LOCUS       NM_001005384            4708 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus oncostatin M receptor (Osmr), mRNA.
ACCESSION   NM_001005384 XM_039102189 XM_226813
VERSION     NM_001005384.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4708)
  AUTHORS   Shen,M., Siu,S., Byrd,S., Edelmann,K.H., Patel,N., Ketchem,R.R.,
            Mehlin,C., Arnett,H.A. and Hasegawa,H.
  TITLE     Diverse functions of reactive cysteines facilitate unique
            biosynthetic processes of aggregate-prone interleukin-31
  JOURNAL   Exp Cell Res 317 (7), 976-993 (2011)
   PUBMED   21182835
REFERENCE   2  (bases 1 to 4708)
  AUTHORS   Li,R., Wen,R., Banzon,T., Maminishkis,A. and Miller,S.S.
  TITLE     CNTF mediates neurotrophic factor secretion and fluid absorption in
            human retinal pigment epithelium
  JOURNAL   PLoS One 6 (9), e23148 (2011)
   PUBMED   21912637
REFERENCE   3  (bases 1 to 4708)
  AUTHORS   Okaya,A., Kitanaka,J., Kitanaka,N., Satake,M., Kim,Y., Terada,K.,
            Sugiyama,T., Takemura,M., Fujimoto,J., Terada,N., Miyajima,A. and
            Tsujimura,T.
  TITLE     Oncostatin M inhibits proliferation of rat oval cells, OC15-5,
            inducing differentiation into hepatocytes
  JOURNAL   Am J Pathol 166 (3), 709-719 (2005)
   PUBMED   15743783
REFERENCE   4  (bases 1 to 4708)
  AUTHORS   Tanaka,M., Hara,T., Copeland,N.G., Gilbert,D.J., Jenkins,N.A. and
            Miyajima,A.
  TITLE     Reconstitution of the functional mouse oncostatin M (OSM) receptor:
            molecular cloning of the mouse OSM receptor beta subunit
  JOURNAL   Blood 93 (3), 804-815 (1999)
   PUBMED   9920829
REFERENCE   5  (bases 1 to 4708)
  AUTHORS   Lindberg,R.A., Juan,T.S., Welcher,A.A., Sun,Y., Cupples,R.,
            Guthrie,B. and Fletcher,F.A.
  TITLE     Cloning and characterization of a specific receptor for mouse
            oncostatin M
  JOURNAL   Mol Cell Biol 18 (6), 3357-3367 (1998)
   PUBMED   9584176
REFERENCE   6  (bases 1 to 4708)
  AUTHORS   Mosley,B., De Imus,C., Friend,D., Boiani,N., Thoma,B., Park,L.S.
            and Cosman,D.
  TITLE     Dual oncostatin M (OSM) receptors. Cloning and characterization of
            an alternative signaling subunit conferring OSM-specific receptor
            activation
  JOURNAL   J Biol Chem 271 (51), 32635-32643 (1996)
   PUBMED   8999038
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On or before Oct 5, 2022 this sequence version replaced
            XM_039102189.1, NM_001005384.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887622.2710000.1,
                                           SRR26643290.7410.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                JAXUCZ010000002.1  57688488-57688561   c
            75-162              JAXUCZ010000002.1  57677016-57677103   c
            163-332             JAXUCZ010000002.1  57669043-57669212   c
            333-504             JAXUCZ010000002.1  57663663-57663834   c
            505-783             JAXUCZ010000002.1  57660795-57661073   c
            784-919             JAXUCZ010000002.1  57659356-57659491   c
            920-1071            JAXUCZ010000002.1  57658538-57658689   c
            1072-1211           JAXUCZ010000002.1  57654431-57654570   c
            1212-1365           JAXUCZ010000002.1  57653592-57653745   c
            1366-1442           JAXUCZ010000002.1  57650077-57650153   c
            1443-1665           JAXUCZ010000002.1  57648581-57648803   c
            1666-1845           JAXUCZ010000002.1  57646989-57647168   c
