LOCUS       NM_001191700            3832 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus OTU deubiquitinase 4 (Otud4), mRNA.
ACCESSION   NM_001191700 XM_226388
VERSION     NM_001191700.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3832)
  AUTHORS   Zhao,Y., Mudge,M.C., Soll,J.M., Rodrigues,R.B., Byrum,A.K.,
            Schwarzkopf,E.A., Bradstreet,T.R., Gygi,S.P., Edelson,B.T. and
            Mosammaparast,N.
  TITLE     OTUD4 Is a Phospho-Activated K63 Deubiquitinase that Regulates
            MyD88-Dependent Signaling
  JOURNAL   Mol Cell 69 (3), 505-516 (2018)
   PUBMED   29395066
REFERENCE   2  (bases 1 to 3832)
  AUTHORS   Zhao,Y., Majid,M.C., Soll,J.M., Brickner,J.R., Dango,S. and
            Mosammaparast,N.
  TITLE     Noncanonical regulation of alkylation damage resistance by the
            OTUD4 deubiquitinase
  JOURNAL   EMBO J 34 (12), 1687-1703 (2015)
   PUBMED   25944111
REFERENCE   3  (bases 1 to 3832)
  AUTHORS   Mevissen,T.E., Hospenthal,M.K., Geurink,P.P., Elliott,P.R.,
            Akutsu,M., Arnaudo,N., Ekkebus,R., Kulathu,Y., Wauer,T., El
            Oualid,F., Freund,S.M., Ovaa,H. and Komander,D.
  TITLE     OTU deubiquitinases reveal mechanisms of linkage specificity and
            enable ubiquitin chain restriction analysis
  JOURNAL   Cell 154 (1), 169-184 (2013)
   PUBMED   23827681
REFERENCE   4  (bases 1 to 3832)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1 and BF284741.1.
            
            On Jul 17, 2010 this sequence version replaced XM_226388.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.61091.1,
                                           SRR26643429.55650.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-384               JAXUCZ010000019.1  45183753-45184136   c
            385-468             JAXUCZ010000019.1  45180124-45180207   c
            469-519             JAXUCZ010000019.1  45177590-45177640   c
            520-566             JAXUCZ010000019.1  45170582-45170628   c
            567-635             BF284741.1         559-627
            636-639             JAXUCZ010000019.1  45169918-45169921   c
            640-721             JAXUCZ010000019.1  45168059-45168140   c
            722-854             JAXUCZ010000019.1  45165457-45165589   c
            855-909             JAXUCZ010000019.1  45162547-45162601   c
            910-1027            JAXUCZ010000019.1  45162194-45162311   c
            1028-1092           JAXUCZ010000019.1  45162036-45162100   c
            1093-1187           JAXUCZ010000019.1  45160405-45160499   c
            1188-1288           JAXUCZ010000019.1  45157467-45157567   c
            1289-1478           JAXUCZ010000019.1  45157182-45157371   c
            1479-1641           JAXUCZ010000019.1  45148985-45149147   c
            1642-1762           JAXUCZ010000019.1  45147384-45147504   c
            1763-1818           JAXUCZ010000019.1  45146600-45146655   c
            1819-1893           JAXUCZ010000019.1  45145822-45145896   c
            1894-2032           JAXUCZ010000019.1  45144897-45145035   c
            2033-2287           JAXUCZ010000019.1  45144132-45144386   c
            2288-2328           JAXUCZ010000019.1  45143113-45143153   c
            2329-3832           JAXUCZ010000019.1  45141043-45142546   c
FEATURES             Location/Qualifiers
     source          1..3832
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q11"
