LOCUS       NM_001107697            5958 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus OTU deubiquitinase 7B (Otud7b), mRNA.
ACCESSION   NM_001107697 XM_001058882 XM_227454
VERSION     NM_001107697.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5958)
  AUTHORS   Du,B.B., Zhang,J.L., Kong,L.Y., Shi,H.T., Zhang,D.H., Wang,X.,
            Yang,C.L., Li,P.C., Yao,R., Liang,C., Wu,L.M. and Huang,Z.
  TITLE     Ovarian Tumor Domain-Containing 7B Attenuates Pathological Cardiac
            Hypertrophy by Inhibiting Ubiquitination and Degradation of
            Kruppel-Like Factor 4
  JOURNAL   J Am Heart Assoc 12 (24), e029745 (2023)
   PUBMED   38084712
  REMARK    GeneRIF: Ovarian Tumor Domain-Containing 7B Attenuates Pathological
            Cardiac Hypertrophy by Inhibiting Ubiquitination and Degradation of
            Kruppel-Like Factor 4.
REFERENCE   2  (bases 1 to 5958)
  AUTHORS   Zhang,J., Zha,Y., Jiao,Y., Li,Y., Wang,J. and Zhang,S.
  TITLE     OTUD7B (Cezanne) ameliorates fibrosis after myocardial infarction
            via FAK-ERK/P38 MAPK signaling pathway
  JOURNAL   Arch Biochem Biophys 724, 109266 (2022)
   PUBMED   35523269
  REMARK    GeneRIF: OTUD7B (Cezanne) ameliorates fibrosis after myocardial
            infarction via FAK-ERK/P38 MAPK signaling pathway.
REFERENCE   3  (bases 1 to 5958)
  AUTHORS   Cheng,J., Fan,Y.Q., Jiang,H.X., Chen,S.F., Chen,J., Liao,X.Y.,
            Zou,Y.Y., Lan,H.Y., Cui,Y., Chen,Z.B., Chen,Q.X. and Wan,Q.
  TITLE     Transcranial direct-current stimulation protects against cerebral
            ischemia-reperfusion injury through regulating Cezanne-dependent
            signaling
  JOURNAL   Exp Neurol 345, 113818 (2021)
   PUBMED   34324860
  REMARK    GeneRIF: Transcranial direct-current stimulation protects against
            cerebral ischemia-reperfusion injury through regulating
            Cezanne-dependent signaling.
REFERENCE   4  (bases 1 to 5958)
  AUTHORS   Wilson,R., Geyer,S.H., Reissig,L., Rose,J., Szumska,D., Hardman,E.,
            Prin,F., McGuire,C., Ramirez-Solis,R., White,J., Galli,A.,
            Tudor,C., Tuck,E., Mazzeo,C.I., Smith,J.C., Robertson,E.,
            Adams,D.J., Mohun,T. and Weninger,W.J.
  TITLE     Highly variable penetrance of abnormal phenotypes in embryonic
            lethal knockout mice
  JOURNAL   Wellcome Open Res 1, 1 (2017)
   PUBMED   27996060
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5958)
  AUTHORS   Mevissen,T.E., Hospenthal,M.K., Geurink,P.P., Elliott,P.R.,
            Akutsu,M., Arnaudo,N., Ekkebus,R., Kulathu,Y., Wauer,T., El
            Oualid,F., Freund,S.M., Ovaa,H. and Komander,D.
  TITLE     OTU deubiquitinases reveal mechanisms of linkage specificity and
            enable ubiquitin chain restriction analysis
  JOURNAL   Cell 154 (1), 169-184 (2013)
   PUBMED   23827681
REFERENCE   6  (bases 1 to 5958)
  AUTHORS   Bremm,A., Freund,S.M. and Komander,D.
  TITLE     Lys11-linked ubiquitin chains adopt compact conformations and are
            preferentially hydrolyzed by the deubiquitinase Cezanne
  JOURNAL   Nat Struct Mol Biol 17 (8), 939-947 (2010)
   PUBMED   20622874
REFERENCE   7  (bases 1 to 5958)
  AUTHORS   Tran,H., Hamada,F., Schwarz-Romond,T. and Bienz,M.
