LOCUS       NM_001191983            1528 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus OTU deubiquitinase 3 (Otud3), mRNA.
ACCESSION   NM_001191983 XM_575939
VERSION     NM_001191983.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1528)
  AUTHORS   Yuan,L., Lv,Y., Li,H., Gao,H., Song,S., Zhang,Y., Xing,G., Kong,X.,
            Wang,L., Li,Y., Zhou,T., Gao,D., Xiao,Z.X., Yin,Y., Wei,W., He,F.
            and Zhang,L.
  TITLE     Deubiquitylase OTUD3 regulates PTEN stability and suppresses
            tumorigenesis
  JOURNAL   Nat Cell Biol 17 (9), 1169-1181 (2015)
   PUBMED   26280536
REFERENCE   2  (bases 1 to 1528)
  AUTHORS   Mevissen,T.E., Hospenthal,M.K., Geurink,P.P., Elliott,P.R.,
            Akutsu,M., Arnaudo,N., Ekkebus,R., Kulathu,Y., Wauer,T., El
            Oualid,F., Freund,S.M., Ovaa,H. and Komander,D.
  TITLE     OTU deubiquitinases reveal mechanisms of linkage specificity and
            enable ubiquitin chain restriction analysis
  JOURNAL   Cell 154 (1), 169-184 (2013)
   PUBMED   23827681
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Jul 17, 2010 this sequence version replaced XM_575939.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.31151.1,
                                           SRR22582419.1487335.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-218               JAXUCZ010000005.1  156445124-156445341 c
            219-367             JAXUCZ010000005.1  156440925-156441073 c
            368-480             JAXUCZ010000005.1  156434622-156434734 c
            481-603             JAXUCZ010000005.1  156431446-156431568 c
            604-723             JAXUCZ010000005.1  156426235-156426354 c
            724-820             JAXUCZ010000005.1  156425323-156425419 c
            821-1005            JAXUCZ010000005.1  156424601-156424785 c
            1006-1528           JAXUCZ010000005.1  156423332-156423854 c
FEATURES             Location/Qualifiers
     source          1..1528
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1528
                     /gene="Otud3"
                     /gene_synonym="RGD1560468"
                     /note="OTU deubiquitinase 3"
                     /db_xref="GeneID:500572"
                     /db_xref="RGD:1560468"
     CDS             1..1179
                     /gene="Otud3"
                     /gene_synonym="RGD1560468"
                     /EC_number="3.4.19.12"
                     /note="OTU domain containing 3"
                     /codon_start=1
                     /product="OTU domain-containing protein 3"
                     /protein_id="NP_001178912.1"
                     /db_xref="GeneID:500572"
                     /db_xref="RGD:1560468"
                     /translation="MSRKQAAKSRPGSGGRRAEAERKRDERAARRALAKERRNRPEPG
                     SSGCEEEFVSFANQLQALGLKLREVPGDGNCLFRALGDQLEGHSRNHLKHRQETVDYM
                     IRQREDFEPFVEDDIPFEKHVASLAKPGTFAGNDAIVAFARNHQLNVVIHQLNAPLWQ
                     IRGTDKSSARELHIAYRYGEHYDSVRRINDNSEAPAHLLTDFQMLHQDRTNKKEKMKT
                     QGDSLRDDMEDAVQKAGSATGCTDSNLIVQNLEAESHTIEPSVTALLQMNQGTSKDAE
                     KSLEPGDRVKQRGPSCEEAGGGSRLSGNQGRNEGRVETSEARASPGEESRARKKSQCP
                     KVTNKQRREQQRLEKKKRQEERHRLKALENRNGSRDRGREADVNTQVTLVKTFAALNI
                     "
     exon            1..218
                     /gene="Otud3"
                     /gene_synonym="RGD1560468"
                     /inference="alignment:Splign:2.1.0"
     exon            219..367
                     /gene="Otud3"
                     /gene_synonym="RGD1560468"
                     /inference="alignment:Splign:2.1.0"
     exon            368..480
                     /gene="Otud3"
                     /gene_synonym="RGD1560468"
                     /inference="alignment:Splign:2.1.0"
     exon            481..603
                     /gene="Otud3"
                     /gene_synonym="RGD1560468"
                     /inference="alignment:Splign:2.1.0"
     exon            604..723
                     /gene="Otud3"
                     /gene_synonym="RGD1560468"
                     /inference="alignment:Splign:2.1.0"
     exon            724..820
                     /gene="Otud3"
                     /gene_synonym="RGD1560468"
                     /inference="alignment:Splign:2.1.0"
     exon            821..1005
                     /gene="Otud3"
                     /gene_synonym="RGD1560468"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1528
                     /gene="Otud3"
                     /gene_synonym="RGD1560468"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtcccgaa agcaagcggc gaagagccgg ccgggcagcg gcggccgcag agccgaggcg
       61 gagcgcaagc gggacgagcg ggcagcgcgc cgggcgctgg ccaaggagcg gcggaaccgg
      121 ccggagcctg gcagcagcgg ctgcgaagaa gagtttgtga gcttcgccaa ccaactgcag
      181 gccctgggac tgaagctgcg ggaggtgccg ggggacggca attgcctgtt cagagcgctg
      241 ggcgaccagt tggagggcca ttctcggaac catctgaagc accgacagga gaccgtggac
      301 tacatgataa ggcagcgtga agattttgag ccctttgtgg aagatgacat cccctttgag
      361 aagcatgtgg ccagtttggc aaagcctggt acttttgctg gcaatgatgc aattgtagcg
      421 tttgcaagaa accatcagtt gaatgtggtg atccatcaac ttaatgcccc tttgtggcag
      481 attcgaggca cagacaagag cagcgcgagg gagctccaca tcgcctaccg gtacggggaa
      541 cactatgaca gcgtccggag gatcaatgac aactcagaag cgccagctca tctcctaact
      601 gacttccaga tgcttcatca agatagaaca aataaaaaag agaaaatgaa gacacaaggg
      661 gacagtctga gagatgacat ggaagatgct gtccagaaag ctggcagtgc aactggatgc
      721 acggattcta acttaatagt ccagaacctg gaagctgaga gtcacactat cgagccttca
      781 gtaaccgccc tgcttcagat gaaccagggg acaagcaagg atgcggagaa gagccttgag
      841 cctggtgaca gagtgaagca gcgtggccct tcgtgtgagg aggcaggcgg cggctccaga
      901 ctctctggaa atcagggcag aaacgaaggc agagtggaga ccagtgaggc tcgggccagc
      961 cctggtgaag agagcagagc gcgtaagaag agccagtgcc cgaaggtcac aaacaagcag
     1021 cggagggaac aacagcggct ggagaagaag aagcgtcagg aggagaggca ccgcctcaaa
     1081 gccctggaga acagaaatgg cagcagagac cggggcagag aagcagacgt gaacacgcag
     1141 gtcaccttgg tgaagacctt cgctgctctg aacatctgac tctcgcaccc gagagctgaa
     1201 cgatgcacat tgcagacaag gcttcccagc cacgtgtccc ctgaggatga gacaactgtc
     1261 agcacccaca cacgagcccg aggagccagt gtccttcaag ctgcctcttt ctctcctgtg
     1321 ctctgttgtg tgagagtgtg gtgacaccat tcaccttctg gaactcaaac aaaatactaa
     1381 gtcataggtg ggtcatgggg ccaggaggct tcgcttgccc tgcgaatcag agtgtggtgg
     1441 ctctaggctc ttcccttgat gcgtgagggg ggttccttgt aataattctt gaagtcgtta
     1501 gcacaatcat tagacatctt catgacaa
//