     gene            1..3832
                     /gene="Otud4"
                     /gene_synonym="RGD1305606"
                     /note="OTU deubiquitinase 4"
                     /db_xref="GeneID:307774"
                     /db_xref="RGD:1305606"
     exon            1..384
                     /gene="Otud4"
                     /gene_synonym="RGD1305606"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..3543
                     /gene="Otud4"
                     /gene_synonym="RGD1305606"
                     /EC_number="3.4.19.12"
                     /note="OTU domain containing 4"
                     /codon_start=1
                     /product="OTU domain-containing protein 4"
                     /protein_id="NP_001178629.1"
                     /db_xref="GeneID:307774"
                     /db_xref="RGD:1305606"
                     /translation="MEAAVGAPDGVDQGGAGPLEDATPMDAYLRKLGLYRKLVAKDGS
                     CLFRAVAEQVLHSQSRHVEVRMACIRYLRDNREKFEAFIEGSFEEYLKRLENPQEWVG
                     QVEISALSLMYRKDFVIYQEPNVSPSHVTENNFPEKVLLCFSNGNHYDIVYPITYRDS
                     SAVCQSLLYELLYEKVFKTDVSKIMMGLETSEVADESNSEISDSEDDSCKSKSTAATD
                     VNGFKSSGSENPKNHGNSADLPLSRKVLKSLSPAVYRNVEYEIWLKSKQAQQKRDYSI
                     AAGLQYEGGERCHVRLDHNGKLSNADIHGVHSENGPVLSEELGKKQTPKNLKPPPPES
                     WNTVSGKKMKKPNSGQNFHSDTDYRGPKNLNKPIKAPSALPPRLQHPPAGVRQHALSS
                     HSTGPQSQKSSSEHKNLSRVPSQITRKPDRERAEDFDHVSRESYYFGLSPEERREKQA
                     IEESRLLYEIQNRDEQAFPALSSSSVSQSPQNSNACVPRKSSHARDRKGSMRRVDAEE
                     RKDKDSLRGHTHMDKKPEPSTLEISDDKCTRVSSPSKSKKECPSPVEQKPAEHIPLSN
                     PAPLLVSPEVHLTPAVPSLPATVPAWPSEPTTFGPTGVPAQIPILSVTQTTGPDAAVS
                     QAHLTPSPVPVSIQAVNQPLMPLPQTMSLYQDPLYPGFPCSEKGDRAIAPPYSLCQTG
                     EDLPKDKNILRFFFNLGVKAYSCPMWAPHSYLYPLHQAYMAACRVYPKVPVPVYPQST
                     WFQEAPPAQSESDCPCADAHYSMHPEASVNGQMPQAEIGPPAFSSPLVIPPSQVSEGH
                     GQLSYQPELESESPGQLLHAEYEESLSGKNMYPQQSFGPNPFLGPVPIAPPFFPHVWY
                     GYPFQGFVENPVMRQNIVLPPDDKGELDLPLENLDLSKECDSVSAVDEFPEARVEGAH
                     SLSEASVSSKHEGRVEQSSQTRKADIDLSSGSSGVEGKAHPPTQILNREREAVSAEPE
                     PKRTIQSLKEKPEKVKDPKTAADVLSSGANSVDRLQRPKEESSEDENEVSNILRSGRS
                     KQFYNQTYGSRKYKSDWGSSGRGGYQHVRGEESWKGQPNRSRDEGYQYHRHVRGRPYR
                     GDRRRSGMGDGHRGQHT"
     exon            385..468
                     /gene="Otud4"
                     /gene_synonym="RGD1305606"
                     /inference="alignment:Splign:2.1.0"
     exon            469..519
                     /gene="Otud4"
                     /gene_synonym="RGD1305606"
                     /inference="alignment:Splign:2.1.0"
     exon            520..566
                     /gene="Otud4"
                     /gene_synonym="RGD1305606"
                     /inference="alignment:Splign:2.1.0"
     exon            567..639
                     /gene="Otud4"
                     /gene_synonym="RGD1305606"
                     /inference="alignment:Splign:2.1.0"
     exon            640..721
                     /gene="Otud4"
                     /gene_synonym="RGD1305606"
                     /inference="alignment:Splign:2.1.0"
     exon            722..854
                     /gene="Otud4"
                     /gene_synonym="RGD1305606"
                     /inference="alignment:Splign:2.1.0"
     exon            855..909
