LOCUS       NM_207612               1393 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus osteocrin (Ostn), mRNA.
ACCESSION   NM_207612 XM_008768801 XM_346911
VERSION     NM_207612.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1393)
  AUTHORS   Shimomura,M., Horii,N., Fujie,S., Inoue,K., Hasegawa,N.,
            Iemitsu,K., Uchida,M. and Iemitsu,M.
  TITLE     Decreased muscle-derived musclin by chronic resistance exercise is
            associated with improved insulin resistance in rats with type 2
            diabetes
  JOURNAL   Physiol Rep 9 (9), e14823 (2021)
   PUBMED   33955191
  REMARK    GeneRIF: Decreased muscle-derived musclin by chronic resistance
            exercise is associated with improved insulin resistance in rats
            with type 2 diabetes.
REFERENCE   2  (bases 1 to 1393)
  AUTHORS   Ataman,B., Boulting,G.L., Harmin,D.A., Yang,M.G.,
            Baker-Salisbury,M., Yap,E.L., Malik,A.N., Mei,K., Rubin,A.A.,
            Spiegel,I., Durresi,E., Sharma,N., Hu,L.S., Pletikos,M.,
            Griffith,E.C., Partlow,J.N., Stevens,C.R., Adli,M., Chahrour,M.,
            Sestan,N., Walsh,C.A., Berezovskii,V.K., Livingstone,M.S. and
            Greenberg,M.E.
  TITLE     Evolution of Osteocrin as an activity-regulated factor in the
            primate brain
  JOURNAL   Nature 539 (7628), 242-247 (2016)
   PUBMED   27830782
REFERENCE   3  (bases 1 to 1393)
  AUTHORS   Li,Y.X., Cheng,K.C., Asakawa,A., Kato,I., Sato,Y., Amitani,H.,
            Kawamura,N., Cheng,J.T. and Inui,A.
  TITLE     Role of musclin in the pathogenesis of hypertension in rat
  JOURNAL   PLoS One 8 (8), e72004 (2013)
   PUBMED   23940802
  REMARK    GeneRIF: Musclin is involved in blood pressure regulation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1393)
  AUTHORS   Moffatt,P., Thomas,G., Sellin,K., Bessette,M.C., Lafreniere,F.,
            Akhouayri,O., St-Arnaud,R. and Lanctot,C.
  TITLE     Osteocrin is a specific ligand of the natriuretic Peptide clearance
            receptor that modulates bone growth
  JOURNAL   J Biol Chem 282 (50), 36454-36462 (2007)
   PUBMED   17951249
  REMARK    GeneRIF: Ostn is a naturally occurring ligand of the NPR-C
            clearance receptor and may act to locally modulate the actions of
            the natriuretic system in bone by blocking the clearance action of
            NPR-C, thus locally elevating levels of C-type natriuretic peptide.
REFERENCE   5  (bases 1 to 1393)
  AUTHORS   Banzet,S., Koulmann,N., Sanchez,H., Serrurier,B., Peinnequin,A. and
            Bigard,A.X.
  TITLE     Musclin gene expression is strongly related to fast-glycolytic
            phenotype
  JOURNAL   Biochem Biophys Res Commun 353 (3), 713-718 (2007)
   PUBMED   17189616
  REMARK    GeneRIF: musclin is produced by myocytes in a highly fiber-type
            specific manner and that physiological changes in type IIb myosin
            heavy chain lead to coordinated musclin expression.
REFERENCE   6  (bases 1 to 1393)
  AUTHORS   Nishizawa,H., Matsuda,M., Yamada,Y., Kawai,K., Suzuki,E.,
            Makishima,M., Kitamura,T. and Shimomura,I.
  TITLE     Musclin, a novel skeletal muscle-derived secretory factor
  JOURNAL   J Biol Chem 279 (19), 19391-19395 (2004)
   PUBMED   15044443
REFERENCE   7  (bases 1 to 1393)
  AUTHORS   Thomas,G., Moffatt,P., Salois,P., Gaumond,M.H., Gingras,R.,
            Godin,E., Miao,D., Goltzman,D. and Lanctot,C.
  TITLE     Osteocrin, a novel bone-specific secreted protein that modulates
            the osteoblast phenotype
  JOURNAL   J Biol Chem 278 (50), 50563-50571 (2003)
   PUBMED   14523025
  REMARK    GeneRIF: osteocrin represents a novel, unique vitamin D-regulated
            bone-specific protein that appears to act as a soluble osteoblast
            regulator.
REFERENCE   8  (bases 1 to 1393)
  AUTHORS   Pattee,J.J.
