LOCUS       NM_001414730            2668 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus OTU deubiquitinase 5 (Otud5), transcript variant
            1, mRNA.
ACCESSION   NM_001414730
VERSION     NM_001414730.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2668)
  AUTHORS   Rutz,S., Kayagaki,N., Phung,Q.T., Eidenschenk,C., Noubade,R.,
            Wang,X., Lesch,J., Lu,R., Newton,K., Huang,O.W., Cochran,A.G.,
            Vasser,M., Fauber,B.P., DeVoss,J., Webster,J., Diehl,L.,
            Modrusan,Z., Kirkpatrick,D.S., Lill,J.R., Ouyang,W. and Dixit,V.M.
  TITLE     Deubiquitinase DUBA is a post-translational brake on interleukin-17
            production in T cells
  JOURNAL   Nature 518 (7539), 417-421 (2015)
   PUBMED   25470037
REFERENCE   2  (bases 1 to 2668)
  AUTHORS   Mevissen,T.E., Hospenthal,M.K., Geurink,P.P., Elliott,P.R.,
            Akutsu,M., Arnaudo,N., Ekkebus,R., Kulathu,Y., Wauer,T., El
            Oualid,F., Freund,S.M., Ovaa,H. and Komander,D.
  TITLE     OTU deubiquitinases reveal mechanisms of linkage specificity and
            enable ubiquitin chain restriction analysis
  JOURNAL   Cell 154 (1), 169-184 (2013)
   PUBMED   23827681
REFERENCE   3  (bases 1 to 2668)
  AUTHORS   Huang,O.W., Ma,X., Yin,J., Flinders,J., Maurer,T., Kayagaki,N.,
            Phung,Q., Bosanac,I., Arnott,D., Dixit,V.M., Hymowitz,S.G.,
            Starovasnik,M.A. and Cochran,A.G.
  TITLE     Phosphorylation-dependent activity of the deubiquitinase DUBA
  JOURNAL   Nat Struct Mol Biol 19 (2), 171-175 (2012)
   PUBMED   22245969
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2668)
  AUTHORS   Kayagaki,N., Phung,Q., Chan,S., Chaudhari,R., Quan,C.,
            O'Rourke,K.M., Eby,M., Pietras,E., Cheng,G., Bazan,J.F., Zhang,Z.,
            Arnott,D. and Dixit,V.M.
  TITLE     DUBA: a deubiquitinase that regulates type I interferon production
  JOURNAL   Science 318 (5856), 1628-1632 (2007)
   PUBMED   17991829
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.2143963.1,
                                           SRR26360194.2495659.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760476 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-631               JAXUCZ010000021.1  17329889-17330519   c
            632-725             JAXUCZ010000021.1  17316172-17316265   c
            726-790             JAXUCZ010000021.1  17305821-17305885   c
            791-947             JAXUCZ010000021.1  17305576-17305732   c
            948-1096            JAXUCZ010000021.1  17305330-17305478   c
            1097-1300           JAXUCZ010000021.1  17301101-17301304   c
            1301-1502           JAXUCZ010000021.1  17299629-17299830   c
            1503-1616           JAXUCZ010000021.1  17299431-17299544   c
            1617-2668           JAXUCZ010000021.1  17298100-17299151   c
FEATURES             Location/Qualifiers
     source          1..2668
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq12"
     gene            1..2668
                     /gene="Otud5"
                     /note="OTU deubiquitinase 5"
                     /db_xref="GeneID:363452"
                     /db_xref="RGD:1563027"
     exon            1..631
                     /gene="Otud5"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..1738
                     /gene="Otud5"
                     /EC_number="3.4.19.12"
                     /note="isoform 1 is encoded by transcript variant 1; OTU
                     domain-containing protein 5; DUBA; deubiquinating enzyme
                     A; deubiquitinating enzyme A; OTU domain containing 5"
                     /codon_start=1
                     /product="OTU domain-containing protein 5 isoform 1"
                     /protein_id="NP_001401659.1"
                     /db_xref="GeneID:363452"
                     /db_xref="RGD:1563027"
                     /translation="MTILPKKKPPPPDADPANEPPPPGPLPPAPRRGGGVGVGGGGTG
                     VGGGERDRDSGVVGARPRASPPPQGPLPGPPGALHRWALAVPPGAVAGPRPQQASPPP
                     CGGPGGPGGGPGDALGATTAGVGAAGVVVGVGGPVGVGGCCSGPGHSKRRRQAPGVGA
                     VGGASPEREEVGAGYNSEDEYEAAAARIEAMDPATVEQQEHWFEKALRDKKGFIIKQM
                     KEDGACLFRAVADQVYGDQDMHEVVRKHCMDYLMKNADYFSNYVTEDFTTYINRKRKN
                     NCHGNHIEMQAMAEMYNRPVEVYQYSTEPINTFHGIHQNEDEPIRVSYHRNIHYNSVV
                     NPNKATIGVGLGLPSFKPGFAEQSLMKNAIKTSEESWIEQQMLEDKKRATDWEATNEA