  TITLE     Trabid, a new positive regulator of Wnt-induced transcription with
            preference for binding and cleaving K63-linked ubiquitin chains
  JOURNAL   Genes Dev 22 (4), 528-542 (2008)
   PUBMED   18281465
REFERENCE   8  (bases 1 to 5958)
  AUTHORS   Lau,N.C., Seto,A.G., Kim,J., Kuramochi-Miyagawa,S., Nakano,T.,
            Bartel,D.P. and Kingston,R.E.
  TITLE     Characterization of the piRNA complex from rat testes
  JOURNAL   Science 313 (5785), 363-367 (2006)
   PUBMED   16778019
REFERENCE   9  (bases 1 to 5958)
  AUTHORS   Evans,P.C., Smith,T.S., Lai,M.J., Williams,M.G., Burke,D.F.,
            Heyninck,K., Kreike,M.M., Beyaert,R., Blundell,T.L. and
            Kilshaw,P.J.
  TITLE     A novel type of deubiquitinating enzyme
  JOURNAL   J Biol Chem 278 (25), 23180-23186 (2003)
   PUBMED   12682062
REFERENCE   10 (bases 1 to 5958)
  AUTHORS   Evans,P.C., Taylor,E.R., Coadwell,J., Heyninck,K., Beyaert,R. and
            Kilshaw,P.J.
  TITLE     Isolation and characterization of two novel A20-like proteins
  JOURNAL   Biochem J 357 (Pt 3), 617-623 (2001)
   PUBMED   11463333
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474015.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001058882.1, XM_227454.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132265 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..5958
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..5958
                     /gene="Otud7b"
                     /gene_synonym="RGD1308111"
                     /note="OTU deubiquitinase 7B"
                     /db_xref="GeneID:310677"
                     /db_xref="RGD:1308111"
     exon            1..290
                     /gene="Otud7b"
                     /gene_synonym="RGD1308111"
                     /inference="alignment:Splign:2.1.0"
     exon            291..441
                     /gene="Otud7b"
                     /gene_synonym="RGD1308111"
                     /inference="alignment:Splign:2.1.0"
     CDS             357..2882
                     /gene="Otud7b"
                     /gene_synonym="RGD1308111"
                     /EC_number="3.4.19.12"
                     /note="cellular zinc finger anti-NF-kappaB Cezanne; OTU
                     domain containing 7B"
                     /codon_start=1
                     /product="OTU domain-containing protein 7B"
                     /protein_id="NP_001101167.1"
                     /db_xref="GeneID:310677"
                     /db_xref="RGD:1308111"
                     /translation="MTLDMDAVLSDFVRSTGAEPGLARDLLEGKNWDVSAALSDFEQL
                     RQVHAGNLSPPFSGGSTCPKTPEKGGSDREPTRPSRPILQRQDDIIQEKRLSRGISHA
                     SSSIVSLARSHVSSNGGGGGSSEHPLEMPICAFQLPDLTVYKEDFRSFIERDLIEQSM
                     LVALEQAGRLNWWVSVDSTCQRLLPLATTGDGNCLLHAASLGMWGFHDRDLVLRKALY
                     ALMEKGVEKEALKRRWRWQQTQQNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTN
                     GASGGGVESSEEPVYESLEEFHVFVLAHVLKRPIVVVADTMLRDSGGEAFAPIPFGGI
                     YLPLEVPASQCHRSPLVLAYDQAHFSALVSMEQKDSAKEQAVIPLTDSEHKLLPLHFA
                     VDPGKGWEWGKDDNDNVRLASVILSLEVKLHLLHSYMNVKWIPLSSESQAPLAQPESP