                     /gene="Otud4"
                     /gene_synonym="RGD1305606"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1027
                     /gene="Otud4"
                     /gene_synonym="RGD1305606"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1092
                     /gene="Otud4"
                     /gene_synonym="RGD1305606"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1187
                     /gene="Otud4"
                     /gene_synonym="RGD1305606"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1288
                     /gene="Otud4"
                     /gene_synonym="RGD1305606"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1478
                     /gene="Otud4"
                     /gene_synonym="RGD1305606"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1641
                     /gene="Otud4"
                     /gene_synonym="RGD1305606"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1762
                     /gene="Otud4"
                     /gene_synonym="RGD1305606"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1818
                     /gene="Otud4"
                     /gene_synonym="RGD1305606"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..1893
                     /gene="Otud4"
                     /gene_synonym="RGD1305606"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..2032
                     /gene="Otud4"
                     /gene_synonym="RGD1305606"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2287
                     /gene="Otud4"
                     /gene_synonym="RGD1305606"
                     /inference="alignment:Splign:2.1.0"
     exon            2288..2328
                     /gene="Otud4"
                     /gene_synonym="RGD1305606"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..3832
                     /gene="Otud4"
                     /gene_synonym="RGD1305606"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggccgcgt gcggatggcc atgcactagg ctgggctccc ctatgctccg ggagagcgcc
       61 ggccaccgcc tcgggccgcc gccgcctctt cctgccgccg ctcgcagtgt ccgcgtcgga
      121 gccggagccc gagccacagc ctgccccagg cccgggcgtc gagcagccgg cggcgcggcc
      181 atgtggggct agtccgcccc gcgcacgctg cagcggaccg gcaacatgga ggcagctgtc
      241 ggcgcgcccg acggcgtgga ccagggcggc gcgggaccgc tggaggatgc gacgcccatg
      301 gacgcctatc tgcgcaagct gggattgtat cggaaattgg tcgccaagga cgggtcgtgc
      361 ttgttccggg ctgtggccga gcaggtatta cactctcagt ctcgacatgt ggaagttaga
      421 atggcttgta ttcgctacct tcgagataac agagagaaat ttgaagcgtt tatagaaggg
      481 tcatttgaag aatatttaaa acgtttggaa aacccacagg aatgggtagg acaagtggag
      541 ataagcgccc tctctcttat gtacaggaaa gattttgtaa tatatcagga gccaaatgtt
      601 tctccttcgc atgtaactga aaataatttt cctgagaagg tgttactgtg cttttcgaat
      661 ggaaatcatt atgacattgt ctatcctata acatacagag atagttctgc tgtgtgtcag
      721 tctctccttt atgaattgct gtatgagaag gtatttaaaa ctgacgtcag taaaatcatg
      781 atgggactag aaacttctga agtggctgat gaaagcaaca gtgaaatatc agattctgag
      841 gatgacagtt gcaagagtaa aagcactgct gctactgatg tgaatggatt taagtcctca
      901 ggcagtgaga accctaagaa ccatgggaac tcagctgacc ttcctttgtc cagaaaggtt
      961 cttaagtccc tcagcccagc agtctataga aatgtggagt atgaaatttg gttgaagtct
     1021 aagcaagctc aacaaaaacg tgattattcc attgctgctg gcttacaata tgaaggagga
     1081 gagagatgcc atgttagatt ggatcataat gggaagttat ctaatgcaga cattcatggg
