LOCUS       NP_001005384             962 aa            linear   ROD 01-APR-2024
DEFINITION  oncostatin-M-specific receptor subunit beta precursor [Rattus
            norvegicus].
ACCESSION   NP_001005384 XP_038958117 XP_226813
VERSION     NP_001005384.2
DBSOURCE    REFSEQ: accession NM_001005384.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 962)
  AUTHORS   Shen,M., Siu,S., Byrd,S., Edelmann,K.H., Patel,N., Ketchem,R.R.,
            Mehlin,C., Arnett,H.A. and Hasegawa,H.
  TITLE     Diverse functions of reactive cysteines facilitate unique
            biosynthetic processes of aggregate-prone interleukin-31
  JOURNAL   Exp Cell Res 317 (7), 976-993 (2011)
   PUBMED   21182835
REFERENCE   2  (residues 1 to 962)
  AUTHORS   Li,R., Wen,R., Banzon,T., Maminishkis,A. and Miller,S.S.
  TITLE     CNTF mediates neurotrophic factor secretion and fluid absorption in
            human retinal pigment epithelium
  JOURNAL   PLoS One 6 (9), e23148 (2011)
   PUBMED   21912637
REFERENCE   3  (residues 1 to 962)
  AUTHORS   Okaya,A., Kitanaka,J., Kitanaka,N., Satake,M., Kim,Y., Terada,K.,
            Sugiyama,T., Takemura,M., Fujimoto,J., Terada,N., Miyajima,A. and
            Tsujimura,T.
  TITLE     Oncostatin M inhibits proliferation of rat oval cells, OC15-5,
            inducing differentiation into hepatocytes
  JOURNAL   Am J Pathol 166 (3), 709-719 (2005)
   PUBMED   15743783
REFERENCE   4  (residues 1 to 962)
  AUTHORS   Tanaka,M., Hara,T., Copeland,N.G., Gilbert,D.J., Jenkins,N.A. and
            Miyajima,A.
  TITLE     Reconstitution of the functional mouse oncostatin M (OSM) receptor:
            molecular cloning of the mouse OSM receptor beta subunit
  JOURNAL   Blood 93 (3), 804-815 (1999)
   PUBMED   9920829
REFERENCE   5  (residues 1 to 962)
  AUTHORS   Lindberg,R.A., Juan,T.S., Welcher,A.A., Sun,Y., Cupples,R.,
            Guthrie,B. and Fletcher,F.A.
  TITLE     Cloning and characterization of a specific receptor for mouse
            oncostatin M
  JOURNAL   Mol Cell Biol 18 (6), 3357-3367 (1998)
   PUBMED   9584176
REFERENCE   6  (residues 1 to 962)
  AUTHORS   Mosley,B., De Imus,C., Friend,D., Boiani,N., Thoma,B., Park,L.S.
            and Cosman,D.
  TITLE     Dual oncostatin M (OSM) receptors. Cloning and characterization of
            an alternative signaling subunit conferring OSM-specific receptor
            activation
  JOURNAL   J Biol Chem 271 (51), 32635-32643 (1996)
   PUBMED   8999038
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On or before Oct 5, 2022 this sequence version replaced
            XP_038958117.1, NP_001005384.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887622.2710000.1,
                                           SRR26643290.7410.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..962
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q16"
     Protein         1..962
                     /product="oncostatin-M-specific receptor subunit beta
                     precursor"
                     /note="oncostatin-M-specific receptor subunit beta;
                     oncostatin M specific receptor; IL-31RB; IL-31R-beta;
                     IL-31R subunit beta; IL-31 receptor subunit beta;
                     interleukin-31 receptor subunit beta"
                     /calculated_mol_wt=105677
     sig_peptide     1..28
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3074
     mat_peptide     29..962
                     /product="Oncostatin-M-specific receptor subunit beta.
                     /id=PRO_0000259761"
                     /note="propagated from UniProtKB/Swiss-Prot (Q65Z14.1)"
                     /calculated_mol_wt=105677
     Region          33..124
                     /region_name="LIFR_D2"
                     /note="Leukemia inhibitory factor receptor D2 domain;
                     pfam17971"
                     /db_xref="CDD:375455"
     Site            219
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q65Z14.1)"
     Site            324
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q65Z14.1)"
     Site            order(331,394,409)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          333..414
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Region          413..417
                     /region_name="WSXWS motif. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q65Z14.1)"
     Site            492
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q65Z14.1)"
     Region          539..605
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cl21522"
                     /db_xref="CDD:473895"
     Site            578
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q65Z14.1)"
     Region          623..731
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(623,704,719)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Site            order(720..721,723..724)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Site            723
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q65Z14.1)"
     Site            739..759
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q65Z14.1)"
     Region          768..776
                     /region_name="Box 1 motif. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q65Z14.1)"
     Region          818..840
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q65Z14.1)"
     CDS             1..962
                     /gene="Osmr"
                     /coded_by="NM_001005384.2:87..2975"
                     /db_xref="GeneID:310132"
                     /db_xref="RGD:1302983"
ORIGIN      
        1 mafsvvlhqv tfllavlslr tsrskvlgep lqltpeihtv slqsalqean lewtvptfsh
       61 qelnivfqie isrmrtsnti wvgnysttvk heetvhwkwt sdiplecath firiramvdd
      121 tqyppqssws nwsswkevna qvsvppdtll ifpedrllee gsnvticlmi gqnlynvsck
      181 lqeepirgeq ldshlslikl nnvvflnnag tninckamng tkntfgtvlf vskvleepkn
      241 fscetrdfkt lnclwepgid ttlswhkqrs qhytlyesfs grrevsnhrn shtwqiteds
      301 qetynftlta ennlrkrsvs isfnlthrvh pkaphdvtlk tvgatkahmt wkvpsrgdyt
      361 llcqvelqce gevihehnvs vhtsanylfs dlepdteyka cvrcasahhf wkwsdwmqkk
      421 frtpeaapse aldvwrdvrt engrhvvtlf wkpllksqan gkiisynivv eneanptese
      481 qysvrapalg tnlsldlhpy kihisannsa gaspeslvvl sshsgheevh ektikgikng
      541 fniswepvsg daigyvvdwc ahsqtqrcdl qwknvgpnit stiitsdafe pgvrynfrif
      601 ersveenvrl vekqrgytqe lapsvnpgvt ihnltpnsfs lkwqdyasdf qsgfikgylv
      661 ylkskelqcn pnwertvlsd ksvlckydvd dpetktltve nlrpeslyef lvtpytsagq
      721 gpnetytkvt tpdvrshmll qiilpmtlgv flsiivcywk sqwvkekcyp dipnpykssi
      781 lslikskknp hlimnvkdci pdvlevinka egsktqcvgs gklhtedvpt kpplvptekd
      841 ssgpmpfvfl enftydqsaf dsgshgfipg plkntphqlg llappnklqn vlendymksl
      901 vespteetsl iyvsqlaspi cgdkdslvtn ppmpvygsey kkqmalpgsl tsaslkennl
      961 ts
//
