LOCUS       NM_001106332            1687 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus OTU deubiquitinase, ubiquitin aldehyde binding 1
            (Otub1), mRNA.
ACCESSION   NM_001106332 XM_001072480 XM_215178
VERSION     NM_001106332.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1687)
  AUTHORS   Xie,L., Li,A., Shen,J., Cao,M., Ning,X., Yuan,D., Ji,Y., Wang,H.
            and Ke,K.
  TITLE     OTUB1 attenuates neuronal apoptosis after intracerebral hemorrhage
  JOURNAL   Mol Cell Biochem 422 (1-2), 171-180 (2016)
   PUBMED   27629786
  REMARK    GeneRIF: OTUB1 may play a role in protecting the brain from
            secondary damage following intracerebral hemorrhage.
REFERENCE   2  (bases 1 to 1687)
  AUTHORS   Panier,S. and Durocher,D.
  TITLE     Push back to respond better: regulatory inhibition of the DNA
            double-strand break response
  JOURNAL   Nat Rev Mol Cell Biol 14 (10), 661-672 (2013)
   PUBMED   24002223
  REMARK    Review article
REFERENCE   3  (bases 1 to 1687)
  AUTHORS   Mevissen,T.E., Hospenthal,M.K., Geurink,P.P., Elliott,P.R.,
            Akutsu,M., Arnaudo,N., Ekkebus,R., Kulathu,Y., Wauer,T., El
            Oualid,F., Freund,S.M., Ovaa,H. and Komander,D.
  TITLE     OTU deubiquitinases reveal mechanisms of linkage specificity and
            enable ubiquitin chain restriction analysis
  JOURNAL   Cell 154 (1), 169-184 (2013)
   PUBMED   23827681
REFERENCE   4  (bases 1 to 1687)
  AUTHORS   Zhang,Y., Hu,R., Wu,H., Jiang,W., Sun,Y., Wang,Y., Song,Y., Jin,T.,
            Zhang,H., Mao,X., Zhao,Z. and Zhang,Z.
  TITLE     OTUB1 overexpression in mesangial cells is a novel regulator in the
            pathogenesis of glomerulonephritis through the decrease of DCN
            level
  JOURNAL   PLoS One 7 (1), e29654 (2012)
   PUBMED   22279542
  REMARK    GeneRIF: Data show that the overexpression of OTUB1 enhanced the
            ubiquitination and degradation of Decorin (DCN)in mesangial cells
            (MC).
REFERENCE   5  (bases 1 to 1687)
  AUTHORS   Nakada,S., Tai,I., Panier,S., Al-Hakim,A., Iemura,S., Juang,Y.C.,
            O'Donnell,L., Kumakubo,A., Munro,M., Sicheri,F., Gingras,A.C.,
            Natsume,T., Suda,T. and Durocher,D.
  TITLE     Non-canonical inhibition of DNA damage-dependent ubiquitination by
            OTUB1
  JOURNAL   Nature 466 (7309), 941-946 (2010)
   PUBMED   20725033
REFERENCE   6  (bases 1 to 1687)
  AUTHORS   Wang,T., Yin,L., Cooper,E.M., Lai,M.Y., Dickey,S., Pickart,C.M.,
            Fushman,D., Wilkinson,K.D., Cohen,R.E. and Wolberger,C.
  TITLE     Evidence for bidentate substrate binding as the basis for the K48
            linkage specificity of otubain 1
  JOURNAL   J Mol Biol 386 (4), 1011-1023 (2009)
   PUBMED   19211026
REFERENCE   7  (bases 1 to 1687)
  AUTHORS   Edelmann,M.J., Iphofer,A., Akutsu,M., Altun,M., di Gleria,K.,
            Kramer,H.B., Fiebiger,E., Dhe-Paganon,S. and Kessler,B.M.
