LOCUS       NM_013078               1520 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus ornithine transcarbamylase (Otc), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_013078
VERSION     NM_013078.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1520)
  AUTHORS   Wang,W., Zhang,Y., Ding,M., Huang,X., Zhang,M., Gu,Y., Wu,L.,
            Zhang,C., Lu,C., Shen,B., Xing,C. and Song,L.
  TITLE     Circadian oscillation expression of ornithine carbamoyltransferase
            and its significance in sleep disturbance
  JOURNAL   Biochem Biophys Res Commun 559, 217-221 (2021)
   PUBMED   33957483
  REMARK    GeneRIF: Circadian oscillation expression of ornithine
            carbamoyltransferase and its significance in sleep disturbance.
REFERENCE   2  (bases 1 to 1520)
  AUTHORS   Cao,Y., Ding,W., Zhang,J., Gao,Q., Yang,H., Cao,W., Wang,Z.,
            Fang,L. and Du,R.
  TITLE     Significant Down-Regulation of Urea Cycle Generates Clinically
            Relevant Proteomic Signature in Hepatocellular Carcinoma Patients
            with Macrovascular Invasion
  JOURNAL   J Proteome Res 18 (5), 2032-2044 (2019)
   PUBMED   30901224
REFERENCE   3  (bases 1 to 1520)
  AUTHORS   Murayama,H., Ikemoto,M. and Hamaoki,M.
  TITLE     Ornithine carbamyltransferase is a sensitive marker for
            alcohol-induced liver injury
  JOURNAL   Clin Chim Acta 401 (1-2), 100-104 (2009)
   PUBMED   19101528
  REMARK    GeneRIF: Mitochondrion-derived markers, especially OCT, appeared
            superior to cytosol-derived markers in the detection of
            alcohol-induced liver injury.
REFERENCE   4  (bases 1 to 1520)
  AUTHORS   Murayama,H., Ikemoto,M. and Nagata,A.
  TITLE     Marked elevation of serum mitochondrion-derived markers in mild
            models of non-alcoholic steatohepatitis in rats
  JOURNAL   J Gastroenterol Hepatol 24 (2), 270-277 (2009)
   PUBMED   18823438
REFERENCE   5  (bases 1 to 1520)
  AUTHORS   Nagy,G.R., Largiader,C.R., Nuoffer,J.M., Nagy,B., Lazar,L. and
            Papp,Z.
  TITLE     Novel mutation in OTC gene causes neonatal death in twin brothers
  JOURNAL   J Perinatol 27 (2), 123-124 (2007)
   PUBMED   17262046
REFERENCE   6  (bases 1 to 1520)
  AUTHORS   Yamini,S., Carswell,N., Michaelis,O.E. 4th and Szepesi,B.
  TITLE     Adaptation in enzyme (metabolic) pathways to obesity, carbohydrate
            diet and to the occurrence of NIDDM in male and female SHR/N-cp
            rats
  JOURNAL   Int J Obes Relat Metab Disord 16 (10), 765-774 (1992)
   PUBMED   1330956
REFERENCE   7  (bases 1 to 1520)
  AUTHORS   Lim,S.P., Andrews,F.J., Christophi,C. and O'Brien,P.E.
  TITLE     Misoprostol hepatoprotection against ischemia-reperfusion-induced
            liver injury in the rat
  JOURNAL   Dig Dis Sci 37 (8), 1275-1281 (1992)
   PUBMED   1499453
REFERENCE   8  (bases 1 to 1520)
  AUTHORS   McDowall,S., van Heeswijck,R. and Hoogenraad,N.
  TITLE     Site-directed mutagenesis of Arg60 and Cys271 in ornithine
            transcarbamylase from rat liver
  JOURNAL   Protein Eng 4 (1), 73-77 (1990)
   PUBMED   2290837
REFERENCE   9  (bases 1 to 1520)
  AUTHORS   Lee,J.T. and Nussbaum,R.L.
  TITLE     An arginine to glutamine mutation in residue 109 of human ornithine
            transcarbamylase completely abolishes enzymatic activity in Cos1
            cells
  JOURNAL   J Clin Invest 84 (6), 1762-1766 (1989)
   PUBMED   2556444
REFERENCE   10 (bases 1 to 1520)
  AUTHORS   Hodges,P.E. and Rosenberg,L.E.