                     TASAGDEPRSTPESGESDKESVGSSSISNEGSRRKEKSKRDREKDKKRADSVANKLGS
                     FGKTLGSKLKKNMGGLMHSKGPKPGGLGSGSGISSGTETLEKKKKNNALKSWKGGKEE
                     AAGDGPVSEKPTSEPVGNGGSKYSQEVMQSLSILRIAMQGEGKYIFVGTLKMGHRHQY
                     QEEMIQRYLADAEERFLAEQKQKEAERKIMNGGLVSGPPPAKKPEPDGGEDQPSDSPA
                     ESKATGFSPGYPGGFTIPRPSGGGVHCQEPRRQLAGGPCVGGLPSYATFPRQYPPGRP
                     YSHQDSIPSLEPGKDGVHRGALLPPQFRVADSYSNGYREPPEPDGWAGAPRGLPPTQT
                     KCKQPNCSFYGHPETNNFCSCCYREELRRREREPGGELLAHRF"
     exon            442..630
                     /gene="Otud7b"
                     /gene_synonym="RGD1308111"
                     /inference="alignment:Splign:2.1.0"
     exon            631..858
                     /gene="Otud7b"
                     /gene_synonym="RGD1308111"
                     /inference="alignment:Splign:2.1.0"
     exon            859..960
                     /gene="Otud7b"
                     /gene_synonym="RGD1308111"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1088
                     /gene="Otud7b"
                     /gene_synonym="RGD1308111"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1201
                     /gene="Otud7b"
                     /gene_synonym="RGD1308111"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1329
                     /gene="Otud7b"
                     /gene_synonym="RGD1308111"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1479
                     /gene="Otud7b"
                     /gene_synonym="RGD1308111"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1594
                     /gene="Otud7b"
                     /gene_synonym="RGD1308111"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1679
                     /gene="Otud7b"
                     /gene_synonym="RGD1308111"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..5958
                     /gene="Otud7b"
                     /gene_synonym="RGD1308111"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggacggcca aaagccaccg atcctgaacc agccgctgga gtcggagtgg cgacccggtg
       61 tggagccggc ggaaagccat tgggaagagg ccagctccgg tcagtcccgg cttggctcca
      121 gctccatctc ctgtggagag caacagccgc ggtcgcagtg tccgcctccg cctccatcgt
      181 cgtcggggga ggggccgctc ggaccccggg gtcactgccg aggaatgagg cgaggcggcc
      241 gggccccgcg ctccgccccg gcctaaagcc ttgccctgag agtcgcgagg gtcagagcct
      301 ggagtttgat ctgtgttctg gtcacatcct gctgcctgag agtacttgat gaccccatga
      361 ccctggacat ggatgctgtc ctgtcggatt ttgttcgttc cacaggtgca gagccagggc
      421 tggctcgaga tcttctagaa ggaaagaact gggatgtgag tgctgccctc agtgactttg
      481 aacaattgcg ccaagtccat gctgggaacc tgtccccacc ctttagtgga gggagtactt
      541 gccctaagac ccctgaaaag gggggttcgg atagagagcc cactcgccct tctcgaccca
      601 tcctacagag acaggatgac atcattcaag aaaaacgcct gtctaggggc atctcccacg
      661 ccagctccag cattgtttcc ctggcccgct cccatgtctc ctccaatggt gggggtgggg
      721 ggagcagtga gcaccccctg gaaatgccca tctgtgcctt ccagcttcca gacctcactg
      781 tgtacaaaga agacttccgc agcttcatag agagagacct cattgagcag tccatgctgg
      841 ttgccttgga acaggcaggg cgtttgaatt ggtgggtcag tgtggactcc acctgccaga
