LOCUS       NM_001106716            1691 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus odd-skipped related transcription factor 1
            (Osr1), mRNA.
ACCESSION   NM_001106716 XM_001072238 XM_233962
VERSION     NM_001106716.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1691)
  AUTHORS   Vorontsova,I., Lam,L., Delpire,E., Lim,J. and Donaldson,P.
  TITLE     Identification of the WNK-SPAK/OSR1 signaling pathway in rodent and
            human lenses
  JOURNAL   Invest Ophthalmol Vis Sci 56 (1), 310-321 (2014)
   PUBMED   25515571
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1691)
  AUTHORS   Fezai,M., Elvira,B., Borras,J., Ben-Attia,M., Hoseinzadeh,Z. and
            Lang,F.
  TITLE     Negative regulation of the creatine transporter SLC6A8 by SPAK and
            OSR1
  JOURNAL   Kidney Blood Press Res 39 (6), 546-554 (2014)
   PUBMED   25531585
REFERENCE   3  (bases 1 to 1691)
  AUTHORS   Nugent,B.M., Valenzuela,C.V., Simons,T.J. and McCarthy,M.M.
  TITLE     Kinases SPAK and OSR1 are upregulated by estradiol and activate
            NKCC1 in the developing hypothalamus
  JOURNAL   J Neurosci 32 (2), 593-598 (2012)
   PUBMED   22238094
  REMARK    GeneRIF: SPAK and OSR1 may be critical factors in the regulation of
            depolarizing GABA-mediated processes in the developing brain.
REFERENCE   4  (bases 1 to 1691)
  AUTHORS   Gao,Y., Lan,Y., Liu,H. and Jiang,R.
  TITLE     The zinc finger transcription factors Osr1 and Osr2 control
            synovial joint formation
  JOURNAL   Dev Biol 352 (1), 83-91 (2011)
   PUBMED   21262216
REFERENCE   5  (bases 1 to 1691)
  AUTHORS   Drews,C., Senkel,S. and Ryffel,G.U.
  TITLE     The nephrogenic potential of the transcription factors osr1, osr2,
            hnf1b, lhx1 and pax8 assessed in Xenopus animal caps
  JOURNAL   BMC Dev Biol 11, 5 (2011)
   PUBMED   21281489
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1691)
  AUTHORS   Mugford,J.W., Sipila,P., McMahon,J.A. and McMahon,A.P.
  TITLE     Osr1 expression demarcates a multi-potent population of
            intermediate mesoderm that undergoes progressive restriction to an
            Osr1-dependent nephron progenitor compartment within the mammalian
            kidney
  JOURNAL   Dev Biol 324 (1), 88-98 (2008)
   PUBMED   18835385
REFERENCE   7  (bases 1 to 1691)
  AUTHORS   Kawai,S., Yamauchi,M., Wakisaka,S., Ooshima,T. and Amano,A.
  TITLE     Zinc-finger transcription factor odd-skipped related 2 is one of
            the regulators in osteoblast proliferation and bone formation
  JOURNAL   J Bone Miner Res 22 (9), 1362-1372 (2007)
   PUBMED   17547533
REFERENCE   8  (bases 1 to 1691)
  AUTHORS   James,R.G., Kamei,C.N., Wang,Q., Jiang,R. and Schultheiss,T.M.
  TITLE     Odd-skipped related 1 is required for development of the
            metanephric kidney and regulates formation and differentiation of
            kidney precursor cells
  JOURNAL   Development 133 (15), 2995-3004 (2006)
   PUBMED   16790474
REFERENCE   9  (bases 1 to 1691)
  AUTHORS   Vitari,A.C., Thastrup,J., Rafiqi,F.H., Deak,M., Morrice,N.A.,
            Karlsson,H.K. and Alessi,D.R.
  TITLE     Functional interactions of the SPAK/OSR1 kinases with their
            upstream activator WNK1 and downstream substrate NKCC1
  JOURNAL   Biochem J 397 (1), 223-231 (2006)
   PUBMED   16669787
REFERENCE   10 (bases 1 to 1691)
  AUTHORS   Wang,Q., Lan,Y., Cho,E.S., Maltby,K.M. and Jiang,R.
  TITLE     Odd-skipped related 1 (Odd 1) is an essential regulator of heart
            and urogenital development
  JOURNAL   Dev Biol 288 (2), 582-594 (2005)
   PUBMED   16223478
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000164.1.
            
            [WARNING] On Apr 1, 2024 this sequence was replaced by
            NM_001106716.4.