  TITLE     The spfash mouse: a missense mutation in the ornithine
            transcarbamylase gene also causes aberrant mRNA splicing
  JOURNAL   Proc Natl Acad Sci U S A 86 (11), 4142-4146 (1989)
   PUBMED   2471197
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Nov 26, 2020 this sequence version replaced NM_013078.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M11266.1, K00001.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-177               JAXUCZ010000021.1  15202297-15202473   c
            178-316             JAXUCZ010000021.1  15188966-15189104   c
            317-398             JAXUCZ010000021.1  15187132-15187213   c
            399-486             JAXUCZ010000021.1  15171811-15171898   c
            487-640             JAXUCZ010000021.1  15144654-15144807   c
            641-763             JAXUCZ010000021.1  15141761-15141883   c
            764-817             JAXUCZ010000021.1  15136561-15136614   c
            818-967             JAXUCZ010000021.1  15136326-15136475   c
            968-1105            JAXUCZ010000021.1  15133256-15133393   c
            1106-1520           JAXUCZ010000021.1  15126358-15126772   c
FEATURES             Location/Qualifiers
     source          1..1520
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq12"
     gene            1..1520
                     /gene="Otc"
                     /note="ornithine transcarbamylase"
                     /db_xref="GeneID:25611"
                     /db_xref="RGD:3236"
     exon            1..177
                     /gene="Otc"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..1165
                     /gene="Otc"
                     /EC_number="2.1.3.3"
                     /note="ornithine carbamoyltransferase, mitochondrial;
                     OTCase; ornithine transcarbamylase, mitochondrial"
                     /codon_start=1
                     /product="ornithine transcarbamylase, mitochondrial
                     precursor"
                     /protein_id="NP_037210.1"
                     /db_xref="GeneID:25611"
                     /db_xref="RGD:3236"
                     /translation="MLSNLRILLNKAALRKAHTSMVRNFRYGKPVQSQVQLKGRDLLT
                     LKNFTGEEIQYMLWLSADLKFRIKQKGEYLPLLQGKSLGMIFEKRSTRTRLSTETGFA
                     LLGGHPSFLTTQDIHLGVNESLTDTARVLSSMTDAVLARVYKQSDLDILAKEATIPIV
                     NGLSDLYHPIQILADYLTLQEHYGSLKGLTLSWIGDGNNILHSIMMSAAKFGMHLQAA
                     TPKGYEPDPNIVKLAEQYAKENGTRLSMTNDPLEAARGGNVLITDTWISMGQEDEKKK
                     RLQAFQGYQVTMKTAKVAASDWTFLHCLPRKPEEVDDEVFYSPRSLVFPEAENRKWTI
                     MAVMVSLLTDYSPVLQKPKF"
     exon            178..316
                     /gene="Otc"
                     /inference="alignment:Splign:2.1.0"
     exon            317..398
                     /gene="Otc"
                     /inference="alignment:Splign:2.1.0"
     exon            399..486
                     /gene="Otc"
                     /inference="alignment:Splign:2.1.0"
     exon            487..640
                     /gene="Otc"
                     /inference="alignment:Splign:2.1.0"
     exon            641..763
                     /gene="Otc"
                     /inference="alignment:Splign:2.1.0"
     exon            764..817
                     /gene="Otc"
                     /inference="alignment:Splign:2.1.0"
     exon            818..967
                     /gene="Otc"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1105
                     /gene="Otc"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1520
                     /gene="Otc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgcaactgaa agcattctta gcttgccagt ggcccccact gcctgcctgc ctgcggaact
       61 ctctagacca tagattcctc ctccactcta gcaagagaag atgctgtcta atttgaggat
      121 cctgctcaac aaggcagctc ttagaaaggc tcacacttcc atggttcgaa attttcggta
      181 tgggaagcca gtccagagtc aagtacagct gaaaggccgt gacctcctca ccctgaagaa
      241 cttcacagga gaggagattc agtacatgct atggctctct gcagatctga aattcaggat
      301 caaacagaaa ggagaatact tgcctttatt gcaagggaaa tccttaggga tgatttttga
      361 gaaaagaagt actcgaacaa gactgtccac agaaacaggc ttcgctcttc tgggaggaca
      421 tccttctttt cttaccacac aagacattca cttgggcgtg aatgaaagtc tcacagacac
      481 agctcgtgtg ttatctagca tgacagatgc agtgttagct cgagtgtata aacaatcaga
      541 tctggacatc ctggctaagg aagcaaccat cccaattgtc aacggactgt cagacctgta
      601 tcatcctatc cagatcctgg ctgattacct tacactccag gaacactatg gctctctcaa
      661 aggtctcacc ctcagctgga taggagatgg gaacaatatc ctgcactcca tcatgatgag
      721 tgctgcaaaa ttcgggatgc accttcaagc agctactcca aagggttatg agccagatcc
      781 taatatagtc aagctagcag agcagtatgc caaggagaat ggtaccaggt tgtcaatgac
      841 aaatgatcca ctggaagcag cacgtggagg caatgtatta attacagata cttggataag
      901 catgggacaa gaggatgaga agaaaaagcg tcttcaagct ttccaaggtt accaggttac
      961 aatgaagact gctaaagtgg ctgcgtctga ctggacgttt ttacactgct tgcctagaaa
     1021 gccagaagaa gtagatgatg aagtgtttta ttctccgcgg tcattagtgt tcccagaggc
     1081 agaaaataga aagtggacaa tcatggctgt catggtatcc ctgctgacag actactcacc
     1141 tgtgctccag aagccaaagt tctgatgcct gtcaagagga cgaaaaaccc aaaagacaaa
     1201 aaaatctgtt ctttagcagc agaataagtc agtttatgta gaaaagagaa gaattgaaat
     1261 tgtaaacaca tccctagtgc gtgatataat tatgtaattg ctttgctatt gtgagaattg
     1321 cttaaagctt ttagtttaag tgctgggcat tttattatcc tgcttgactt gacttaagca
     1381 ctctcttcaa ttcacaactt ctgaatgata tttgggtttc atattaatta tcatacacat
     1441 ttccttccac taagcattaa acactatgct tacaatgcat accatctaag tcattaaatg
     1501 taatccatgc ttattacctt
//
