LOCUS       NP_852098                600 aa            linear   ROD 02-APR-2025
DEFINITION  proton channel OTOP1 [Rattus norvegicus].
ACCESSION   NP_852098
VERSION     NP_852098.1
DBSOURCE    REFSEQ: accession NM_181433.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 600)
  AUTHORS   Tu,Y.H., Cooper,A.J., Teng,B., Chang,R.B., Artiga,D.J.,
            Turner,H.N., Mulhall,E.M., Ye,W., Smith,A.D. and Liman,E.R.
  TITLE     An evolutionarily conserved gene family encodes proton-selective
            ion channels
  JOURNAL   Science 359 (6379), 1047-1050 (2018)
   PUBMED   29371428
REFERENCE   2  (residues 1 to 600)
  AUTHORS   Wang,G.X., Cho,K.W., Uhm,M., Hu,C.R., Li,S., Cozacov,Z., Xu,A.E.,
            Cheng,J.X., Saltiel,A.R., Lumeng,C.N. and Lin,J.D.
  TITLE     Otopetrin 1 protects mice from obesity-associated metabolic
            dysfunction through attenuating adipose tissue inflammation
  JOURNAL   Diabetes 63 (4), 1340-1352 (2014)
   PUBMED   24379350
REFERENCE   3  (residues 1 to 600)
  AUTHORS   Hurle,B., Ignatova,E., Massironi,S.M., Mashimo,T., Rios,X.,
            Thalmann,I., Thalmann,R. and Ornitz,D.M.
  TITLE     Non-syndromic vestibular disorder with otoconial agenesis in
            tilted/mergulhador mice caused by mutations in otopetrin 1
  JOURNAL   Hum Mol Genet 12 (7), 777-789 (2003)
   PUBMED   12651873
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BK000651.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK000651.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN09345238
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..600
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     Protein         1..600
                     /product="proton channel OTOP1"
                     /calculated_mol_wt=65798
     Region          1..50
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7M734.1)"
     Site            57..78
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7M734.1)"
     Site            87..110
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7M734.1)"
     Site            129..151
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7M734.1)"
     Region          131..586
                     /region_name="Otopetrin"
                     /note="pfam03189"
                     /db_xref="CDD:460840"
     Site            162..186
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7M734.1)"
     Site            195..221
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7M734.1)"
     Site            263..288
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7M734.1)"
     Site            310..332
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7M734.1)"
     Site            343..368
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7M734.1)"
     Site            387..411
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7M734.1)"
     Site            422..442
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7M734.1)"
     Site            533..551
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7M734.1)"
     Site            570..593
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7M734.1)"
     Region          584..596
                     /region_name="putative FYR-box"
                     /note="consensus F-Y-R-[FM]-H-[SA]-X3[LF]-X-E-[VI]"
     CDS             1..600
                     /gene="Otop1"
                     /coded_by="NM_181433.1:25..1827"
                     /db_xref="GeneID:305427"
                     /db_xref="RGD:631389"
ORIGIN      
        1 mpgdrgalss paassgspsa apsgiaacpp ppsplarasp qasgprrgas vpqklaetls
       61 sqyglnvfva gllfllawav hatgvgksdl lcvltalmll qllwmlwyvg rsymqrrlir
      121 pkdthagarw lrgsitlfaf itivlgclkv ayfigfsecl sategvfpvt havhtllqvy
      181 flwghakdii msfktlerfg vihsvftnll lwansvlnes khqlnehker litlgfgnit
      241 ivlddhtpqc nctppalcsa lshgiyylyp fnieyqilas tmlyvlwkni grrvdssrhq
      301 kmqcrfdgvl vgsvlgltvl aatiavvvvy mihigrsksk sesalimfyl yaitvlllmg
      361 aaglvgswiy rvdeksldes knparkldad llvatasgsw llswgsilai acaetrppyt
      421 wynlpysvlv ivekyvqnif iiesvhlepe gvpedvrtlr vvtvcsgeaa alaasslgsq
      481 gtaqdgspav ngnlhlqqrc ekedqeadwe gatgttrcld flqggmkrrl lrnitaflfl
      541 cnislwippa fgcrpeydng leeivfgfep wiivvnlamp fsifyrmhaa aalfevycki
//