  TITLE     Structural basis and specificity of human otubain 1-mediated
            deubiquitination
  JOURNAL   Biochem J 418 (2), 379-390 (2009)
   PUBMED   18954305
REFERENCE   8  (bases 1 to 1687)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473953.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_215178.4, XM_001072480.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166771.1, FQ229739.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1687
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..1687
                     /gene="Otub1"
                     /note="OTU deubiquitinase, ubiquitin aldehyde binding 1"
                     /db_xref="GeneID:293705"
                     /db_xref="RGD:1311329"
     exon            1..83
                     /gene="Otub1"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..841
                     /gene="Otub1"
                     /EC_number="3.4.19.12"
                     /note="OTU domain, ubiquitin aldehyde binding 1;
                     otubain-1; deubiquitinating enzyme OTUB1;
                     ubiquitin-specific-processing protease OTUB1; OTU
                     domain-containing ubiquitin aldehyde-binding protein 1"
                     /codon_start=1
                     /product="ubiquitin thioesterase OTUB1"
                     /protein_id="NP_001099802.1"
                     /db_xref="GeneID:293705"
                     /db_xref="RGD:1311329"
                     /translation="MAAEEPQQQKQEPLGSDSEGVNCLAYDEAIMAQQDRIQQEIAVQ
                     NPLVSERLELSVLYKEYAEDDNIYQQKIKDLHKKYSYIRKTRPDGNCFYRAFGFSHLE
                     ALLDDSKELQRFKAVSAKSKEDLVSQGFTEFTIEDFHNTFMDLIEQVEKQTSVADLLA
                     SFNDQSTSDYLVVYLRLLTSGYLQRESKFFEHFIEGGRTVKEFCQQEVEPMCKESDHI
                     HIIALAQALSVSIQVEYMDRGEGGTTNPHVFPEGSEPKVYLLYRPGHYDILYK"
     exon            84..145
                     /gene="Otub1"
                     /inference="alignment:Splign:2.1.0"
     exon            146..244
                     /gene="Otub1"
                     /inference="alignment:Splign:2.1.0"
     exon            245..363
                     /gene="Otub1"
                     /inference="alignment:Splign:2.1.0"
     exon            364..448
                     /gene="Otub1"
                     /inference="alignment:Splign:2.1.0"
     exon            449..643
                     /gene="Otub1"
                     /inference="alignment:Splign:2.1.0"
     exon            644..1687
                     /gene="Otub1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcgccagtg cagcgctgtt taaagatggc ggcggaggaa cctcagcagc agaagcagga
       61 gccgctgggc agcgattccg aaggtgttaa ctgtctagcc tatgatgaag ccattatggc
      121 tcagcaagac cggattcagc aagagattgc tgtgcagaat cctctggtgt cagagcgact
      181 ggaactctca gttctgtata aggagtatgc tgaggatgac aacatttacc aacagaagat
      241 caaggacctc cacaaaaagt actcctacat acggaagacc aggcccgacg ggaactgctt
      301 ctatcgagcg tttggcttct cccacttgga ggcactgctc gatgacagca aggaactgca
      361 gcggttcaaa gccgtgtctg ccaagagtaa agaggacctg gtgtcccagg gcttcactga
      421 attcacaatc gaggacttcc acaacacatt catggacctt atcgagcagg tggagaagca
      481 gacctcagta gctgacctgc tggcctcctt caacgaccag agcacctcag actaccttgt
      541 ggtctacctg cgactgctca cctcaggcta cctgcagcgg gagagcaagt tcttcgagca
      601 cttcatagag ggtggccgga ctgttaagga gttctgccag caggaggtgg aacccatgtg
      661 caaggagagc gaccacatcc acatcatcgc cctggcccag gccctcagtg tgtccatcca
      721 ggtggagtac atggaccgcg gcgagggcgg caccaccaat ccacacgtct tccccgaggg
      781 ctctgagccc aaggtctacc tgctctaccg acctggacac tacgatatcc tctacaaatg
      841 accggctggc ctaccgcgcc ctgcctgcct cccctgccag gcgctagaca tgtacagagg
      901 gttttttctt ttcttttttc tttctttttt tttttttttt gtgtggttgt aaatggtcat
      961 atttcactcc tcccttttcc tgtcatagaa ccttccatgt tttattaaag gggatgctgg
     1021 tggtgagcct gagtgtgcgt ttccctgctc tgctgccctt ccctacctgc ccgctggctg
     1081 ctgtgtgtct ggctgtccct ttccctaaga caggtacccc agcttccacc tatgtactgc
     1141 caggcattcc tgccaggaga tgtttgaagg ggactaggcc tccatgggcc ccttctggct
     1201 tcttgaagtt ctgctttcta cccatacttc tgccctttct ctttaacctc cccagggttc
     1261 ctgtgggaac tgtgggaagt tccttgggaa cttgaccaga gctctcaagc tccatactca
     1321 aagcacttct agccagggcc ccagatcaca cctctctgcc caccctcagg gtctgcatga
     1381 ttgaggagtc ctggggtgag aggcttatgg ggggagactg gcctagagta ggtggaggag
     1441 ctaggcatcc tcagtgggcc cttggagaag ctgacctggt gtgagagaaa cattctagta
     1501 gggcttgcct gttacctgtt tcccagagcc cctgcctgtg cttgctctgt accccctctg
     1561 cttgggccat atctgcatta cctgcctcgt tgccttctcc ccacccccag cacatgtggg
     1621 gtctcagccc aggctgtgag ctccttgggg gcaggccctc aataaatgtg aagtgctgct
     1681 gccgctg
//
