LOCUS       NM_001006961            1713 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus oncostatin M (Osm), mRNA.
ACCESSION   NM_001006961 XM_223567
VERSION     NM_001006961.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1713)
  AUTHORS   Chang,R., Yi,S., Tan,X., Huang,Y., Wang,Q., Su,G., Zhou,C., Cao,Q.,
            Yuan,G., Kijlstra,A. and Yang,P.
  TITLE     MicroRNA-20a-5p suppresses IL-17 production by targeting OSM and
            CCL1 in patients with Vogt-Koyanagi-Harada disease
  JOURNAL   Br J Ophthalmol 102 (2), 282-290 (2018)
   PUBMED   28972028
REFERENCE   2  (bases 1 to 1713)
  AUTHORS   Chang,S.H., Hwang,C.S., Yin,J.H., Chen,S.D. and Yang,D.I.
  TITLE     Oncostatin M-dependent Mcl-1 induction mediated by JAK1/2-STAT1/3
            and CREB contributes to bioenergetic improvements and protective
            effects against mitochondrial dysfunction in cortical neurons
  JOURNAL   Biochim Biophys Acta 1853 (10 Pt A), 2306-2325 (2015)
   PUBMED   25986861
  REMARK    GeneRIF: findings indicated that OSM induces Mcl-1 expression via
            activation of ERK1/2, JAK1/2, STAT1/3, and CREB; furthermore,
            OSM-mediated Mcl-1 induction contributes to bioenergetic
            improvements
REFERENCE   3  (bases 1 to 1713)
  AUTHORS   Qin,S., Zou,Y. and Zhang,C.L.
  TITLE     Cross-talk between KLF4 and STAT3 regulates axon regeneration
  JOURNAL   Nat Commun 4, 2633 (2013)
   PUBMED   24129709
REFERENCE   4  (bases 1 to 1713)
  AUTHORS   Li,R., Wen,R., Banzon,T., Maminishkis,A. and Miller,S.S.
  TITLE     CNTF mediates neurotrophic factor secretion and fluid absorption in
            human retinal pigment epithelium
  JOURNAL   PLoS One 6 (9), e23148 (2011)
   PUBMED   21912637
REFERENCE   5  (bases 1 to 1713)
  AUTHORS   Brounais,B., David,E., Chipoy,C., Trichet,V., Ferre,V.,
            Charrier,C., Duplomb,L., Berreur,M., Redini,F., Heymann,D. and
            Blanchard,F.
  TITLE     Long term oncostatin M treatment induces an osteocyte-like
            differentiation on osteosarcoma and calvaria cells
  JOURNAL   Bone 44 (5), 830-839 (2009)
   PUBMED   19168167
  REMARK    GeneRIF: Results indicate that osteosarcoma cells stably producing
            OSM do not develop resistance to this cytokine and thus could be a
            valuable new tool to study the anti-cancer effect of OSM in vivo.
REFERENCE   6  (bases 1 to 1713)
  AUTHORS   Chuma,S. and Nakatsuji,N.
  TITLE     Autonomous transition into meiosis of mouse fetal germ cells in
            vitro and its inhibition by gp130-mediated signaling
  JOURNAL   Dev Biol 229 (2), 468-479 (2001)
   PUBMED   11203703
REFERENCE   7  (bases 1 to 1713)
  AUTHORS   Szpirer,C., Van Vooren,P., Riviere,M., Scohy,S., Collau,G. and
            Szpirer,J.
  TITLE     Localization of 54 rat genes, and definition of new synteny groups
            conserved in the human and the rat
  JOURNAL   Mamm Genome 11 (9), 729-735 (2000)
   PUBMED   10967130
REFERENCE   8  (bases 1 to 1713)
  AUTHORS   Mosley,B., De Imus,C., Friend,D., Boiani,N., Thoma,B., Park,L.S.
            and Cosman,D.
  TITLE     Dual oncostatin M (OSM) receptors. Cloning and characterization of
            an alternative signaling subunit conferring OSM-specific receptor
            activation
  JOURNAL   J Biol Chem 271 (51), 32635-32643 (1996)
   PUBMED   8999038
REFERENCE   9  (bases 1 to 1713)
  AUTHORS   Yamaguchi,M., Miki,N., Ono,M., Ohtsuka,C., Demura,H., Kurachi,H.,
            Inoue,M., Endo,H., Taga,T., Kishimoto,T. et al.
  TITLE     Inhibition of growth hormone-releasing factor production in mouse
            placenta by cytokines using gp130 as a signal transducer
  JOURNAL   Endocrinology 136 (3), 1072-1078 (1995)
   PUBMED   7867561
REFERENCE   10 (bases 1 to 1713)
  AUTHORS   Yin,T. and Yang,Y.C.