            1846-1950           JAXUCZ010000002.1  57646095-57646199   c
            1951-2124           JAXUCZ010000002.1  57644209-57644382   c
            2125-2292           JAXUCZ010000002.1  57643159-57643326   c
            2293-2374           JAXUCZ010000002.1  57637771-57637852   c
            2375-2447           JAXUCZ010000002.1  57637463-57637535   c
            2448-4708           JAXUCZ010000002.1  57634517-57636777   c
FEATURES             Location/Qualifiers
     source          1..4708
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q16"
     gene            1..4708
                     /gene="Osmr"
                     /note="oncostatin M receptor"
                     /db_xref="GeneID:310132"
                     /db_xref="RGD:1302983"
     exon            1..74
                     /gene="Osmr"
                     /inference="alignment:Splign:2.1.0"
     exon            75..162
                     /gene="Osmr"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..2975
                     /gene="Osmr"
                     /note="oncostatin-M-specific receptor subunit beta;
                     oncostatin M specific receptor; IL-31RB; IL-31R-beta;
                     IL-31R subunit beta; IL-31 receptor subunit beta;
                     interleukin-31 receptor subunit beta"
                     /codon_start=1
                     /product="oncostatin-M-specific receptor subunit beta
                     precursor"
                     /protein_id="NP_001005384.2"
                     /db_xref="GeneID:310132"
                     /db_xref="RGD:1302983"
                     /translation="MAFSVVLHQVTFLLAVLSLRTSRSKVLGEPLQLTPEIHTVSLQS
                     ALQEANLEWTVPTFSHQELNIVFQIEISRMRTSNTIWVGNYSTTVKHEETVHWKWTSD
                     IPLECATHFIRIRAMVDDTQYPPQSSWSNWSSWKEVNAQVSVPPDTLLIFPEDRLLEE
                     GSNVTICLMIGQNLYNVSCKLQEEPIRGEQLDSHLSLIKLNNVVFLNNAGTNINCKAM
                     NGTKNTFGTVLFVSKVLEEPKNFSCETRDFKTLNCLWEPGIDTTLSWHKQRSQHYTLY
                     ESFSGRREVSNHRNSHTWQITEDSQETYNFTLTAENNLRKRSVSISFNLTHRVHPKAP
                     HDVTLKTVGATKAHMTWKVPSRGDYTLLCQVELQCEGEVIHEHNVSVHTSANYLFSDL
                     EPDTEYKACVRCASAHHFWKWSDWMQKKFRTPEAAPSEALDVWRDVRTENGRHVVTLF
                     WKPLLKSQANGKIISYNIVVENEANPTESEQYSVRAPALGTNLSLDLHPYKIHISANN
                     SAGASPESLVVLSSHSGHEEVHEKTIKGIKNGFNISWEPVSGDAIGYVVDWCAHSQTQ
                     RCDLQWKNVGPNITSTIITSDAFEPGVRYNFRIFERSVEENVRLVEKQRGYTQELAPS
                     VNPGVTIHNLTPNSFSLKWQDYASDFQSGFIKGYLVYLKSKELQCNPNWERTVLSDKS
                     VLCKYDVDDPETKTLTVENLRPESLYEFLVTPYTSAGQGPNETYTKVTTPDVRSHMLL
                     QIILPMTLGVFLSIIVCYWKSQWVKEKCYPDIPNPYKSSILSLIKSKKNPHLIMNVKD
                     CIPDVLEVINKAEGSKTQCVGSGKLHTEDVPTKPPLVPTEKDSSGPMPFVFLENFTYD
                     QSAFDSGSHGFIPGPLKNTPHQLGLLAPPNKLQNVLENDYMKSLVESPTEETSLIYVS
                     QLASPICGDKDSLVTNPPMPVYGSEYKKQMALPGSLTSASLKENNLTS"
     exon            163..332
                     /gene="Osmr"
                     /inference="alignment:Splign:2.1.0"
     exon            333..504
                     /gene="Osmr"
                     /inference="alignment:Splign:2.1.0"
     exon            505..783
                     /gene="Osmr"
                     /inference="alignment:Splign:2.1.0"
     exon            784..919
                     /gene="Osmr"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1071
                     /gene="Osmr"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1211
