LOCUS       NM_181433               1827 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus otopetrin 1 (Otop1), mRNA.
ACCESSION   NM_181433
VERSION     NM_181433.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1827)
  AUTHORS   Tu,Y.H., Cooper,A.J., Teng,B., Chang,R.B., Artiga,D.J.,
            Turner,H.N., Mulhall,E.M., Ye,W., Smith,A.D. and Liman,E.R.
  TITLE     An evolutionarily conserved gene family encodes proton-selective
            ion channels
  JOURNAL   Science 359 (6379), 1047-1050 (2018)
   PUBMED   29371428
REFERENCE   2  (bases 1 to 1827)
  AUTHORS   Wang,G.X., Cho,K.W., Uhm,M., Hu,C.R., Li,S., Cozacov,Z., Xu,A.E.,
            Cheng,J.X., Saltiel,A.R., Lumeng,C.N. and Lin,J.D.
  TITLE     Otopetrin 1 protects mice from obesity-associated metabolic
            dysfunction through attenuating adipose tissue inflammation
  JOURNAL   Diabetes 63 (4), 1340-1352 (2014)
   PUBMED   24379350
REFERENCE   3  (bases 1 to 1827)
  AUTHORS   Hurle,B., Ignatova,E., Massironi,S.M., Mashimo,T., Rios,X.,
            Thalmann,I., Thalmann,R. and Ornitz,D.M.
  TITLE     Non-syndromic vestibular disorder with otoconial agenesis in
            tilted/mergulhador mice caused by mutations in otopetrin 1
  JOURNAL   Hum Mol Genet 12 (7), 777-789 (2003)
   PUBMED   12651873
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BK000651.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK000651.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN09345238
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1827
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..1827
                     /gene="Otop1"
                     /note="otopetrin 1"
                     /db_xref="GeneID:305427"
                     /db_xref="RGD:631389"
     exon            1..421
                     /gene="Otop1"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..1827
                     /gene="Otop1"
                     /codon_start=1
                     /product="proton channel OTOP1"
                     /protein_id="NP_852098.1"
                     /db_xref="GeneID:305427"
                     /db_xref="RGD:631389"
                     /translation="MPGDRGALSSPAASSGSPSAAPSGIAACPPPPSPLARASPQASG
                     PRRGASVPQKLAETLSSQYGLNVFVAGLLFLLAWAVHATGVGKSDLLCVLTALMLLQL
                     LWMLWYVGRSYMQRRLIRPKDTHAGARWLRGSITLFAFITIVLGCLKVAYFIGFSECL
                     SATEGVFPVTHAVHTLLQVYFLWGHAKDIIMSFKTLERFGVIHSVFTNLLLWANSVLN
                     ESKHQLNEHKERLITLGFGNITIVLDDHTPQCNCTPPALCSALSHGIYYLYPFNIEYQ
                     ILASTMLYVLWKNIGRRVDSSRHQKMQCRFDGVLVGSVLGLTVLAATIAVVVVYMIHI
                     GRSKSKSESALIMFYLYAITVLLLMGAAGLVGSWIYRVDEKSLDESKNPARKLDADLL
                     VATASGSWLLSWGSILAIACAETRPPYTWYNLPYSVLVIVEKYVQNIFIIESVHLEPE
                     GVPEDVRTLRVVTVCSGEAAALAASSLGSQGTAQDGSPAVNGNLHLQQRCEKEDQEAD
                     WEGATGTTRCLDFLQGGMKRRLLRNITAFLFLCNISLWIPPAFGCRPEYDNGLEEIVF
                     GFEPWIIVVNLAMPFSIFYRMHAAAALFEVYCKI"
     exon            422..558
                     /gene="Otop1"
                     /inference="alignment:Splign:2.1.0"
     exon            559..617
                     /gene="Otop1"
                     /inference="alignment:Splign:2.1.0"
     exon            618..748
                     /gene="Otop1"
                     /inference="alignment:Splign:2.1.0"
     exon            749..1656
                     /gene="Otop1"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1827
                     /gene="Otop1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgcctggg gaccagactg gaagatgcct ggggaccggg gcgcactatc ttctcccgca
       61 gcatcatcag gctccccgag tgccgcgccg tcggggatcg ccgcatgccc tccgcccccg
      121 tctcccctag cccgggcgtc tccacaagct tccggtcccc gacgcggtgc cagcgtcccg
      181 cagaagctgg cggagactct gagcagccag tatggactga acgtgttcgt ggcggggctt
      241 cttttcctgc tggcctgggc ggtgcacgcg acgggtgtgg gcaagagcga cctgttgtgc
      301 gtattaaccg cactcatgct gctgcagctg ctctggatgc tgtggtacgt gggtcgcagc
      361 tacatgcagc gccgcctcat ccgccccaag gacacgcacg cgggtgcgcg ctggctccgc
      421 ggaagcatca cattgttcgc attcatcacc atcgtcctgg ggtgcctgaa agtcgcatac
      481 ttcattggat tctcagagtg cttgtcagct acagagggag ttttcccagt cacccatgca
      541 gtgcatacat tgttgcaggt ctattttctc tggggccacg ctaaagatat tatcatgtct
      601 ttcaaaacac tggaaaggtt tggggtgatc cattcagtgt tcacaaacct gctgctgtgg
      661 gccaacagcg tcctgaatga gtcaaaacac cagctgaatg aacacaagga acggctgatc
      721 actctgggct tcggcaacat caccatagtt ttggatgacc acacaccaca gtgtaactgc
      781 acaccgcctg ccctctgctc tgccctctcc cacgggattt actatctgta ccccttcaac
      841 attgagtacc agatcctggc ctcgaccatg ctctatgtgc tgtggaagaa cattgggcgc
      901 agggtggaca gctcccggca ccagaagatg cagtgcagat tcgacggggt cctggtgggc
      961 tcagtgctgg gcctgacagt gctggctgcc accatcgcgg tggttgtggt gtacatgatc
     1021 catatcgggc gctccaagtc caagagtgag tcggctctta tcatgttcta tttgtatgcg
     1081 atcacggtgc tgctgctcat gggggctgcg gggctggtag gaagctggat ttacagggtg
     1141 gatgagaagt ctctggatga gtcaaagaac ccagcccgca agctggatgc tgacctcttg
     1201 gtggccactg cctcgggttc ctggctcctc tcctggggtt ccattttggc catcgcctgc
     1261 gctgagaccc gcccaccgta cacctggtac aacctcccct actctgtcct ggtgatcgtg
     1321 gagaagtacg tccagaacat tttcatcatt gagtcggtgc acctcgagcc tgagggggtc
     1381 cccgaggatg tgcgcactct gcgtgtggtc accgtctgca gtggggaggc tgctgcactg
     1441 gctgcatcga gtctcgggag ccaggggacg gcccaggatg ggtcacctgc tgtcaatggg
     1501 aatctgcatc tgcagcagag gtgtgagaaa gaggaccagg aggctgactg ggaaggagct
     1561 acggggacaa cccgatgtct ggacttcctt cagggaggca tgaagaggag gctgctcaga
     1621 aacatcacag cctttctgtt cctttgcaac atctcgcttt ggattccccc tgcctttggc
     1681 tgccgtcccg agtatgacaa cggactggag gaaattgtct ttggctttga accctggata
     1741 attgtggtca acctggccat gcccttctcc attttctaca ggatgcacgc agctgccgcc
     1801 ctctttgagg tctattgtaa aatctag
//