      901 ggctgctccc tttagcaact actggggacg ggaactgcct cctgcatgca gcctctcttg
      961 ggatgtgggg tttccatgat agagacttgg tgctgagaaa agccttgtat gcactgatgg
     1021 agaagggcgt tgagaaggaa gcactgaaaa ggcgctggag gtggcagcaa acacaacaga
     1081 ataaagagtc aggactggtg tatacggaag atgagtggca gaaagaatgg aatgaactga
     1141 tcaaacttgc ctcaagtgaa cccagaatgc atctaggtac caacggagcc agtggtggag
     1201 gagtggagag ttcagaagag ccggtatatg agagcctaga ggaattccat gtcttcgtcc
     1261 ttgctcatgt tctcaagagg cccatagtgg tcgtggcaga caccatgctg agggactctg
     1321 gaggggaagc atttgcccct atcccgtttg gagggatcta tctgccattg gaggtcccag
     1381 ccagccagtg tcaccgatcc cctctggtgc tcgcctatga ccaggcccac ttctctgcac
     1441 ttgtgtcgat ggagcagaag gacagcgcca aggaacaagc tgtgatccca ctcacagatt
     1501 cagagcataa gctgctgccc ctgcactttg ctgtggaccc aggaaagggc tgggagtggg
     1561 gcaaagatga caatgacaat gtccgcttgg ccagtgtaat cctgtctctg gaagtgaagt
     1621 tgcatctgct gcatagctat atgaatgtga agtggatccc tctgtcttcc gagtctcaag
     1681 cccctctggc ccagcccgag tcccccacag cctcagctgg agatgaaccc aggtccactc
     1741 ctgagtcagg ggagtcggac aaggagtcgg ttggcagcag ttctatcagc aacgagggca
     1801 gcaggcggaa ggagaagtca aagcgcgaca gggagaagga caagaagaga gcagattccg
     1861 tggctaacaa actgggcagc tttggcaaaa ccttgggcag caagcttaag aagaacatgg
     1921 ggggcctgat gcatagcaag ggccccaagc ctggagggct ggggagtggg tctggaataa
     1981 gcagtggtac ggagacatta gagaagaaga agaagaacaa cgcattgaag agctggaagg
     2041 gtggcaagga ggaggcagct ggcgatgggc ctgtgtctga gaagcccaca tctgagcctg
     2101 tcggcaacgg agggagcaag tatagccagg aggtgatgca aagcctgagc attctgagga
     2161 tcgccatgca aggggagggc aaatacattt ttgtcggaac cctgaagatg ggccaccggc
     2221 accagtatca ggaggagatg atccagcgct accttgcaga tgctgaggag agattcctgg
     2281 cagagcagaa gcagaaggag gctgagagga agatcatgaa tggagggtta gttagtgggc
     2341 ctcctccagc caaaaagcca gagccggacg gcggggagga ccagcccagt gactccccag
     2401 cagagtccaa ggcaacgggc ttctctcctg gttaccctgg gggctttact attcctcgac
     2461 cttctggggg tggagtccac tgccaggaac ctcggaggca gttggcaggg ggtccatgtg
     2521 tagggggcct tccatcgtat gccacctttc ccagacagta ccctcctggg cgaccctact
     2581 cccaccagga cagcatccca tctctggagc caggcaaaga tggagttcac aggggtgcct
     2641 tgttaccacc ccagttccgt gtggctgact cctatagcaa tggctacaga gagccaccag
     2701 agccagatgg atgggctgga gctccccggg gacttccccc aacccagacc aaatgcaaac
     2761 aaccgaactg cagcttctat ggacaccctg agacaaacaa cttctgctct tgctgttaca
     2821 gggaagaact gaggcggagg gaacgggaac ctggtgggga actgctggca cacaggttct
     2881 gaatggctag aaccttagtg gggaaaggga ctaaacaaag aaagttaagc tcaactctgg
     2941 ctcatcagga cccagcccct gtgttgatgg ggcaagtgca gaaatgtgtg tgggagctgg
     3001 agtgctggca ggctggcgag agagcaggac agggctagct actccgaggg cagtagtgct
     3061 cctctgcaca gttgacttga gactgcaagg cagaagaggg agggaggttc tagctcaacc
     3121 tcttgggtcc caatcccagg acccaagggg aagtagggaa atactaggtg tgtgtgggtg
     3181 ggaggtgggt ggacaccttc agggagtacc ctgggaagaa agttctcaat cggttaagga
     3241 aaaaatagac caaagttcat tgactttaga agaaaagcac atggtagtgt acttgggagt
     3301 atagagtgag tctggtactg aacaagtttg attttggttt gaattaggta gattttaggg
     3361 ttggataaat ttttcctgaa ggatcaaggc agtaatgtgt gtgcttggcc tggtcacaca
