LOCUS       NM_001106639            1323 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus OTU deubiquitinase 6B (Otud6b), mRNA.
ACCESSION   NM_001106639 XM_001055937 XM_232795
VERSION     NM_001106639.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1323)
  AUTHORS   Santiago-Sim T, Burrage LC, Ebstein F, Tokita MJ, Miller M, Bi W,
            Braxton AA, Rosenfeld JA, Shahrour M, Lehmann A, Cogne B, Kury S,
            Besnard T, Isidor B, Bezieau S, Hazart I, Nagakura H, Immken LL,
            Littlejohn RO, Roeder E, Kara B, Hardies K, Weckhuysen S, May P,
            Lemke JR, Elpeleg O, Abu-Libdeh B, James KN, Silhavy JL, Issa MY,
            Zaki MS, Gleeson JG, Seavitt JR, Dickinson ME, Ljungberg MC, Wells
            S, Johnson SJ, Teboul L, Eng CM, Yang Y, Kloetzel PM, Heaney JD and
            Walkiewicz MA.
  CONSRTM   EuroEPINOMICS RES Consortium Autosomal Recessive working group, S.
            Hande Caglayan
  TITLE     Biallelic Variants in OTUD6B Cause an Intellectual Disability
            Syndrome Associated with Seizures and Dysmorphic Features
  JOURNAL   Am J Hum Genet 100 (4), 676-688 (2017)
   PUBMED   28343629
REFERENCE   2  (bases 1 to 1323)
  AUTHORS   Sobol A, Askonas C, Alani S, Weber MJ, Ananthanarayanan V, Osipo C
            and Bocchetta M.
  TITLE     Deubiquitinase OTUD6B Isoforms Are Important Regulators of Growth
            and Proliferation
  JOURNAL   Mol Cancer Res 15 (2), 117-127 (2017)
   PUBMED   27864334
REFERENCE   3  (bases 1 to 1323)
  AUTHORS   Xu Z, Zheng Y, Zhu Y, Kong X and Hu L.
  TITLE     Evidence for OTUD-6B participation in B lymphocytes cell cycle
            after cytokine stimulation
  JOURNAL   PLoS One 6 (1), e14514 (2011)
   PUBMED   21267069
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473962.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001055937.1, XM_232795.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ121865.1, SRR8487226.202980.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1323
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q13"
     gene            1..1323
                     /gene="Otud6b"
                     /gene_synonym="RGD1310024"
                     /note="OTU deubiquitinase 6B"
                     /db_xref="GeneID:297911"
                     /db_xref="RGD:1310024"
     exon            1..296
                     /gene="Otud6b"
                     /gene_synonym="RGD1310024"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..1096
                     /gene="Otud6b"
                     /gene_synonym="RGD1310024"
                     /EC_number="3.4.19.12"
                     /note="OTU domain-containing protein 6B; OTU domain
                     containing 6B"
                     /codon_start=1
                     /product="deubiquitinase OTUD6B"
                     /protein_id="NP_001100109.1"
                     /db_xref="GeneID:297911"
                     /db_xref="RGD:1310024"
                     /translation="MAPRVRVEGWEALACLRCRTPPARVPGHLVVMEEILAEELDDEE
                     QLMRRHRKEKKELQAKIQGMKNAVPKNDKKRRKQLTEDVAKLEREMEQKHREELEQLK
                     LTFKDSKIDSVAVNVSNLVLDSQPPRISKAQKRREKKAALEKEREERIAEAEIENLSG
                     ARHLESEKLAQILAARELEIKHIPSDGHCMYGALEDQLREQDSALTVATLRRQTAEYM
                     QSHSDDFLPFLTNPNTGDMYTPEEFGKYCDDIVNTAAWGGQLELRALSHILKTPIEIL
                     QADAPPIIVGEEYPRNPLVLVYMRHAYGLGEHYNSVTRLVNSTTENCS"
     exon            297..448
                     /gene="Otud6b"
                     /gene_synonym="RGD1310024"
                     /inference="alignment:Splign:2.1.0"
     exon            449..529
                     /gene="Otud6b"
                     /gene_synonym="RGD1310024"
                     /inference="alignment:Splign:2.1.0"
     exon            530..842
                     /gene="Otud6b"
                     /gene_synonym="RGD1310024"
                     /inference="alignment:Splign:2.1.0"
     exon            843..904
                     /gene="Otud6b"
                     /gene_synonym="RGD1310024"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1011
                     /gene="Otud6b"
                     /gene_synonym="RGD1310024"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1323
                     /gene="Otud6b"
                     /gene_synonym="RGD1310024"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgccgccca gagcggtccg agcacgcagg cgccctagcc catgtcggct tctccgggtt
       61 tcagtggtta gacctggatc cggagccgcc ttgaggcggg gctgggcctt cccggcggcc
      121 aatggcgccc cgggtgaggg ttgaggggtg ggaggcgctg gcctgcctga ggtgccgaac
      181 tcctccagcg cgtgttcccg gccacttggt cgtcatggag gagatcttgg ctgaagagct
      241 tgatgatgag gagcagctga tgagaaggca tcggaaggag aagaaggagc tgcaagctaa
      301 aattcaggga atgaagaacg ccgttcccaa aaacgacaaa aagaggagga agcaactcac
      361 ggaagatgtt gctaaattgg agagggaaat ggagcaaaaa cacagggaag aactggagca
      421 attgaaactg actttcaagg acagtaagat agattctgtt gctgttaacg tttcaaactt
      481 ggtacttgac agtcagccac ctcggatttc aaaagcacaa aagagacggg agaagaaggc
      541 tgcattggaa aaggagcggg aagaaaggat agctgaggca gagattgaga acttatctgg
      601 agccagacat ctagagagtg aaaaacttgc tcagatattg gcagccagag aactggaaat
      661 taaacatatt ccatctgacg gtcattgtat gtatggggca cttgaggatc agctaagaga
      721 acaagactct gctctgactg tggctaccct aaggaggcag actgctgagt acatgcagag
      781 ccattcagac gacttcctgc cattcctaac caaccccaac acaggagaca tgtacactcc
      841 agaagagttt ggaaagtact gtgacgatat tgtaaacacg gccgcgtggg gtggtcagct
      901 tgagctaaga gctctgtctc acatcttaaa gacaccgatc gagatactac aggcagatgc
      961 tcctcctatt atagttggtg aagagtatcc aaggaatcca ttagtactag tatacatgag
     1021 gcatgcgtat ggcttaggag aacattataa ttctgttaca cggttggtga actcaactac
     1081 tgaaaattgc agctagttta caaaatgtta cactgtttat agagtgtgcc catctaccaa
     1141 gtgctagatt gttgtaaatg ctactgaaaa acacagctac cttaaatgag ttttatgaat
     1201 aagcttacta acgggctttt tacaaataca ttggagtgac tttaatcagt gctctcttag
     1261 tggcattttt acaacttagt ctattgtgga gaagaatatc attcacaggc caaggcgtta
     1321 ctc
//