                     /gene="Osmr"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1365
                     /gene="Osmr"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1442
                     /gene="Osmr"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1665
                     /gene="Osmr"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1845
                     /gene="Osmr"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..1950
                     /gene="Osmr"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2124
                     /gene="Osmr"
                     /inference="alignment:Splign:2.1.0"
     exon            2125..2292
                     /gene="Osmr"
                     /inference="alignment:Splign:2.1.0"
     exon            2293..2374
                     /gene="Osmr"
                     /inference="alignment:Splign:2.1.0"
     exon            2375..2447
                     /gene="Osmr"
                     /inference="alignment:Splign:2.1.0"
     exon            2448..4708
                     /gene="Osmr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acgcccggac agacgtccgc acccgcgccc ctgaggccga ggaccggacg ggctcggagc
       61 aggtcgccag gtcgataatc agaccaatgg ctttctctgt ggtccttcat caagtgacct
      121 tccttctggc agtgctgtcc ctgaggactt cccgaagtaa agtcttgggg gagcctttac
      181 agttgactcc tgagatacac acagtttctc ttcaatctgc acttcaagaa gcgaatttag
      241 aatggactgt cccaaccttt agtcatcaag aattaaacat tgtatttcag atagagatca
      301 gtcggatgag aacatccaac accatctggg tggggaatta cagcaccact gtgaagcatg
      361 aagaaactgt gcattggaaa tggacatctg atatcccctt ggaatgtgcc acacatttca
      421 taagaataag ggctatggta gatgacaccc agtaccctcc acagagttcc tggagcaact
      481 ggagttcctg gaaagaagtt aatgcacaag tttcagttcc acctgataca ttattaatat
      541 ttcctgaaga cagactgttg gaagaaggtt ccaatgtcac catctgtttg atgattgggc
      601 agaatctata taatgtatcc tgtaagttgc aagaagagcc aatccgtgga gagcaacttg
      661 attcacacct gtcactaata aaattgaata atgtagtgtt ccttaacaac gcagggacaa
      721 acatcaattg taaagccatg aatggtacta aaaatacatt tggtactgtt ctctttgtct
      781 caaaagtgct tgaggaacct aagaattttt cctgtgaaac ccgagacttt aagactttga
      841 actgtttgtg ggaacctggg atagacacga ctttgagttg gcataaacaa cgttcccaac
      901 actacacttt atatgaatcg ttctctggga gacgtgaggt ttctaaccac agaaactcgc
      961 atacctggca aatcactgaa gactcacagg aaacatataa cttcactctc acagctgaaa
     1021 acaacctaag gaaaagaagt gtcagcatca gttttaacct gacccacaga gttcatccaa
     1081 aggctcccca tgatgtcact cttaaaactg taggtgctac aaaagcccac atgacttgga
     1141 aggttccctc ccgtggagac tacacacttt tgtgtcaggt tgaactccag tgtgaaggag
     1201 aagtgataca tgagcacaac gtttctgtcc acacgagcgc caactacctc ttcagtgatc
     1261 tggagccaga cacagagtac aaggcttgtg tgcgctgtgc gagtgcccac cacttctgga
     1321 aatggagtga ctggatgcaa aaaaagttca gaacacccga ggctgccccc tcagaagctc
     1381 ttgatgtgtg gagagacgtg cggacagaga atggaagaca tgttgtgact ttattctgga
     1441 agccactatt aaaatcacag gccaatggca aaatcatatc ctataatata gttgtagaaa
     1501 atgaagccaa tccaacggag tcagaacagt actctgttcg ggcgccagcc cttggcacaa
     1561 acctgagcct ggacctgcat ccctacaaga ttcacatctc agccaacaac agcgcggggg
     1621 catctcctga gtccttggtg gtcctttcta gtcattctgg acatgaagag gtccatgaaa
     1681 aaacaattaa aggtataaag aatggattca atatttcctg ggagccggta tctggagacg
     1741 cgataggcta tgttgtggac tggtgtgcac attctcagac ccaacgctgt gatttgcagt
     1801 ggaagaacgt aggtcccaat atcacaagca ccatcatcac ctcagacgct tttgagccag
     1861 gggtccgtta caacttcaga atttttgaaa gatctgtgga agagaatgtt cggttagtag