                     IEEQVARESYLQWLRDQEKQARQVRGPSQPRKASATCSSATAAASSGLEEWTSRSPRQ
                     RSSASSPEHPELHAELGIKPPSPGTVLALAKPPSPCAPGTSSQFSAGADRATSPLVSL
                     YPALECRALIQQMSPSAFGLNDWDDDEILASVLAVSQQEYLDSMKKNKVHRDPPPDKS
                     "
     exon            632..725
                     /gene="Otud5"
                     /inference="alignment:Splign:2.1.0"
     exon            726..790
                     /gene="Otud5"
                     /inference="alignment:Splign:2.1.0"
     exon            791..947
                     /gene="Otud5"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1096
                     /gene="Otud5"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1300
                     /gene="Otud5"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1502
                     /gene="Otud5"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1616
                     /gene="Otud5"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..2668
                     /gene="Otud5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgtctggtt tgctgtgggg tacttggcgg tgccgccatg actattctcc ccaaaaagaa
       61 gccgccacct cccgacgccg acccggccaa cgaaccgccg ccgcccgggc cgctgccccc
      121 agcgcctcgg cgcggtgggg gtgtaggcgt gggcggcggc ggcacgggcg tgggcggagg
      181 agagcgcgac cgtgactccg gcgtcgtggg ggcccgtccc cgggcttcac caccacctca
      241 gggaccgcta ccggggccgc ctggtgctct tcatcgttgg gcactagccg tgccgcctgg
      301 cgcagtcgcg ggccctcggc cacagcaggc ttctccacct ccttgtgggg gccctggtgg
      361 ccccggcggc ggtcccggtg acgctcttgg tgcgacaact gcgggggtgg gcgcggcagg
      421 ggtggtggtg ggcgtgggtg gtcccgtggg cgtgggcggc tgctgctcgg ggcccgggca
      481 cagcaagcgg cggcgtcaag ctcccggcgt tggcgcagtt ggcggggcca gtccggaacg
      541 tgaagaggtc ggagcaggct acaacagcga agacgaatat gaagctgctg cagcacgaat
      601 cgaggccatg gatcccgcca ctgtagaaca gcaggaacac tggtttgaaa aggccttgcg
      661 ggacaagaaa ggcttcatca tcaagcagat gaaggaggat ggtgcctgtc tattccgggc
      721 tgtagctgac caggtgtatg gagaccagga catgcatgag gttgtgcgaa agcattgcat
      781 ggactatctg atgaagaatg ccgattactt ttccaactat gtcacagaag acttcaccac
      841 ctatatcaat cggaagcgga aaaacaactg ccatgggaac cacattgaga tgcaggctat
      901 ggcagagatg tacaaccgtc ctgtggaggt gtatcagtat agcacagaac ctatcaacac
      961 attccatggg atccatcaaa atgaagatga acccatccgt gtcagctacc accggaatat
     1021 ccactataat tcagtggtga atcctaacaa ggccactatt ggtgtggggc tgggcctgcc
     1081 atcatttaaa ccagggtttg cagagcagtc cctgatgaag aatgccataa agacatcaga
     1141 agagtcatgg attgaacagc aaatgctgga agacaagaaa cgagctacag actgggaggc
     1201 cacaaatgag gccatagagg agcaggtggc tcgagaatct tacctgcagt ggctgaggga
     1261 tcaagagaaa caggcccgcc aggtccgggg acccagccag ccacggaaag ccagtgccac
     1321 atgcagttca gccacagcag cagcctccag tggcctggag gaatggacta gtcggtcccc
     1381 acggcaacga agttcagcct cgtcacctga gcaccctgaa ctgcatgccg agctaggcat
     1441 taagccccct tccccaggca ctgtgttagc tcttgccaaa cctccttcac cctgtgcacc
     1501 aggtacaagc agtcagttct cagcaggggc tgatcgggcc acctctcctc ttgtgtccct
     1561 ctaccctgct ctggagtgcc gggccctcat ccagcagatg tccccctctg cctttggtct
     1621 gaatgattgg gatgatgatg agatcctagc atcggtgctg gcagtgtccc aacaggaata
     1681 cctagacagt atgaagaaaa acaaagtgca cagagaccca cccccagaca agagttgatg
     1741 gagacccagg gactggacac catccccgat cccccactcc tgccctttaa tgccacccaa
     1801 acttctttgg ctttcttccc tcttggcttc cttcctttgt ttcctctttt ccttcttttc
     1861 cacttccctc tggctggccc acccatgcgc tccatccatc tcatccctgc caccaccatt
     1921 ggtctctgcc agctgatgtg ccctattgcc cccctgcaca gcaccatctc agcattccac
     1981 aggggactct ggacagggtg cggaaggtag gcaagagacc cacagagaca gaccatctgg
     2041 cagccaggca gccccagaag agagacattc agacaaagga agtcttctgc tcgtccttcc
     2101 ttaaagatca gataaacttg tcacccaaca atgatgacaa gaaaagtggg agtgggaaat
     2161 tttccttcct aagtccctga agaatctgag ccttcaatgt taaaattttc ttgattaaaa
     2221 tgtgctttat ctcacaaaat caacaaatga aaaccaatgt acacagcaac gctggccctg
     2281 tgaagatgac attctgcttt ggaactgggc aggttggcca tggggcatag agggcaagaa
     2341 ggagatggat ttctgctgtc tttcggcccc caattccttg gaagggctaa ggatatgagc
     2401 cagagggaag tggcaggaga tgcgggtggc agactggctt tggacagtga cagtctgacc
     2461 ttgctgcatc gctttgcctt ccaccaccgc taatctgttt ggaagcttga agtggggtgt
     2521 cttcagaaat catggccact actcaagatt tgaatttagg gagtgggagc agcctcagca
     2581 gatggggcac ccgtgcactg caggtgttga caagatccac catctgtaat gtccttggca
     2641 caataaaacc aaatgtcagt ttccctga
//
