta
      661 aggaagaagt gggtcagcct ggctgcaatg gaagccgctg aagcaaggca gacagcctgt
      721 gacgagctgt tcacaaacga ggaggaggag tacagcctct acgaagctat gaagttcctg
      781 atgttagcca gagccatcca actgtatgat gacaaggaaa agggaaagga agttcctttt
      841 ttctctgtgc tcttgtttgc ccgagacaca tcaaatgacc ctgaacagct cctgaggaac
      901 cacctgaacc aggtgggaca cactggcggc cttgaacagg ttgaaatgtt ccttcttgcc
      961 tatgctgttc gccacaccat ccaggtgtac cggctgtcca agtataacac tgaggaattc
     1021 atcacagtct atcccactga tccccccaag gactggccaa tggtgaccct catagctgag
     1081 gacgatcggc actataacat ccctgtcaga gtgtgtgagg agacaagtct gtgagggaca
     1141 catgtgaaca gccaagtgat gtgcatgtac agctcctttg ggggcctcag atctgcaggt
     1201 gtccaaggac aatccgggag aactcttggg cccctggagc caactttgga ccattatgtt
     1261 ctgaagacta gctgttgata atgagaatta attagccaag tcttcactca ttgttctgtt
     1321 acgcagtgtg tttcactggg ggcttcagca tgtgcctttg gaaggtgcaa actatgtctc
     1381 cataaggcat atgcctttgg gtcagaggaa actgtttgga aagaatctgt ccaatgaaag
     1441 ttctgatggt aaactggttt ttacttctct ttttaaaaca gtagttttgt ttttgatttt
     1501 gattcctttt ctttggattg gtggtgatgg gtctcattgc tggtcttcct atgagatatg
     1561 tttaaatggt agtgtcctgg gatgagtagt tacagtatct tttgatagcc tgtttttgga
     1621 gggatgggca gtgaatgtat atgccaatta atagtatttt gagtagattg tctcttagaa
     1681 gactaagaac agggtcccag aatagttttt tgaaagctgg aagaggttca gaggagagtg
     1741 gggaggagtc taggctctgg ttgctgaggc tttggtgccc tggcattggg agatctctct
     1801 gcacatgtgc tctagtgttg gggttgtggg tcacagtgat tccagtgttt atagaggtgg
     1861 gaatcaaaac ctgtcacttc agttcagagg tgggcgcccc tttcatgctg ttgacgatgc
     1921 catgtcctgc tgggcacatg taactcatcc tgagacagga tgtgacccag ctgactatct
     1981 gggatctctg ataagtaagt cagagcagaa gcgcgtgcta agctaggagg cagccgccag
     2041 gttggctagg ataagtttgt gtgcatggca taagccatgt tcctgacttg agcagggcca
     2101 actggggaga tgtcctgagc atgggctgcc ttggggcctt tatttccctt tgggaacgta
     2161 gcctttgtcc gtggggacca gacacatcct tctttaggat atcatctgta gcacctgaat
     2221 cagttcaaca tttgttgttg atgttatcct aatgtgttga acttattttg tgatagttaa
     2281 aattcttaat ttaactcagt ttcatataga taagcaactt tttttgacaa acctttaaaa
     2341 tatgaatttt tgtttcaata aaaattaagt cttatgtatg aaaactcagg atataaaaag
     2401 cagtcagacc cttgtagtat ttctttcatt gcctcatgag caaaatcacc acatttcatt
     2461 aactgtttat tgattagagt gctggcatca aatgctgttc tgaatgtgtg tgagtgacta
     2521 tgctgagagg cattgtgttg tcactgtgaa atgctgtgat gcccttacct aagaaggccc
     2581 tgagcagcaa attaaaatta ggaataatga cctattgtgg actttgacac tttattttgt
     2641 tgcttgtaat taaatagcag gtaacgtctg ccattcatgt ttgtacagtt ttggaagaag
     2701 aacttgaaat gtttagatat tccagcagga gtgacctctg ccctttgggt gccttgaaac
     2761 tgaccattgg gtttatatca ccattgaaat ttagtaatgc tcttggtaat agtcacaatt
     2821 atctgcattt aaaagacaat gaatttgaac tcattttctg gggaacttct ttatatttcc
     2881 tatttcgttc ttgtttgtta tattattagg tacagtttcc ttgtattatg tcccatgtca
     2941 gatcttgctc tcctacactg gttgtggatg tgcagtaccc atgggttcac tcgtgcgtga
     3001 attcgtgaca gcagcattag tgcctttaac ttagtatttg ggtctgtgtg aatgtgatct
     3061 gagacagtca catttccttc tgtaggcata aggacatatt cccagtgcac aggggttcat
     3121 cctgttttcc tgtaggcctc agacactttc cttatactac agagtaggaa tgtttgagga
     3181 gctttttctt aaagggaaat ggcattgcat gttctttgtt tattttttct tccagtttca
     3241 ggacttatta ggtaaaatct catacaaatg tgaattgata aagtttttgt tgtggttttt
     3301 gtcttgtttt t
//
