LOCUS       NM_001029925            3150 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus osteoclastogenesis associated transmembrane
            protein 1 (Ostm1), mRNA.
ACCESSION   NM_001029925 XM_574797
VERSION     NM_001029925.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3150)
  AUTHORS   Leisle,L., Ludwig,C.F., Wagner,F.A., Jentsch,T.J. and Stauber,T.
  TITLE     ClC-7 is a slowly voltage-gated 2Cl(-)/1H(+)-exchanger and requires
            Ostm1 for transport activity
  JOURNAL   EMBO J 30 (11), 2140-2152 (2011)
   PUBMED   21527911
REFERENCE   2  (bases 1 to 3150)
  AUTHORS   Fischer,T., De Vries,L., Meerloo,T. and Farquhar,M.G.
  TITLE     Promotion of G alpha i3 subunit down-regulation by GIPN, a putative
            E3 ubiquitin ligase that interacts with RGS-GAIP
  JOURNAL   Proc Natl Acad Sci U S A 100 (14), 8270-8275 (2003)
   PUBMED   12826607
  REMARK    GeneRIF: GIPN (Ostm1) is a 38-kDa protein with an N-terminal
            Leu-rich region, a central RING finger-like domain & a C-terminal
            transmembrane domain. It has E3 ubiquitin ligase activity. It is
            involved in the degradation of G alpha i3 subunits via proteasomes.
REFERENCE   3  (bases 1 to 3150)
  AUTHORS   Chalhoub,N., Benachenhou,N., Rajapurohitam,V., Pata,M., Ferron,M.,
            Frattini,A., Villa,A. and Vacher,J.
  TITLE     Grey-lethal mutation induces severe malignant autosomal recessive
            osteopetrosis in mouse and human
  JOURNAL   Nat Med 9 (4), 399-406 (2003)
   PUBMED   12627228
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Mar 15, 2021 this sequence version replaced NM_001029925.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.1056450.1,
                                           SRR26360194.2127308.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-484               JAXUCZ010000020.1  47735322-47735805
            485-599             JAXUCZ010000020.1  47746906-47747020
            600-697             JAXUCZ010000020.1  47757948-47758045
            698-865             JAXUCZ010000020.1  47763166-47763333
            866-1031            JAXUCZ010000020.1  47764856-47765021
            1032-3150           JAXUCZ010000020.1  47767130-47769248
FEATURES             Location/Qualifiers
     source          1..3150
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q13"
     gene            1..3150
                     /gene="Ostm1"
                     /gene_synonym="Gipn"
                     /note="osteoclastogenesis associated transmembrane protein
                     1"
                     /db_xref="GeneID:499474"
                     /db_xref="RGD:1564976"
     exon            1..484
                     /gene="Ostm1"
                     /gene_synonym="Gipn"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..1087
                     /gene="Ostm1"
                     /gene_synonym="Gipn"
                     /note="GAIP interacting protein N terminus; osteopetrosis
                     associated transmembrane protein 1-like"
                     /codon_start=1
                     /product="osteopetrosis-associated transmembrane protein 1
                     precursor"
                     /protein_id="NP_001025096.1"
                     /db_xref="GeneID:499474"
                     /db_xref="RGD:1564976"
                     /translation="MAGDAELARRGGWPWRWLPALLLLQLLRWRCALGALPFTSSRHP
                     GFADLLSEQQLLEVQDLTLSLLQGGGLGPLSLLPPDLPDLEPECRELLMDFANSSAEL
                     TACMVRSARPVRLCQTCYPLFQQVAIKMDNISRNVGNASESQRCAGSLLMADRMQIVV
                     MVSEFFNSTWKEANCANCLTKNSEDLSNNTQDFLSLFNKTLACFEHNLQGRTYSLPPP
                     KNYSEVCKNCKEAYRTLSLLYSEMQKMNGLESKAEPGTHLCIDVEDAMNITRKLWSRT
                     FNCSVTCSDTVSVVAVSVFILFLPVVFYLSSFLHSEQKKRKLILPKRLKSSTSFANIQ
                     ENST"
     exon            485..599
                     /gene="Ostm1"
                     /gene_synonym="Gipn"
                     /inference="alignment:Splign:2.1.0"
     exon            600..697
                     /gene="Ostm1"
                     /gene_synonym="Gipn"
                     /inference="alignment:Splign:2.1.0"
     exon            698..865
                     /gene="Ostm1"
                     /gene_synonym="Gipn"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1031