            
            On Nov 27, 2020 this sequence version replaced NM_001106716.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC159410.1, DY312238.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-705               JACYVU010000164.1  8666619-8667323
            706-1691            JACYVU010000164.1  8667995-8668980
FEATURES             Location/Qualifiers
     source          1..1691
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q14"
     gene            1..1691
                     /gene="Osr1"
                     /gene_synonym="Odd1"
                     /note="odd-skipped related transcription factor 1"
                     /db_xref="GeneID:298878"
                     /db_xref="RGD:1311807"
     exon            1..705
                     /gene="Osr1"
                     /gene_synonym="Odd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..841
                     /gene="Osr1"
                     /gene_synonym="Odd1"
                     /note="odd-skipped related 1; odd-skipped related
                     transciption factor 1"
                     /codon_start=1
                     /product="protein odd-skipped-related 1"
                     /protein_id="NP_001100186.1"
                     /db_xref="GeneID:298878"
                     /db_xref="RGD:1311807"
                     /translation="MGSKTLPAPVPIHPSLQLTNYSFLQAVNGLPTVPSDHLPNLYGF
                     SALHAVHLHQWTLGYPAMHLPRSSFSKVPGAVSSLMDARFQLPAFPWFPHVIHPKPEI
                     TAGGSGAALKTKPRFDFANLALAATQEDPTKLGRGEGPGSPAGGLGALLDVTKLSPEK
                     KPTRGRLPSKTKKEFVCKFCGRHFTKSYNLLIHERTHTDERPYTCDICHKAFRRQDHL
                     RDHRYIHSKEKPFKCQECGKGFCQSRTLAVHKTLHSQVKELKTSKIKC"
     exon            706..1691
                     /gene="Osr1"
                     /gene_synonym="Odd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agatcgatta ttgaagccat tgcggttacc agcgacagaa atgggcagca aaaccttgcc
       61 agcaccggtg cccatccacc catccctgca gcttaccaat tactctttcc ttcaggcagt
      121 gaatggctta cccacagtgc cctcggacca cctgcccaac ctgtatggtt tcagcgctct
      181 tcacgcggtg catctgcacc aatggacgct gggctaccca gccatgcact tgcctcgttc
      241 ctctttttct aaagtgccag gtgcggtgtc cagcctaatg gacgctcgct tccagctgcc
      301 agcttttccc tggtttccac acgtcattca ccctaagcca gagatcaccg cgggaggcag
      361 cggtgcagcg cttaagacca agccgcgctt tgatttcgct aacctggcct tggctgccac
      421 acaagaggat cccaccaagc ttggccgagg ggagggccct ggctcccctg ctggtgggct
      481 gggcgccctc ctggacgtga ccaagctgtc tccagaaaag aagccaacaa ggggtcgcct
      541 gccttccaag accaagaagg aattcgtctg caagttctgt ggccgccact tcactaagtc
      601 ctataaccta cttatccacg agcggacgca caccgatgag cggccttaca cctgtgacat
      661 ctgccacaaa gctttccgga ggcaagacca cctacgggac cacagatata ttcactccaa
      721 agagaagcct ttcaagtgtc aagagtgtgg aaaaggattc tgccagtccc ggactctcgc
      781 tgtccacaag acgctacact cacaagtgaa ggagctcaaa acctccaaga tcaaatgcta
      841 aataaacaaa gcctgcgggg caccaggaac ctggggcgtg ctgccgcctt ctctactaga
      901 gggacccgag ctgaaggcaa ctctgcgggc agcgggaggg gcttttggga tcctcgttcc
      961 acagcaacaa agtcccctgg gtccctagcg cttgcggcgc tcctgagcct tggcccgggc
     1021 cgcgactcct acagcctggg cggctctcct aggacgcggc taaaactctt ggccaaaggg
     1081 cggtactcaa ctcacatggc ggaaggaaaa ctgcattaaa acacacacac acacacacac
     1141 acacacacac acacacacac acacacacac acacacacac acaacgaaaa ctgctgagcc
     1201 gcagcggcgc ctctcacaga agtattactt tttctattgt tattttatac gttttcttta
     1261 tcctcctccc tcccctgact atataagctt gtaaagtctt gactgtggag agggggaaag
     1321 aaaagatcta tgcaccctgg caatttccag tcccccttcc tttccctatc cccacaccgg
     1381 ggagcctgcg aaagtgtaat ccttgtatct gcttctgcca tccggcccca ggggccgctg
     1441 gctccgcgcg actcctgggc ctccagctga ccttcagctc cgggcgcgga aaccgggctg
     1501 agaaccaggc gcccggggct aggggggccg agcctccgct cccctgttcc aacggtgcgt
     1561 gtgagcgagc gagcagccgg ccaggagccg ggcgttgtat tgcgactggc actttatgct
     1621 gacatcggta acggacattt atcactggag tttttttttt aactattaaa taaacggtta
     1681 ttttacaggc a
//