     1141 gttcactctg agaatggacc ggttttgtct gaagaactgg ggaaaaagca aacaccgaag
     1201 aacctcaagc cacctccccc agaaagctgg aacacggtgt ccggaaagaa gatgaaaaaa
     1261 cctaattctg ggcaaaattt ccattcagat acggattaca gagggccaaa gaatctaaac
     1321 aagccaatca aagccccgtc tgcactacct cctcgcctgc agcatcctcc agcgggtgta
     1381 aggcagcacg cgctctccag tcattctacg gggccccagt ctcagaaatc ctccagtgag
     1441 cataagaatc taagtcgggt gccatcacag atcacaagaa aacctgatcg tgaaagagct
     1501 gaggactttg atcatgtgag tcgtgaatct tactattttg gcctctcgcc agaagaacgc
     1561 agagagaagc aagctattga agagtctcgg ctactctatg agattcagaa ccgggatgaa
     1621 caggcttttc cggctctttc tagttcatca gtcagtcagt cacctcagaa tagcaacgcg
     1681 tgcgtcccaa ggaagtcttc acatgcgagg gacaggaaag gaagcatgcg gagagtagat
     1741 gcagaggaac ggaaggacaa agactctcta cgtggccata ctcacatgga taaaaaaccc
     1801 gagccaagca cactggagat cagcgatgat aaatgtacaa gagtttcatc accatctaag
     1861 tcaaagaaag agtgcccatc tcctgtagaa caaaagccag cagaacatat acctttgtca
     1921 aatccagccc ccctcctagt ctctccagaa gttcatctca ctcctgcggt gccttcttta
     1981 ccagccactg tgccagcctg gccaagtgaa cccacaactt tcggaccaac aggtgtccct
     2041 gctcagattc ccattttgtc agtgacacag accactggac ctgatgctgc cgtgtcacaa
     2101 gcgcatttaa caccctctcc ggttcctgtg tcaattcagg cagttaacca gcccttgatg
     2161 cctttgcctc agacaatgag cctctatcaa gacccactct atcctgggtt tccttgtagt
     2221 gagaagggag atcgagccat tgcaccaccc tattcactgt gtcagaccgg cgaggacctg
     2281 cctaaagata agaatattct tcgattcttc ttcaatcttg gtgtaaaggc atatagttgc
     2341 cctatgtggg ccccacactc ttacctgtat cctctgcacc aggcgtacat ggcagcctgc
     2401 agggtgtacc caaaggtccc tgttcctgtg tatcctcaga gtacttggtt ccaagaagcc
     2461 cctcctgctc agagtgaaag tgactgcccc tgtgctgacg cccactactc tatgcaccct
     2521 gaggccagtg ttaatggcca gatgccacag gcagagatcg gaccacctgc gttttcttcc
     2581 cctctggtta tccctccatc tcaggtgtct gaaggtcatg gacagttgtc ttaccaacct
     2641 gaactggagt ctgagagccc agggcagctt cttcacgctg agtatgaaga gtcacttagc
     2701 ggcaagaaca tgtacccaca gcagtccttt gggcctaatc cattcttagg tcctgttccc
     2761 attgcacctc ctttcttccc tcatgtttgg tatgggtatc cttttcaggg atttgtggaa
     2821 aatcctgtaa tgaggcaaaa tattgtcctg ccccctgatg ataaaggaga gttggatttg
     2881 cctttggaaa atctagatct gtctaaagag tgcgattctg tctcagcagt agacgagttc
     2941 ccagaagcca gagttgaagg cgcacattct ctctctgaag caagtgtgag cagcaagcat
     3001 gaaggccggg tggagcagtc gtcccagacg cggaaggcag acatagactt gtcttcaggt
     3061 tcttctggag tggagggaaa ggctcacccc cctactcaga ttctaaaccg agagagagag
     3121 gctgtgtctg ctgaacctga gcctaagagg accattcaaa gtctgaaaga aaaaccagag
     3181 aaagtcaaag accccaagac tgctgccgat gtgctcagct ctggggccaa ctctgtggat
     3241 agattgcaaa gaccaaaaga agagagttca gaagatgaga acgaagtgtc taatattttg
     3301 agaagtggca gatccaagca gttttataat caaacttatg gaagcaggaa gtacaaaagt
     3361 gattggggct cttctggtag aggtggctat caacatgtga gaggcgagga gtcctggaaa
     3421 gggcagccta acagaagccg ggatgaaggt tatcagtacc atcgacatgt tagaggacgc
     3481 ccttacaggg gagataggag gaggtcaggg atgggagatg gccacagggg acaacacact
     3541 taatggctgg ttgtcgctcg tactgtagag ctctagcctt ttcttaggtg gaatatttct
     3601 gaaggcttta aaatcattat aataaaaacc caaattggaa ctatctcctc ccctcccctt
     3661 ttccccttaa tttcctattc tgatgagact ttggacataa gtttaagggg cagatgaatt
     3721 tttggcattg tggttttttc ttactcagaa tctgtttatt gggttactgc ccccataaga
     3781 agtaaacatg acttttaagt atttttttat aaacagctca atataaaaca ta
//