                     /gene="Ostm1"
                     /gene_synonym="Gipn"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..3150
                     /gene="Ostm1"
                     /gene_synonym="Gipn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggccgaagc cggaagcggc tgctgtcgga agcaccgggc gagcgatctg gctgcgggcc
       61 ggccccgggg atggctgggg acgcggagct ggcgcggcgc ggtgggtggc cgtggcggtg
      121 gctgccggcg ttgctgctgc tgcaactgct gcggtggagg tgcgccctgg gcgcgctccc
      181 cttcaccagc agtcggcacc caggctttgc ggacctgctg tcggagcagc agctgctgga
      241 ggtgcaggac ttgaccctgt ctctgctgca gggcggaggt ctggggccgc tgtcactgct
      301 acctcccgac ctgccggatc tggagcctga atgccgggag ctgctgatgg acttcgccaa
      361 tagcagcgcc gagctgaccg cctgtatggt gcgcagcgct cggcccgtgc gcctctgcca
      421 gacctgctac ccgctcttcc aacaggtcgc aatcaagatg gacaacatca gccgaaacgt
      481 cgggaacgcc tccgagagcc agcgctgtgc aggaagtctc ctgatggcgg acagaatgca
      541 gatagttgtg atggtctctg agttcttcaa cagcacgtgg aaggaggcga actgtgcaaa
      601 ttgcctaaca aaaaacagtg aggatctgtc aaataacacc caggacttcc tcagtctgtt
      661 taacaagact ttggcctgct ttgagcataa cctgcagggg cgcacgtaca gcctcccccc
      721 accaaagaat tactcagaag tgtgcaagaa ctgtaaagag gcgtacagaa ctctgagcct
      781 cctgtacagc gaaatgcaga aaatgaacgg gctggagagc aaggcggagc cgggaacgca
      841 cttgtgcatc gacgtggagg atgcaatgaa cattacccgg aagctatgga gccgaacctt
      901 caactgttcc gtcacctgca gcgacacagt gtctgtggtt gccgtttccg tgttcattct
      961 ctttctgcct gtcgtcttct acctgagtag cttccttcac tccgagcaaa agaagcgcaa
     1021 gctcattcta cccaaacgtc tcaagtcgag caccagtttt gccaacattc aagaaaattc
     1081 cacctgaagc ctgcaaaacg ggactggacc gcacaccacg ccaatcagtg gttggaccac
     1141 agcagagtgg agaagatgag ccgtgatctg acaaatcaaa ttcttaagaa tcgctgggct
     1201 gtggacctat aatttattct gaataagggt tctcaaattc ccttttcctg agcaccccat
     1261 ctttgaagat ttctgtattt ttaattttca gacatagcaa tgtgacacat tttaaggtat
     1321 atctgttaca gtaacaagcg agggcttttg tttgttttta caagaatatg aatgactact
     1381 tgacactttt gatatatcct tgctaacaga aatccacaga acagaaacag ctgagttgtg
     1441 ccagttacac actagtcagt cactgggagc caagccagct ttgaaaagga aatacacggg
     1501 gttggggact tagctcagtg gtagagtgct tgcctagcaa acgcaaggcc ctgggttcag
     1561 tccccagctc cgaaaaaaag aaaaagaaaa gaaaaaaaaa aagaaaagaa aaggaaatac
     1621 acttgccaaa tggtagcagg ctcaatgatt agcttaaatg aattcccatt tcagtattat
     1681 tgtatgtaca tacatacaca cacacacaca cacacacaca cacacacacc ccatacacac
     1741 atacatatat atgtatatat agtatatatt taatatatca cacagtaaaa gaatgttctc
     1801 tagtcccctg aagtctcttt tgaaaccact aactgactat aaacctcctt aacagttttc
     1861 aggaagtgat gccacgccat ccatttatct ttgttacaga tttacagtaa ctgggtttct
     1921 aacatgtctt ttagaaatac cgttttacgt cttacttttg cctttatttc ataagtaatt
     1981 aaaaaaaaat cactggactg cttaattttc tctgaggaca agatggattc attcatctta
     2041 agccagggat ttgcatcgtg aatttcatta agttatttgg caacctgtaa actatcagta
     2101 gttcaagtca tatgtggcac gagtgtgtca cgccgtgttt aaatctgtgg tttttaatga
     2161 aaatctcatg ttggaatatt tggagagtta gggagaaacg gaagacgaat acaagagttt
     2221 aagttctaga aaatagacaa tggatgctca cggaagacag ccaggtagtc tatagtggag
     2281 atgactggga taacaggctc aaacaggaag ccccaccccc ggaagtccca cccccacccc
     2341 cagttaaggc aatgcattta ctgtcaggaa acttctcctt tggaatattt ctagcagcct
     2401 ttaaaatgat gtttatctca atgtctttca gttttctctc tcaagataga gaagttgatg
     2461 gttttgttgg ttaattcgtt tgccgggttc ccggtggaaa caggcctcgc tttaaaggtt
     2521 gtgaatggga agtgtcctcg ggttcagcgg ttaagaaagt gtgactccct tcacagaggg
     2581 agacaggagt gttcggggac ttttgtatgt ttaccacaaa tacaggctgc gagagctctt
     2641 ccggcactgt gtgacacagg gtgtgtgaca accggatgat accgtcccag cgttctgctg
     2701 cgatctacca gatgcgccat ggttcattgt gtcgtcactg ttcctgtggc tgtgaccaag
     2761 ggcactgcct tgatttgaag cacatggttg agagcctttg aaagccatct ccaccaatac
     2821 gcacagcctg cttacatgtg caaggttaga aaagtgacac atttaaactg agagcagcga
     2881 ctcctcaggc accattcagt actgtgtgta caaaccattg cttttggaaa agaagccaga
     2941 gagtacttta acaggccagc catctctggt cctcatcagg gcctgctctc tagaagtcgg
     3001 atcagaaaca gacttgaaaa tgtgccgaag aatttcatct tagggtccga cgaaaaatgt
     3061 atatagtttc tgagtcctga gactcatgtg tgtgcacaag aaaacctggt tttcccttag
     3121 attttacaat aaaggaagta acaagaaaaa
//
