LOCUS       NM_001100523            1391 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus orthopedia homeobox (Otp), mRNA.
ACCESSION   NM_001100523 XM_001059871
VERSION     NM_001100523.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1391)
  AUTHORS   Ryu,S., Mahler,J., Acampora,D., Holzschuh,J., Erhardt,S.,
            Omodei,D., Simeone,A. and Driever,W.
  TITLE     Orthopedia homeodomain protein is essential for diencephalic
            dopaminergic neuron development
  JOURNAL   Curr Biol 17 (10), 873-880 (2007)
   PUBMED   17481897
  REMARK    Erratum:[Curr Biol. 2008 Feb 26;18(4):310]
REFERENCE   2  (bases 1 to 1391)
  AUTHORS   Acampora,D., Postiglione,M.P., Avantaggiato,V., Di Bonito,M.,
            Vaccarino,F.M., Michaud,J. and Simeone,A.
  TITLE     Progressive impairment of developing neuroendocrine cell lineages
            in the hypothalamus of mice lacking the Orthopedia gene
  JOURNAL   Genes Dev 13 (21), 2787-2800 (1999)
   PUBMED   10557207
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Jan 15, 2010 this sequence version replaced XM_001059871.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760393, SAMN12840113
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-180               JAXUCZ010000002.1  27842892-27843071
            181-590             JAXUCZ010000002.1  27844326-27844735
            591-1391            JAXUCZ010000002.1  27850293-27851093
FEATURES             Location/Qualifiers
     source          1..1391
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q12"
     gene            1..1391
                     /gene="Otp"
                     /note="orthopedia homeobox"
                     /db_xref="GeneID:294640"
                     /db_xref="RGD:727945"
     exon            1..180
                     /gene="Otp"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..1121
                     /gene="Otp"
                     /note="orthopedia homolog"
                     /codon_start=1
                     /product="homeobox protein orthopedia"
                     /protein_id="NP_001093993.1"
                     /db_xref="GeneID:294640"
                     /db_xref="RGD:727945"
                     /translation="MLSHADLLDARLGMKDAAELLGHREAVKCRLGVGGSDPGGHPGD
                     LAPNSDPVEGATLLPGEDITTVGSTPASLAVSAKDPDKQPGPQGGPNPSQAGQQQGQQ
                     KQKRHRTRFTPAQLNELERSFAKTHYPDIFMREELALRIGLTESRVQVWFQNRRAKWK
                     KRKKTTNVFRAPGTLLPTPGLPQFPSAAAAAAAAMGDSLCSFHANDTRWAAAAMPGVS
                     QLPLPPALGRQQAMAQSLSQCSLAAGPPPNSMGLSNSLAGSNGAGLQSHLYQPAFPGM
                     VPASLPGPSNVSGSPQLCSSPDSSDVWRGTSIASLRRKALEHTVSMSFT"
     exon            181..590
                     /gene="Otp"
                     /inference="alignment:Splign:2.1.0"
     exon            591..1391
                     /gene="Otp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttttaacca caaaccgaat tttctttcat ttaggtgatc tatatatatc tatatcgtat
       61 agcttatagc ttatatctat tttaaataac ttaaagccgc taaaatttgg gggggaacag
      121 ctttcgccct ggagcggtgc gcgatgctgt ctcacgccga cctcctggac gccaggctag
      181 gtatgaaaga tgccgccgag cttctgggcc accgggaggc ggtgaagtgt aggctgggcg
      241 tggggggctc tgaccctggg ggccatccag gggacctggc gcccaactcc gacccagtcg
      301 aaggagccac tctgctgccg ggcgaggaca tcaccaccgt gggctctact cctgcttcgc
      361 tggcggtgag cgccaaagac ccagacaagc agccggggcc ccagggcggc cccaacccca
      421 gccaagccgg ccagcagcag ggccaacaga aacagaagcg ccaccggaca cgcttcaccc
      481 cagcgcagct caacgaattg gagaggagct tcgccaagac tcactacccc gacatcttta
      541 tgcgtgagga gctagcgctg cgtatcgggc tgaccgaatc gcgagtgcag gtctggttcc
      601 agaatcgccg cgccaagtgg aagaagcgca agaagaccac caacgtgttc cgcgcgcccg
      661 gcacgctgct gcccacgccg gggctgcccc agttcccgtc ggccgccgcc gccgcggccg
      721 ccgccatggg cgacagcctg tgctctttcc acgccaacga cacccgctgg gcggcggccg
      781 ccatgcccgg ggtgtcccag ctccctctgc cgcctgcgct cggccgccag caggccatgg
      841 cgcagtcgct gtcccagtgc agcctggcgg cggggccacc gcccaactcc atgggtttgt
      901 ccaacagcct ggcgggctcc aacggagcgg ggctgcagtc gcacctctac cagcccgcct
      961 tccccggcat ggtgcccgct tccctccccg gccccagcaa cgtctccggc tcgccccagc
     1021 tctgcagctc tccggacagc agcgacgtgt ggcggggcac gagcatcgcc tccctgcgcc
     1081 gcaaggcgct cgagcacaca gtctccatga gcttcaccta atgccgccgc gcgccgcccg
     1141 ctgcgcccgg gcgccgcccc cgtcccctcc cccagaaccc cggccgcgcg cgccgggatg
     1201 ccagcccctc cccttccccg gtgtcctccg tccttcccga gccccggcga ggtcgcctcc
     1261 cgagttccct ccccgagccc ggctcccctc gccccgtgct gcccgccgcc tcggcctccc
     1321 gctcgcccag gtcgtgctcg cgccctcctc ccggcctctg ccaggcggcg acccgggcca
     1381 cacttcggtc a
//