     3421 gaaagcatac tttaaatcct agtgaatgga aataggaaag ggaggactta aaggagggct
     3481 ctttcctaga gagttttagg ttctagatac tcatctgcca tccactctag ttttagggga
     3541 gactgcctgt tgccccatcc tttccgcatc ctttttaagg actgagctca gctaagttaa
     3601 gatgttgtga tttttttttt ttgatatttt attttaaaag caagttcctt ttgggaaaga
     3661 gaaaagtggt aaaagcagcc ttgtatgtgg gattttcttc aggtgaacgg gtgcagagtg
     3721 atctattttt taactcctta gcaataacta cacgtggact tgagtgcacc tgagaaggga
     3781 cggaggagcc aggtgtttgg ccagactgtt tgaaacaata ccaaaacctc tatcgagcac
     3841 tgtcctctgc tgctgtgttt ccgtagagag caacctattt tattgactaa tttttttaaa
     3901 gaaaaactcg actctgacaa aatttaaaaa ttacttactc ccctccccta tctaaatgat
     3961 ttttttctcc ttcctgtgta cttctggaga atgaacttaa cgtcctggct tcttttgtta
     4021 agccatcgct gaccttagtc tgtggttagt ttattaaaat aataaaaaac actttgtaag
     4081 aagaattatt tttgatatta ggactggagt tgaagcatgg tatgggggct aggggccact
     4141 tataaaaagg tagctagaga aatatatttt agtgaactgt agccacaggc cacagattag
     4201 ttccagtgag ctgatctggc tttggatttc tcccttttcc tgagccagcc ctgttctcca
     4261 gagaagtagg ggtggaccca atggcgagag ctcccttgca atttgcacaa agcacaagtc
     4321 tggacagttt atgctctgac cagagctgtt tctaagagct ttaaacctga agactatcct
     4381 gcgccattgc cctttctcct tatttttttt cctggggaaa aaaatcatct atgcaattct
     4441 atacacttgt ggatgcgtgt gaagagggtg tgagtgtgct gcccgtgtcc agacagctcc
     4501 ggtttctctg ctgaggcatg ccgtcaccca ctagtggaat gtagtcccca aatttgattt
     4561 aagtcacaaa tggctctata tgtgcatgta tacgtttgtg tgtgtgtgtg tgtgtgtgtg
     4621 tgtgtgtgtg agagagagag agagaggaga aggctttggg actcccagtc aggaagataa
     4681 tcagagagag agagaggggg gggggggagg aaggagaagg ctttgggact cccagtcagg
     4741 aagatgatca catagctttc ttcggtaaca aagctagtca agacttcttt atggaactag
     4801 taagtttaag aagttgtctc tcgccccctc aaaaagtttg aaagtcgctt ccaggtctgc
     4861 caatctgttg atttaataat ttcctgtcat catttttaga ctattttttt gtttgtttct
     4921 ttgctgtgta gccctggctt gccagcctgg tacttattat atagcccagg ttagcctcca
     4981 actcatagca accctcccgt ttcagtcttc tgagtgctgg tatctaggcg tgagccacca
     5041 cacccagctt tcttcaggct gaaacctagt atgagacaag catttctggc aggtgcttac
     5101 tttaaaggtc tactaggaaa ttgaggattg gtttggtttt ggcttatttt ttaggtaggc
     5161 tccttcctat agcccaggct ggccttaaat gtatgatctt gcttcaaatt ttccaagtgc
     5221 tgggatcaca tcatgccaga cattttttta tttcagtata taaacattaa aaacccagat
     5281 tgaacaaaac atcaaaatct taggatataa caggaaccgt attaaggtga aagaggggag
     5341 agcccttaat tgaacaaata tgaagacaaa tcctgtctat ttaaattgtg atgtttataa
     5401 aggtgttttt acattttttt catttttttt aaaatactgc atcaagatag tatttatctt
     5461 ggttcgtgag ttttaagcac tcctgttttt ctccccatga atggtggact aacgccttgt
     5521 gccttgtcat catcacctta gacttgtccc agtttccgaa gcttgaatga cacaggtgaa
     5581 accttcacca tgagccccct cttcttgact gcagacacct gtgtgcactg ctctccctga
     5641 ctgcagacac ctgtgtgcac tggtggcgtc ctcctcccac agcatacatg gggtgcctgc
     5701 ctaggtgggt gggggtgcag atagcccagc agggcttttc ctggagaata aaccagggaa
     5761 ttccatctcc actggactgc tgtgtttgga cttgatctgt tattagattg tactagatta
     5821 tacttaacac tcctgtttct aaaaactgag gacaaatgaa gagactcaga aaccttgtat
     5881 catgcttgtt tttatttcta tggtacccag tttcaattct gcttgccttt ccaaagaaaa
     5941 aataagaaag ttccaggg
//