  TITLE     Training objectives of a well developed geriatrics program
  JOURNAL   J Am Geriatr Soc 26 (4), 167-169 (1978)
   PUBMED   632499
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On or before Oct 22, 2022 this sequence version replaced
            XM_008768801.3, NM_207612.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FN805604.1, SRR26643296.29959.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676806 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-184               JAXUCZ010000011.1  86983139-86983322   c
            185-283             JAXUCZ010000011.1  86973327-86973425   c
            284-498             JAXUCZ010000011.1  86969822-86970036   c
            499-595             JAXUCZ010000011.1  86951272-86951368   c
            596-1393            JAXUCZ010000011.1  86947023-86947820   c
FEATURES             Location/Qualifiers
     source          1..1393
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q22"
     gene            1..1393
                     /gene="Ostn"
                     /note="osteocrin"
                     /db_xref="GeneID:360730"
                     /db_xref="RGD:1303110"
     exon            1..184
                     /gene="Ostn"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..583
                     /gene="Ostn"
                     /note="musclin"
                     /codon_start=1
                     /product="osteocrin precursor"
                     /protein_id="NP_997495.1"
                     /db_xref="GeneID:360730"
                     /db_xref="RGD:1303110"
                     /translation="MLDWRLASAHFLLAMILMLWGSGKAFSVDLASEASEFGAESLQS
                     PPTTREEKSATELAAKLLLLDDLVSLENDVFETKKKRSFSGFGSPLDRLSAGSVEHRG
                     KQRRVVDHSKKRFGIPMDRIGRNRLSSSRG"
     exon            185..283
                     /gene="Ostn"
                     /inference="alignment:Splign:2.1.0"
     exon            284..498
                     /gene="Ostn"
                     /inference="alignment:Splign:2.1.0"
     exon            499..595
                     /gene="Ostn"
                     /inference="alignment:Splign:2.1.0"
     exon            596..1393
                     /gene="Ostn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgtgttggt gaaccgttcc gtggaaaatc tgtagaactg atgtaagaga aagcaccgac
       61 aggggtcgga gtaagtggag tagaactgag actataaaaa cacagaaaga aacttggatc
      121 agggctaagt ttgggataag ctgcaggcag gactctaaag ttaggagctc tgacttctca
      181 caagatgctg gactggagat tggcaagtgc acacttcctc ctggctatga tcctgatgct
      241 gtggggctca ggaaaggcat tctccgtgga cttagcatca gaggcctccg agtttggagc
      301 agaaagcttg cagtccccac ccacaaccag agaagagaag tcagccacgg agcttgcagc
      361 taagctcctg cttcttgatg atctggtgtc cttggagaat gatgtgtttg agaccaagaa
      421 gaagagaagc ttctctggct tcgggtctcc ccttgacaga ctctcggctg ggtctgtaga
      481 gcatagaggg aaacaaagga gagtagttga tcattcaaaa aagcgatttg gtattcccat
      541 ggatcgaatt ggtagaaacc gtctctccag ttccaggggc tgatggattc tcatcatatg
      601 acttactttc gtgaaatgcc accaaaggat agaagacact tcagtgaagt tctttcctac
      661 cccttttgtc aaggaactgc cttctacaaa cctttccaaa acctgatact cctcagcccg
      721 tcatgtcctg gtgttgctat tcaattgagt tgtgcatgga tacctttgaa agtatttttc
      781 aatgattcac acattataac atggcccttg atcctacttt ttaaaacagc agtcaaatat
      841 aatgtatttt cttgccatta atattttcac atttcagtta tccaatgtac tttctagtaa
      901 cctagtgttt aaaggtctga tgatgtaaag aaataagaaa tgaacacata gtgatttata
      961 ttggattttt tttttagttt ttctgaagtt tgtcaaattg ttgaaaactt caactccaag
     1021 cttagaaaag agacagtaaa tgagtgtttg cttcaactgt gacagaaggc tacagtaaag
     1081 acaaataaat tttgagaaac ctgagcattt gtgtttttta gtaactaata actaaacgtt
     1141 aatataggga aagctagcat aattgccccg tgtgtaatat tctgacaagc tctgaatttg
     1201 aaagactcat ttgaaaagaa gttactgcct ctcttgttta tttttactag cctaagtgtg
     1261 aattgtgcaa atgtttcctc actagcagct tttttctttt ttcttttttt cagcattcag
     1321 tgattttaag ctaaaatccc aaccaaatag tgctttgtgt ttttaaaaag gtattaaaat
     1381 caatattagc cta
//