  TITLE     Mitogen-activated protein kinases and ribosomal S6 protein kinases
            are involved in signaling pathways shared by interleukin-11,
            interleukin-6, leukemia inhibitory factor, and oncostatin M in
            mouse 3T3-L1 cells
  JOURNAL   J Biol Chem 269 (5), 3731-3738 (1994)
   PUBMED   7508917
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Oct 3, 2022 this sequence version replaced NM_001006961.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB167521.1, SRR26643292.52454.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN06680412
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                JAXUCZ010000014.1  83327984-83328069
            87-223              JAXUCZ010000014.1  83329605-83329741
            224-1713            JAXUCZ010000014.1  83330338-83331827
FEATURES             Location/Qualifiers
     source          1..1713
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..1713
                     /gene="Osm"
                     /note="oncostatin M"
                     /db_xref="GeneID:289747"
                     /db_xref="RGD:1585012"
     exon            1..86
                     /gene="Osm"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..772
                     /gene="Osm"
                     /codon_start=1
                     /product="oncostatin-M precursor"
                     /protein_id="NP_001006962.1"
                     /db_xref="GeneID:289747"
                     /db_xref="RGD:1585012"
                     /translation="MRAQPPPRTLLSLALALLFLSMSWAKRGCSSSSPKLLSQLKSQA
                     NITGNTASLLEPYILHQNLNTLTLRAACTEHPVAFPSEDMLRQLSKPDFLSTVHATLG
                     RVWHQLGAFRQQFPKIQDFPELERARQNIQGIRNNVYCMARLLHPPLEIPEPTQADSG
                     TSRPTTTAPGIFQIKIDSCRFLWGYHRFMGSVGRVFEEWGDGSRRSRRHSPLWAWLKG
                     DHRIRPSRSSQSAMLRSLVPR"
     exon            87..223
                     /gene="Osm"
                     /inference="alignment:Splign:2.1.0"
     exon            224..1713
                     /gene="Osm"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agccaagccg tgtcacccct gagaggcacg ggccgaatca ccaggaccca gcatgcgggc
       61 tcagcctcca ccgagaacac tgcttagttt ggcccttgcg ctcctgttcc tgagcatgtc
      121 atgggccaag cgtggctgct ccagctcttc cccgaagctc ctcagccagt tgaagagtca
      181 ggcgaacatc acggggaaca cggcatcgct cttggagccc tatatcctcc accaaaacct
      241 gaacacgctc accctgagag ctgcctgcac agagcaccct gtggccttcc ccagtgagga
      301 catgctccgg cagctgagta agcctgactt cctgagcact gtgcacgcca cgctgggcag
      361 agtctggcac caactgggtg ctttcagaca gcaatttccc aagattcagg attttccaga
      421 gctggagagg gccaggcaga acatccaagg gatcaggaac aatgtttact gcatggctcg
      481 gctgctccac ccacccctgg agatccctga gcccacacag gcagactctg ggacctcacg
      541 acccactacc acagcaccag gcatctttca gatcaagata gacagctgcc gcttcctctg
      601 gggctaccat cgcttcatgg gttcagtggg gagagtcttc gaggagtggg gggatggctc
      661 caggcgcagc cggagacaca gcccactctg ggcctggctc aagggagacc acagaatcag
      721 accctcccgg agcagccaga gcgccatgct caggtccctg gtgccccggt aacctaaaga
      781 cacactgaca gacagcgtag tctgttgaga cgggatgccg cctcgtagag gccttcaaag
      841 ctactcctgt gatcagggcc acgcagaaga gcactttaag gggtgacgtt gagtgctccc
      901 tactaccact ctggaccaca aggatagtca ggtcgtggtg atcccactcc aagcctccag
      961 tcccagtggg gtggctgggt caggccacgt gtgaccagag gctttccatc gattcagggg
     1021 tctgatgaca caagctgatt caccaccggg ctgaacccct caggatgttt ggtcctttcc
     1081 tcttatgact tgaagccgtt gcctccagac ttcctccttt ccctgtggct gggttccaaa
     1141 gagaggtctg gtctggtgct ctctctctta tgcctccgtc ccactcacgc cagatacctg
     1201 gacatctggg tgacctcact ggtggcagtt gcagtggggg cagggtgtcc tagaaggagc
     1261 actgatctgg aagtttaaag gaagagagct cagagcctag tttgttccct agtatgaatg
     1321 tcagcagtgt tgtgtgtgtg ggtccttatg taatgccccc cttcctcctg tcagctggtc
     1381 tctgacagag ggtggacatc aaagtctgta aatgggaacc tatggtgcaa atggtagtgg
     1441 ggtgggctta tgggagatct cccagcgcct ggtagcccca tcttgagtcc ttgctgcttg
     1501 gtgctccctc tggtggtgtg ttgtggaatt tttcacaggc tgaaccagtc ctcttgaaga
     1561 ctctggtgag caactacttg gaaggacatg actaatttat tgttttattt tttttatcat
     1621 ttttaatctg ttttatattt ataaggtcta tttataatgt atatttaatg ttaatatttt
     1681 gctaacatat ttaaaatttg ccttgtttct aaa
//