     1921 agaaacaaag aggatacacc caggaattgg ctccgtcggt gaatccagga gtgacgattc
     1981 ataacttgac cccaaactcc ttcagtctaa aatggcagga ttatgccagc gacttccagt
     2041 ctggctttat aaaagggtac ctcgtatatt tgaaatccaa ggagctgcag tgcaacccaa
     2101 actgggagag gactgttctg tcagataagt cagtgctctg taaatatgac gtcgatgacc
     2161 cagagacaaa gacactcact gtggaaaacc ttcggccaga gtccctctat gagtttctcg
     2221 tcactccata taccagcgct ggccagggac ccaatgaaac atacacaaag gtcacgactc
     2281 cagatgtacg ctcccacatg ctgctgcaga tcatattacc catgaccctc ggcgtcttcc
     2341 tcagcatcat tgtgtgttac tggaaaagtc agtgggtgaa ggagaagtgc tatcctgaca
     2401 ttcccaatcc atacaagagc agcatcctat cactcataaa atccaagaag aatcctcact
     2461 taataatgaa tgtcaaagac tgcattccag atgtccttga agttataaac aaagcagaag
     2521 gcagcaagac acagtgtgta ggctctggga aacttcacac tgaagatgta cccactaagc
     2581 ctccattggt gccaacagaa aaggattcct ctggccccat gcccttcgtc ttccttgaga
     2641 attttactta cgatcagtca gcttttgatt ctggttctca tggcttcatt ccaggacccc
     2701 taaaaaacac accgcaccaa ctcggactat tggctccgcc taacaagtta cagaatgtat
     2761 tagaaaatga ttacatgaag tccctggtcg aaagtccaac tgaagaaact agtttgattt
     2821 atgtgtccca gctggcttca cctatatgcg gagacaagga cagtcttgtc acgaacccac
     2881 ccatgccagt gtacggttca gagtataaaa agcaaatggc acttccgggg agcctcacat
     2941 cagcttctct gaaggagaac aacttgactt cttaggccaa ggtgaacagt aaacaccaag
     3001 ctgcaccaat gcacttcaca cactacaggc actttggggg atgtagctgg caccatacaa
     3061 acaccacgtg ccctggcctt tggccctggg gtgctcatta tccgcaccac tacagactgg
     3121 cagactgaag accagaagtt tacaatgtgg tctccattca ccccgaaggg ttccttagaa
     3181 ctggcaggat cctggagcat gctgacctta ttagtcaggc tcgccctgat tgtagtaccc
     3241 ctgagcttgc cctagggtag acgccagtca tttcacagag cccacctact cagaactgca
     3301 caacacggct ctggtcctgg gattttggtt tgcagtgaga agaaaacatc ttcgtgtaaa
     3361 cttgacctca cgcttaatag tttaagggtg aaaacaagtg gatcagatgt gtgatgaatg
     3421 ccacaagaga ctgattgctt ttattgtata gatttatcac atttaatgga gaggttacaa
     3481 actagacttt ggccatacct tgaaatgaga acttgtagtc actgataaag tacaaagaac
     3541 tctcttcgtg tctacactaa acctaaccag agatgtagaa atggagagga ggctcttcac
     3601 aggtctccca ctgtctagct tatggcagta aaccaggaga gcaaagagct ccacgcttac
     3661 tgtccaggtg actctaccct gttcaacaga cttcattctt ctttagttgt tgactacctc
     3721 agaagagaag aaaaggacat ttcacagagt gatgcctttt acacataata tacccccccc
     3781 cacacgctgt aactagagga cccacttcac aaactaacct ctgctctttg gacgctcggt
     3841 tgtctggttc acgagaattc cgtctcacat tcttgtgcta aaatacaaaa gccctagtac
     3901 cgggtgcaat ttagctagaa ctttaaatgt agaagtcagt tgtgttggct ccgaattcat
     3961 gtcttttgac aaaatacact tggtcctatc tacgggttcc acatccagac tcaaccaacc
     4021 tcagaaagaa gatattcagg aaaaatagcc tgtactaaac tcatgtattt ttcttgttat
     4081 tccttaaggt attaataatt tccacggcat ttgcacgcat caggcattgt ggcacagtat
     4141 gaagaacacc cactatatta caatgctatt tttaggtaag gcttgaattc ctgcagatct
     4201 tggcgctcct ttaattaact cctggaaagt gccataaagg aatgactata tgtaatggct
     4261 gaacacatac attggttccc tcttcttaac gcttgtcaca ttgcagaaca aggtggaaag
     4321 gtattctttt ttcttgttgt tagctaagcc taataggaat gatgactttg tgcacatgtg
     4381 tggctgttaa gtgcatgtgg ccacagaaca tatagtaata gtaaccatga atgttctaca
     4441 caagctgtcc aatcttctct ttacagaata gaagcctttg ttagaaaaca tggctaaacc
     4501 caacccagga ccaggcagta tcttgaatag tctaggtggg agaagacttt gctcagtatt
     4561 gtttatgttt tcctgtcact ggatttctca ccagaaatgt taatgacatt tatttgtgat
     4621 gtttttcatt tcaattttgt ttaaaaaaca atccacaaaa cattagttat tttttttgct
     4681 gtttcaataa agtccaaatt aaaacatg
//
